Blocked negative selection of developing T cells in mice expressing the baculovirus p35 caspase inhibitor

Detection of specific sequences among DNA fragments separated by gel electrophoresis

1975 • 33,059 citations

Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade

1997 • 7,177 citations

Apoptosis by Death Factor

1997 • 5,038 citations

Manipulating the mouse embryo: A laboratory manual

1986 • 4,548 citations

FLICE, A Novel FADD-Homologous ICE/CED-3–like Protease, Is Recruited to the CD95 (Fas/APO-1) Death-Inducing Signaling Complex

1996 • 3,065 citations

Two CD95 (APO-1/Fas) signaling pathways

1998 • 3,045 citations

Caspases: killer proteases

1997 • 2,440 citations

Involvement of MACH, a Novel MORT1/FADD-Interacting Protease, in Fas/APO-1- and TNF Receptor–Induced Cell Death

1996 • 2,306 citations

Caspases: Intracellular Signaling by Proteolysis

1997 • 2,114 citations

X-linked IAP is a direct inhibitor of cell-death proteases

1997 • 1,961 citations

The Staphylococcal Enterotoxins and Their Relatives

1990 • 1,914 citations

Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice

1996 • 1,902 citations

Reduced Apoptosis and Cytochrome c–Mediated Caspase Activation in Mice Lacking Caspase 9

1998 • 1,642 citations

Altered Cytokine Export and Apoptosis in Mice Deficient in Interleukin-1β Converting Enzyme

1995 • 1,625 citations

Generalized lymphoproliferative disease in mice, caused by a point mutation in the fas ligand

1994 • 1,549 citations

IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases

1998 • 1,394 citations

Differential Requirement for Caspase 9 in Apoptotic Pathways In Vivo

1998 • 1,292 citations

bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes

1991 • 1,223 citations

Changes in size and secondary structure of the ribosomal transcription unit during vertebrate evolution

1975 • 1,188 citations

The Vβ-specific superantigen staphylococcal enterotoxin B: Stimulation of mature T cells and clonal deletion in neonatal mice

1989 • 1,095 citations

T-cell apoptosis detected in situ during positive and negative selection in the thymus

1994 • 1,071 citations

Negative selection of lymphocytes

1994 • 810 citations

Defects in regulation of apoptosis in caspase-2-deficient mice

1998 • 688 citations

IMMUNE REGULATION BY CD40 AND ITS LIGAND GP39

1996 • 653 citations

Inhibition of ICE Family Proteases by Baculovirus Antiapoptotic Protein p35

1995 • 645 citations

Caspases and caspase inhibitors

1997 • 573 citations

Target Protease Specificity of the Viral Serpin CrmA

1997 • 517 citations

Targeted mutation in the Fas gene causes hyperplasia in peripheral lymphoid organs and liver

1995 • 377 citations

Involvement of p21ras distinguishes positive and negative selection in thymocytes.

1995 • 278 citations

A Role for FADD in T Cell Activation and Development

1998 • 241 citations

Dissection of thymocyte signaling pathways by in vivo expression of pertussis toxin ADP-ribosyltransferase.

1990 • 235 citations

Interaction of the Baculovirus Anti-apoptotic Protein p35 with Caspases. Specificity, Kinetics, and Characterization of the Caspase/p35 Complex

1998 • 212 citations

Enhanced and accelerated lymphoproliferation in Fas-null mice.

1996 • 211 citations

Intrathymic and extrathymic clonal deletion of T cells

1995 • 201 citations

Selective apoptosis of CD4+CD8+ thymocytes by the anti-Fas antibody.

1995 • 197 citations

Positive and Negative Selection in Transgenic Mice Expressing a T-Cell Receptor Specific for Influenza Nucleoprotein and Endogenous Superantigen

1993 • 181 citations

The fight of viruses against apoptosis

1998 • 177 citations

CrmA expression in T lymphocytes of transgenic mice inhibits CD95 (Fas/APO-1)-transduced apoptosis, but does not cause lymphadenopathy or autoimmune disease.

1996 • 174 citations

Apoptotic suppression by baculovirus P35 involves cleavage by and inhibition of a virus-induced CED-3/ICE-like protease

1996 • 170 citations

A Role for Fas in Negative Selection of Thymocytes In Vivo

1998 • 167 citations

Different Interleukin-1β Converting Enzyme (ICE) Family Protease Requirements for the Apoptotic Death of T Lymphocytes Triggered by Diverse Stimuli

1996 • 164 citations

Fas Modulation of Apoptosis during Negative Selection of Thymocytes

1996 • 162 citations

Thymic depletion and peripheral activation of class I major histocompatibility complex-restricted T cells by soluble peptide in T-cell receptor transgenic mice.

1992 • 149 citations

Spodoptera frugiperda Caspase-1, a Novel Insect Death Protease That Cleaves the Nuclear Immunophilin FKBP46, Is the Target of the Baculovirus Antiapoptotic Protein p35

1997 • 143 citations

Caspase activity is required for commitment to Fas-mediated apoptosis

1997 • 132 citations

Developmental regulation of lck gene expression in T lymphocytes.

1991 • 124 citations

Activation of caspase-3-like enzymes in non-apoptotic T cells

1998 • 105 citations

The apoptotic suppressor P35 is required early during baculovirus replication and is targeted to the cytosol of infected cells

1994 • 100 citations

Specific Activation of the Cysteine Protease CPP32 during the Negative Selection of T Cells in the Thymus

1997 • 92 citations

The Bacterial and Mouse Mammary Tumor Virus Superantigens; Two Different Families of Proteins with the Same Functions

1993 • 91 citations

T-cell receptor ligation by peptide/MHC induces activation of a caspase in immature thymocytes: the molecular basis of negative selection

1997 • 88 citations

TNF Receptor-Deficient Mice Reveal Striking Differences Between Several Models of Thymocyte Negative Selection

1998 • 84 citations

T cell deletion follows chronic antigen specific T cell activation in vivo

1993 • 68 citations

Identification of transgenic mice carrying the CAT gene with PCR amplification.

1989 • 43 citations