Functional redundancy of the Nur77 and Nor-1 orphan steroid receptors in T-cell apoptosis

Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.

1992 • 9,540 citations

Rapid detection of octamer binding proteins with ‘mini extracts’, prepared from a small number of cells

1989 • 4,279 citations

The Fas Death Factor

1995 • 4,070 citations

Role of the Ubiquitin-Proteasome Pathway in Regulating Abundance of the Cyclin-Dependent Kinase Inhibitor p27

1995 • 1,848 citations

Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair

1993 • 1,638 citations

Generalized lymphoproliferative disease in mice, caused by a point mutation in the fas ligand

1994 • 1,549 citations

Lpr and gld: Single Gene Models of Systemic Autoimmunity and Lymphoproliferative Disease

1991 • 1,185 citations

Induction of apoptosis in mature T cells by tumour necrosis factor

1995 • 1,139 citations

T-cell apoptosis detected in situ during positive and negative selection in the thymus

1994 • 1,071 citations

Steroid Receptor Family: Structure and Functions

1990 • 820 citations

Negative selection of lymphocytes

1994 • 810 citations

Nerve growth factor induces a gene homologous to the glucocorticoid receptor gene

1988 • 661 citations

Unique response pathways are established by allosteric interactions among nuclear hormone receptors

1995 • 629 citations

Requirement for the orphan steroid receptor Nur77 in apoptosis of T-cell hybridomas

1994 • 571 citations

Identification of the DNA Binding Site for NGFI-B by Genetic Selection in Yeast

1991 • 566 citations

Positive selection of lymphocytes

1994 • 563 citations

Apoptotic signals delivered through the T-cell receptor of a T-cell hybrid require the immediate–early gene nur77

1994 • 551 citations

A novel pathway for vitamin A signaling mediated by RXR heterodimerization with NGFI-B and NURR1.

1995 • 548 citations

A gene inducible by serum growth factors encodes a member of the steroid and thyroid hormone receptor superfamily.

1988 • 532 citations

Selective Events in T Cell Development

1994 • 486 citations

The orphan receptors NGFI-B and steroidogenic factor 1 establish monomer binding as a third paradigm of nuclear receptor-DNA interaction.

1993 • 397 citations

Identification of a new brain-specific transcription factor, NURR1.

1992 • 373 citations

Identification of Human and Mouse p19, a Novel CDK4 and CDK6 Inhibitor with Homology to p16^ink4

1995 • 336 citations

A role for the orphan steroid receptor Nur77 in apoptosis accompanying antigen-induced negative selection

1995 • 305 citations

Unimpaired Thymic and Peripheral T Cell Death in Mice Lacking the Nuclear Receptor NGFI-B (Nur77)

1995 • 273 citations

The Role of APO‐1‐Mediated Apoptosis in the Immune System

1994 • 242 citations

Die and Let Live: Eliminating Dangerous Lymphocytes

1996 • 242 citations

Dissection of thymocyte signaling pathways by in vivo expression of pertussis toxin ADP-ribosyltransferase.

1990 • 235 citations

Regulation of the Nur77 Orphan Steroid Receptor in Activation-Induced Apoptosis

1995 • 216 citations

Structure, mapping and expression of a growth factor inducible gene encoding a putative nuclear hormonal binding receptor.

1989 • 188 citations

Molecular Cloning of a Novel Thyroid/Steroid Receptor Superfamily Gene from Cultured Rat Neuronal Cells

1994 • 187 citations

Inhibition of Nur77/Nurr1 leads to inefficient clonal deletion of self-reactive T cells.

1996 • 161 citations

Peptides in positive and negative selection: A delicate balance

1994 • 153 citations

Adrenocortical Function and Regulation of the Steroid 21-Hydroxylase Gene in NGFI-B-Deficient Mice

1995 • 146 citations

Functional domains and phosphorylation of the orphan receptor Nur77.

1993 • 128 citations

Apoptosis of nur77/N10-transgenic thymocytes involves the Fas/Fas ligand pathway.

1996 • 126 citations

Domains regulating transcriptional activity of the inducible orphan receptor NGFI-B.

1992 • 110 citations

A Human Early Response Gene Homologous to Murine nur77 and Rat NGFI-B, and Related to the Nuclear Receptor Superfamily

1990 • 110 citations

Constitutive Expression of Bcl-3 in Thymocytes Increases the DNA Binding of NF-κB1 (p50) Homodimers In Vivo

1996 • 98 citations

NOT, a human immediate-early response gene closely related to the steroid/thyroid hormone receptor NAK1/TR3.

1994 • 95 citations

Autocrine Feedback Death and the Regulation of Mature T Lymphocyte Antigen Responses

1995 • 72 citations

The isolation and characterization of MINOR, a novel mitogen-inducible nuclear orphan receptor.

1995 • 67 citations

The Orphan Receptors NGFI-B and Steroidogenic Factor 1 Establish Monomer Binding as a Third Paradigm of Nuclear Receptor-DNA Interaction

1993 • 62 citations

Chronic treatment of C3H-lpr/lpr and C3H-gld/gld mice with anti-CD8 monoclonal antibody prevents the accumulation of double negative T cells but not autoantibody production.

1994 • 56 citations

Overexpression of RelA in Transgenic Mouse Thymocytes: Specific Increase in Levels of the Inhibitor Protein IκBα

1995 • 49 citations

Selective Events in T Cell Development

1994 • 37 citations