Lymphostromal interactions in thymic development and function

Deficient T Cell Fate Specification in Mice with an Induced Inactivation of Notch1

1999 • 1,392 citations

Fate of the mammalian cardiac neural crest

2000 • 1,123 citations

Notch1 Expression in Early Lymphopoiesis Influences B versus T Lineage Determination

1999 • 956 citations

Heparan sulphate bound growth factors: a mechanism for stromal cell mediated haemopoiesis

1988 • 845 citations

Pax9-deficient mice lack pharyngeal pouch derivatives and teeth and exhibit craniofacial and limb abnormalities

1998 • 817 citations

Expression of relB is required for the development of thymic medulla and dendritic cells

1995 • 794 citations

Transient Notch Activation Initiates an Irreversible Switch from Neurogenesis to Gliogenesis by Neural Crest Stem Cells

2000 • 715 citations

New member of the winged-helix protein family disrupted in mouse and rat nude mutations

1994 • 651 citations

FGF10 Acts as a Major Ligand for FGF Receptor 2 IIIb in Mouse Multi-Organ Development

2000 • 617 citations

Cellular Interactions in Thymocyte Development

1996 • 503 citations

An Activated Form of Notch Influences the Choice between CD4 and CD8 T Cell Lineages

1996 • 488 citations

Early T Lymphocyte Progenitors

1996 • 473 citations

Dependence of Thymus Development on Derivatives of the Neural Crest

1984 • 463 citations

Two Genetically Separable Steps in the Differentiation of Thymic Epithelium

1996 • 447 citations

RelB Is Essential for the Development of Myeloid-Related CD8α− Dendritic Cells but Not of Lymphoid-Related CD8α+ Dendritic Cells

1998 • 443 citations

The role of Hoxa-3 in mouse thymus and thyroid development

1995 • 421 citations

Defects in limb, craniofacial, and thymic development in Jagged2 mutant mice

1998 • 409 citations

Tracing of cells of the avian thymus through embryonic life in interspecific chimeras.

1975 • 409 citations

Notch Activity Influences the αβ versus γδ T Cell Lineage Decision

1997 • 399 citations

Shaping of the autoreactive T-cell repertoire by a splice variant of self protein expressed in thymic epithelial cells

2000 • 399 citations

Mapping Precursor Movement through the Postnatal Thymus Reveals Specific Microenvironments Supporting Defined Stages of Early Lymphoid Development

2001 • 394 citations

Constitutive activation of NF-kappaB and T-cell leukemia/lymphoma in Notch3 transgenic mice

2000 • 365 citations

MHC class II-positive epithelium and mesenchyme cells are both required for T-cell development in the thymus

1993 • 359 citations

Correlating Notch Signaling with Thymocyte Maturation

1998 • 350 citations

Morphogenetic interactions in the development of the mouse thymus gland

1960 • 336 citations

Effect of deoxyguanosine on lymphopoiesis in the developing thymus rudiment in vitro: Application in the production of chimeric thymus rudiments

1982 • 324 citations

Inactivation of Notch1 in immature thymocytes does not perturb CD4 or CD8 T cell development

2001 • 300 citations

Developmental control point in induction of thymic cortex regulated by a subpopulation of prothymocytes

1995 • 295 citations

Interdependence of cortical thymic epithelial cell differentiation and T-lineage commitment

1998 • 292 citations

Development in the thymus: it takes two to tango

1993 • 281 citations

Crosstalk in the mouse thymus

1994 • 275 citations

Development of thymus, parathyroids, and ultimo‐branchial bodies in NMRI and nude mice

1980 • 264 citations

Fibroblast Growth Factor Receptor 2-IIIb Acts Upstream of Shh and Fgf4 and Is Required for Limb Bud Maintenance but Not for the Induction of Fgf8, Fgf10, Msx1, or Bmp4

2001 • 262 citations

Normal Thymic Architecture and Negative Selection Are Associated with Aire Expression, the Gene Defective in the Autoimmune-Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy (APECED)

2000 • 261 citations

Jagged2: A Serrate-like Gene Expressed during Rat Embryogenesis

1996 • 243 citations

Development of the Thymus Requires Signaling Through the Fibroblast Growth Factor Receptor R2-IIIb

2001 • 241 citations

Pax1 is expressed during development of the thymus epithelium and is required for normal T-cell maturation

1996 • 228 citations

The nu gene acts cell-autonomously and is required for differentiation of thymic epithelial progenitors.

1996 • 225 citations

Cutting Edge: Protective Effects of Notch-1 on TCR-Induced Apoptosis

1999 • 223 citations

Stepwise development of thymic microenvironments in vivo is regulated by thymocyte subsets

2000 • 219 citations

Identification of pro-thymocytes in murine fetal blood: T lineage commitment can precede thymus colonization.

1994 • 206 citations

Bone marrow origin of Ia-positive cells in the medulla rat thymus.

1981 • 197 citations

Expression pattern of Notch1, 2 and 3 and Jagged1 and 2 in lymphoid and stromal thymus components: distinct ligand–receptor interactions in intrathymic T cell development

1999 • 197 citations

Thymic epithelial cells provide unique signals for positive selection of CD4+CD8+ thymocytes in vitro.

1994 • 197 citations

A Role for Pref-1 and HES-1 in Thymocyte Development

2000 • 196 citations

Disorganization and restoration of thymic medullary epithelial cells in T cell receptor‐negative scid mice: Evidence that receptor‐bearing lymphocytes influence maturation of the thymic microenvironment

1991 • 190 citations

Peripheral-antigen-expressing cells in thymic medulla: factors in self-tolerance and autoimmunity

1998 • 188 citations

Thymic emigration: conveyor belts or lucky dips?

1995 • 186 citations

Pancreatic gene expression in rare cells of thymic medulla: evidence for functional contribution to T cell tolerance

1997 • 183 citations

Notch1 Regulates Maturation of CD4+ and CD8+ Thymocytes by Modulating TCR Signal Strength

2001 • 182 citations

Commitment of Common T/Natural Killer (Nk) Progenitors to Unipotent T and Nk Progenitors in the Murine Fetal Thymus Revealed by a Single Progenitor Assay

1999 • 169 citations

Ontogeny of primary lymphoid organs and lymphoid stem cells

1984 • 169 citations

CD4 T Cell Tolerance to Human C-reactive Protein, an Inducible Serum Protein, Is Mediated by Medullary Thymic Epithelium

1998 • 162 citations

Thymus organogenesis and molecular mechanisms of thymic epithelial cell differentiation

2000 • 162 citations

Fibroblast growth factor receptors (FGFRs) and their roles in limb development

1999 • 160 citations

Receptor editing in developing T cells

2000 • 157 citations

An Essential Role for Thymic Mesenchyme in Early T Cell Development

2000 • 157 citations

Proneural gene self-stimulation in neural precursors: an essential mechanism for sense organ development that is regulated byNotch signaling

1998 • 154 citations

Notch signaling in T cell development

2000 • 141 citations

Thymic microenvironments, 3-D versus 2-D?

1999 • 139 citations

Molecular and Cellular Events in Early Thymocyte Development 11Received for publication October 14, 1997

1998 • 137 citations

In Thymic Selection, Peptide Diversity Gives and Takes Away

1997 • 136 citations

Self-antigen presentation by thymic stromal cells: a subtle division of labor

2000 • 135 citations

Signal strength in thymic selection and lineage commitment

2001 • 132 citations

Growth of epithelial cells in the thymic medulla is under the control of mature T cells.

1992 • 128 citations

Production, selection, and maturation of thymocytes with high surface density of TCR.

1994 • 113 citations

Stat3 in Thymic Epithelial Cells Is Essential for Postnatal Maintenance of Thymic Architecture and Thymocyte Survival

2001 • 109 citations

Recent thymic emigrants are distinct from most medullary thymocytes

1997 • 108 citations

REGULATION OF T CELL FATE BY NOTCH

1999 • 105 citations

Anergy induced by thymic medullary epithelium

1992 • 101 citations

Requirement for the Thymus in αβ T Lymphocyte Lineage Commitment

1998 • 99 citations

Heparan Sulfate Proteoglycans Mediate Interleukin-7– Dependent B Lymphopoiesis

1999 • 89 citations

Presence of progenitors restricted to T, B, or myeloid lineage, but absence of multipotent stem cells, in the murine fetal thymus.

1998 • 84 citations

Thymic cortical epithelium is sufficient for the development of mature T cells in relB-deficient mice.

1997 • 83 citations

Thymic selection and cell division.

1995 • 83 citations

CD69 Expression Discriminates MHC-Dependent and -Independent Stages of Thymocyte Positive Selection

1999 • 83 citations

Hoxa3 and Pax1 Transcription Factors Regulate the Ability of Fetal Thymic Epithelial Cells to Promote Thymocyte Development

2000 • 80 citations

Fibroblast dependency during early thymocyte development maps to the CD25⁺ CD44⁺ stage and involves interactions with fibroblast matrix molecules

1997 • 78 citations

A Kinetic Window Constricts the T Cell Receptor Repertoire in the Thymus

2001 • 76 citations

An Essential Role for the IL-7 Receptor During Intrathymic Expansion of the Positively Selected Neonatal T Cell Repertoire

2000 • 73 citations

Identification of a Committed T Cell Precursor Population in Adult Human Peripheral Blood

1997 • 72 citations

Cutting Edge: Presence of Progenitors Restricted to T, B, or Myeloid Lineage, but Absence of Multipotent Stem Cells, in the Murine Fetal Thymus

1998 • 71 citations

Emergence of T, B, and Myeloid Lineage-Committed as well as Multipotent Hemopoietic Progenitors in the Aorta-Gonad- Mesonephros Region of Day 10 Fetuses of the Mouse

1999 • 68 citations

Emergence of T Cell Progenitors Without B Cell or Myeloid Differentiation Potential at the Earliest Stage of Hematopoiesis in the Murine Fetal Liver

1999 • 68 citations

Expression of The αβ T‐Cell Receptor Is Necessary for The Generation of The Thymic Medulla

1993 • 65 citations

Cell migration and the anatomic control of thymocyte precursor differentiation

2000 • 59 citations

Lineage commitment and differentiation of T and natural killer lymphocytes in the fetal mouse

1998 • 54 citations

A Common Stem Cell for Murine Cortical and Medullary Thymic Epithelial Cells?

1994 • 49 citations

Distinct Mechanisms Contribute to Generate and Change the CD4:CD8 Cell Ratio During Thymus Development: A Role for the Notch Ligand, Jagged1

2001 • 46 citations

Thymocytes and RelB‐dependent medullary epithelial cells provide growth‐promoting and organization signals, respectively, to thymic medullary stromal cells

1997 • 46 citations

Studies on the role of IL-7 presentation by mesenchymal fibroblasts during early thymocyte development

2000 • 46 citations

Identification of a Developmentally Regulated Phase of Postselection Expansion Driven by Thymic Epithelium

1998 • 46 citations

T cell function and expression are dramatically altered in T cell receptor Vγ1.1Jγ4Cγ4 transgenic mice

1989 • 44 citations

Roles of Integrins and CD44 on the Adhesion and Migration of Fetal Liver Cells to the Fetal Thymus

1999 • 39 citations

Epidermal growth factor can replace thymic mesenchyme in induction of embryonic thymus morphogenesis in vitro

1996 • 37 citations

Discrimination between maintenance‐ and differentiation‐inducing signals during initial and intermediate stages of positive selection

1997 • 35 citations

Studies in vitro on the mechanism of the epithelial/mesenchymal interaction in the early fetal thymus

1997 • 35 citations

The Role of Mesenchyme in Thymus Development

2000 • 32 citations

Phenotypic identification of the subgroups of murine T‐cell receptor αβ⁺ CD4⁺ CD8⁻ thymocytes and its implication in the late stage of thymocyte development

1999 • 31 citations

Threshold of pre-T-cell-receptor surface expression is associated with αβ T-cell lineage commitment

1999 • 27 citations

Thymic Medulla Epithelial Cells Acquire Specific Markers by Post-Mitotic Maturation

1996 • 26 citations

Positive Selection by Purified MHC Class II / Thymic Epithelial CellsIn Vitro: Costimulatory Signals Mediated by B7 Are Not Involved

1993 • 24 citations

Immunodeficiency: Trapping the nude mouse gene

1995 • 21 citations

Developing Thymocytes Organize Thymic Microenvironments

2000 • 16 citations

Establishment of efficient reaggregation culture system for gene transfection into immature T cells by retroviral vectors

2000 • 13 citations

Thymus Epithelial Cell Reaggregate Grafts

2000 • 11 citations

Protocols for high efficiency, stage-specific retroviral transduction of murine fetal thymocytes and thymic epithelial cells

2001 • 11 citations

The role of cell traffic in the emergence of the T lymphoid system

2000 • 9 citations

Role of β1 Integrin for Hemato-Lymphopoiesis in Mouse Development

2000 • 4 citations

InVivoDetection of Intracellular Signaling Pathways in Developing Thymocytes

2000 • 4 citations

Ia Positive Cells in the Medulla of Rat Thymus are Bone Marrow Derived

1982 • 2 citations

Genetic modulation of immature T lymphocytes and its application.

2001 • 2 citations

Essential defects of athymic nude mice affect also the nu/+heterozygotes

1998 • 1 citations