Induction of the Early Growth Response (Egr) Family of Transcription Factors during Thymic Selection

Zinc Finger-DNA Recognition: Crystal Structure of a Zif268-DNA Complex at 2.1 Å

1991 • 2,034 citations

A zinc finger-encoding gene coregulated with c-fos during growth and differentiation, and after cellular depolarization

1988 • 1,278 citations

A Nerve Growth Factor-Induced Gene Encodes a Possible Transcriptional Regulatory Factor

1987 • 1,217 citations

T-cell apoptosis detected in situ during positive and negative selection in the thymus

1994 • 1,071 citations

β2-Microglobulin deficient mice lack CD4−8+ cytolytic T cells

1990 • 997 citations

Identifying differences in mRNA expression by representational difference analysis of cDNA

1994 • 904 citations

A gene activated in mouse 3T3 cells by serum growth factors encodes a protein with "zinc finger" sequences.

1988 • 733 citations

Cyclosporin A Specifically Inhibits Function of Nuclear Proteins Involved in T Cell Activation

1989 • 679 citations

Depletion of CD4 ⁺ T Cells in Major Histocompatibility Complex Class II-Deficient Mice

1991 • 673 citations

Selective development of CD4+ T cells in transgenic mice expressing a class II MHC-restricted antigen receptor

1989 • 646 citations

Early Growth Response Protein 1 (Egr-1): Prototype of a Zinc-finger Family of Transcription Factors

1995 • 593 citations

Two mouse genes encoding potential transcription factors with identical DNA-binding domains are activated by growth factors in cultured cells.

1988 • 580 citations

DNA binding site of the growth factor-inducible protein Zif268.

1989 • 563 citations

Egr-1-Induced Endothelial Gene Expression: A Common Theme in Vascular Injury

1996 • 525 citations

Crucial role of the pre-T-cell receptor α gene in development of ap but not γδ T cells

1995 • 519 citations

Disruption of Krox-20 results in alteration of rhombomeres 3 and 5 in the developing hindbrain

1993 • 452 citations

A gene encoding a protein with zinc fingers is activated during G0/G1 transition in cultured cells.

1988 • 428 citations

Selective requirement for MAP kinase activation in thymocyte differentiation

1995 • 398 citations

The zinc finger transcription factor Egr-1 is essential for and restricts differentiation along the macrophage lineage

1993 • 384 citations

Cloning of tetradecanoyl phorbol ester-induced 'primary response' sequences and their expression in density-arrested Swiss 3T3 cells and a TPA non-proliferative variant.

1987 • 360 citations

Effects of Cyclosporine A on T Cell Development and Clonal Deletion

1988 • 354 citations

Identification and characterization of the Egr-1 gene product, a DNA-binding zinc finger protein induced by differentiation and growth signals.

1990 • 343 citations

Activation events during thymic selection.

1992 • 326 citations

A role for the orphan steroid receptor Nur77 in apoptosis accompanying antigen-induced negative selection

1995 • 305 citations

DNA-Binding Specificity of NGFI-A and Related Zinc Finger Transcription Factors

1995 • 304 citations

Molecular cloning, sequencing, and mapping of EGR2, a human early growth response gene encoding a protein with "zinc-binding finger" structure.

1988 • 301 citations

A novel early growth response gene rapidly induced by fibroblast, epithelial cell and lymphocyte mitogens.

1987 • 292 citations

Abnormal differentiation of thymocytes in mice treated with cyclosporin A

1988 • 281 citations

Involvement of p21ras distinguishes positive and negative selection in thymocytes.

1995 • 278 citations

Identification of NAB1, a repressor of NGFI-A- and Krox20-mediated transcription.

1995 • 258 citations

Negative selection of CD4+CD8+ thymocytes by T cell receptor-induced apoptosis requires a costimulatory signal that can be provided by CD28.

1994 • 257 citations

CD 69 expression during selection and maturation of CD4⁺8⁺ thymocytes

1993 • 242 citations

A novel repression module, an extensive activation domain, and a bipartite nuclear localization signal defined in the immediate-early transcription factor Egr-1.

1993 • 223 citations

EGR3, a novel member of the Egr family of genes encoding immediate-early transcription factors.

1991 • 218 citations

The early response gene NGFI-C encodes a zinc finger transcriptional activator and is a member of the GCGGGGGCG (GSG) element-binding protein family.

1991 • 201 citations

The accessory function of murine intercellular adhesion molecule-1 in T lymphocyte activation. Contributions of adhesion and co-activation.

1991 • 197 citations

Detection and characterization of cellular EGR-1 binding to its recognition site

1993 • 193 citations

Early transcriptional events in cell growth

1990 • 192 citations

In vivo and in vitro clonal deletion of double-positive thymocytes.

1992 • 172 citations

Growth and Differentiation Proceeds Normally in Cells Deficient in the Immediate Early Gene NGFI-A

1995 • 165 citations

Transcriptional Regulation of the Tissue Factor Gene in Human Epithelial Cells Is Mediated by Sp1 and EGR-1

1996 • 160 citations

Structure, chromosome location, and expression of the mouse zinc finger gene Krox-20: multiple gene products and coregulation with the proto-oncogene c-fos.

1989 • 155 citations

Involvement of p21^ras activation in T cell CD69 expression

1994 • 154 citations

A Regulatory Element in the Human Interleukin 2 Gene Promoter Is a Binding Site for the Zinc Finger Proteins Sp1 and EGR-1

1995 • 150 citations

Complexity of the primary genetic response to mitogenic activation of human T cells.

1989 • 149 citations

Activation of the inducible orphan receptor gene nur77 by serum growth factors: dissociation of immediate-early and delayed-early responses.

1993 • 138 citations

Transcriptional regulation of the Icam-1 gene in antigen receptor- and phorbol ester-stimulated B lymphocytes: role for transcription factor EGR1.

1996 • 127 citations

Characterization of an Krox-24/Egr-1-responsive element in the human tumor necrosis factor promoter

1994 • 126 citations

Transcriptional Regulation of the Gene Encoding the Human C-type Lectin Leukocyte Receptor AIM/CD69 and Functional Characterization of Its Tumor Necrosis Factor-α-responsive Elements

1995 • 123 citations

The Zinc Finger Transcription Factor Egr-1 Potentiates Macrophage Differentiation of Hematopoietic Cells

1995 • 120 citations

Regulation of RAG‐1 and CD69 expression in the thymus during positive and negative selection

1994 • 112 citations

Identification and Characterization of the Egr-1 Gene Product, a DNA-Binding Zinc Finger Protein Induced by Differentiation and Growth Signals

1990 • 108 citations

Molecular basis for developmental changes in interleukin-2 gene inducibility.

1993 • 96 citations

Transcriptional activity of the zinc finger protein NGFI-A is influenced by its interaction with a cellular factor.

1993 • 94 citations

Expression of the nerve growth factor-regulated NGFI-A and NGFI-B genes in the developing rat

1990 • 93 citations

p21ras function is important for T cell antigen receptor and protein kinase C regulation of nuclear factor of activated T cells.

1993 • 91 citations

Identification of residues critical for Ras(17N) growth-inhibitory phenotype and for Ras interaction with guanine nucleotide exchange factors.

1994 • 90 citations

The thymic compartment responsible for positive selection of CD4⁺ T cells

1992 • 89 citations

Differential expression of a zinc finger-encoding gene in response to positive versus negative signaling through receptor immunoglobulin in murine B lymphocytes.

1989 • 86 citations

Role of EGR1 in Regulation of Stimulus-Dependent CD44 Transcription in B Lymphocytes

1996 • 85 citations

Egr-1 expression in surface Ig-mediated B cell activation. Kinetics and association with protein kinase C activation.

1990 • 82 citations

Methylation of an Immediate-Early Inducible Gene as a Mechanism for B Cell Tolerance Induction

1990 • 74 citations

A Novel Repression Module, an Extensive Activation Domain, and a Bipartite Nuclear Localization Signal Defined in the Immediate-Early Transcription Factor Egr-1

1993 • 66 citations

Differentiation of an immature T cell line: A model of thymic positive selection

1992 • 63 citations

NGFI-A gene expression is necessary for T lymphocyte proliferation.

1993 • 61 citations

Activation of the p21ras pathway couples antigen receptor stimulation to induction of the primary response gene egr-1 in B lymphocytes.

1995 • 54 citations

Mitogen-induced genes are subject to multiple pathways of regulation in the initial stages of T-cell activation.

1989 • 54 citations

The Early Response Gene NGFI-C Encodes a Zinc Finger Transcriptional Activator and Is a Member of the GCGGGGGCG (GSG) Element-Binding Protein Family

1991 • 54 citations

Intracellular signaling events during positive and negative selection of CD4+CD8+ thymocytes in vitro.

1995 • 53 citations

Complexity of the Primary Genetic Response to Mitogenic Activation of Human T Cells

1989 • 50 citations

The Phosphorylated Forms of the Transcription Factor, Egr-1, Bind to DNA More Efficiently than Non-phosphorylated

1994 • 44 citations

Cyclosporin A-mediated inhibition of mitogen-induced gene transcription is specific for the mitogenic stimulus and cell type.

1989 • 43 citations

Expression of PILOT, a putative transcription factor, requires two signals and is cyclosporin A sensitive in T cells

1993 • 42 citations

Clone pAT 133 identifies a gene that encodes another human member of a class of growth factor-induced genes with almost identical zinc-finger domains.

1991 • 41 citations

Structure, Chromosome Location, and Expression of the Mouse Zinc Finger Gene Krox-20: Multiple Gene Products and Coregulation with the Proto-Oncogene c-fos

1989 • 38 citations

Generation of mature T cell populations in the thymus: CD4 or CD8 down‐regulation occurs at different stages of thymocyte differentiation

1994 • 36 citations

Phorbol ester-mediated inhibition of growth and regulation of proto-oncogene expression in the human T cell leukemia line JURKAT.

1991 • 31 citations

Molecular Basis for Developmental Changes in Interleukin-2 Gene Inducibility

1993 • 30 citations

Identification of Residues Critical for Ras(17N) Growth-Inhibitory Phenotype and for Ras Interaction with Guanine Nucleotide Exchange Factors

1994 • 23 citations

Transcriptional Activity of the Zinc Finger Protein NGFI-A Is Influenced by Its Interaction with a Cellular Factor

1993 • 21 citations

Activation of the Inducible Orphan Receptor Gene nur77 by Serum Growth Factors: Dissociation of Immediate-Early and Delayed-Early Responses

1993 • 20 citations

Mitogen-Induced Genes Are Subject to Multiple Pathways of Regulation in the Initial Stages of T-Cell Activation

1989 • 19 citations

Differential Expression of a Zinc Finger-Encoding Gene in Response to Positive versus Negative Signaling through Receptor Immunoglobulin in Murine B Lymphocytes

1989 • 19 citations

Discrimination between thymic epithelial cells and peripheral antigen-presenting cells in the induction of immature T cell differentiation

1994 • 18 citations

The EGR1 Protein Contains a Discrete Transcriptional Regulatory Domain Whose Deletion Results in a Truncated Protein That Blocks EGR1-Induced Transcription

1995 • 17 citations

Fc gamma RII cross-linking inhibits anti-Ig-induced erg-1 and erg-2 expression in BCL1.

1994 • 10 citations

Contrast between class I and class II MHC-mediated differentiation of a CD4⁺CD8⁺ T cell line: implications for lineage commitment

1995 • 6 citations

Effects of IL-4 and Fcγ receptor II engagement on Egr-1 expression during stimulation of B lymphocytes by membrane immunoglobulin crosslinking

1993 • 4 citations

Requirements for Differentiation of an Immature CD4⁺8⁺ T‐Cell Line

1997 • 1 citations