Positive Selection Through a Motif in the αβ T Cell Receptor

T cell tolerance by clonal elimination in the thymus

1987 • 2,248 citations

Restriction of in vitro T cell-mediated cytotoxicity in lymphocytic choriomeningitis within a syngeneic or semiallogeneic system

1974 • 2,058 citations

Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes

1988 • 1,711 citations

Positive selection of antigen-specific T cells in thymus by restricting MHC molecules

1988 • 618 citations

Exclusion and inclusion of α and β T cell receptor alleles

1992 • 346 citations

H-2 antigens of the thymus determinelymphocyte specificity

1978 • 321 citations

Impaired Negative Selection of T Cells in Hodgkin's Disease Antigen CD30–Deficient Mice

1996 • 316 citations

Involvement of p21ras distinguishes positive and negative selection in thymocytes.

1995 • 278 citations

Negative selection of CD4+CD8+ thymocytes by T cell receptor-induced apoptosis requires a costimulatory signal that can be provided by CD28.

1994 • 257 citations

Clonal deletion of immature CD4+8+ thymocytes in suspension culture by extrathymic antigen-presenting cells

1991 • 249 citations

Positive and negative selection invoke distinct signaling pathways.

1996 • 234 citations

CD3delta deficiency arrests development of the alpha beta but not the gamma delta T cell lineage

1997 • 209 citations

Asymmetric signaling requirements for thymocyte commitment to the CD4+ versus CD8+ T cell lineages: A new perspective on thymic commitment and selection

1995 • 207 citations

T cell tolerance to Mlsa encoded antigens in T cell receptor V beta 8.1 chain transgenic mice.

1989 • 182 citations

Most gamma delta T cells develop normally in beta 2-microglobulin-deficient mice.

1992 • 147 citations

Two signals are required for negative selection of CD4+CD8+ thymocytes.

1993 • 143 citations

A Motif within the T Cell Receptor α Chain Constant Region Connecting Peptide Domain Controls Antigen Responsiveness

1996 • 102 citations

Structure and diversity of the TCR alpha-chain in a teleost fish.

1996 • 97 citations

Raf regulates positive selection

1996 • 90 citations

Most gamma delta T cells develop normally in the absence of MHC class II molecules.

1993 • 72 citations

Positive selection is not required for thymic maturation of transgenic gamma delta T cells.

1996 • 66 citations

Developmental regulation of the TCR zeta-chain. Differential expression and tyrosine phosphorylation of the TCR zeta-chain in resting immature and mature T lymphocytes.

1994 • 38 citations

An analysis of sequence variation in the β chain framework and complementarity determining regions of an allo-reactive T cell receptor

1994 • 23 citations

T cell receptor α‐chain tail is required for protein kinase C‐mediated down‐regulation, but not for signaling

1997 • 20 citations

Flow‐cytometric analysis of apoptotic and nonapoptotic T‐cell receptor‐transgenic thymocytes following in vitro presentation of antigen

1994 • 19 citations