Impact of Negative Selection on the T Cell Repertoire Reactive to a Self-Peptide

Phenotypic Analysis of Antigen-Specific T Lymphocytes

1996 • 3,611 citations

Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes

1988 • 1,711 citations

Evidence for a differential avidity model of T cell selection in the thymus

1994 • 679 citations

The sizes of the CDR3 hypervariable regions of the murine T-cell receptor beta chains vary as a function of the recombined germ-line segments.

1993 • 664 citations

Human T-cell receptor variable gene segment families

1995 • 663 citations

T-cell-receptor affinity and thymocyte positive selection

1996 • 620 citations

Down-regulation of T cell receptors on self-reactive T cells as a novel mechanism for extrathymic tolerance induction

1991 • 523 citations

Detection of Antigen-Specific T Cells with Multivalent Soluble Class II MHC Covalent Peptide Complexes

1998 • 465 citations

Antigen-Specific Development of Primary and Memory T Cells in Vivo

1995 • 444 citations

A TCR Binds to Antagonist Ligands with Lower Affinities and Faster Dissociation Rates Than to Agonists

1996 • 430 citations

Isolation of High Avidity Melanoma-Reactive CTL from Heterogeneous Populations Using Peptide-MHC Tetramers

1999 • 423 citations

The Repertoire of T Cells Shaped by a Single MHC/Peptide Ligand

1996 • 417 citations

Low avidity recognition of self-antigen by T cells permits escape from central tolerance

1995 • 415 citations

In transgenic mice the introduced functional T cell receptor β gene prevents expression of endogenous β genes

1988 • 374 citations

T cell receptor genes in a series of class I major histocompatibility complex-restricted cytotoxic T lymphocyte clones specific for a Plasmodium berghei nonapeptide: implications for T cell allelic exclusion and antigen-specific repertoire.

1991 • 323 citations

Lower receptor avidity required for thymic clonal deletion than for effector T-cell function

1991 • 263 citations

Deletion of autospecific T cells in T cell receptor (TCR) transgenic mice spares cells with normal TCR levels and low levels of CD8 molecules.

1989 • 231 citations

Leu 23 induction as an early marker of functional CD3/T cell antigen receptor triggering. Requirement for receptor cross-linking, prolonged elevation of intracellular [Ca++] and stimulation of protein kinase C.

1989 • 226 citations

Induction of Rapid T Cell Activation and Tolerance by Systemic Presentation of an Orally Administered Antigen

1998 • 219 citations

Quantitative Impact of Thymic Clonal Deletion on the T Cell Repertoire

1997 • 198 citations

Murine natural killer cells contribute to the granulomatous reaction caused by mycobacterial cell walls

1999 • 196 citations

Public and private V beta T cell receptor repertoires against hen egg white lysozyme (HEL) in nontransgenic versus HEL transgenic mice.

1994 • 194 citations

Individual Variations in the Murine T Cell Response to a Specific Peptide Reflect Variability in Naive Repertoires

1998 • 192 citations

Endogenous Myelin Basic Protein Inactivates the High Avidity T Cell Repertoire

1998 • 188 citations

Long-term T cell memory requires the surface expression of self-peptide/major histocompatibility complex molecules

1998 • 186 citations

The Human T-Cell Receptor TCRAC/TCRDC (Cα/Cdelta;) Region: Organization, Sequence, and Evolution of 97.6 kb of DNA

1994 • 169 citations

T Lymphocyte Tolerance: From Thymic Deletion to Peripheral Control Mechanisms

1998 • 158 citations

Mouse T-cell receptor variable gene segment families

1995 • 138 citations

The level of CD8 expression can determine the outcome of thymic selection

1992 • 134 citations

Acceleration of spontaneous diabetes in TCR-beta-transgenic nonobese diabetic mice by beta-cell cytotoxic CD8+ T cells expressing identical endogenous TCR-alpha chains.

1996 • 130 citations

Expression of a second receptor rescues self-specific T cells from thymic deletion and allows activation of autoreactive effector function.

1996 • 121 citations

Mechanisms underlying T-cell tolerance

1996 • 108 citations

The Imprint of Intrathymic Self-Peptides on the Mature T Cell Receptor Repertoire

1997 • 105 citations

Quantitative Analysis of the T Cell Repertoire that Escapes Negative Selection

1999 • 103 citations

A Molecular Map of T Cell Development

1998 • 94 citations

T Cell Tolerance Based on Avidity Thresholds Rather Than Complete Deletion Allows Maintenance of Maximal Repertoire Diversity

2000 • 77 citations

Negative Selection of T Cells Occurs Throughout Thymic Development

1999 • 70 citations

V beta 5+ T cell receptors skew toward OVA+H-2Kb recognition.

1994 • 63 citations

Tracing and characterization of the low-avidity self-specific T cell repertoire

2000 • 58 citations

Intracellular signals that mediate thymic negative selection

1994 • 54 citations

The Avidity Spectrum of T Cell Receptor Interactions Accounts for T Cell Anergy in a Double Transgenic Model

1999 • 51 citations

Evidence for Two Subgroups of CD4−CD8− NKT Cells with Distinct TCRαβ Repertoires and Differential Distribution in Lymphoid Tissues

2000 • 42 citations

Preferential association of α and β chains of the T cell antigen receptor

1992 • 29 citations

Influence of antigen density on degree of clonal deletion in T cell receptor transgenic mice

1992 • 29 citations

Highly Restricted T Cell Repertoire Shaped by a Single Major Histocompatibility Complex–Peptide Ligand in the Presence of a Single Rearranged T Cell Receptor β Chain

1998 • 26 citations

T cell unresponsiveness correlates with quantitative TCR levels in a transgenic model

1993 • 17 citations