The Insulin-Like Growth Factor System and Its Pleiotropic Functions in Brain

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Insulin-Like Growth Factors and Their Binding Proteins: Biological Actions*

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Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r)

1993 • 2,880 citations

Role of insulin-like growth factors in embryonic and postnatal growth

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Role of Brain Insulin Receptor in Control of Body Weight and Reproduction

2000 • 2,178 citations

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IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice

2002 • 2,057 citations

Insulin-like growth factors and their binding proteins: biological actions

1995 • 1,976 citations

Tau protein isoforms, phosphorylation and role in neurodegenerative disorders11These authors contributed equally to this work.

2000 • 1,878 citations

Insulin-like growth factor I receptor primary structure: comparison with insulin receptor suggests structural determinants that define functional specificity.

1986 • 1,866 citations

Insulin-Like Growth Factors I and II. Peptide, Messenger Ribonucleic Acid and Gene Structures, Serum, and Tissue Concentrations*

1989 • 1,796 citations

The insulin signaling system.

1994 • 1,733 citations

Cellular Actions of the Insulin-Like Growth Factor Binding Proteins

2002 • 1,717 citations

Translating cell biology into therapeutic advances in Alzheimer's disease

1999 • 1,592 citations

Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein

1991 • 1,590 citations

Nutritional Regulation of the Insulin-Like Growth Factors*

1994 • 1,537 citations

The amino acid sequence of human insulin-like growth factor I and its structural homology with proinsulin.

1978 • 1,530 citations

Normal growth and development in the absence of hepatic insulin-like growth factor I

1999 • 1,430 citations

From charcot to lou gehrig: deciphering selective motor neuron death in als

2001 • 1,373 citations

Amyloid, the presenilins and Alzheimer's disease

1997 • 1,370 citations

The Endocrine Regulation of Aging by Insulin-like Signals

2003 • 1,342 citations

Extended Longevity in Mice Lacking the Insulin Receptor in Adipose Tissue

2003 • 1,328 citations

Receptor Protein-Tyrosine Kinases and Their Signal Transduction Pathways

1994 • 1,309 citations

Sniffing neuropeptides: a transnasal approach to the human brain

2002 • 1,243 citations

Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene

1994 • 1,240 citations

Tissue concentrations of somatomedin C: further evidence for multiple sites of synthesis and paracrine or autocrine mechanisms of action.

1984 • 1,171 citations

A hormonally controlled serum factor which stimulates sulfate incorporation by cartilage in vitro. 1956.

1990 • 1,075 citations

Insulin-Like Growth Factor-Binding Proteins in Serum and Other Biological Fluids: Regulation and Functions*

1997 • 1,056 citations

Insulin‐like growth factors I and II

1990 • 1,006 citations

Circulating Insulin-Like Growth Factor I Mediates Exercise-Induced Increases in the Number of New Neurons in the Adult Hippocampus

2001 • 976 citations

Liver-derived insulin-like growth factor I (IGF-I) is the principal source of IGF-I in blood but is not required for postnatal body growth in mice

1999 • 938 citations

Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body

2004 • 932 citations

In vivo evidence that erythropoietin protects neurons from ischemic damage

1998 • 931 citations

LYSOSOMAL ENZYMES AND THEIR RECEPTORS

1986 • 915 citations

Insulin Receptor Isoform A, a Newly Recognized, High-Affinity Insulin-Like Growth Factor II Receptor in Fetal and Cancer Cells

1999 • 865 citations

Retrograde Viral Delivery of IGF-1 Prolongs Survival in a Mouse ALS Model

2003 • 863 citations

Insulin-like growth factor II receptor as a multifunctional binding protein

1987 • 858 citations

Role of IRS-2 in insulin and cytokine signalling

1995 • 843 citations

Somatomedin: Proposed Designation for Sulphation Factor

1972 • 840 citations

Neurotrophic factors: from molecule to man

1994 • 800 citations

Primary structure of human insulin‐like growth factor II

1978 • 776 citations

Insulin-like Growth Factor Binding Proteins

1993 • 754 citations

Brain insulin and insulin receptors in aging and sporadic Alzheimer's disease

1998 • 728 citations

Conformation of the Bax C-terminus regulates subcellular location and cell death

1999 • 723 citations

Cellular Localization of Somatomedin (Insulin-Like Growth Factor) Messenger RNA in the Human Fetus

1987 • 663 citations

Regulation of C. elegans Life-Span by Insulinlike Signaling in the Nervous System

2000 • 661 citations

Reciprocal positive regulation of hypoxia-inducible factor 1alpha and insulin-like growth factor 2.

1999 • 645 citations

Igf1 gene disruption results in reduced brain size, CNS hypomyelination, and loss of hippocampal granule and striatal parvalbumin-containing neurons

1995 • 629 citations

Structure and function of the type 1 insulin-like growth factor receptor

2000 • 602 citations

Circulating Insulin-Like Growth Factor I Mediates the Protective Effects of Physical Exercise against Brain Insults of Different Etiology and Anatomy

2001 • 593 citations

Regulation of lifespan by sensory perception in Caenorhabditis elegans

1999 • 554 citations

The role of neuronal growth factors in neurodegenerative disorders of the human brain

1998 • 539 citations

Clearing the Brain's Amyloid Cobwebs

2001 • 538 citations

Insulin-like Growth Factor Binding Protein-1: Recent Findings and New Directions

1997 • 532 citations

Somatomedin-C/insulin-like growth factor-I and insulin-like growth factor-II mRNAs in rat fetal and adult tissues.

1986 • 531 citations

Insulin and Insulin-like Growth Factor-1 Regulate Tau Phosphorylation in Cultured Human Neurons

1997 • 517 citations

Insulin-like growth factor receptor I mediates resistance to anti-epidermal growth factor receptor therapy in primary human glioblastoma cells through continued activation of phosphoinositide 3-kinase signaling.

2002 • 508 citations

The IGF-1/Akt Pathway Is Neuroprotective in Huntington's Disease and Involves Huntingtin Phosphorylation by Akt

2002 • 498 citations

Alzheimer's beta-amyloid peptides compete for insulin binding to the insulin receptor.

2002 • 497 citations

Insulin/Insulin-like Growth Factor I Hybrid Receptors Have Different Biological Characteristics Depending on the Insulin Receptor Isoform Involved

2002 • 492 citations

Insulin-like growth factor (IGF)-independent action of IGF-binding protein-3 in Hs578T human breast cancer cells. Cell surface binding and growth inhibition

1993 • 481 citations

Stimulation of β-Amyloid Precursor Protein Trafficking by Insulin Reduces Intraneuronal β-Amyloid and Requires Mitogen-Activated Protein Kinase Signaling

2001 • 479 citations

Mouse Mutants Lacking the Type 2 IGF Receptor (IGF2R) Are Rescued from Perinatal Lethality inIgf2andIgf1rNull Backgrounds

1996 • 479 citations

Brain Injury Causes a Time-Dependent Increase in Neuronotrophic Activity at the Lesion Site

1982 • 477 citations

Differential expression of insulin-like growth factor genes in rat central nervous system.

1988 • 477 citations

Insulin-like growth factor I increases brain growth and central nervous system myelination in tTransgenic mice

1993 • 468 citations

Insulin Receptor Substrate-2 Deficiency Impairs Brain Growth and Promotes Tau Phosphorylation

2003 • 468 citations

The role of the insulin-like growth factors in the central nervous system

1996 • 443 citations

Nerve sprouting in innervated adult skeletal muscle induced by exposure to elevated levels of insulin-like growth factors.

1990 • 441 citations

Serum insulin-like growth factor I regulates brain amyloid-β levels

2002 • 440 citations

Insulin/IGF-I-signaling pathway: an evolutionarily conserved mechanism of longevity from yeast to humans

2003 • 439 citations

Intracerebroventricular infusion of insulin-like growth factor-I ameliorates the age-related decline in hippocampal neurogenesis

2001 • 430 citations

Effects of insulin, insulin-like growth factor-II, and nerve growth factor on neurite formation and survival in cultured sympathetic and sensory neurons

1986 • 426 citations

Tau phosphorylation: physiological and pathological consequences

2004 • 413 citations

Continuous Nerve Cell Renewal in the Olfactory System

1978 • 411 citations

Apoptosis in cerebellar granule cells is blocked by high KCl, forskolin, and IGF-1 through distinct mechanisms of action: the involvement of intracellular calcium and RNA synthesis

1995 • 403 citations

Sequence of cDNA encoding human insulin-like growth factor I precursor

1983 • 401 citations

A role for IGF-1 in the rescue of CNS neurons following hypoxic-ischemic injury

1992 • 381 citations

Expression of Somatomedin/Insulin-Like Growth Factor Messenger Ribonucleic Acids in the Human Fetus: Identification, Characterization, and Tissue Distribution*

1988 • 375 citations

Insulin-like growth factor I is required for vessel remodeling in the adult brain

2004 • 375 citations

Interleukin 3-dependent survival by the Akt protein kinase

1997 • 374 citations

Regulation of C. elegans Longevity by Specific Gustatory and Olfactory Neurons

2004 • 372 citations

Cellular pattern of type-I insulin-like growth factor receptor gene expression during maturation of the rat brain: Comparison with insulin-like growth factors I and II

1992 • 370 citations

Wild-type and mutant p53 differentially regulate transcription of the insulin-like growth factor I receptor gene.

1996 • 365 citations

Effect of recombinant human insulin-like growth factor-I on progression of ALS

1997 • 359 citations

Insulin-Like Growth Factor-I Promotes Neurogenesis and Synaptogenesis in the Hippocampal Dentate Gyrus during Postnatal Development

2000 • 341 citations

Developmental regulation of the rat insulin-like growth factor I receptor gene.

1989 • 338 citations

A placebo-controlled trial of insulin-like growth factor-I in amyotrophic lateral sclerosis

1998 • 338 citations

A partially purified polypeptide fraction from rat liver cell conditioned medium with multiplication‐stimulating activity for embryo fibroblasts

1973 • 335 citations

Erythropoietin as an antiapoptotic, tissue-protective cytokine

2004 • 326 citations

Insulin-like growth factor I protects and rescues hippocampal neurons against β-amyloid- and human amylin-induced toxicity

1997 • 325 citations

Signaling by insulin-like growth factor 1 in brain

2004 • 322 citations

Cellular Pattern of Insulin-Like Growth Factor-I (IGF-I) and Type I IGF Receptor Gene Expression in Early Organogenesis: Comparison with IGF-II Gene Expression

1990 • 320 citations

Localization and Characterization of Insulin Receptors in Rat Brain and Pituitary Gland Usingin VitroAutoradiography and Computerized Densitometry*

1987 • 319 citations

Polypeptides with nonsuppressible insulin-like and cell-growth promoting activities in human serum: isolation, chemical characterization, and some biological properties of forms I and II.

1976 • 319 citations

Demonstration of receptors for insulin-like growth factor binding protein-3 on Hs578T human breast cancer cells.

1993 • 317 citations

Insulin-like growth factor-I receptor. Its role in cell proliferation, apoptosis, and tumorigenicity.

1995 • 314 citations

Alternative splicing of human insulin receptor messenger RNA

1989 • 312 citations

Insulin-like growth factor-I and neurogenesis in the adult mammalian brain

2002 • 307 citations

Intranasal administration of nerve growth factor (NGF) rescues recognition memory deficits in AD11 anti-NGF transgenic mice

2005 • 295 citations

The IGF-I Receptor in Cancer Research

1999 • 295 citations

Insulin-Like Growth Factor and Potassium Depolarization Maintain Neuronal Survival by Distinct Pathways: Possible Involvement of PI 3-Kinase in IGF-1 Signaling

1997 • 294 citations

Growth-controlling molluscan neurons produce the precursor of an insulin-related peptide

1988 • 288 citations

Mosaic evolution of the insulin-like growth factors. Organization, sequence, and expression of the rat insulin-like growth factor I gene.

1987 • 279 citations

A dominant negative mutant of the insulin-like growth factor-I receptor inhibits the adhesion, invasion, and metastasis of breast cancer.

1998 • 274 citations

IGF-I has a direct proliferative effect in adult hippocampal progenitor cells

2003 • 272 citations

Potential roles of insulin and IGF-1 in Alzheimer's disease

2003 • 272 citations

Insulin-like Growth Factor-binding Protein (IGFBP)-3 and IGFBP-5 Share a Common Nuclear Transport Pathway in T47D Human Breast Carcinoma Cells

1998 • 269 citations

Mechanisms of Neuronal Death in Alzheimer's Disease

1996 • 267 citations

Alzheimer's β-Amyloid Peptides Compete for Insulin Binding to the Insulin Receptor

2002 • 264 citations

Interaction between the Alzheimer's survival peptide humanin and insulin-like growth factor-binding protein 3 regulates cell survival and apoptosis

2003 • 263 citations

Gonadal hormones as promoters of structural synaptic plasticity: Cellular mechanisms

1994 • 263 citations

Expression of the insulin-like growth factor II gene in the choroid plexus and the leptomeninges of the adult rat central nervous system.

1988 • 262 citations

Insulin-Like Growth Factor-I Protects Axotomized Rat Retinal Ganglion Cells from Secondary Death via PI3-K-Dependent Akt Phosphorylation and Inhibition of Caspase-3In Vivo

2000 • 260 citations

Insulin-like Growth Factor I Receptor β-Subunit Heterogeneity

1989 • 259 citations

Insulin-Like Growth Factor-I Is Necessary for Neural Stem Cell Proliferation and Demonstrates Distinct Actions of Epidermal Growth Factor and Fibroblast Growth Factor-2

2001 • 259 citations

The role of insulin and insulin-like growth factor I in the molecular and cellular mechanisms underlying the pathology of Alzheimer's disease

2004 • 258 citations

In vivo actions of insulin-like growth factor-I (IGF-I) on brain myelination: studies of IGF-I and IGF binding protein-1 (IGFBP-1) transgenic mice

1995 • 257 citations

Insulin-like growth factor I binding in hepatocytes from human liver, human hepatoma, and normal, regenerating, and fetal rat liver.

1988 • 252 citations

Structure, Evolution, Expression and Regulation of Insulin-Like Growth Factors I and II

1991 • 247 citations

Fibroblast growth factor-mediated proliferation of central nervous system precursors depends on endogenous production of insulin-like growth factor I.

1991 • 245 citations

Intranasal administration of insulin-like growth factor-I bypasses the blood–brain barrier and protects against focal cerebral ischemic damage

2001 • 244 citations

Insulin-Like Growth Factors/Somatomedins: Structure, Secretion, Biological Actions and Physiological Role

1986 • 240 citations

An antibody that blocks insulin-like growth factor (IGF) binding to the type II IGF receptor is neither an agonist nor an inhibitor of IGF-stimulated biologic responses in L6 myoblasts.

1987 • 237 citations

The contradictions of the insulin-like growth factor 1 receptor

2000 • 236 citations

Sonic hedgehog and insulin-like growth factor signaling synergize to induce medulloblastoma formation from nestin-expressing neural progenitors in mice

2004 • 234 citations

Insulin Transiently Increases Tau Phosphorylation

1999 • 233 citations

Insulin-like Growth Factor-I Extends in VitroReplicative Life Span of Skeletal Muscle Satellite Cells by Enhancing G1/S Cell Cycle Progression via the Activation of Phosphatidylinositol 3′-Kinase/Akt Signaling Pathway

2000 • 232 citations

Neural and Head Induction by Insulin-like Growth Factor Signals

2001 • 231 citations

Insulin-Like Growth Factor-1 Inhibits Mature Oligodendrocyte Apoptosis during Primary Demyelination

2000 • 230 citations

Insulin‐like growth factors: Putative muscle‐derived trophic agents that promote motoneuron survival

1993 • 225 citations

Activation of Hypoxia-Inducible Factor-1 in the Rat Cerebral Cortex after Transient Global Ischemia: Potential Role of Insulin-Like Growth Factor-1

2002 • 225 citations

Molecular Cloning of the Bombyx mori Prothoracicotropic Hormone

1990 • 222 citations

Myelination Is Altered in Insulin-Like Growth Factor-I Null Mutant Mice

2002 • 218 citations

Overexpression of Insulin-Like Growth Factor-Binding Protein-2 in Transgenic Mice Reduces Postnatal Body Weight Gain

1999 • 216 citations

Results of a Pilot Study Involving the Use of an Antisense Oligodeoxynucleotide Directed Against the Insulin-Like Growth Factor Type I Receptor in Malignant Astrocytomas

2001 • 214 citations

Growth hormone rapidly activates insulin-like growth factor I gene transcription in vivo.

1992 • 211 citations

Quantitative autoradiographic localization of [¹²⁵I]insulin‐like growth factor I, [¹²⁵I]insulin‐like growth factor II, and [¹²⁵I]insulin receptor binding sites in developing and adult rat brain

1993 • 207 citations

Insulin-like growth factor I treatment reduces demyelination and up-regulates gene expression of myelin-related proteins in experimental autoimmune encephalomyelitis.

1995 • 207 citations

Insulin-like Growth Factor-1-mediated Neuroprotection against Oxidative Stress Is Associated with Activation of Nuclear Factor κB

1999 • 205 citations

Inhibitory Insulin-Like Growth Factor-Binding Protein: Cloning, Complete Sequence, and Physiological Regulation

1990 • 204 citations

The Effects of IGF-1 Treatment after Hypoxic-Ischemic Brain Injury in Adult Rats

1993 • 202 citations

Receptors for insulin and insulin-like growth factor-I can form hybrid dimers. Characterisation of hybrid receptors in transfected cells

1990 • 199 citations

Structural Determinants for High-Affinity Binding of Insulin-Like Growth Factor II to Insulin Receptor (IR)-A, the Exon 11 Minus Isoform of the IR

2004 • 199 citations

Insulin-like growth factor 1 regulates developing brain glucose metabolism

2000 • 199 citations

Co-ordinated and cellular specific induction of the components of the IGF/IGFBP axis in the rat brain following hypoxic–ischemic injury

1998 • 197 citations

Insulin-like growth factor-1 and post-ischemic brain injury

2003 • 196 citations

Immunological relationships between receptors for insulin and insulin-like growth factor I. Evidence for structural heterogeneity of insulin-like growth factor I receptors involving hybrids with insulin receptors

1989 • 196 citations

Neuroprotective effects of estradiol in the adult rat hippocampus: Interaction with insulin-like growth factor-I signalling

1999 • 196 citations

Evolution of the insulin superfamily: cloning of a hybrid insulin/insulin-like growth factor cDNA from amphioxus.

1990 • 192 citations

Insulin-like Growth Factors Regulate Neuronal Differentiation and Survival

1997 • 189 citations

Biosynthetic labeling of insulin receptor: studies of subunits in cultured human IM-9 lymphocytes.

1981 • 188 citations

Biology of Aβ Amyloid in Alzheimer's Disease

1997 • 187 citations

The mitogen activated protein kinase signal transduction pathway: From the cell surface to the nucleus

1994 • 187 citations

Erythropoietin protects neurons against chemical hypoxia and cerebral ischemic injury by up‐regulating Bcl‐x_L expression

2002 • 186 citations

Insulin-like growth factor-1 is a potent neuronal rescue agent after hypoxic-ischemic injury in fetal lambs.

1996 • 182 citations

Insulin-like Growth Factor-1 (IGF-1) Improves both Neurological Motor and Cognitive Outcome Following Experimental Brain Injury

1997 • 182 citations

Discussion

1997 • 179 citations

Growth hormone as a neuronal rescue factor during recovery from CNS injury

2001 • 176 citations

Regulation of Oligodendrocyte Development and CNS Myelination by Growth Factors: Prospects for Therapy of Demyelinating Disease

1996 • 176 citations

Localization of insulin-like growth factor I (IGF-I)-like immunoreactivity in the developing and adult rat brain

1991 • 176 citations

Insulin-Like Growth Factor-I and Central Nervous System Development

1999 • 175 citations

Delayed Inner Ear Maturation and Neuronal Loss in PostnatalIgf-1-Deficient Mice

2001 • 168 citations

Inactivation of the acid labile subunit gene in mice results in mild retardation of postnatal growth despite profound disruptions in the circulating insulin-like growth factor system

2000 • 168 citations

Insulin-like Growth Factor-I: Potential for Treatment of Motor Neuronal Disorders

1993 • 166 citations

Insulin-Like Growth Factor-1–Induced Phosphorylation of Transcription Factor FKHRL1 Is Mediated by Phosphatidylinositol 3-Kinase/Akt Kinase and Role of This Pathway in Insulin-Like Growth Factor-1–Induced Survival of Cultured Hippocampal Neurons

2002 • 165 citations

Identification of Somatomedin/Insulin-Like Growth Factor Immunoreactive Cells in the Human Fetus

1987 • 165 citations

Nucleotide sequences of cDNAs encoding precursors of human insulin‐like growth factor II (IGF‐II) and an IGF‐II variant

1985 • 164 citations

Two types of receptor for insulin-like growth factors in mammalian brain.

1985 • 163 citations

Type-2 IGF Receptor: A Multi-Ligand Binding Protein

1999 • 163 citations

Type I Insulin-like Growth Factor Receptor Activation Regulates Apoptotic Proteins

1996 • 162 citations

Interactions of estrogens and insulin-like growth factor-I in the brain: implications for neuroprotection

2001 • 162 citations

Amino-terminal sequences of two polypeptides from human serum with nonsuppressible insulin-like and cell-growth-promoting activities: evidence for structural homology with insulin B chain.

1976 • 161 citations

Gene Expression Patterns in Ependymomas Correlate with Tumor Location, Grade, and Patient Age

2003 • 161 citations

In vivo effects of insulin‐like growth factor‐I (IGF‐I) on prenatal and early postnatal development of the central nervous system

2004 • 158 citations

Insulin‐like growth factor 1 is essential for normal dendritic growth

2003 • 156 citations

The insulin-like growth factor-II/mannose-6-phosphate receptor: structure, distribution and function in the central nervous system

2004 • 154 citations

The type I insulin-like growth factor receptor is a motility receptor in human melanoma cells

1989 • 151 citations

p53 Regulates Insulin-Like Growth Factor-I (IGF-I) Receptor Expression and IGF-I-Induced Tyrosine Phosphorylation in an Osteosarcoma Cell Line: Interaction between p53 and Sp1

1998 • 151 citations

IGF-I prevents glutamate-induced motor neuron programmed cell death

2004 • 150 citations

Non-invasive intranasal insulin-like growth factor-I reduces infarct volume and improves neurologic function in rats following middle cerebral artery occlusion

2001 • 150 citations

Coordinate expression of insulin-like growth factor system components by neurons and neuroglia during retinal and cerebellar development

1992 • 150 citations

Insulin-Like Growth Factor-I Blocks Bcl-2 Interacting Mediator of Cell Death (Bim) Induction and Intrinsic Death Signaling in Cerebellar Granule Neurons

2002 • 149 citations

Integrin-mediated action of insulin-like growth factor binding protein-2 in tumor cells

2004 • 149 citations

Estrogen receptor alpha forms estrogen-dependent multimolecular complexes with insulin-like growth factor receptor and phosphatidylinositol 3-kinase in the adult rat brain

2003 • 149 citations

Expression of IGF-I and -II mRNA in the brain and craniofacial region of the rat fetus

1991 • 146 citations

The design, expression, and characterization of human insulin-like growth factor II (IGF-II) mutants specific for either the IGF-II/cation-independent mannose 6-phosphate receptor or IGF-I receptor.

1991 • 146 citations

ATM-dependent expression of the insulin-like growth factor-I receptor in a pathway regulating radiation response

2001 • 145 citations

The type II insulin-like growth factor receptor does not mediate increased DNA synthesis in H-35 hepatoma cells.

1984 • 145 citations

Insulin-like growth factors and insulin-like growth factor binding proteins in cerebrospinal fluid and serum of patients with dementia of the Alzheimer type

1993 • 145 citations

Estrogen interacts with the IGF‐1 system to protect nigrostriatal dopamine and maintain motoric behavior after 6‐hydroxdopamine lesions

2003 • 143 citations

Phenotypic Manifestations of Insulin-Like Growth Factor-Binding Protein-3 Overexpression in Transgenic Mice*

2001 • 142 citations

Locally Born Olfactory Bulb Stem Cells Proliferate in Response to Insulin-Related Factors and Require Endogenous Insulin-Like Growth Factor-I for Differentiation into Neurons and Glia

2003 • 141 citations

Localization of Insulin-Like Growth Factor-I mRNA in Rat Brain byin SituHybridization—Relationship to IGF-I Receptors

1990 • 140 citations

Targeted Expression of IGF‐1 Transgene to Skeletal Muscle Accelerates Muscle and Motor Neuron Regeneration

2002 • 140 citations

Endogenous IGF-1 regulates the neuronal differentiation of adult stem cells

2000 • 139 citations

Neurodegeneration Is Associated to Changes in Serum Insulin-like Growth Factors

2000 • 138 citations

Correlation between insulin-like growth factor (IGF)-binding protein 5 and IGF-I gene expression during brain development

1993 • 138 citations

Alzheimer Disease: Current Concepts and Emerging Diagnostic and Therapeutic Strategies

2003 • 137 citations

Insulin-like growth factor-I, cognition and brain aging

2004 • 136 citations

IGF‐I and microglia/macrophage proliferation in the ischemic mouse brain

2002 • 136 citations

Insulin-like growth factor II-mediated proliferation of human neuroblastoma.

1991 • 135 citations

Gonadal Hormone Regulation of Insulin-Like Growth Factor-I Like Immunoreactivity in Hypothalamic Astroglia of Developing and Adult Rats

1994 • 135 citations

Insulin and IGF-I Receptors Signaling in Protection from Apoptosis

1999 • 133 citations

Relationship between Cognitive Function, Growth Hormone and Insulin-Like Growth Factor I Plasma Levels in Aged Subjects

1998 • 133 citations

Localization of insulin-like growth factor binding protein-2 messenger RNA during postnatal brain development: Correlation with insulin-like growth factors I and II

1993 • 133 citations

Production of insulin‐like growth factors and their carrier by rat pituitary gland and brain explants in culture

1981 • 132 citations

A Prospective Study on Circulating Insulin-Like Growth Factor I (IGF-I), IGF-Binding Proteins, and Cognitive Function in the Elderly

2000 • 131 citations

Characterization of the affinities of insulin-like growth factor (IGF)-binding proteins 1-4 for IGF-I, IGF-II, IGF-I/insulin hybrid, and IGF-I analogs.

1993 • 129 citations

Patterns of Insulin‐like Growth Factor and IGF Receptor Gene Expression in the Brain: Functional Implications

1993 • 129 citations

Insulin-like growth factor I receptor prevents apoptosis and enhances neuroblastoma tumorigenesis.

1996 • 128 citations

Insulin-Like Growth Factor-I and Over-Expression of Bcl-xL Prevent Glucose-Mediated Apoptosis in Schwann Cells

2001 • 125 citations

Glioblastoma and Cerebral Microvascular Endothelial Cell Migration in Response to Tumor-associated Growth Factors

2003 • 125 citations

Alterations in insulin-like growth factor-1 gene and protein expression and type 1 insulin-like growth factor receptors in the brains of ageing rats

1999 • 124 citations

Characterization of Insulin-Like Growth Factor Binding Protein-3 (IGFBP-3) Binding to Human Breast Cancer Cells: Kinetics of IGFBP-3 Binding and Identification of Receptor Binding Domain on the IGFBP-3 Molecule*

1999 • 123 citations

cDNAs from neurosecretory cells of brains of Locusta migratoria (Insecta, Orthoptera) encoding a novel member of the superfamily of insulins

1990 • 123 citations

The expression of insulin-like growth factor I and insulin-like growth factor II genes in the human fetal and adult brain and in glioma

1988 • 123 citations

The effects of insulin-like growth factor (IGF)-1, IGF-2, and des-IGF-1 on neuronal loss after hypoxic-ischemic brain injury in adult rats: evidence for a role for IGF binding proteins.

1996 • 122 citations

Structure and function of the insulin-like growth factor I receptor

1998 • 122 citations

Non-suppressible insulin-like activity of human serum I. Physicochemical properties, extraction and partial purification

1966 • 122 citations

Insulin-like growth factor-I prevents apoptosis in neurons after nerve growth factor withdrawal

1998 • 121 citations

Expression of IGF‐I and insulin receptor genes in the rat central nervous system: A developmental, regional, and cellular analysis

1991 • 121 citations

Insulin-like growth factor-1 and insulin mediate transient site-selective increases in tau phosphorylation in primary cortical neurons

2000 • 119 citations

Different Effects on Mitogenesis and Transformation of a Mutation at Tyrosine 1251 of the Insulin-like Growth Factor I Receptor

1995 • 119 citations

Brain Repair and Neuroprotection by Serum Insulin-Like Growth Factor I

2003 • 119 citations

Evidence for an important role of IGF-I and IGF-II for the early development of chick sympathetic neurons

1995 • 119 citations

Insulin-Like Growth Factor Binding Protein-2 Binds to Cell Surface Proteoglycans in the Rat Brain Olfactory Bulb*

1997 • 118 citations

Selective Alterations in Organ Sizes in Mice with a Targeted Disruption of the Insulin-Like Growth Factor Binding Protein-2 Gene

2000 • 118 citations

Systemically and Topically Administered Leptin Both Accelerate Wound Healing in Diabetic ob/ob Mice

2000 • 117 citations

Protective effect of insulin-like-growth-factor-1 against dopamine-induced neurotoxicity in human and rodent neuronal cultures: possible implications for Parkinson’s disease

2001 • 115 citations

Characterization of Insulin-Like Growth Factor Binding Proteins Produced in the Rat Central Nervous System*

1990 • 115 citations

Insulin-Like Growth Factors as Mediators of Functional Plasticity in the Adult Brain

1999 • 114 citations

Insulin‐like growth factors protect against diabetic neuropathy: Effects on sensory nerve regeneration in rats

1995 • 113 citations

Growth Hormone Action on Proliferation and Differentiation of Cerebral Cortical Cells from Fetal Rat

2003 • 112 citations

Acute neuroprotective synergy of erythropoietin and insulin-like growth factor I

2004 • 112 citations

The insulin‐like growth factor I system in the rat cerebellum: Developmental regulation and role in neuronal survival and differentiation

1994 • 112 citations

Differing expression of insulin‐like growth factor I in the developing and in the adult rat cerebellum

1988 • 110 citations

Insulin-Like Growth Factor (IGF)-1 Suppresses Oligodendrocyte Caspase-3 Activation and Increases Glial Proliferation after Ischemia in Near-Term Fetal Sheep

2003 • 110 citations

Cell death of spinal motoneurons in the chick embryo following deafferentation: rescue effects of tissue extracts, soluble proteins, and neurotrophic agents

1994 • 110 citations

The IGF Pathway Regulates Head Formation by Inhibiting Wnt Signaling in Xenopus

2002 • 110 citations

Identification of Gly-Pro-Glu (GPE), the aminoterminal tripeptide of insulin-like growth factor 1 which is truncated in brain, as a novel neuroactive peptide

1989 • 110 citations

Spatial and Temporal Changes in the Insulin-Like Growth Factor (IGF) Axis Indicate Autocrine/Paracrine Actions of IGF-I within Wounds of the Rat Brain*

1997 • 110 citations

Nerve growth factor: from animal models of cholinergic neuronal degeneration to gene therapy in Alzheimer's disease

2004 • 109 citations

Neural stem cells and the regulation of adult neurogenesis

2003 • 109 citations

Characterization of Insulin‐Like Growth Factor‐I and Its Receptor and Binding Proteins in Transected Nerves and Cultured Schwann Cells

1996 • 108 citations

Insulin‐like Growth Factors

1993 • 107 citations

Characterization of somatomedin/insulin-like growth factor receptors and correlation with biologic action in cultured neonatal rat astroglial cells

1987 • 107 citations

A Metabolic Model for Life Span Determination in Caenorhabditis elegans

2003 • 106 citations

Increased Neurogenesis in Dentate Gyrus of Long-Lived Ames Dwarf Mice

2004 • 106 citations

Biochemical and Morphometric Analyses Show that Myelination in the Insulin-like Growth Factor 1 Null Brain Is Proportionate to Its Neuronal Composition

1998 • 106 citations

Insulin-Like Growth Factor-1 Reduces Postischemic White Matter Injury in Fetal Sheep

2001 • 105 citations

Effectiveness of insulin-like growth factor I receptor antisense strategy against Ewing's sarcoma cells

2002 • 105 citations

Erythropoietin as a Tissue-Protective Cytokine in Brain Injury: What Do We Know and Where Do We Go?

2004 • 104 citations

Serum Growth Factors and Neuroprotective Surveillance

2000 • 104 citations

Distinct expression patterns of insulin-like growth factor binding proteins 2 and 5 during fetal and postnatal development.

1994 • 104 citations

Mutational analysis of the mitogenic and transforming activities of the insulin-like growth factor I receptor.

1996 • 104 citations

Simultaneous activation of several second messengers in hypoxia‐induced hyperpermeability of brain derived endothelial cells

2003 • 103 citations

Non-suppressible insulin-like activity of human serum

1966 • 103 citations

Astrocytes Express Insulin-like Growth Factor-I (IGF-I) and Its Binding Protein, IGFBP-2, during Demyelination Induced by Experimental Autoimmune Encephalomyelitis

1994 • 103 citations

Growth Inhibition in Giant Growth Hormone Transgenic Mice by Overexpression of Insulin-Like Growth Factor-Binding Protein-2

2001 • 102 citations

Insulin-Like Growth Factor-I Prevents Apoptosis in Sympathetic Neurons Exposed to High Glucose

1999 • 101 citations

Mitogenicity and transforming activity of the insulin-like growth factor-I receptor with mutations in the tyrosine kinase domain.

1994 • 101 citations

Localization and Characterization of Insulin‐Like Growth Factor‐I Receptors in Rat Brain and Pituitary Gland Using in vitro Autoradiography and Computerized Densitometry* A Distinct Distribution from Insulin Receptors

1989 • 100 citations

Insulin Resistance in the Liver-Specific IGF-1 Gene-Deleted Mouse Is Abrogated by Deletion of the Acid-Labile Subunit of the IGF-Binding Protein-3 Complex

2003 • 100 citations

The Expression Pattern of an Insulin-Like Growth Factor (IGF)-Binding Protein Gene Is Distinct from IGF-II in the Midgestational Rat Embryo

1990 • 100 citations

A Role for Insulin-Like Growth Factor-I in the Regulation of Schwann Cell Survival

1999 • 100 citations

Insulin and non-suppressible insulin-like activity (NSILA-s): Evidence for separate plasma membrane receptor sites

1974 • 99 citations

Structural and functional analysis of the insulin-like growth factor I receptor gene promoter.

1992 • 98 citations

Regulation of Oligodendrocyte Development and Central Nervous System Myelination by Insulin‐like Growth Factors^a

1993 • 97 citations

Structure of the chicken insulin-like growth factor I gene reveals conserved promoter elements

1991 • 96 citations

Insulin-Like Growth Factor Binding Protein-6: The “Forgotten” Binding Protein?

1999 • 96 citations

Preclinical Testing of Neuroprotective Neurotrophic Factors in a Model of Chronic Motor Neuron Degeneration

1999 • 96 citations

Increase of insulin-like growth factor (IGF)-1, IGF binding protein-2 and −4 mRNAs following cerebral contusion

1996 • 94 citations

Genetic blockade of the insulin-like growth factor-I receptor: a promising strategy for human pancreatic cancer.

2003 • 94 citations

Insulin-Like Growth Factor-I (IGF-I) and IGF-II Hormonal Action in Cultured Rat Granulosa Cells: Mediation via Type I but not Type II IGF Receptors*

1990 • 92 citations

Brain derived neurotrophic factor and insulin like growth factor-1 attenuate upregulation of nitric oxide synthase and cell injury following trauma to the spinal cord

1998 • 92 citations

Type I insulin-like growth factor receptor function in breast cancer

1998 • 92 citations

Insulin-like growth factor (IGF) gene expression is reduced in neural tissues and liver from rats with non-insulin-dependent diabetes mellitus, and IGF treatment ameliorates diabetic neuropathy.

1997 • 89 citations

Coordinated pattern of expression and localization of insulin-like growth factor-II (IGF-II) and IGF-binding protein-2 in the adult rat brain.

1994 • 89 citations

Free insulin-like growth factor (IGF)-I and IGF binding proteins 2, 5, and 6 in spinal motor neurons in amyotrophic lateral sclerosis

2003 • 88 citations

Nuclear localization signal in insulin-like growth factor-binding protein type 3

1994 • 87 citations

The peripheral insulin-like growth factor system in amyotrophic lateral sclerosis and in multiple sclerosis

1998 • 87 citations

Decreased Plasma Insulin-Like Growth Factor-I Level in Familial Alzheimer’s Disease Patients Carrying the Swedish APP 670/671 Mutation

1999 • 86 citations

Structure and organization of four clustered genes that encode bombyxin, an insulin-related brain secretory peptide of the silkmoth Bombyx mori.

1989 • 86 citations

Insulin-like Growth Factor I Reverses Experimental Diabetic Autonomic Neuropathy

1999 • 85 citations

Brain growth retardation due to the expression of human insulin like growth factor binding protein-1 in transgenic mice: an in vivo model for the analysis of igf function in the brain

1994 • 84 citations

Neuroprotective effects of the N-terminal tripeptide of insulin-like growth factor-1, glycine-proline-glutamate (GPE) following intravenous infusion in hypoxic–ischemic adult rats

2004 • 83 citations

Regulation of experimental autoimmune encephalomyelitis with insulin-like growth factor (IGF-1) and IGF-1/IGF-binding protein-3 complex (IGF-1/IGFBP3).

1998 • 82 citations

Effect of Mutations at Serines 1280–1283 on the Mitogenic and Transforming Activities of the Insulin-like Growth Factor I Receptor

1996 • 82 citations

Neuronal protection from glucose deprivation via modulation of glucose transport and inhibition of apoptosis: a role for the insulin-like growth factor system

2004 • 82 citations

Insulin-like growth factor-I signaling in human neuroblastoma cells

2004 • 82 citations

Identification of the Extracellular Matrix Binding Sites for Insulin-like Growth Factor-binding Protein 5

1996 • 81 citations

Insulin-like growth factor-1 improves somatosensory function and reduces the extent of cortical infarction and ongoing neuronal loss after hypoxia–ischemia in rats

2001 • 81 citations

A Role for the Somatotropic Axis in Neural Development, Injury and Disease

2000 • 81 citations

Regulation of insulin-like growth factor I receptor gene expression by Sp1: physical and functional interactions of Sp1 at GC boxes and at a CT element.

1995 • 80 citations

The IGF/IGFBP system in CNS malignancy

2001 • 80 citations

Inhibition of insulin-like growth factor I receptor expression in neuroblastoma cells induces the regression of established tumors in mice.

1998 • 80 citations

Activation of the IGF-IR system contributes to malignant growth of human and mouse medulloblastomas

2001 • 79 citations

Endogenous IGF1 enhances cell survival in the postnatal dentate gyrus

2001 • 78 citations

Amyotrophic lateral sclerosis and other motor neuron diseases

2003 • 78 citations

Expression of insulin-like growth factor-1 (IGF-1) and IGF-binding protein 2 (IGF-BP2) in the hippocampus following cytotoxic lesion of the dentate gyrus

1996 • 78 citations

Expression of human insulin-like growth factor-binding protein-3 in transgenic mice

1995 • 77 citations

Insulin-Like Growth Factor I (IGF-I) Protects Cells from Apoptosis by Alzheimer's V642I Mutant Amyloid Precursor Protein through IGF-I Receptor in an IGF-Binding Protein-Sensitive Manner

2001 • 77 citations

Expression of insulin-like growth factors and corresponding binding proteins (IGFBP 1-6) in rat spinal cord and peripheral nerve after axonal injuries

1998 • 77 citations

Insulin-like growth factor II is induced during wound repair following hypoxic-ischemic injury in the developing rat brain

1995 • 77 citations

Treatment of human breast cancer cells with antisense RNA to the type I insulin-like growth factor receptor inhibits cell growth, suppresses tumorigenesis, alters the metastatic potential, and prolongs survival in vivo

2000 • 75 citations

Binding of Insulin-like Growth Factor (IGF)–Binding Protein-5 to Smooth-Muscle Cell Extracellular Matrix Is a Major Determinant of the Cellular Response to IGF-I

1998 • 75 citations

Dissociation of Mitogenesis and Transforming Activity by C-Terminal Truncation of the Insulin-like Growth Factor-I Receptor

1995 • 75 citations

Mannose 6-Phosphate/Insulin-like Growth Factor II Receptor Mediates Internalization and Degradation of Leukemia Inhibitory Factor but Not Signal Transduction

1999 • 73 citations

Basic FGF and IGF-I Promote Differentiation of Human SH-SY5Y Neuroblastoma Cells in Culture

1994 • 73 citations

Role of serum insulin-like growth factor I in mammalian brain aging

2004 • 73 citations

IGF-Binding Protein mRNAs in the Human Fetus: Tissue and Cellular Distribution of Developmental Expression

1996 • 73 citations

Impaired brain development and reduced astrocyte response to injury in transgenic mice expressing IGF binding protein-1

1997 • 73 citations

Aging as a major risk for degenerative diseases of the central nervous system

1994 • 73 citations

The Hypothalamic Insulin‐Like Growth Factor‐1 Receptor and Its Relationship to Gonadotropin‐Releasing Hormones Neurones During Postnatal Development

2004 • 72 citations

Insulin-Like Growth Factor-1 Fails to Enhance Central Nervous System Myelin Repair during Autoimmune Demyelination

2000 • 72 citations

Insulin-like growth factor-1 content and pattern of expression correlates with histopathologic grade in diffusely infiltrating astrocytomas

1999 • 72 citations

Differential association of insulin-like growth factor I mRNA variants with polysomes in vivo.

1991 • 72 citations

Role of the IGF-I receptor in mutagenesis and tumor promotion

1997 • 71 citations

Insulin-Like Growth Factor I

2000 • 71 citations

Insulin-like Growth Factor-I in Muscle Metabolism and Myotherapies

2001 • 71 citations

Effects of Insulin-Like Growth Factors I and II and Insulin on the Immortalized Hypothalamic GTI-7 Cell Line

1995 • 71 citations

Insulin‐like Growth Factor Receptors: Implications for Nervous System Function

1993 • 70 citations

Estradiol and progesterone regulate the expression of insulin-like growth factor-I receptor and insulin-like growth factor binding protein-2 in the hypothalamus of adult female rats

2000 • 70 citations

Intranuclear Localization of Insulin-Like Growth Factor Binding Protein-3 (IGFBP-3) During Cell Division in Human Keratinocytes

1998 • 70 citations

Trophic effects of basic fibroblast growth factor on fetal rat hypothalamic cells: interactions with insulin-like growth factor I

1990 • 69 citations

Uptake of Circulating Insulin-Like Growth Factors (IGFs) into Cerebrospinal Fluid Appears to Be Independent of the IGF Receptors as Well as IGF-Binding Proteins**This work was supported by Centers for Disease Control and Prevention Grant R49/CCR811509.

2001 • 69 citations

The Role of the Insulin-Like Growth Factor System in the Developing Brain

1998 • 69 citations

Somatomedins/insulin-like growth factors and fetal growth.

1987 • 69 citations

The effects of the N-terminal tripeptide of insulin-like growth factor-1, glycine-proline-glutamate in different regions following hypoxic-ischemic brain injury in adult rats

1999 • 69 citations

Relaxin and its structural relationship to insulin

1978 • 68 citations

IGF-I receptor signalling: lessons from the somatotroph.

1996 • 68 citations

Recombinant human insulin-like growth factor I (rhIGF-I) for amyotrophic lateral sclerosis/motor neuron disease

2002 • 67 citations

Insulin-like growth factors act synergistically withbasic fibroblast growth factor and nerve growth factor to promote chromaffincell proliferation.

1994 • 67 citations

The Biological Role of Truncated Insulin‐like Growth Factor‐1 and the Tripeptide GPE in the Central Nervous System^a

1993 • 67 citations

Insulin-like growth factor I is the key growth factor in serum that protects neuroblastoma cells from hyperosmotic-induced apoptosis

2000 • 66 citations

Alterations in the neural growth hormone axis following hypoxic–ischemic brain injury

1999 • 66 citations

Stimulation of tumor growth by recombinant human insulin-like growth factor-I (IGF-I) is dependent on the dose and the level of IGF-I receptor expression.

1998 • 66 citations

Early Reduction in Insulin-like Growth Factor Gene Expression in Diabetic Nerve

1994 • 65 citations

Regulation and Physiological Role of Insulin-Like Growth Factor Binding Proteins.

1996 • 64 citations

Insulin-Like Growth Factor I (IGF-I) Regulates IGF Binding Protein-5 Gene Expression in the Brain*

1998 • 64 citations

Expression of Insulin-like Growth Factor-I and Related Peptides during Motoneuron Regeneration

1994 • 64 citations

Differential spatio-temporal expression of the insulin-like growth factor genes in regenerating sciatic nerve

1995 • 64 citations

Insulin-like growth factor-I given subcutaneously reduces clinical deficits, decreases lesion severity and upregulates synthesis of myelin proteins in experimental autoimmune encephalomyelitis

1996 • 64 citations

Insulin‐like growth factor‐II/mannose‐6‐phosphate receptor: Widespread distribution in neurons of the central nervous system including those expressing cholinergic phenotype

2003 • 63 citations

The N-myc proto-oncogene and IGF-II growth factor mRNAs are expressed by distinct cells in human fetal kidney and brain.

1989 • 63 citations

IGF-I receptor activation and BCL-2 overexpression prevent early apoptotic events in human neuroblastoma

2000 • 63 citations

The role of insulin and insulin-like growth factor-I in mammalian ageing

2004 • 62 citations

Insulin-like growth factor-I (IGF-I) immunoreactivity in the Alzheimer's disease temporal cortex and hippocampus

1997 • 62 citations

Differential expression of insulin-like growth factor binding proteins (IGFBP) 4 and 5 mRNA in the rat brain after transient hypoxic-ischemic injury

1993 • 62 citations

Expression of the IGFBP-2 gene in post-implantation rat embryos

1992 • 61 citations

Trophic effects of insulin-like growth factor-I (IGF-I) in the inner ear

2004 • 61 citations

Insulin-like growth factor-I is an osmoprotectant in human neuroblastoma cells

1997 • 60 citations

Neuroprotective effects of Gly-Pro-Glu, the N- terminal tripeptide of IGF-1, in the hippocampus in vitro

1999 • 60 citations

Insulin‐like Growth Factor‐I and IGF‐I Receptors in Diabetic Patients with Neuropathy

1995 • 60 citations

Somatomedins/insulin-like growth factors, their receptors and binding proteins are present during mouse embryogenesis

1987 • 60 citations

Expression of insulin-like growth factor-II (IGF-II) and IGF-II/mannose-6-phosphate receptor in the rat hippocampus: an in situ hybridization and immunocytochemical study.

1992 • 60 citations

Insulin-like growth factor I receptor signaling in differentiation of neuronal H19-7 cells.

2000 • 59 citations

Effects of partially purified preparations with nonsuppressible insulin-like activity (NSILA-S) on sulfate incorporation into rat and chicken cartilage

1973 • 59 citations

Endocrine-dependent accumulation of IGF-I by hypothalamic glia

1996 • 59 citations

Insulin-like Growth Factor-II as a Paracrine Growth Factor in Human Neuroblastoma Cells

1995 • 59 citations

Neurotrophins and other growth factors in the regenerative milieu of proximal nerve stump tips

2000 • 59 citations

Expression of the BRL-3A Insulin-like Growth Factor Binding Protein (rBP-30) in the Rat Central Nervous System

1989 • 59 citations

Insulin-Like Growth Factor-I Receptors in Human Glial Tumors

1990 • 59 citations

Developmental Expression of Insulin-Like Growth Factor-II Receptor Immunoreactivity in the Rat Central Nervous System*

1990 • 58 citations

Systemic administration of insulin-like growth factor decreases motor neuron cell death and promotes muscle reinnervation

1998 • 57 citations

Hybrid and Atypical Insulin/lnsulin-Like Growth Factor I Receptors

1994 • 57 citations

Mutant IGF-I Receptors as Dominant Negatives for Growth and Transformation

1995 • 57 citations

IGF‐I Promotes Peripheral Nervous System Myelination

1999 • 57 citations

Insulin-like growth factors prevent apoptosis in cortical neurons isolated from stroke-prone spontaneously hypertensive rats.

1997 • 56 citations

Potential mechanism of estrogen-mediated decrease in bone formation: estrogen increases production of inhibitory insulin-like growth factor-binding protein-4.

1996 • 56 citations

Inhibition of rat C6 glioblastoma tumor growth by expression of insulin-like growth factor I receptor antisense mRNA

1996 • 55 citations

Systemic administration of rhIGF-I enhanced regeneration after sciatic nerve crush in mice.

1995 • 55 citations

Insulinlike growth factor binding proteins

1997 • 55 citations

Insulin‐like growth factor‐I increases astrocyte intercellular gap junctional communication and connexin43 expression in vitro

2003 • 54 citations

The evolution of longevity

2002 • 54 citations

Insulin-like growth factor-I prevents development of a vincristine neuropathy in mice

1997 • 54 citations

Insulin-Like Growth Factor II (IGF-II) and the IGF-II/ Mannose-6-Phosphate Receptor: The Myth Continues

1994 • 54 citations

Insulin-Like Growth Factor Binding Protein-6 Transgenic Mice: Postnatal Growth, Brain Development, and Reproduction Abnormalities

2004 • 54 citations

Sedentary Life Impairs Self-Reparative Processes in the Brain: The Role of Serum Insulin-like Growth Factor-I

2002 • 54 citations

Phenotypic manifestations of insulin-like growth factor binding protein-1 (IGFBP-1) and IGFBP-3 overexpression in transgenic mice

1995 • 54 citations

Rapid changes in gene expression after in vivo growth hormone treatment.

1995 • 53 citations

Insulin-like growth factor-1 receptors in human spinal cord: changes in amyotrophic lateral sclerosis

1994 • 53 citations

Controlling IGF-receptor function: a possible strategy for tumor therapy

1996 • 53 citations

Localization of insulin‐like growth factor binding protein‐4 expression in the developing and adult rat brain: Analysis by in situ hybridization

1993 • 53 citations

IGFs and the Nervous System

1999 • 52 citations

The human IGF-I gene contains two cell type-specifically regulated promoters

1992 • 52 citations

Role of Insulin-Like Growth Factor Binding Protein-2 and Its Limited Proteolysis in Neuroblastoma Cell Proliferation: Modulation by Transforming Growth Factor-β and Retinoic Acid*

1997 • 52 citations

Microspheres containing insulin-like growth factor I for treatment of chronic neurodegeneration

2003 • 51 citations

Insulin-like growth factor-II increases and IGF is required for postnatal rat spinal motoneuron survival following sciatic nerve axotomy

1999 • 50 citations

Insulin-Like Growth Factor I Receptor Signaling System in JC Virus T Antigen-Induced Primitive Neuroectodermal Tumors--Medulloblastomas

2002 • 50 citations

Protective effects of insulin‐like growth factor‐I on the somatostatinergic system in the temporal cortex of β‐amyloid‐treated rats

2004 • 49 citations

Insulin-like growth factor-I treatment reduces immune cell responses in acute non-demyelinative experimental autoimmune encephalomyelitis

1997 • 49 citations

Mechanisms of insulin-like growth factor regulation of programmed cell death of developing avian motoneurons

1998 • 49 citations

Insulin-like growth factor-I regulates glucose-induced mitochondrial depolarization and apoptosis in human neuroblastoma

2004 • 49 citations

Genetic ablation of IGFBP-2 suggests functional redundancy in the IGFBP family

1995 • 48 citations

The IGF-I Amino-Terminal Tripeptide Glycine-Proline-Glutamate (GPE) Is Neuroprotective to Striatum in the Quinolinic Acid Lesion Animal Model of Huntington's Disease

1999 • 48 citations

Inhibition of protein phosphatases induces IGF‐1‐blocked neurotrophin‐insensitive neuronal apoptosis

1996 • 48 citations

IGF-I and End-to-Side Nerve Repair: A Dose-Response Study

2001 • 48 citations

Effects of age and insulin-like growth factor-1 on neuron and synapse numbers in area CA3 of hippocampus

2001 • 47 citations

Involvement of protein kinase-C in the mitogenic effect of insulin-like growth factor-I on rat astrocytes.

1992 • 46 citations

Recombinant human insulin-like growth factor-I in ALS

1996 • 46 citations

Interactions between Growth Hormone, Insulin-Like Growth Factor I, and Basic Fibroblast Growth Factor in Melanocyte Growth1

1999 • 46 citations

Insulin-like growth factor-1-mediated protection from neuronal apoptosis is linked to phosphorylation of the pro-apoptotic protein BAD but not to inhibition of cytochrome c translocation in rat cerebellar neurons

2000 • 46 citations

Hypoxia and hypoxia/ischemia affect the expression of insulin-like growth factor binding protein 2 in the developing rat brain

1993 • 46 citations

Growth hormone induces insulin‐like growth factor‐I gene transcription by a synergistic action of STAT5 and HNF‐1α

1999 • 46 citations

Protective and Rescuing Abilities of IGF‐I and Some Putative Free Radical Scavengers against β‐Amyloid‐Inducing Toxicity in Neurons

1999 • 46 citations

Neuroprotective effect of insulin-like growth factor I in immortalized hypothalamic cells.

1996 • 45 citations

High-affinity insulin binding to an atypical insulin-like growth factor-I receptor in human breast cancer cells.

1992 • 45 citations

N-terminal tripeptide of IGF-1 improves functional deficits after 6-OHDA lesion in rats

2004 • 45 citations

Overexpression of insulin-like growth factor binding protein-1 in transgenic mice

2000 • 45 citations

Expression of the cytokine leukemia inhibitory factor and pro-apoptotic insulin-like growth factor binding protein-3 in Alzheimer's disease

2002 • 45 citations

Multifactorial regulation of IGF‐I gene expression

1993 • 45 citations

Insulin-Like Growth Factor-I (IGF-I) Ameliorates and IGF Binding Protein-1 (IGFBP-1) Exacerbates the Effects of Undernutrition on Brain Growth during Early Postnatal Life: Studies in IGF-I and IGFBP-1 Transgenic Mice

1999 • 44 citations

Regulation of insulin-like growth factor I receptor gene expression by Sp1: physical and functional interactions of Sp1 at GC boxes and at a CT element

1995 • 44 citations

Truncated IGF-1 exerts trophic effects on fetal brain tissue grafts

1990 • 44 citations

Regulation of insulin‐like growth factor‐II expression and its role in autocrine growth of human neuroblastoma cells

1993 • 44 citations

IGF-I stimulates chemotaxis of human neuroblasts. Involvement of type 1 IGF receptor, IGF binding proteins, phosphatidylinositol-3 kinase pathway and plasmin system

2000 • 44 citations

Early Developmental Changes in IGF-I, IGF-II, IGF Binding Protein-1, and IGF Binding Protein-3 Concentration in the Cerebrospinal Fluid of Children

2005 • 44 citations

Mannose-6-Phosphate/IGF-II Receptors Mediate the Effects of IGF-1-Induced Latent Transforming Growth Factor β1 on Expression of Type I Collagen and Collagenase in Dermal Fibroblasts

2000 • 43 citations

Localization of growth hormone receptor/binding protein messenger ribonucleic acid (mRNA) during rat fetal development: relationship to insulin-like growth factor-I mRNA.

1995 • 43 citations

Insulin-like growth factor-1 promotes neuronal glucose utilization during brain development and repair processes

2002 • 43 citations

Modulation of human basophil histamine release by insulin-like growth factors.

1993 • 42 citations

Impaired brain development and hydrocephalus in a line of transgenic mice with liver-specific expression of human insulin-like growth factor binding protein-1

2000 • 42 citations

IGF-binding protein-6 is involved in growth inhibition in SH-SY5Y human neuroblastoma cells: its production is both IGF- and cell density-dependent

1997 • 41 citations

Targeted disruption of IGFBP-2 gene.

1993 • 40 citations

Insulin-like growth factor II in the pathogenesis of human neuroblastoma.

1995 • 40 citations

Ontogeny of insulin-like growth factor I, its receptor, and its binding proteins in the rat hypothalamus

1991 • 39 citations

Deficient expression of insulin receptor substrate-1 (IRS-1) fails to block insulin-like growth factor-I (IGF-I) stimulation of brain growth and myelination

2002 • 39 citations

Biological Properties of NSILA-S

1975 • 39 citations

Insulin‐like Growth Factors and Cerebral Ischemia

1993 • 39 citations

Identification, localization, and regulation of insulin-like growth factor binding proteins and their messenger ribonucleic acids in the newborn rat olfactory bulb.

1994 • 38 citations

Basic Fibroblast Growth Factor Induces Proteolysis of Secreted and Cell Membrane-Associated Insulin-Like Growth Factor Binding Protein-2 in Human Neuroblastoma Cells*

1999 • 38 citations

Interaction of the Signalling Pathways of Insulin-Like Growth Factor-I and Sex Steroids in the Neuroendocrine Hypothalamus

1996 • 37 citations

Human neuroblastoma cells use either insulin-like growth factor-I or insulin-like growth factor-II in an autocrine pathway via the IGF-I receptor: Variability of IGF, IGF binding protein (IGFBP) and IGF receptor gene expression and IGF and IGFBP secretion in human neuroblastoma cells in relation to cellular proliferation

1997 • 37 citations

Insulin-like growth factors in central nervous system tumors.

1997 • 37 citations

Effects of serum and insulin-like growth factors on human neuroblastoma cell growth

1993 • 36 citations

Delineation of atypical insulin receptors from classical insulin and type I insulin-like growth factor receptors in human placenta

1989 • 36 citations

The trophic requirements of mature motoneurons

1998 • 36 citations

Growth Hormone-Mediated Regulation of Insulin-Like Growth Factor I Promoter Activity in C6 Glioma Cells*

1999 • 36 citations

Potential Role of IGF-I in Hypoxia Tolerance Using a Rat Hypoxic-Ischemic Model: Activation of Hypoxia-Inducible Factor 1α

2004 • 36 citations

Autocrine secreted insulin-like growth factor-I stimulates MAP kinase-dependent mitogenic effects in human primitive neuroectodermal tumor/medulloblastoma.

2000 • 35 citations

Peri/nuclear localization of intact insulin-like growth factor binding protein-2 and a distinct carboxyl-terminal IGFBP-2 fragment in vivo

2004 • 35 citations

Olfactory bulb organ culture is supported by combined insulin-like growth factor-I and basic fibroblast growth factor

1993 • 35 citations

Long-Term Effects of Gestational Protein Malnutrition on Postnatal Growth, Insulin-Like Growth Factor (IGF)-I, and IGF-Binding Proteins in Rat Progeny

1996 • 35 citations

Human glioma cells transformed by IGF-I triple helix technology show immune and apoptotic characteristics determining cell selection for gene therapy of glioblastoma

2001 • 34 citations

SOMATOMEDIN-C SHARES THE CARBOXY-TERMINAL ANTIGENIC DETERMINANTS WITH INSULIN-LIKE GROWTH FACTOP-I

1980 • 34 citations

Estrogen and brain vulnerability

2002 • 33 citations

PTEN/MMAC1 overexpression decreases insulin-like growth factor-I-mediated protection from apoptosis in neuroblastoma cells.

2001 • 33 citations

Rediscovering good old friend IGF-I in the new millenium: possible usefulness in Alzheimer's disease and stroke

2000 • 33 citations

Immunohistochemical localization of insulin-like growth factor binding protein-5 in the developing rat nervous system

1996 • 33 citations

Perinatal Hypoxia-Ischemia Decreased Neuronal But Increased Cerebral Vascular Endothelial IGFBP3 Expression

1999 • 33 citations

Hypothalamic Growth Hormone-Insulin-like Growth Factor-I Axis across the Human Life Span

2000 • 32 citations

Brain and cancer: The protective role of erythropoietin

2004 • 32 citations

Comparison of insulin and insulin-like growth factor I receptors from rat skeletal muscle and L-6 myocytes

1987 • 32 citations

Intracerebral transportation and cellular localisation of insulin-like growth factor-1 following central administration to rats with hypoxic–ischemic brain injury

2000 • 31 citations

IGF receptor function and regulation in autocrine human neuroblastoma cell growth

1993 • 30 citations

Expression of rat insulin-like growth factor binding protein-6 in the brain, spinal cord, and sensory ganglia

2000 • 29 citations

Role of insulin-like growth factor binding proteins in limitation of IGF-I degradation into the N-methyl-d-aspartate receptor antagonist GPE: evidence from gonadotrophin-releasing hormone secretion in vitro at two developmental stages

1999 • 28 citations

Metabolic actions of insulin-like growth factor II in cultured adult rat hepatocytes are not mediated through the insulin-like growth factor II receptor

1992 • 28 citations

Synthesis and secretion of insulin-like growth factor (IGF)-II and IGF binding protein-2 by cultivated brain meningeal cells

1995 • 28 citations

Insulin-like growth factor-binding protein-4 inhibits growth of the thymus in transgenic mice

2004 • 28 citations

Cerebral myelinogenesis in theSnell dwarf mouse: Stimulatory effects of GH and T4 restricted to the first 20 days of postnatal life

1985 • 27 citations

Expression of insulin-like growth factor binding protein-4 (IGFBP-4) by rat neural cells — comparison to other IGFBPs

1993 • 27 citations

Insulin‐like growth factor binding protein 5 and type‐1 insulin‐like growth factor receptor are differentially regulated during apoptosis in cerebellar granule cells

2001 • 27 citations

Dysregulation of the Type 1 IGF receptor as a paradigm in tumor progression

1998 • 26 citations

Cellular Response to Latent TGF-β1 Is Facilitated by Insulin-Like Growth Factor-II/Mannose-6-phosphate Receptors on MS-9 Cells

1999 • 26 citations

Insulin-like growth factor II receptors in human brain and their absence in astrogliotic plaques in multiple sclerosis

2000 • 26 citations

Antitumor effects elicited by antisense-mediated downregulation of the insulin-like growth factor I receptor (review).

1998 • 26 citations

Receptors for Insulin-Like Growth Factors in the Central Nervous System: Structure and Function

1988 • 26 citations

Des (1-3) IGF-I Potently Enhances Differentiated Cell Growth in Olfactory Bulb Organ Culture

1994 • 25 citations

IGFs and IGF-binding proteins as diagnostic markers and biological modulators in brain tumors

2002 • 25 citations

Nonsuppressible insulin-like activity of human serum.

1967 • 25 citations

Retroviral expression of a kinase-defective IGF-I receptor suppresses growth and causes apoptosis of CHO and U87 cells in-vivo

2002 • 24 citations

Insulin-like growth factor binding to the atypical insulin receptors of a human lymphoid-derived cell line (IM-9)

1990 • 24 citations

Fibroblast growth factor‐2 over‐rides insulin‐like growth factor‐I induced proliferation and cell survival in human neuroblastoma cells

2003 • 24 citations

Antiproliferative and apoptotic effect of ascorbyl stearate in human glioblastoma multiforme cells: modulation of insulin-like growth factor-I receptor (IGF-IR) expression.

2001 • 24 citations

Gene expression of insulin-like growth factor II in human intracranial meningioma

1993 • 23 citations

Glycosaminoglycans boost insulin-like growth factor-I-promoted neuroprotection: blockade of motor neuron death in the wobbler mouse

1999 • 23 citations

Presence and differential internalization of two distinct insulin-like growth factor receptors in rat hippocampal neurons

1997 • 23 citations

Molecular biology of neurotrophic factors.

1995 • 22 citations

Cost Effectiveness of Recombinant Human Insulin-Like Growth Factor I Therapy in Patients with ALS

1999 • 22 citations

Expression of insulin-like growth factor-I (IGF-I) receptor gene in rat brain and liver during development and in regenerating adult rat liver

1994 • 22 citations

Does erythropoietin protect the preterm brain?

2004 • 21 citations

Inhibition of IGFBP-5 binding to extracellular matrix and IGF-I–stimulated DNA synthesis by a peptide fragment of IGFBP-5

1998 • 21 citations

Insulin‐like Growth Factor Binding Proteins in Nervous‐Tissue‐Derived Cells

1993 • 20 citations

IGF-I triple helix gene therapy of rat and human gliomas.

2003 • 19 citations

The biosynthesis of somatomedins and their role in the fetus

1986 • 19 citations

Growth hormone (GH) and insulin-like growth factor-I (IGF-I) treatment of the GH-deficient dwarf rat: differential effects on IGF-I transcription start site expression in hepatic and extrahepatic tissues and lack of effect on type I IGF receptor mRNA expression

1994 • 19 citations

Nutrient regulation of insulin-like growth factor-I.

1997 • 19 citations

Coordinate expression of insulin-like growth factor II (IGF-II) and IGF-II/mannose-6-phosphate receptor mRNA and stable expression of IGF-I receptor mRNA during differentiation of human colon carcinoma cells (Caco-2)

1996 • 18 citations

IGF-I: from diagnostic to triple-helix gene therapy of solid tumors.

2002 • 18 citations

Glycosaminoglycans co‐administration enhance insulin‐like growth factor‐I neuroprotective and neuroregenerative activity in traumatic and genetic models of motor neuron disease: a review

2000 • 18 citations

Characterization of a Salmon Insulin-Like Growth Factor I Promoter

1994 • 16 citations

IGF-1 influences olfactory bulb maturation. Evidence from anti-IGF-1 antibody treatment of developing grafts in oculo

1995 • 16 citations

Potential Utility of rhIGF-1 in Neuromuscular and/or Degenerative Disease

2007 • 15 citations

Stimulation ofSnell dwarf mouse neuronal growth by GH and T4

1984 • 15 citations

Estrogen induces insulin-like growth factor-1 mRNA expression in the immortalized hippocampal cell: determination by quantitative real-time polymerase chain reaction.

2003 • 15 citations

Gene therapy for malignant neoplasms of the CNS.

1996 • 15 citations

Effects of IGF-I gene therapy on the injured rat pudendal nerve

2003 • 14 citations

Stimulation of myenteric plexus neurite outgrowth by insulin and insulin-like growth factors I and II

1992 • 14 citations

Insulin-Like Growth Factor Binding Proteins in the Nervous System

1991 • 14 citations

Fetal growth signals.

1989 • 14 citations

The Role of Neurotrophic Factors in Disorders of Peripheral Nerves and Motor Neurons

2001 • 14 citations

Immunoreactive insulin, suppressible, and non suppressible insulinlike activities in rats after administration of glucose and induction of hyperglycaemia by mannoheptulose

1966 • 14 citations

High‐level expression of Dok‐1 in neurons of the primate prefrontal cortex and hippocampus

2003 • 14 citations

Radioimmunoassay of Insulin-like Growth Factors I and II in the Cerebrospinal Fluid of Patients with Pituitary and Other Central Nervous System Tumors

1995 • 14 citations

The two nonallelic insulin-like growth factor-I genes in Xenopus laevis are differentially regulated during development.

1994 • 14 citations

Insulin‐like growth factor II mRNA is expressed in neurones of the brain of the bony fish Oreochromis mossambicus, the tilapia

2003 • 13 citations

Atypical Mouse Cerebellar Development Is Caused by Ectopic Expression of the Forkhead Box Transcription Factor HNF-3β

2001 • 13 citations

Insulin-like growth factor-I promotes nerve regeneration through a nerve graft in an experimental model of facial paralysis

1999 • 13 citations

Altered affinity of insulin-like growth factor II (IGF-II) for receptors and IGF-binding proteins, resulting from limited modifications of the IGF-II molecule

1991 • 12 citations

IGF-I mRNA Localization in Trigeminal and Sympathetic Nerve Target Zones During Rat Embryonic Development

1991 • 11 citations

Expression and synthesis of insulin-like growth factor-binding proteins in human glioma cell lines.

1998 • 9 citations

A conformational change in the beta-subunit of the insulin-like growth factor I receptor identified by antipeptide antibodies.

1995 • 9 citations

Insulin-like growth factor-I is an autocrine regulator for the brain metastatic variant of a human non-small cell lung cell line

1995 • 9 citations

Insulin-like growth factor I receptor gene is concordant with C-fes protooncogene and mouse chromosome 7 in somatic cell hybrids

1989 • 9 citations

Down-regulation of 14-3-3 η gene expression by IGF-I in mouse cerebellum during postnatal development

2003 • 7 citations

Functional Alteration of the Somatotrophic Axis in Transgenic Mice with Liver-Specific Expression of Human Insulin-like Growth Factor Binding Protein-1

2002 • 7 citations

The human somatomedin/insulin‐like growth factor genes: organization and development‐specific expression

1989 • 6 citations

Inside Insulin Signaling, Communication Is Key to Long Life

2004 • 6 citations

Neurodegenerative diseases and model systems.

1996 • 4 citations

IGFBP-2/IGF-I/Proteoglycan complexes in the rat brain olfactory bulb

2004 • 4 citations

Differential Effects of Insulin‐like Growth Factor‐1 in the Developing Rat Olfactory Bulb and Cerebral Cortex: Evidence from Intraocular Grafting

1993 • 2 citations

Deleted Work

1955 • 0 citations