Insulin-Like Growth Factor-I and Over-Expression of Bcl-xL Prevent Glucose-Mediated Apoptosis in Schwann Cells

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

1972 • 15,349 citations

Caspases: Enemies Within

1998 • 6,923 citations

The Bcl-2 Protein Family: Arbiters of Cell Survival

1998 • 5,359 citations

Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria Blocked

1997 • 4,921 citations

The Release of Cytochrome c from Mitochondria: A Primary Site for Bcl-2 Regulation of Apoptosis

1997 • 4,728 citations

Regulation of Neuronal Survival by the Serine-Threonine Protein Kinase Akt

1997 • 2,442 citations

Movement of Bax from the Cytosol to Mitochondria during Apoptosis

1997 • 1,805 citations

Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair

1993 • 1,638 citations

Chromatin cleavage in apoptosis: Association with condensed chromatin morphology and dependence on macromolecular synthesis

1984 • 1,586 citations

Bax directly induces release of cytochrome c from isolated mitochondria

1998 • 1,514 citations

Bcl-xL Regulates the Membrane Potential and Volume Homeostasis of Mitochondria

1997 • 1,389 citations

Oxidative Stress in Neurodegenerative Diseases

1996 • 1,336 citations

Regressive Events in Neurogenesis

1984 • 1,330 citations

Massive Cell Death of Immature Hematopoietic Cells and Neurons in Bcl-x-Deficient Mice

1995 • 1,167 citations

Cytosol-to-membrane redistribution of Bax and Bcl-X_Lduring apoptosis

1997 • 1,117 citations

The changing landscape of ischaemic brain injury mechanisms

1999 • 1,111 citations

Caspase Cleaved BID Targets Mitochondria and Is Required for Cytochrome c Release, while BCL-XL Prevents This Release but Not Tumor Necrosis Factor-R1/Fas Death

1999 • 1,024 citations

Bcl-2/Bax: a rheostat that regulates an anti-oxidant pathway and cell death.

1993 • 855 citations

Glial growth factors are alternatively spliced erbB2 ligands expressed in the nervous system

1993 • 744 citations

Bcl‐2 family: Life‐or‐death switch

2000 • 665 citations

Immunohistochemical determination of in vivo distribution of Bax, a dominant inhibitor of Bcl-2.

1994 • 664 citations

Phosphatidylinositol 3-Kinase and Akt Protein Kinase Are Necessary and Sufficient for the Survival of Nerve Growth Factor-Dependent Sympathetic Neurons

1998 • 577 citations

Apoptosis and the Nervous System

2000 • 469 citations

The Roles of Oxidative Stress and Antioxidant Treatment in Experimental Diabetic Neuropathy

1997 • 436 citations

bcl-2 protein expression is widespread in the developing nervous system and retained in the adult PNS

1994 • 432 citations

Subcellular and submitochondrial mode of action of Bcl-2-like oncoproteins

1998 • 421 citations

Neurons Undergo Apoptosis in Animal and Cell Culture Models of Diabetes

1999 • 410 citations

Hyperglycemia induces apoptosis in pre-implantation embryos through cell death effector pathways

1998 • 342 citations

Expression of Neuregulins and their Putative Receptors, ErbB2 and ErbB3, Is Induced during Wallerian Degeneration

1997 • 329 citations

Schwann Cell–Derived Desert Hedgehog Controls the Development of Peripheral Nerve Sheaths

1999 • 324 citations

Rescue of the Cardiac Defect in ErbB2 Mutant Mice Reveals Essential Roles of ErbB2 in Peripheral Nervous System Development

1999 • 321 citations

Axonal Interactions Regulate Schwann Cell Apoptosis in Developing Peripheral Nerve: Neuregulin Receptors and the Role of Neuregulins

1996 • 321 citations

Metabolic and Vascular Factors in the Pathogenesis of Diabetic Neuropathy

1997 • 314 citations

Schwann cells and their precursors emerge as major regulators of nerve development

1999 • 302 citations

Bcl-2 family proteins as ion-channels

1998 • 299 citations

The schwann cell precursor and its fate: A study of cell death and differentiation during gliogenesis in rat embryonic nerves

1994 • 295 citations

Peroxynitrite‐Induced Cytotoxicity in PC12 Cells: Evidence for an Apoptotic Mechanism Differentially Modulated by Neurotrophic Factors

1995 • 292 citations

Pathologic Alterations in the Diabetic Neuropathies of Humans

1996 • 286 citations

Insulin-Like Growth Factor-I Protects Axotomized Rat Retinal Ganglion Cells from Secondary Death via PI3-K-Dependent Akt Phosphorylation and Inhibition of Caspase-3In Vivo

2000 • 260 citations

Insulin-like growth factor-I prevents caspase-mediated apoptosis in Schwann cells

1999 • 254 citations

Nineteenth century research on naturally occurring cell death and related phenomena

1996 • 253 citations

Schwann cell survival mediated by the signaling phospholipid lysophosphatidic acid

1999 • 253 citations

The Neurobiology of Schwann Cells

1999 • 244 citations

Bcl-x_Lis an Antiapoptotic Regulator for Postnatal CNS Neurons

1998 • 244 citations

Multiple Pathways of Neuronal Death Induced by DNA-Damaging Agents, NGF Deprivation, and Oxidative Stress

1998 • 243 citations

Bax Protein Expression Is Increased in Alzheimerʼs Brain

1997 • 241 citations

Glucose-induced oxidative stress and programmed cell death in diabetic neuropathy

1999 • 239 citations

Purification and preliminary characterization of a glial growth factor from the bovine pituitary.

1980 • 225 citations

Bcl-xL is expressed in neuroblastoma cells and modulates chemotherapy-induced apoptosis.

1995 • 220 citations

Activation of Akt Kinase Inhibits Apoptosis and Changes in Bcl‐2 and Bax Expression Induced by Nitric Oxide in Primary Hippocampal Neurons

1999 • 218 citations

Bax promotes neuronal cell death and is downregulated during the development of the nervous system

1997 • 217 citations

Insulin-Like Growth Factor-1 Inhibition of Apoptosis Is Associated with Increased Expression of the bcl-xL Gene Product

1997 • 208 citations

Size Control: The Regulation of Cell Numbers in Animal Development

1996 • 202 citations

Evidence that elevated glucose causes altered gene expression, apoptosis, and neural tube defects in a mouse model of diabetic pregnancy.

1999 • 195 citations

Aberrant development of motor axons and neuromuscular synapses in erbB2-deficient mice

2000 • 181 citations

Insulin-like growth factor I rescues SH-SY5Y human neuroblastoma cells from hyperosmotic induced programmed cell death

1996 • 169 citations

Type I Insulin-like Growth Factor Receptor Activation Regulates Apoptotic Proteins

1996 • 162 citations

Apoptosis Decision Cascades and Neuronal Degeneration in Alzheimer’s Disease

1998 • 146 citations

Pathogenesis of Diabetic Neuropathy

1998 • 139 citations

PATHOLOGICAL OBSERVATIONS ON SIX CASES OF DIABETIC NEUROPATHY

1964 • 131 citations

Insulin-like growth factor I receptor prevents apoptosis and enhances neuroblastoma tumorigenesis.

1996 • 128 citations

Oligodendrocytes and their precursors require phosphatidylinositol 3-kinase signaling for survival

1996 • 127 citations

Cell death and birth in multiple sclerosis brain

1997 • 127 citations

Methods for the Detection of Apoptosis

1994 • 125 citations

Reactive, degenerative, and proliferative Schwann cell responses in experimental galactose and human diabetic neuropathy

1998 • 122 citations

Oxidative injury in the nervous system

1998 • 122 citations

Insulin-like growth factor-I prevents apoptosis in neurons after nerve growth factor withdrawal

1998 • 121 citations

Cell death of dopamine neurons in aging and Parkinson’s disease

1999 • 121 citations

Axon–Schwann cell interactions during peripheral nerve degeneration and regeneration

1997 • 118 citations

Inhibition of Oligodendrocyte Apoptosis by Sublytic C5b-9 Is Associated with Enhanced Synthesis of Bcl-2 and Mediated by Inhibition of Caspase-3 Activation

1999 • 115 citations

New insights into the pathogenesis of diabetic neuropathy

1999 • 114 citations

Gram positive bacteria induce IL-6 and IL-8 production in human alveolar macrophages and epithelial cells.

1998 • 105 citations

Insulin-Like Growth Factor-I Prevents Apoptosis in Sympathetic Neurons Exposed to High Glucose

1999 • 101 citations

Glial Growth Factor Rescues Schwann Cells of Mechanoreceptors from Denervation-Induced Apoptosis

1997 • 100 citations

A Role for Insulin-Like Growth Factor-I in the Regulation of Schwann Cell Survival

1999 • 100 citations

NGF, BDNF and NT-5, but not NT-3 protect against MPP+ toxicity and oxidative stress in neonatal animals

1996 • 99 citations

Phosphatidylinositol 3-kinase and Akt protein kinase mediate IGF-I- and prosaptide-induced survival in schwann cells

1999 • 96 citations

Diabetic Neuropathies: Features and Mechanisms

1999 • 96 citations

Bcl-2 regulates amplification of caspase activation by cytochrome c

1999 • 94 citations

Function and expression of the Bcl-x gene in the developing and adult nervous system

1995 • 91 citations

Role of superoxide in apoptosis induced by growth factor withdrawal

1998 • 90 citations

Myelin splitting, Schwann cell injury and demyelination in feline diabetic neuropathy

1998 • 84 citations

Etiology of Parkinson's Disease

2003 • 81 citations

Schwann Cell Apoptosis during Normal Development and after Axonal Degeneration Induced by Neurotoxins in the Chick Embryo

1996 • 78 citations

Relative level of expression of Bax and Bcl-XL determines the cellular fate of apoptosis/necrosis induced by the overexpression of Bax

1999 • 75 citations

Overexpression of Akt (protein kinase B) confers protection against apoptosis and prevents formation of ceramide in response to pro-apoptotic stimuli

1999 • 73 citations

Apoptosis in Ca² + reperfusion injury of cultured astrocytes: roles of reactive oxygen species and NF‐κB activation

1999 • 69 citations

Insulin-Like Growth Factor-1 Inhibition of Apoptosis Is Associated with Increased Expression of the bcl-xL Gene Product

1997 • 69 citations

Insulin-like growth factor I is the key growth factor in serum that protects neuroblastoma cells from hyperosmotic-induced apoptosis

2000 • 66 citations

IGF-I receptor activation and BCL-2 overexpression prevent early apoptotic events in human neuroblastoma

2000 • 63 citations

IGF-I promotes Schwann cell motility and survival via activation of Akt

2000 • 63 citations

Free radicals and reactive oxygen species in programmed cell death

1999 • 62 citations

Insulin-like growth factor-I is an osmoprotectant in human neuroblastoma cells

1997 • 60 citations

Insulin-like Growth Factor-II as a Paracrine Growth Factor in Human Neuroblastoma Cells

1995 • 59 citations

Apoptosis of bcl-x-deficient telencephalic cells in vitro

1996 • 59 citations

p21WAF1 induces permanent growth arrest and enhances differentiation, but does not alter apoptosis in PC12 cells

1998 • 57 citations

Oxygen Toxicity Induces Apoptosis in Neuronal Cells

1998 • 57 citations

Apoptosis Regulates the Number of Schwann Cells at the Premyelinating Stage

1997 • 56 citations

Tyrosine Phosphorylation and Enhanced Expression of Paxillin during Neuronal Differentiation in Vitro

1996 • 52 citations

Overexpression of bcl-xLProtects Astrocytes from Glucose Deprivation and Is Associated with Higher Glutathione, Ferritin, and Iron Levels

1999 • 52 citations

Oxidative stress and antioxidant treatment in diabetic neuropathy

1997 • 41 citations

Immunochemical and immunohistochemical localization of Bcl-x protein in the rat central nervous system

1996 • 37 citations

Multi-Step Chromatin Degradation in Apoptosis

1994 • 36 citations

Fate of Schwann Cells in CMT1A and HNPP: Evidence for Apoptosis

1998 • 36 citations

Zinc and Copper inhibit nerve growth factor-mediated protection from oxidative stress-induced apoptosis

1999 • 36 citations

Etiology of Parkinson's Disease

1999 • 34 citations

Depletion of Phospholipid Arachidonoyl‐Containing Molecular Species in a Human Schwann Cell Line Grown in Elevated Glucose and Their Restoration by an Aldose Reductase Inhibitor

1998 • 33 citations

Future prevention and treatment of diabetic neuropathy.

1998 • 32 citations

Delayed neuronal death in hippocampal CA1 pyramidal neurons after forebrain ischemia in hyperglycemic gerbils: amelioration by indomethacin

2000 • 31 citations

Characterization of polyol pathway in schwann cells isolated from adult rat sciatic nerves

1999 • 28 citations

Schwann cell undergoes apoptosis during experimental allergic neuritis (EAN)

1998 • 27 citations

Regulation of Reactive Oxygen Species by Nerve Growth Factor but not Bcl-2 as a Novel Mechanism of Protection of PC12 Cells from Superoxide Anion-Induced Death

1999 • 27 citations

Nerve Growth Factor and Oxidative Stress in the Nervous System

1997 • 25 citations

Caspases mediate C2-ceramide-induced apoptosis of the human oligodendroglial cell line, MO3.13

2000 • 21 citations

Multiple polyphosphoinositide pathways regulate apoptotic signalling in a dorsal root ganglion derived cell line

2000 • 19 citations

Schwann cell changes induced as early as one week after galactose intoxication

1997 • 18 citations

Neuregulins as Potential Neuroprotective Agents

1997 • 13 citations

Case report: DNA fragmentation in glial cells in a cerebral biopsy from a multiple sclerosis patient.

1998 • 11 citations

Review ■ : Insulin-like Growth Factor-I and Apoptosis in Glial Cell Biology

2000 • 4 citations