Characterization of Insulin‐Like Growth Factor‐I and Its Receptor and Binding Proteins in Transected Nerves and Cultured Schwann Cells

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Re-examination and further development of a precise and rapid dye method for measuring cell growth/cell kill

1989 • 3,477 citations

Number and evolutionary conservation of α- and β-tubulin and cytoplasmic β- and γ-actin genes using specific cloned cDNA probes

1980 • 1,884 citations

Insulin-Like Growth Factors I and II. Peptide, Messenger Ribonucleic Acid and Gene Structures, Serum, and Tissue Concentrations*

1989 • 1,796 citations

Changes of nerve growth factor synthesis in nonneuronal cells in response to sciatic nerve transection.

1987 • 1,012 citations

Insulin-like growth factors and their binding proteins

1990 • 929 citations

Insulin-like Growth Factor Binding Proteins

1993 • 754 citations

Identification and molecular characterization of insulin-like growth factor binding proteins (IGFBP-1, -2, -3, -4, -5 and -6)

1991 • 680 citations

Human insulin receptors mutated at the ATP-binding site lack protein tyrosine kinase activity and fail to mediate postreceptor effects of insulin.

1987 • 648 citations

Induction of nerve growth factor receptor in Schwann cells after axotomy.

1986 • 614 citations

Growth factors in wound healing. Single and synergistic effects on partial thickness porcine skin wounds.

1989 • 539 citations

Expression of nerve growth factor receptors by Schwann cells of axotomized peripheral nerves: ultrastructural location, suppression by axonal contact, and binding properties

1988 • 539 citations

Expression of Somatomedin/Insulin-Like Growth Factor Messenger Ribonucleic Acids in the Human Fetus: Identification, Characterization, and Tissue Distribution*

1988 • 375 citations

Insulin‐like growth factor I promotes cell proliferation and oligodendroglial commitment in rat glial progenitor cells developing in vitro

1988 • 361 citations

Isolation of an inhibitory insulin-like growth factor (IGF) binding protein from bone cell-conditioned medium: a potential local regulator of IGF action.

1989 • 358 citations

Human osteoblast-derived insulin-like growth factor (IGF) binding protein-5 stimulates osteoblast mitogenesis and potentiates IGF action.

1992 • 351 citations

Developmental regulation of the rat insulin-like growth factor I receptor gene.

1989 • 338 citations

Regulation of ciliary neurotrophic factor expression in myelin-related Schwann cells in vivo

1992 • 309 citations

Insulinlike Growth Factor-Binding Proteins

1990 • 291 citations

Monoclonal antibody to the type I insulin-like growth factor (IGF-I) receptor blocks IGF-I receptor-mediated DNA synthesis: clarification of the mitogenic mechanisms of IGF-I and insulin in human skin fibroblasts.

1986 • 269 citations

Evidence for a functional role of endogenously produced somatomedinlike peptides in the regulation of DNA synthesis in cultured human fibroblasts and porcine smooth muscle cells.

1985 • 257 citations

Insulin growth factors regulate the mitotic cycle in cultured rat sympathetic neuroblasts.

1988 • 239 citations

Characterization of recombinant human insulin-like growth factor binding proteins 4, 5, and 6 produced in yeast.

1992 • 183 citations

Insulin-like growth factor (IGF-1) as a stimulator of regeneration in the freeze-injured rat sciatic nerve

1989 • 167 citations

Heparin, heparan sulfate, and dermatan sulfate regulate formation of the insulin-like growth factor-I and insulin-like growth factor-binding protein complexes.

1994 • 165 citations

Macrophage-mediated myelin-related mitogenic factor for cultured Schwann cells.

1988 • 157 citations

Insulin and insulin-like growth factor I enhance regeneration in cultured adult rat sensory neurones

1993 • 153 citations

A highly conserved insulin-like growth factor-binding protein (IGFBP-5) is expressed during myoblast differentiation.

1993 • 146 citations

Regulation and biological effect of endogenous insulin-like growth factor binding protein-5 in human osteoblastic cells.

1993 • 145 citations

Insulin‐like growth factor (IGF) binding to human fibroblast and glioblastoma cells: The modulating effect of cell released IGF binding proteins (IGFBPs)

1990 • 143 citations

Insulin-like growth factor II stimulates motor nerve regeneration.

1992 • 141 citations

Multihormonal Regulation of Insulin-Like Growth Factor-Binding Protein-1 in Rat H4IIE Hepatoma Cells: The Dominant Role of Insulin*

1991 • 127 citations

Growth and Differentiation of Neural Cells in Defined Media

1985 • 117 citations

Characterization of an Insulin-Like Growth Factor Binding Protein (IGFBP-4) Produced by the B104 Rat Neuronal Cell Line: Chemical and Biological Properties and Differential Synthesis by Sublines*

1991 • 109 citations

Axons modulate the expression of transforming growth factor‐betas in Schwann cells

1993 • 107 citations

Insulin-Like Growth Factor (IGF) Binding to Cell Monolayers Is Directly Modulated by the Addition of IGF-Binding Proteins*

1991 • 102 citations

Insulin-like growth factor-I reverses the impairment of wound healing induced by corticosteroids in rats.

1992 • 101 citations

Regulation of insulin-like growth factor binding protein 4 by a specific insulin-like growth factor binding protein 4 proteinase in normal human osteoblast-like cells: Implications in bone cell physiology

1994 • 93 citations

Regulation of insulin-like growth factor I gene expression in the human macrophage-like cell line U937.

1990 • 86 citations

Regulation of insulin-like growth factor binding protein-5 messenger ribonucleic acid expression and protein availability in rat osteoblast-like cells.

1993 • 79 citations

Insulin-like growth factor binding proteins: roles in regulating IGF physiology.

1991 • 76 citations

Structural and functional analysis of insulin-like growth factors

1989 • 76 citations

A unique receptor-independent mechanism by which insulinlike growth factor I regulates the availability of insulinlike growth factor binding proteins in normal and transformed human fibroblasts.

1991 • 75 citations

Abdominal coarctation increases insulin-like growth factor I mRNA levels in rat aorta.

1993 • 71 citations

Classification of the insulin-like growth factor binding proteins into three distinct categories according to their binding specificities

1988 • 70 citations

Parathyroid Hormone and Parathyroid Hormone-Related Peptide Stimulate Insulin-Like Growth Factor-Binding Protein Secretion by Rat Osteoblast-Like Cells through a Adenosine 3′,5′-Monophosphate-Dependent Mechanism*

1991 • 70 citations

Regulation of Schwann cell proliferation: Mechanisms involved in peripheral nerve development

1992 • 67 citations

Gene expression of the insulin-like growth factors and their receptors in cultured human retinal pigment epithelial cells

1992 • 62 citations

The insulin-like growth factor family of ligands, receptors, and binding proteins

1992 • 55 citations

Altered growth factor expression during toxic proximal tubular necrosis and regeneration

1993 • 48 citations

Insulin-like growth factor I regulates c-myc and GAP-43 messenger ribonucleic acid expression in SH-SY5Y human neuroblastoma cells.

1993 • 47 citations

Anabolic and Tissue Repair Functions of Recombinant Insulin‐Like Growth Factor I

1990 • 47 citations

Regulation of insulin‐like growth factor‐II expression and its role in autocrine growth of human neuroblastoma cells

1993 • 44 citations

Insulin-Like Growth Factors (IGFs) and IGF-Binding Proteins in the Developing Rhesus Monkey*

1991 • 44 citations

Isolation of rat Schwann cell lines: Use of SV40 T antigen gene regulated by synthetic metallothionein promoters

1989 • 44 citations

Gene expression of insulin-like growth factor-I and IGF-I receptor during wound healing in rats.

1992 • 44 citations

Effect of epidermal growth factor on insulin-like growth factor-I (IGF-I) and IGF-binding protein synthesis by adult rat hepatocytes

1992 • 37 citations

Kinetics of production of a novel growth factor after peripheral nerve injury

1990 • 30 citations

Mannose 6-phosphate potentiates insulin-like growth factor II effects in cultured human neuroblastoma cells

1991 • 24 citations

Regulation of insulin‐like growth factor binding protein synthesis and secretion in human retinal pigment epithelial cells

1994 • 24 citations

Increased PO glycoprotein gene expression in primary and transfected rat Schwann cells after treatment with axolemma‐enriched fraction

1993 • 21 citations

Heparin, heparan sulfate, and dermatan sulfate regulate formation of the insulin-like growth factor-I and insulin-like growth factor-binding protein complexes

1994 • 13 citations

Antiphosphotyrosine antibodies for studying protein phosphorylation in neural cells: Applications to brain slices and cultured cells

1992 • 8 citations

Characterization of the Biological Activity of IGF I Analogs with Reduced Affinity for IGF Receptors and Binding Proteins

1991 • 6 citations