Insulin-like growth factor-I regulates glucose-induced mitochondrial depolarization and apoptosis in human neuroblastoma

Mitochondria and Apoptosis

1998 • 8,909 citations

Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade

1997 • 7,177 citations

The Bcl-2 Protein Family: Arbiters of Cell Survival

1998 • 5,359 citations

A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry

1991 • 4,682 citations

Apaf-1, a Human Protein Homologous to C. elegans CED-4, Participates in Cytochrome c–Dependent Activation of Caspase-3

1997 • 3,130 citations

THE MITOCHONDRIAL DEATH/LIFE REGULATOR IN APOPTOSIS AND NECROSIS

1998 • 1,982 citations

Bax directly induces release of cytochrome c from isolated mitochondria

1998 • 1,514 citations

Mitochondrial control of apoptosis

1997 • 1,500 citations

Bcl-xL Regulates the Membrane Potential and Volume Homeostasis of Mitochondria

1997 • 1,389 citations

Mitochondrial control of nuclear apoptosis.

1996 • 1,363 citations

Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD-specific caspase activation and independently of mitochondrial transmembrane depolarization

1998 • 1,226 citations

Uncoupling protein‐3: a new member of the mitochondrial carrier family with tissue‐specific expression

1997 • 1,067 citations

Bax interacts with the permeability transition pore to induce permeability transition and cytochromecrelease in isolated mitochondria

1998 • 932 citations

Mitochondrial Release of Caspase-2 and -9 during the Apoptotic Process

1999 • 730 citations

Conformation of the Bax C-terminus regulates subcellular location and cell death

1999 • 723 citations

Bax-induced Cytochrome C Release from Mitochondria Is Independent of the Permeability Transition Pore but Highly Dependent on Mg2+ Ions

1998 • 645 citations

Interaction of CED-4 with CED-3 and CED-9: A Molecular Framework for Cell Death

1997 • 635 citations

Regulated Targeting of BAX to Mitochondria

1998 • 617 citations

Structure and function of the type 1 insulin-like growth factor receptor

2000 • 602 citations

Signaling Pathways in Reactive Oxygen Species–Induced Cardiomyocyte Apoptosis

1999 • 574 citations

Caspases and caspase inhibitors

1997 • 573 citations

Caspase-9, Bcl-XL, and Apaf-1 Form a Ternary Complex

1998 • 523 citations

High glucose‐induced oxidative stress and mitochondrial dysfunction in neurons

2002 • 493 citations

Outer mitochondrial membrane permeability can regulate coupled respiration and cell survival

2000 • 428 citations

Neurons Undergo Apoptosis in Animal and Cell Culture Models of Diabetes

1999 • 410 citations

FLICE Is Predominantly Expressed as Two Functionally Active Isoforms, Caspase-8/a and Caspase-8/b

1997 • 405 citations

p38 Map Kinase Mediates Bax Translocation in Nitric Oxide–Induced Apoptosis in Neurons

2000 • 391 citations

Oxidative Stress and Programmed Cell Death in Diabetic Neuropathy

2002 • 357 citations

The PROSITE dictionary of sites and patterns in proteins, its current status

1993 • 353 citations

Oxidative Injury and Apoptosis of Dorsal Root Ganglion Neurons in Chronic Experimental Diabetic Neuropathy

2003 • 352 citations

Role of hypoxia-induced Bax translocation and cytochrome c release in reoxygenation injury

1998 • 294 citations

Mitochondrial and extramitochondrial apoptotic signaling pathways in cerebrocortical neurons

2000 • 283 citations

Evidence of a Novel Event during Neuronal Death

1998 • 276 citations

The uncoupling proteins, a review

1998 • 269 citations

Diabetic peripheral neuropathy: evidence for apoptosis and associated mitochondrial dysfunction.

2000 • 256 citations

High glucose‐induced oxidative stress causes apoptosis in proximal tubular epithelial cells and is mediated by multiple caspases

2003 • 239 citations

The contradictions of the insulin-like growth factor 1 receptor

2000 • 236 citations

Delayed Mitochondrial Dysfunction in Excitotoxic Neuron Death: CytochromecRelease and a Secondary Increase in Superoxide Production

2000 • 233 citations

Activation of Akt Kinase Inhibits Apoptosis and Changes in Bcl‐2 and Bax Expression Induced by Nitric Oxide in Primary Hippocampal Neurons

1999 • 218 citations

Brain Uncoupling Protein 2: Uncoupled Neuronal Mitochondria Predict Thermal Synapses in Homeostatic Centers

1999 • 177 citations

Bid acts on the permeability transition pore complex to induce apoptosis

2000 • 174 citations

Genetic parameters of neuroblastomas

2002 • 172 citations

Insulin-like growth factor I rescues SH-SY5Y human neuroblastoma cells from hyperosmotic induced programmed cell death

1996 • 169 citations

Type I Insulin-like Growth Factor Receptor Activation Regulates Apoptotic Proteins

1996 • 162 citations

Pathogenesis of Diabetic Neuropathy

1998 • 139 citations

Aggressive childhood neuroblastomas do not express caspase-8: an important component of programmed cell death

2001 • 133 citations

Effects of streptozotocin-induced diabetes and insulin treatment on the hypothalamic melanocortin system and muscle uncoupling protein 3 expression in rats.

2000 • 130 citations

Insulin-like growth factor I receptor prevents apoptosis and enhances neuroblastoma tumorigenesis.

1996 • 128 citations

Neuroblastoma tumour genetics: clinical and biological aspects

2001 • 127 citations

Insulin-Like Growth Factor-I and Over-Expression of Bcl-xL Prevent Glucose-Mediated Apoptosis in Schwann Cells

2001 • 125 citations

Mitochondrial analysis in living cells: the use of rhodamine 123 and flow cytometry

1986 • 122 citations

Insulin-like growth factor-I prevents apoptosis in neurons after nerve growth factor withdrawal

1998 • 121 citations

Caspase-9 processing by caspase-3 via a feedback amplification loop in vivo

2001 • 110 citations

Effectiveness of insulin-like growth factor I receptor antisense strategy against Ewing's sarcoma cells

2002 • 105 citations

Mitogenicity and transforming activity of the insulin-like growth factor-I receptor with mutations in the tyrosine kinase domain.

1994 • 101 citations

Insulin-Like Growth Factor-I Prevents Apoptosis in Sympathetic Neurons Exposed to High Glucose

1999 • 101 citations

Insulin-like Growth Factor-I (IGF-I) Regulates IGF-binding Protein-5 Synthesis through Transcriptional Activation of the Gene in Aortic Smooth Muscle Cells

1996 • 97 citations

Dissipation of Potassium and Proton Gradients Inhibits Mitochondrial Hyperpolarization and Cytochrome c Release during Neural Apoptosis

2001 • 96 citations

Type I insulin-like growth factor receptor function in breast cancer

1998 • 92 citations

Allelic imbalance on chromosome 2q and alterations of the caspase 8 gene in neuroblastoma

2001 • 91 citations

Mechanism underlying anti-apoptotic activity of a (−)deprenyl-related propargylamine, rasagiline

2000 • 85 citations

Evidence for Anion-translocating Plant Uncoupling Mitochondrial Protein in Potato Mitochondria

1996 • 84 citations

IGF-1 inhibits the mitochondrial apoptosis program in mesangial cells exposed to high glucose

2003 • 81 citations

Inhibition of insulin-like growth factor I receptor expression in neuroblastoma cells induces the regression of established tumors in mice.

1998 • 80 citations

Role of the IGF-I receptor in mutagenesis and tumor promotion

1997 • 71 citations

Mechanism of nitric oxide‐induced apoptosis in human neuroblastoma SH‐SY5Y cells

2000 • 71 citations

Insulin-like growth factor I is the key growth factor in serum that protects neuroblastoma cells from hyperosmotic-induced apoptosis

2000 • 66 citations

Stimulation of tumor growth by recombinant human insulin-like growth factor-I (IGF-I) is dependent on the dose and the level of IGF-I receptor expression.

1998 • 66 citations

The role of caspase-8 in resistance to cancer chemotherapy

2001 • 65 citations

IGF-I receptor activation and BCL-2 overexpression prevent early apoptotic events in human neuroblastoma

2000 • 63 citations

Endogenous Bax Translocation in SH‐SY5Y Human Neuroblastoma Cells and Cerebellar Granule Neurons Undergoing Apoptosis

1999 • 60 citations

Insulin-like growth factor-I is an osmoprotectant in human neuroblastoma cells

1997 • 60 citations

Insulin-like Growth Factor-II as a Paracrine Growth Factor in Human Neuroblastoma Cells

1995 • 59 citations

Roles of p53, c-Myc, Bcl-2, Bax and caspases in glutamate-induced neuronal apoptosis and the possible neuroprotective mechanism of basic fibroblast growth factor

1999 • 53 citations

Tyrosine Phosphorylation and Enhanced Expression of Paxillin during Neuronal Differentiation in Vitro

1996 • 52 citations

Caspase-9 and Apaf-1 are expressed and functionally active in human neuroblastoma tumor cell lines with 1p36 LOH and amplified MYCN

2002 • 46 citations

Insulin-like growth factor II in the pathogenesis of human neuroblastoma.

1995 • 40 citations

Doxorubicin-induced apoptosis in caspase-8-deficient neuroblastoma cells is mediated through direct action on mitochondria

2001 • 37 citations

The N-myc paradox: N-myc overexpression in neuroblastomas is associated with sensitivity as well as resistance to apoptosis

2003 • 37 citations

Human neuroblastoma cells use either insulin-like growth factor-I or insulin-like growth factor-II in an autocrine pathway via the IGF-I receptor: Variability of IGF, IGF binding protein (IGFBP) and IGF receptor gene expression and IGF and IGFBP secretion in human neuroblastoma cells in relation to cellular proliferation

1997 • 37 citations

Roles of p53, c-Myc, Bcl-2, Bax and caspases in serum deprivation-induced neuronal apoptosis

1999 • 37 citations

Insulin‐like growth factor‐1 protects peroxynitrite‐induced cell death by preventing cytochromec‐induced caspase‐3 activation

2002 • 33 citations

PTEN/MMAC1 overexpression decreases insulin-like growth factor-I-mediated protection from apoptosis in neuroblastoma cells.

2001 • 33 citations

IGF-I Induces the Uncoupling Protein Gene Expression in Fetal Rat Brown Adipocyte Primary Cultures: Role of C/EBP Transcription Factors

1994 • 28 citations

Dysregulation of the Type 1 IGF receptor as a paradigm in tumor progression

1998 • 26 citations

Detection of caspase-activation in intact lymphoid cells using standard caspase substrates and inhibitors

2000 • 24 citations

Insulin-like Growth Factor Type 1 Upregulates Uncoupling Protein 3

2001 • 17 citations

Maturational sequence of neuroblastoma revealed by molecular analysis on cDNA microarrays

2002 • 9 citations