Overexpression of Insulin-Like Growth Factor-Binding Protein-2 in Transgenic Mice Reduces Postnatal Body Weight Gain

Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r)

1993 • 2,880 citations

Role of insulin-like growth factors in embryonic and postnatal growth

1993 • 2,349 citations

Actions of Insulin-Like Growth Factors

1985 • 1,141 citations

A hormonally controlled serum factor which stimulates sulfate incorporation by cartilage in vitro. 1956.

1990 • 1,075 citations

Growth Enhancement of Transgenic Mice Expressing Human Insulin-Like Growth Factor I*

1988 • 481 citations

Altered body composition and increased frequency of diverse malignancies in insulin-like growth factor-II transgenic mice.

1994 • 274 citations

Growth retardation and hyperglycemia in insulin-like growth factor binding protein-1 transgenic mice.

1995 • 197 citations

Clinical studies of IGFBP-2 by radioimmunoassay.

1993 • 138 citations

The variability in activity of the universally expressed human cytomegalovirus immediate early gene 1 enhancer/promoter in transgenic mice

1991 • 136 citations

Gene expression of insulin-like growth factors (IGFs), the type 1 IGF receptor, and IGF-binding proteins in dexamethasone-induced fetal growth retardation.

1992 • 133 citations

Characterization of the affinities of insulin-like growth factor (IGF)-binding proteins 1-4 for IGF-I, IGF-II, IGF-I/insulin hybrid, and IGF-I analogs.

1993 • 129 citations

Liver-Specific Expression of Human Insulin-Like Growth Factor Binding Protein-1 in Transgenic Mice: Repercussions on Reproduction, Ante- and Perinatal Mortality and Postnatal Growth¹

1997 • 124 citations

Isolation from adult human serum of four insulin-like growth factor (IGF) binding proteins and molecular cloning of one of them that is increased by IGF I administration and in extrapancreatic tumor hypoglycemia.

1990 • 114 citations

Consequences of postnatally elevated insulin-like growth factor-II in transgenic mice: endocrine changes and effects on body and organ growth.

1994 • 108 citations

Maternal Hypoxia as a Model for Intrauterine Growth Retardation: Effects on Insulin-Like Growth Factors and Their Binding Proteins

1994 • 104 citations

Nutritional Regulation of the Growth Hormone and Insulin-Like Growth Factor-Binding Proteins

1996 • 101 citations

Structural aspects of the IGFBP family.

1992 • 99 citations

Impaired glucose homeostasis in insulin-like growth factor binding protein-1 transgenic mice.

1996 • 96 citations

cDNA cloning and mRNA expression of the six mouse insulin-like growth factor binding proteins

1994 • 79 citations

Insulin‐like growth factor‐binding protein‐2 inhibits proliferation of human embryonic kidney fibroblasts and of IGF‐responsive colon carcinoma cell lines

1998 • 75 citations

Insulin-like growth factor (IGF)-I and -II and IGF-binding proteins-1, -2, and -3 in children and adolescents with diabetes mellitus: correlation with metabolic control and height attainment.

1995 • 74 citations

Effects of recombinant insulin-like growth factor-I (IGF-I) and growth hormone on serum IGF-binding proteins in calorically restricted adults.

1992 • 69 citations

Human Insulin-Like Growth Factor I (IGF-I) Produced in the Mammary Glands of Transgenic Rabbits: Yield, Receptor Binding, Mitogenic Activity, and Effects on IGF-Binding Proteins

1997 • 63 citations

Gene expression of the six insulin-like growth factor binding proteins in the mouse conceptus during mid- and late gestation.

1993 • 59 citations

Genetic ablation of IGFBP-2 suggests functional redundancy in the IGFBP family

1995 • 48 citations

Targeted disruption of IGFBP-2 gene.

1993 • 40 citations

Altered growth of mice divergently selected for body weight is associated with complex changes in the growth hormone/insulin-like growth factor system

1998 • 35 citations

Transcription of the insulin-like growth factor-binding protein-2 gene is increased in neonatal and fasted adult rat liver.

1992 • 32 citations

Growth characteristics of metallothionein-human growth hormone transgenic mice as compared to mice selected for high eight-week body weight and unselected controls. I. Body weight gain and external body dimensions.

1991 • 26 citations

Insulin-like growth factor-binding protein-2 and insulin: studies in children with type 1 diabetes mellitus and maturity-onset diabetes of the young.

1995 • 25 citations

Cloning and characterization of the gene encoding murine insulin-like growth factor-binding protein-2, migfbp-2

1993 • 18 citations

Insulin-like growth factor binding proteins in prepubertal children with insulin-dependent diabetes mellitus

1995 • 17 citations

Transcription of the insulin-like growth factor-binding protein-2 gene is increased in neonatal and fasted adult rat liver

1992 • 15 citations

Influence of insulin-like growth factor-binding protein-2 on plasma clearance and transfer of insulin-like growth factors-I and -II from plasma into mammary-derived lymph and milk of goats

1996 • 13 citations

Developmental changes in hepatic IGF-2 and IGFBP-2 mRNA levels in intrauterine growth-retarded and control swine

1993 • 11 citations

Pretreatment with bovine growth hormone is as effective as treatment during metabolic stress to reduce catabolism in fasted lambs.

1996 • 11 citations