Structural Determinants for High-Affinity Binding of Insulin-Like Growth Factor II to Insulin Receptor (IR)-A, the Exon 11 Minus Isoform of the IR

Loss of Insulin Signaling in Hepatocytes Leads to Severe Insulin Resistance and Progressive Hepatic Dysfunction

2000 • 1,213 citations

Tissue-Specific Knockout of the Insulin Receptor in Pancreatic β Cells Creates an Insulin Secretory Defect Similar to that in Type 2 Diabetes

1999 • 1,151 citations

Replacement of insulin receptor tyrosine residues 1162 and 1163 compromises insulin-stimulated kinase activity and uptake of 2-deoxyglucose

1986 • 1,100 citations

Insulin Receptor Isoform A, a Newly Recognized, High-Affinity Insulin-Like Growth Factor II Receptor in Fetal and Cancer Cells

1999 • 865 citations

Aberrant regulation of insulin receptor alternative splicing is associated with insulin resistance in myotonic dystrophy

2001 • 768 citations

Structure and function of the type 1 insulin-like growth factor receptor

2000 • 602 citations

Structural biology of insulin and IGF1 receptors: implications for drug design

2002 • 577 citations

Effect of a null mutation of the insulin-like growth factor I receptor gene on growth and transformation of mouse embryo fibroblasts.

1994 • 527 citations

Insulin/Insulin-like Growth Factor I Hybrid Receptors Have Different Biological Characteristics Depending on the Insulin Receptor Isoform Involved

2002 • 492 citations

Growth-Promoting Interaction of IGF-II with the Insulin Receptor during Mouse Embryonic Development

1997 • 391 citations

Functionally distinct insulin receptors generated by tissue-specific alternative splicing.

1990 • 356 citations

Alternative splicing of human insulin receptor messenger RNA

1989 • 312 citations

Selective Insulin Signaling through A and B Insulin Receptors Regulates Transcription of Insulin and Glucokinase Genes in Pancreatic β Cells

2001 • 268 citations

Development of a Bicistronic Vector Driven by the Human Polypeptide Chain Elongation Factor 1α Promoter for Creation of Stable Mammalian Cell Lines That Express Very High Levels of Recombinant Proteins

1998 • 255 citations

Insulin-like growth factor II stimulates cell proliferation through the insulin receptor

1997 • 234 citations

A Novel Autocrine Loop Involving IGF-II and the Insulin Receptor Isoform-A Stimulates Growth of Thyroid Cancer

2002 • 216 citations

Rearrangements at the 11p15 locus and overexpression of insulin-like growth factor-II gene in sporadic adrenocortical tumors.

1994 • 207 citations

Therapeutic potential of antisense oligonucleotides as modulators of alternative splicing

2003 • 207 citations

Therapeutic potential of antisense oligonucleotides as modulators of alternative splicing

2003 • 192 citations

Knockout of insulin and IGF-1 receptors on vascular endothelial cells protects against retinal neovascularization

2003 • 189 citations

Knockout of insulin and IGF-1 receptors on vascular endothelial cells protects against retinal neovascularization

2003 • 179 citations

Insulin-like Growth Factor Expression in Human Cancer Cell Lines

1996 • 179 citations

A highly sensitive and specific assay for determination of IGF-I bioactivity in human serum

2003 • 176 citations

Functional Properties of Two Naturally Occurring Isoforms of the Human Insulin Receptor in Chinese Hamster Ovary Cells*

1991 • 162 citations

Constitutive expression of insulin-like growth factor 1 and insulin-like growth factor 1 receptor abrogates all requirements for exogenous growth factors.

1992 • 159 citations

In IGF-I receptor-deficient leiomyosarcoma cells autocrine IGF-II induces cell invasion and protection from apoptosis via the insulin receptor isoform A

2002 • 156 citations

The Insulin Receptor Isoform Exon 11- (IR-A) in Cancer and Other Diseases: A Review

2003 • 146 citations

Functional Insulin Receptors on Human Epithelial Ovarian Carcinoma Cells: Implications for IGF-II Mitogenic Signaling

2002 • 143 citations

Solution structure of human insulin-like growth factor 1: a nuclear magnetic resonance and restrained molecular dynamics study

1991 • 143 citations

Impaired glucose tolerance in mice with a targeted impairment of insulin action in muscle and adipose tissue

1998 • 143 citations

The C Region of Human Insulin-like Growth Factor (IGF) I Is Required for High Affinity Binding to the Type 1 IGF Receptor

1989 • 135 citations

The roles of tyrosines 24, 31, and 60 in the high affinity binding of insulin-like growth factor-I to the type 1 insulin-like growth factor receptor.

1990 • 125 citations

A panel of monoclonal antibodies for the type I insulin-like growth factor receptor. Epitope mapping, effects on ligand binding, and biological activity.

1992 • 118 citations

Elevated serum insulin-like growth factor (IGF)-II and IGF binding protein-2 in patients with colorectal cancer

2000 • 111 citations

Different Ligand Affinities of the Two Human Insulin Receptor Splice Variants Are Reflected in Parallel Changes in Sensitivity for Insulin Action

1991 • 108 citations

The two isotypes of the human insulin receptor (HIR-A and HIR-B) follow different internalization kinetics

1991 • 105 citations

Molecular mechanism of insulin resistance in type 2 diabetes mellitus: role of the insulin receptor variant forms

2001 • 96 citations

Isoform-specific insulin receptor signaling involves different plasma membrane domains

2003 • 90 citations

Structural Origins of the Functional Divergence of Human Insulin-Like Growth Factor-I and Insulin^,

2002 • 90 citations

Cross-linking of a B25 azidophenylalanine insulin derivative to the carboxyl-terminal region of the alpha-subunit of the insulin receptor. Identification of a new insulin-binding domain in the insulin receptor.

1994 • 90 citations

Alanine-scanning Mutagenesis of a C-terminal Ligand Binding Domain of the Insulin Receptor α Subunit

1996 • 84 citations

Identification of Common Ligand Binding Determinants of the Insulin and Insulin-like Growth Factor 1 Receptors

1997 • 82 citations

Distinct .alpha.-subunit structures of human insulin receptor A and B variants determine differences in tyrosine kinase activities

1992 • 77 citations

Three‐dimensional structure of human insulin‐like growth factor‐I (IGF‐I) determined by ¹H‐NMR and distance geometry

1993 • 74 citations

Production and characterization of recombinant insulin-like growth factor-I (IGF-I) and potent analogues of IGF-I, with Gly or Arg substituted for Glu 3, following their expression in Escherichia coli as fusion proteins

1992 • 70 citations

Solution structure of human insulin-like growthfactor II. Relationship to receptor and binding protein interactions

1995 • 63 citations

Monoclonal antibodies to the insulin receptor mimic metabolic effects of insulin but do not stimulate receptor autophosphorylation in transfected NIH 3T3 fibroblasts.

1989 • 63 citations

BIAcore Analysis of Bovine Insulin-like Growth Factor (IGF)-binding Protein-2 Identifies Major IGF Binding Site Determinants in Both the Amino- and Carboxyl-terminal Domains

2001 • 61 citations

Bi-directional Regulation of Brown Fat Adipogenesis by the Insulin Receptor

2003 • 59 citations

Solution structure of human insulin-like growth factor II; recognition sites for receptors and binding proteins.

1994 • 51 citations

Comparison of the Functional Insulin Binding Epitopes of the A and B Isoforms of the Insulin Receptor

2002 • 51 citations

A single-chain insulin-like growth factor I/insulin hybrid binds with high affinity to the insulin receptor

1995 • 47 citations

High affinity insulin binding by soluble insulin receptor extracellular domain fused to a leucine zipper

2000 • 41 citations

Functional Reconstitution of Insulin Receptor Binding Site from Non-binding Receptor Fragments

2002 • 41 citations

Human insulin production from a novel mini-proinsulin which has high receptor-binding activity

1998 • 40 citations

Role of Insulin Receptor Dimerization Domains in Ligand Binding, Cooperativity, and Modulation by Anti-receptor Antibodies

2002 • 40 citations

Dimeric Fragment of the Insulin Receptor α-Subunit Binds Insulin with Full Holoreceptor Affinity

2001 • 38 citations

Mutations in the B-domain of insulin-like growth factor-I influence the oxidative folding to yield products with modified biological properties

1995 • 33 citations

Europium-Labeled Epidermal Growth Factor and Neurotensin: Novel Probes for Receptor-Binding Studies

2002 • 28 citations

Insulin-like growth factor (IGF)-I A- and B-domain analogues with altered type 1 IGF and insulin receptor binding specificities

1996 • 17 citations

Genotyping:Insulin receptor variant forms and Type 2 diabetes mellitus

2000 • 17 citations

Involvement of phenylalanine 23 in the binding of IGF-1 to the insulin and type I IGF receptor

1996 • 15 citations

Linkers for improved cleavage of fusion proteins with an engineered α‐lytic protease

2001 • 14 citations