Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene

Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r)

1993 • 2,880 citations

The insulin signaling system.

1994 • 1,733 citations

Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein

1991 • 1,590 citations

Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1

1994 • 1,076 citations

Insulin rapidly stimulates tyrosine phosphorylation of a Mr-185,000 protein in intact cells

1985 • 665 citations

The Function of GRB2 in Linking the Insulin Receptor to Ras Signaling Pathways

1993 • 629 citations

Gene Targeting: A Practical Approach

1994 • 592 citations

Gene targeting: a practical approach.

1993 • 585 citations

Activation of phosphatidylinositol 3-kinase by insulin.

1990 • 531 citations

IRS-1: Essential for Insulin- and IL-4-Stimulated Mitogenesis in Hematopoietic Cells

1993 • 401 citations

The insulin receptor substrate 1 associates with the SH2-containing phosphotyrosine phosphatase Syp

1993 • 384 citations

Mutation of the insulin receptor at tyrosine 960 inhibits signal transmission but does not affect its tyrosine kinase activity

1988 • 368 citations

Expression and function of IRS-1 in insulin signal transmission.

1992 • 331 citations

Regulation of insulin receptor substrate-1 in liver and muscle of animal models of insulin resistance.

1992 • 328 citations

IRS-1 is a common element in insulin and insulin-like growth factor-I signaling to the phosphatidylinositol 3'-kinase.

1993 • 323 citations

An IL-4 receptor region containing an insulin receptor motif is important for IL-4-mediated IRS-1 phosphorylation and cell growth

1994 • 306 citations

Insulin stimulation of phosphatidylinositol 3-kinase activity and association with insulin receptor substrate 1 in liver and muscle of the intact rat.

1992 • 263 citations

Common elements in interleukin 4 and insulin signaling pathways in factor-dependent hematopoietic cells.

1993 • 173 citations

The insulin and insulin-like growth factor-I receptor substrate IRS-1 associates with and activates phosphatidylinositol 3-kinase in vitro.

1993 • 161 citations

Insulin receptor substrate 1 is required for insulin-mediated mitogenic signal transduction.

1994 • 126 citations

Functional expression of insulin receptor substrate-1 is required for insulin-stimulated mitogenic signaling.

1993 • 116 citations

Human Skeletal Muscle Insulin Receptor Substrate-1: Characterization of the cDNA, Gene, and Chromosomal Localization

1993 • 100 citations

Role of p85 subunit of phosphatidylinositol-3-kinase as an adaptor molecule linking the insulin receptor, p62, and GTPase-activating protein.

1994 • 94 citations

Insulin-stimulated oocyte maturation requires insulin receptor substrate 1 and interaction with the SH2 domains of phosphatidylinositol 3-kinase.

1993 • 69 citations

Isolation and characterization of the 160,000-Da phosphotyrosyl protein, a putative participant in insulin signaling

1991 • 59 citations

Identification of SHC as a Substrate of the Insulin Receptor Kinase Distinct from the GAP-Associated 62-kDa Tyrosine Phosphoprotein

1993 • 56 citations

Progression to Diabetes in Nonobese Diabetic (NOD) Mice with Transgenic T Cell Receptors

1993 • 53 citations

Insulin stimulates tyrosine phosphorylation of multiple high molecular weight substrates in Fao hepatoma cells

1992 • 40 citations

Cloning of the mouse insulin receptor substrate-1 (IRS-1) gene and complete sequence of mouse IRS-1

1994 • 27 citations

Differentiation-Dependent Phosphorylation of a 175,000 Molecular Weight Protein in Response to Insulin and Insulin-Like Growth Factor-I in L6 Skeletal Muscle Cells*

1989 • 21 citations