Apoptosis in cerebellar granule cells is blocked by high KCl, forskolin, and IGF-1 through distinct mechanisms of action: the involvement of intracellular calcium and RNA synthesis

A new generation of Ca2+ indicators with greatly improved fluorescence properties.

1985 • 21,873 citations

Cell Death During Development of the Nervous System

1991 • 3,033 citations

Inhibitors of protein synthesis and RNA synthesis prevent neuronal death caused by nerve growth factor deprivation.

1988 • 909 citations

Induction of apoptosis in cerebellar granule neurons by low potassium: inhibition of death by insulin-like growth factor I and cAMP.

1993 • 886 citations

The role of depolarization in the survival and differentiation of cerebellar granule cells in culture

1987 • 764 citations

Distinctive pharmacology and kinetics of cloned neuronal Ca2+ channels and their possible counterparts in mammalian CNS neurons

1993 • 635 citations

N-methyl-d-aspartate promotes the survival of cerebellar granule cells in culture

1988 • 437 citations

An enzymatic mechanism for calcium current inactivation in dialysed Helix neurones.

1986 • 409 citations

Autoradiographic localization and depolarization-induced release of acidic amino acids in differentiating cerebellar granule cell cultures

1984 • 408 citations

Role of Ca2+ channels in the ability of membrane depolarization to prevent neuronal death induced by trophic-factor deprivation: evidence that levels of internal Ca2+ determine nerve growth factor dependence of sympathetic ganglion cells.

1989 • 405 citations

Voltage-activated calcium channels that must be phosphorylated to respond to membrane depolarization.

1987 • 393 citations

Suppression of programmed neuronal death by sustained elevation of cytoplasmic calcium

1992 • 363 citations

Apoptosis mediated neurotoxicity induced by chronic application of β amyloid fragment 25–35

1993 • 343 citations

In situ labeling of granule cells for apoptosis-associated DNA fragmentation reveals different mechanisms of cell loss in developing cerebellum

1993 • 331 citations

Morphometric analysis of rat superior cervical ganglion after axotomy and nerve growth factor treatment

1976 • 311 citations

The role of estrogens on the proliferation of human breast tumor cells (MCF-7)

1985 • 257 citations

Sustained increase in intracellular calcium promotes neuronal survival

1991 • 213 citations

The Death Programme in Cultured Sympathetic Neurones Can Be Suppressed at the Posttranslational Level by Nerve Growth Factor, Cyclic AMP, and Depolarization

1991 • 202 citations

BDNF and NT-3 induce intracellular Ca2+ elevation in hippocampal neurones

1993 • 197 citations

Serum and depolarizing agents cause acute neurotoxicity in cultured cerebellar granule cells: role of the glutamate receptor responsive to N-methyl-D-aspartate.

1990 • 176 citations

Cell Death During Development Of The Nervous System

1991 • 168 citations

Evidence that nerve growth factor dependence of sympathetic neurons for survival in vitro may be determined by levels of cytoplasmic free Ca2+.

1991 • 159 citations

Biochemical characterization of programmed cell death in NGF‐deprived sympathetic neurons

1992 • 146 citations

The role of dihydropyridine-sensitive voltage-gated calcium channels in potassium-mediated neuronal survival

1989 • 127 citations

Voltage-dependent phosphorylation may recruit Ca2+ current facilitation in chromaff in cells

1992 • 126 citations

Lithium Induces Apoptosis in Immature Cerebellar Granule Cells but Promotes Survival of Mature Neurons

1994 • 119 citations

Promotion of granule cell survival by high K+ or excitatory amino acid treatment and Ca2+/calmodulin-dependent protein kinase activity

1993 • 103 citations

Major role for neuronal death during brain development: refinement of topographical connections.

1987 • 91 citations

Ionic events induced by epidermal growth factor. Evidence that hyperpolarization and stimulated cation influx play a role in the stimulation of cell growth.

1991 • 87 citations

Development of a method for measuring cell number: Application to CNS primary neuronal cultures

1994 • 87 citations

Both nerve growth factor and high K+ concentrations support the survival of chick embryo sympathetic neurons Evidence for a common mechanism of action

1983 • 61 citations

The activity of cAMP-dependent protein kinase is required at a posttranslational level for induction of voltage-dependent sodium channels by peptide growth factors in PC12 cells.

1992 • 59 citations

Components of signaling pathways for insulin and insulin-like growth factor-I in muscle myoblasts and myotubes.

1992 • 57 citations

Dihydropyridine Binding Sites Regulate Calcium Influx Through Specific Voltage‐Sensitive Calcium Channels in Cerebellar Granule Cells

1988 • 50 citations

Relationship of Intracellular Calcium to Dependence on Nerve Growth Factor in Dorsal Root Ganglion Neurons in Cell Culture

1992 • 46 citations

Relationship Between Intracellular Free Calcium Concentration and NMDA‐induced Cerebellar Granule Cell Survival In Vitro

1992 • 28 citations

SGP2, ubiquitin, 14K lectin and RP8 mRNAs are not induced in neuronal apoptosis

1993 • 27 citations

Identification of the Serum Complex Which Induces Cerebellar Granule Cell In Vitro Differentiation and Resistance to Excitatory Amino Acids

1992 • 16 citations

Dihydropyridine Modulation of Voltage‐Activated Calcium Channels in PC12 Cells: Effect of Pertussis Toxin Pretreatment

1991 • 10 citations

Deleted Work

1955 • 0 citations