Neuronal protection from glucose deprivation via modulation of glucose transport and inhibition of apoptosis: a role for the insulin-like growth factor system

Proapoptotic BAX and BAK: A Requisite Gateway to Mitochondrial Dysfunction and Death

2001 • 3,867 citations

Re-examination and further development of a precise and rapid dye method for measuring cell growth/cell kill

1989 • 3,477 citations

Insulin-like Growth Factor 1 Inhibits Apoptosis Using the Phosphatidylinositol 3′-Kinase and Mitogen-activated Protein Kinase Pathways

1997 • 662 citations

Glucose transporter proteins in brain: Delivery of glucose to neurons and glia

1997 • 629 citations

Activation of natural killer T cells by α-galactosylceramide treatment prevents the onset and recurrence of autoimmune Type 1 diabetes

2001 • 605 citations

Multiple Signaling Pathways of the Insulin-Like Growth Factor 1 Receptor in Protection from Apoptosis

1999 • 499 citations

The IGF-I receptor in cell growth, transformation and apoptosis

1997 • 446 citations

The role of the insulin-like growth factors in the central nervous system

1996 • 443 citations

Diabetes Control and Complications Trial (DCCT): Results of Feasibility Study. The DCCT Research Group

1987 • 428 citations

Requirement for the CD95 Receptor-Ligand Pathway in c-Myc-Induced Apoptosis

1997 • 370 citations

Glucose Induces β-Cell Apoptosis Via Upregulation of the Fas Receptor in Human Islets

2001 • 365 citations

Microscale autoradiographic method for the qualitative and quantitative analysis of apoptotic DNA fragmentation

1993 • 348 citations

High Glucose Causes Apoptosis in Cultured Human Pancreatic Islets of Langerhans

2001 • 328 citations

Neuropsychological Profiles of Children With Type 1 Diabetes 6 Years After Disease Onset

2001 • 328 citations

Regulation of expression of glucose transporters by glucose: a review of studies in vivo and in cell cultures

1994 • 322 citations

Regulation of GLUT1 Gene Transcription by the Serine/Threonine Kinase Akt1

1999 • 317 citations

Hyperglycemia Activates p53 and p53-Regulated Genes Leading to Myocyte Cell Death

2001 • 303 citations

bcl-2 transgene expression can protect neurons against developmental and induced cell death.

1995 • 261 citations

Insulin-like Growth Factor-1-mediated Neuroprotection against Oxidative Stress Is Associated with Activation of Nuclear Factor κB

1999 • 205 citations

Insulin-like growth factor 1 regulates developing brain glucose metabolism

2000 • 199 citations

Co-ordinated and cellular specific induction of the components of the IGF/IGFBP axis in the rat brain following hypoxic–ischemic injury

1998 • 197 citations

Intellectual Deficits Associated With Early Onset of Insulin-Dependent Diabetes Mellitus in Children

1987 • 173 citations

Insulin-like growth factor I rescues SH-SY5Y human neuroblastoma cells from hyperosmotic induced programmed cell death

1996 • 169 citations

Type I Insulin-like Growth Factor Receptor Activation Regulates Apoptotic Proteins

1996 • 162 citations

Troglitazone enhances differentiation, basal glucose uptake, and Glut1 protein levels in 3T3-L1 adipocytes.

1996 • 159 citations

Glucose transport and apoptosis.

2000 • 157 citations

Insulin-like Growth Factor-I-mediated Neurite Outgrowth in Vitro Requires Mitogen-activated Protein Kinase Activation

1997 • 157 citations

Opposite Translational Control of GLUT1 and GLUT4 Glucose Transporter mRNAs in Response to Insulin

1999 • 152 citations

Neuropsychological Complications of IDDM in Children 2 Years After Disease Onset

1998 • 151 citations

Insulin-Like Growth Factor-I Overexpression Attenuates Cerebellar Apoptosis by Altering the Expression of Bcl Family Proteins in a Developmentally Specific Manner

2001 • 138 citations

Insulin-like growth factor I receptor prevents apoptosis and enhances neuroblastoma tumorigenesis.

1996 • 128 citations

The effects of insulin-like growth factor (IGF)-1, IGF-2, and des-IGF-1 on neuronal loss after hypoxic-ischemic brain injury in adult rats: evidence for a role for IGF binding proteins.

1996 • 122 citations

Suppression of Interleukin-1β-converting Enzyme-mediated Cell Death by Insulin-like Growth Factor

1996 • 121 citations

Insulin-like growth factor-I prevents apoptosis in neurons after nerve growth factor withdrawal

1998 • 121 citations

Glucose Deprivation Causes Posttranscriptional Enhancement of Brain Capillary Endothelial Glucose Transporter Gene Expression via GLUT1 mRNA Stabilization

1993 • 121 citations

Insulin-Like Growth Factor Binding Protein-2 Binds to Cell Surface Proteoglycans in the Rat Brain Olfactory Bulb*

1997 • 118 citations

Alterations in GLUT1 and GLUT3 glucose transporter gene expression following unilateral hypoxia–ischemia in the immature rat brain

1998 • 112 citations

Co-localization of GLUT1 and GLUT4 in the blood–brain barrier of the rat ventromedial hypothalamus

2001 • 102 citations

Synaptic connections of intrinsic cells and basket arborizations in the external plexiform layer of the fly's eye

1973 • 89 citations

Glucose utilization and glucose transporter proteins GLUT-1 and GLUT-3 in brains of diabetic (db/db) mice

1997 • 88 citations

Anti-apoptotic Signaling of the Insulin-like Growth Factor-I Receptor through Mitochondrial Translocation of c-Raf and Nedd4

2001 • 83 citations

Overexpression of Bcl-2 is neuroprotective after experimental brain injury in transgenic mice

1999 • 81 citations

Regulation of cell surface GLUT1, GLUT3, and GLUT4 by insulin and IGF‐I in L6 myotubes

1995 • 76 citations

Regulation of prostate cancer cell division by glucose

1999 • 76 citations

Regulation of brain glucose transporters by glucose and oxygen deprivation

1999 • 73 citations

Glutamine Deprivation Induces the Expression ofGADD45 and GADD153 Primarily by mRNA Stabilization

1999 • 73 citations

Pre-processed caspase-9 contained in mitochondria participates in apoptosis

2002 • 70 citations

Concurrent Assessment of Calpain and Caspase-3 Activation after Oxygen–Glucose Deprivation in Primary Septo-Hippocampal Cultures

2001 • 69 citations

Expression, regulation, and functional role of glucose transporters (GLUTs) in brain

2002 • 68 citations

Insulin-like growth factor I stimulates motility in human neuroblastoma cells

2001 • 66 citations

TACE/ADAM17–TNF-α Pathway in Rat Cortical Cultures after Exposure to Oxygen–Glucose Deprivation or Glutamate

2002 • 66 citations

Hypoxia induces apoptosis via two independent pathways in Jurkat cells: differential regulation by glucose

2001 • 64 citations

IGF-I receptor activation and BCL-2 overexpression prevent early apoptotic events in human neuroblastoma

2000 • 63 citations

Acute and long‐term effects of insulin‐like growth factor I on glucose transporters in muscle cells Translocation and biosynthesis

1992 • 61 citations

Heterogeneity of human neuroblastoma cell lines in their proliferative responses to basic FGF, NGF, and EGF: Correlation with expression of growth factors and growth factor receptors

1995 • 61 citations

Reduced GLUT1 expression in Igf1–/– null oocytes and follicles

2000 • 59 citations

Insulin-like Growth Factor-II as a Paracrine Growth Factor in Human Neuroblastoma Cells

1995 • 59 citations

Developmental modulation of blood-brain barrier and choroid plexus GLUT1 glucose transporter messenger ribonucleic acid and immunoreactive protein in rabbits.

1993 • 53 citations

Tumor Necrosis Factor-α Regulation of Glucose Transporter (GLUT1) mRNA Turnover

1997 • 51 citations

Pathophysiology of central nervous system complications in diabetes mellitus.

1997 • 48 citations

Cis‐Element/Cytoplasmic Protein Interaction Within the 3′‐Untranslated Region of the GLUT1 Glucose Transporter mRNA

1996 • 45 citations

Interactions between Bcl-2 and the IGF system control apoptosis in the developing mouse brain

1999 • 45 citations

Changes of glucose transporters in the cerebral adaptation to hypoglycemia

2000 • 44 citations

Increase in glucose transporter densities of Glut3 and decrease of glucose utilization in rat brain after one week of hypoglycemia

1999 • 43 citations

Insulin-like growth factor-1 promotes neuronal glucose utilization during brain development and repair processes

2002 • 43 citations

Apoptosis: Live Or Die - Hard Work Either Way!

2001 • 41 citations

Distinct regulation of glucose transport and GLUT1/GLUT3 transporters by glucose deprivation and IGF-I in chromaffin cells

2003 • 38 citations

Basic Fibroblast Growth Factor Induces Proteolysis of Secreted and Cell Membrane-Associated Insulin-Like Growth Factor Binding Protein-2 in Human Neuroblastoma Cells*

1999 • 38 citations

Effects of insulin‐like growth factor‐1 on retinal endothelial cell glucose transport and proliferation

2001 • 36 citations

Stabilization of glucose transporter mRNA by insulin/IGF-1 and glucose deprivation

1990 • 35 citations

Olfactory bulb organ culture is supported by combined insulin-like growth factor-I and basic fibroblast growth factor

1993 • 35 citations

Insulin‐like growth factor‐1 protects peroxynitrite‐induced cell death by preventing cytochromec‐induced caspase‐3 activation

2002 • 33 citations

Glucose deprivation induces Akt-dependent synthesis and incorporation of GLUT1, but not of GLUT4, into the plasma membrane of 3T3-L1adipocytes

2000 • 30 citations

Recombinant insulin-like growth factor I normalizes expression of renal glucose transporters in diabetic rats

1997 • 27 citations

Suppression of Death Receptor Signaling in Cerebellar Purkinje Neurons Protects Neighboring Granule Neurons from Apoptosis via an Insulin-like Growth Factor I-dependent Mechanism

2002 • 25 citations

Flow cytometric analysis of glucose transport by rat brain cells

1997 • 23 citations

Insulin‐like growth factor‐1 effects on bovine retinal endothelial cell glucose transport: role of MAP kinase

2002 • 22 citations

Distinct Intracellular Signaling in Tumor Necrosis Factor-related Apoptosis-inducing Ligand- and CD95 Ligand-mediated Apoptosis

2002 • 20 citations

Amplification of blood–brain barrier GLUT1 glucose transporter gene expression by brain-derived peptides

2001 • 17 citations

GLUT1-mediated glucose transport and its regulation by IGF-I in cultured bovine chromaffin cells

1996 • 16 citations

Deleted Work

1955 • 0 citations