Deficient expression of insulin receptor substrate-1 (IRS-1) fails to block insulin-like growth factor-I (IGF-I) stimulation of brain growth and myelination

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r)

1993 • 2,880 citations

Role of insulin-like growth factors in embryonic and postnatal growth

1993 • 2,349 citations

Disruption of IRS-2 causes type 2 diabetes in mice

1998 • 1,766 citations

Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein

1991 • 1,590 citations

Cell death and control of cell survival in the oligodendrocyte lineage

1992 • 1,331 citations

Culturing nerve cells

1998 • 1,304 citations

Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene

1994 • 1,240 citations

Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1

1994 • 1,076 citations

pl Bl5: A cDNA Clone of the Rat mRNA Encoding Cyclophilin

1988 • 1,039 citations

Role of insulin-like growth factors in embryonic and postnatal growth

1993 • 644 citations

Igf1 gene disruption results in reduced brain size, CNS hypomyelination, and loss of hippocampal granule and striatal parvalbumin-containing neurons

1995 • 629 citations

Insulin-like growth factor I increases brain growth and central nervous system myelination in tTransgenic mice

1993 • 468 citations

Assembly of CNS Myelin in the Absence of Proteolipid Protein

1997 • 454 citations

The role of the insulin-like growth factors in the central nervous system

1996 • 443 citations

Insulin-like growth factor I/somatomedin C: a potent inducer of oligodendrocyte development.

1986 • 383 citations

Insulin‐like growth factor I promotes cell proliferation and oligodendroglial commitment in rat glial progenitor cells developing in vitro

1988 • 361 citations

Insulin-like growth factor I protects and rescues hippocampal neurons against β-amyloid- and human amylin-induced toxicity

1997 • 325 citations

IRS-1 is a common element in insulin and insulin-like growth factor-I signaling to the phosphatidylinositol 3'-kinase.

1993 • 323 citations

In vivo actions of insulin-like growth factor-I (IGF-I) on brain myelination: studies of IGF-I and IGF binding protein-1 (IGFBP-1) transgenic mice

1995 • 257 citations

Mice lacking insulin receptor substrate 4 exhibit mild defects in growth, reproduction, and glucose homeostasis

2000 • 227 citations

Aberrant splicing of proteolipid protein mRNA in the dysmyelinating jimpy mutant mouse.

1987 • 174 citations

Insulin‐like growth factor I stimulates oligodendrocyte development and myelination in rat brain aggregate cultures

1991 • 169 citations

Insulin receptor substrate-1 (IRS-1) distribution in the rat central nervous system

1994 • 137 citations

Insulin-Like Growth Factor I Protects Oligodendrocytes from Tumor Necrosis Factor-α-Induced Injury*

1999 • 134 citations

Identification of a cDNA coding for a fifth form of myelin basic protein in mouse.

1987 • 132 citations

The IRS-2 Gene on Murine Chromosome 8 Encodes a Unique Signaling Adapter for Insulin and Cytokine Action

1997 • 130 citations

Evidence for an important role of IGF-I and IGF-II for the early development of chick sympathetic neurons

1995 • 119 citations

Trophic effects of insulin-like growth factor-I on fetal rat hypothalamic cells in culture

1990 • 109 citations

Cloning, Tissue Expression, and Chromosomal Localization of the Mouse IRS-3 Gene

1997 • 89 citations

Astroglia in culture

1991 • 88 citations

Postnatal Growth Responses to Insulin-Like Growth Factor I in Insulin Receptor Substrate-1-Deficient Mice1

1999 • 80 citations

Discrete expression of insulin receptor substrate-4 mRNA in adult rat brain

1999 • 76 citations

Cloning, Tissue Expression, and Chromosomal Location of the Mouse Insulin Receptor Substrate 4 Gene*

1999 • 69 citations

Insulin-like growth factor-I influences the initiation of myelination: studies of the anterior commissure of transgenic mice

1995 • 69 citations

Insulin-Like Growth Factor I (IGF-I) Regulates IGF Binding Protein-5 Gene Expression in the Brain*

1998 • 64 citations

Insulin Receptor Substrate-4 Enhances Insulin-like Growth Factor-I-induced Cell Proliferation

1999 • 59 citations

IRS-1 is a common element in insulin and insulin-like growth factor-I signaling to the phosphatidylinositol 3'-kinase

1993 • 55 citations

Cyclic AMP‐induced upregulation of proteolipid protein and myelin associated glycoprotein gene expression in C6 cells

1992 • 42 citations

Insulin-Like Growth Factor I Protects Oligodendrocytes from Tumor Necrosis Factor- -Induced Injury

1999 • 42 citations

Cloning, Tissue Expression, and Chromosomal Localization of the Mouse IRS-3 Gene

1997 • 34 citations

The IRS-2 Gene on Murine Chromosome 8 Encodes a Unique Signaling Adapter for Insulin and Cytokine Action

1997 • 34 citations

Cloning, Tissue Expression, and Chromosomal Location of the Mouse Insulin Receptor Substrate 4 Gene

1999 • 24 citations

Postnatal Growth Responses to Insulin-Like Growth Factor I in Insulin Receptor Substrate-1-Deficient Mice

1999 • 20 citations

The Insulin-Like Growth Factor I Receptor-Induced Interaction of Insulin Receptor Substrate-4 and Crk-II

2001 • 20 citations

Insulin-Like Growth Factor I (IGF-I) Regulates IGF Binding Protein-5 Gene Expression in the Brain

1998 • 19 citations

The Insulin-Like Growth Factor I Receptor-Induced Interaction of Insulin Receptor Substrate-4 and Crk-II

2001 • 8 citations

Deleted Work

1955 • 0 citations