Presence and differential internalization of two distinct insulin-like growth factor receptors in rat hippocampal neurons

Insulin-Like Growth Factors and Their Binding Proteins: Biological Actions*

1995 • 4,419 citations

Optimized survival of hippocampal neurons in B27‐supplemented neurobasal™, a new serum‐free medium combination

1993 • 2,272 citations

Insulin-like growth factors and their binding proteins: biological actions

1995 • 1,976 citations

Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein

1991 • 1,590 citations

Induction of apoptosis in cerebellar granule neurons by low potassium: inhibition of death by insulin-like growth factor I and cAMP.

1993 • 886 citations

Insulin-like growth factor II receptor as a multifunctional binding protein

1987 • 858 citations

Somatomedin-C Mediates Growth Hormone Negative Feedback by Effects on Both the Hypothalamus and the Pituitary

1981 • 829 citations

The Nature and Regulation of the Receptors for Insulin-Like Growth Factors

1985 • 639 citations

Blocking of EGF-Dependent Cell Proliferation by EGF Receptor Kinase Inhibitors

1988 • 593 citations

Regulation of embryonic growth and lysosomal targeting by the imprintedIgf2/Mpr gene

1994 • 471 citations

Insulin-like growth factor I increases brain growth and central nervous system myelination in tTransgenic mice

1993 • 468 citations

Effects of insulin, insulin-like growth factor-II, and nerve growth factor on neurite formation and survival in cultured sympathetic and sensory neurons

1986 • 426 citations

Cellular pattern of type-I insulin-like growth factor receptor gene expression during maturation of the rat brain: Comparison with insulin-like growth factors I and II

1992 • 370 citations

Insulin and insulin-like growth factors in the CNS

1988 • 334 citations

Structure of the IRS-1 PTB Domain Bound to the Juxtamembrane Region of the Insulin Receptor

1996 • 314 citations

Tyrphostins Inhibit Epidermal Growth Factor (EGF)-Receptor Tyrosine Kinase Activity in Living Cells and EGF-Stimulated Cell Proliferation

1989 • 286 citations

Neurotrophic factor therapy for nervous system degenerative diseases

1994 • 254 citations

IGF-I and IGF-II protect cultured hippocampal and septal neurons against calcium-mediated hypoglycemic damage

1992 • 253 citations

Insulin-like growth factor I (IGF I) stimulates DNA synthesis in fetal rat brain cell cultures

1983 • 230 citations

Differential signalling potential of insulin- and IGF-1-receptor cytoplasmic domains.

1989 • 225 citations

Proliferin secreted by cultured cells binds to mannose 6-phosphate receptors.

1988 • 221 citations

Quantitative autoradiographic localization of [¹²⁵I]insulin‐like growth factor I, [¹²⁵I]insulin‐like growth factor II, and [¹²⁵I]insulin receptor binding sites in developing and adult rat brain

1993 • 207 citations

The Effects of IGF-1 Treatment after Hypoxic-Ischemic Brain Injury in Adult Rats

1993 • 202 citations

Effects of insulin, insulin-like growth factor-II and nerve growth factor on neurite outgrowth in cultured human neuroblastoma cells

1984 • 194 citations

Human Osteoarthritic Chondrocytes Possess an Increased Number of Insulin‐Like Growth Factor 1 Binding Sites but are Unresponsive to its Stimulation

1994 • 191 citations

Insulin-like growth factor I receptors in neuronal and glial cells. Characterization and biological effects in primary culture.

1987 • 190 citations

Frequent loss of heterozygosity on 6q at the mannose 6-phosphate/insulin-like growth factor II receptor locus in human hepatocellular tumors.

1995 • 189 citations

The nature of the trophic action of brain-derived neurotrophic factor, des(1-3)-insulin-like growth FACTOR-1, and basic fibroblast growth factor on mesencephalic dopaminergic neurons developing in culture

1993 • 176 citations

Potential mechanism of the stimulatory action of insulin on insulin-like growth factor II binding to the isolated rat adipose cell. Apparent redistribution of receptors cycling between a large intracellular pool and the plasma membrane.

1984 • 169 citations

Two types of receptor for insulin-like growth factors in mammalian brain.

1985 • 163 citations

The design, expression, and characterization of human insulin-like growth factor II (IGF-II) mutants specific for either the IGF-II/cation-independent mannose 6-phosphate receptor or IGF-I receptor.

1991 • 146 citations

The receptor for insulin-like growth factor II mediates an insulin-like response.

1987 • 145 citations

Insulin-like growth factor I shifts from promoting cell division to potentiating maturation during neuronal differentiation.

1991 • 141 citations

Chicken and Xenopus Mannose 6-Phosphate Receptors Fail to Bind Insulin-like Growth Factor II

1989 • 137 citations

Interactions of recombinant and platelet transforming growth factor-β1 precursor with the insulin-like growth factor II/mannose 6-phosphate receptor

1989 • 127 citations

Insulin and insulinomimetic agents induce activation of phosphatidylinositol 3'-kinase upon its association with pp185 (IRS-1) in intact rat livers.

1992 • 125 citations

Regulation of Rat Brain/HepG2 Glucose Transporter Gene Expression by Insulin and Insulin-Like Growth Factor-I in Primary Cultures of Neuronal and Glial Cells*

1989 • 122 citations

Insulin‐like growth factor‐1 mRNA is increased in deafferented hippocampus: Spatiotemporal correspondence of a trophic event with axon sprouting

1995 • 114 citations

Structure-function relationship of the insulin-like growth factor-I receptor tyrosine kinase.

1993 • 111 citations

Molecular recognition and targeting of lysosomal proteins

1991 • 105 citations

Developmental expression, compartmentalization, and possible role in excitotoxicity of a putative NMDA receptor protein in cultured hippocampal neurons

1991 • 99 citations

Cellular trafficking and processing of the insulin receptor ¹

1991 • 89 citations

Receptor Binding, Endocytosis, and Mitogenesis of Insulin‐Like Growth Factors I and II in Fetal Rat Brain Neurons

1991 • 83 citations

Long-term depression of glutamate-induced gamma-aminobutyric acid release in cerebellum by insulin-like growth factor I.

1993 • 82 citations

Implication of various forms of neurotensin receptors in the mechanism of internalization of neurotensin in cerebral neurons

1993 • 80 citations

Herpes simplex virus glycoprotein D acquires mannose 6-phosphate residues and binds to mannose 6-phosphate receptors.

1994 • 78 citations

Thyroglobulin, the major and obligatory exportable protein of thyroid follicle cells, carries the lysosomal recognition marker mannose-6-phosphate.

1987 • 75 citations

Learning of the conditioned eye-blink response is impaired by an antisense insulin-like growth factor I oligonucleotide.

1994 • 70 citations

Comparison of the intracellular itineraries of insulin-like growth factor-I and insulin and their receptors in Rat-1 fibroblasts.

1994 • 64 citations

Identification and distribution of insulin receptors on cultured bovine brain microvessel endothelial cells: Possible function in insulin processing in the blood–brain barrier

1994 • 61 citations

Protein incorporation by isolated amphibian oocytes. II. A survey of inhibitors

1972 • 61 citations

Distribution and levels of insulin-like growth factor (IGF-I and IGF-II) and insulin receptor binding sites in the spinal cords of amyotrophic lateral sclerosis (ALS) patients

1996 • 59 citations

NPXY motif in the insulin-like growth factor-I receptor is required for efficient ligand-mediated receptor internalization and biological signaling.

1994 • 47 citations

Recombinant human insulin-like growth factor I exerts a trophic action and confers glutamate sensitivity on glutamate-resistant cerebellar granule cells.

1993 • 46 citations

Receptor‐mediated endocytosis and degradation of insulin‐like growth factor I and II in neonatal rat astrocytes

1992 • 42 citations

Functional characterization of hybrid receptors composed of a truncated insulin receptor and wild type insulin-like growth factor 1 or insulin receptors.

1995 • 38 citations

Modulation of the insulin growth factor II/mannose 6-phosphate receptor in microvascular endothelial cells by phorbol ester via protein kinase C.

1990 • 34 citations

Metabolic actions of insulin-like growth factor II in cultured adult rat hepatocytes are not mediated through the insulin-like growth factor II receptor

1992 • 28 citations

Tyrosine kinase-defective insulin receptors undergo insulin-induced microaggregation but do not concentrate in coated pits.

1991 • 26 citations

Long-term cultivation of cryopreserved human fetal brain cells in a chemically defined medium

1989 • 24 citations

Insulin-like Growth Factor 1 Receptor-Mediated Endocytosis in Xenopus laevis Oocytes

1994 • 22 citations

Receptor-mediated internalization of angiotensin II in bovine adrenal medullary chromaffin cells in primary culture

1994 • 22 citations

Reciprocal Modulation of Binding of Lysosomal Enzymes and Insulin-Like Growth Factor-II (IGF-II) to the Mannose 6- Phosphate/IGF-II Receptor

1991 • 22 citations

NPXY motif in the insulin-like growth factor-I receptor is required for efficient ligand-mediated receptor internalization and biological signaling

1994 • 21 citations

Functional characterization of hybrid receptors composed of a truncated insulin receptor and wild type insulin-like growth factor 1 or insulin receptors

1995 • 12 citations

Comparison of the intracellular itineraries of insulin-like growth factor-I and insulin and their receptors in Rat-1 fibroblasts

1994 • 12 citations

Insulin-Like Growth Factor II: Complexity of Biosynthesis and Receptor Binding

1991 • 10 citations

Effects of insulin-like growth factor II on the generation of inositol trisphosphate, diacylglycerol and cAMP in human fibroblasts

1994 • 9 citations