The Role of Neurotrophic Factors in Disorders of Peripheral Nerves and Motor Neurons

Mice lacking nerve growth factor display perinatal loss of sensory and sympathetic neurons yet develop basal forebrain cholinergic neurons

1994 • 1,065 citations

Severe sensory and sympathetic neuropathies in mice carrying a disrupted Trk/NGF receptor gene

1994 • 978 citations

Enhanced synthesis of brain-derived neurotrophic factor in the lesioned peripheral nerve: different mechanisms are responsible for the regulation of BDNF and NGF mRNA.

1992 • 719 citations

Brain-derived neurotrophic factor prevents the death of motoneurons in newborn rats after nerve section

1992 • 712 citations

Brain-derived neurotrophic factor rescues spinal motor neurons from axotomy-induced cell death

1992 • 668 citations

Neurotrophins promote motor neuron survival and are present in embryonic limb bud

1993 • 619 citations

Survival effect of ciliary neurotrophic factor (CNTF) on chick embryonic motoneurons in culture: comparison with other neurotrophic factors and cytokines

1990 • 591 citations

Nerve growth factor-induced hyperalgesia in the neonatal and adult rat

1993 • 560 citations

Evidence that brain-derived neurotrophic factor is a trophic factor for motor neurons in vivo

1993 • 537 citations

Brain-derived neurotrophic factor rescues developing avian motoneurons from cell death

1992 • 458 citations

Nerve sprouting in innervated adult skeletal muscle induced by exposure to elevated levels of insulin-like growth factors.

1990 • 441 citations

A controlled trial of recombinant methionyl human BDNF in ALS

1999 • 437 citations

The effect of systemically administered recombinant human nerve growth factor in healthy human subjects

1994 • 394 citations

Arrest of Motor Neuron Disease in wobbler Mice Cotreated with CNTF and BDNF

1994 • 389 citations

Effect of recombinant human insulin-like growth factor-I on progression of ALS

1997 • 359 citations

A placebo-controlled trial of insulin-like growth factor-I in amyotrophic lateral sclerosis

1998 • 338 citations

The role of endogenous nerve growth factor in human diabetic neuropathy

1996 • 311 citations

Overexpression of nerve growth factor in epidermis of transgenic mice causes hypertrophy of the peripheral nervous system

1994 • 287 citations

Nerve growth factor administration protects against experimental diabetic sensory neuropathy

1994 • 287 citations

A phase II trial of nerve growth factor for sensory neuropathy associated with HIV infection

2000 • 275 citations

Members of several gene families influence survival of rat motoneurons in vitro and in vivo

1993 • 274 citations

Recombinant human nerve growth factor in the treatment of diabetic polyneuropathy

1998 • 274 citations

Neurotrophic agents prevent motoneuron death following sciatic nerve section in the neonatal mouse

1994 • 242 citations

Intradermal recombinant human nerve growth factor induces pressure allodynia and lowered heat-pain threshold in humans

1997 • 241 citations

Insulin‐like growth factors: Putative muscle‐derived trophic agents that promote motoneuron survival

1993 • 225 citations

Evidence indicating trophic importance of IGF‐1 in regenerating peripheral nerves

1986 • 223 citations

Neuroprotection by the Inhibition of Apoptosis

2000 • 222 citations

Insulin-like Growth Factor-I: Potential for Treatment of Motor Neuronal Disorders

1993 • 166 citations

The biological responses of axotomized adult motoneurons to brain- derived neurotrophic factor

1994 • 148 citations

Neurotrophins in Cell Survival/Death Decisions

1999 • 146 citations

Therapeutic potential of neurotrophic factors for neurological disorders

1996 • 143 citations

Insulin-like growth factor II stimulates motor nerve regeneration.

1992 • 141 citations

MURINE MOTOR NEURON DISEASE (THE WOBBLER MOUSE)

1982 • 140 citations

Low serum levels of nerve growth factor in diabetic neuropathy

2009 • 137 citations

Regulation of axonal caliber, neurofilament content, and nuclear localization in mature sensory neurons by nerve growth factor

1991 • 136 citations

Diabetic neuropathy, nerve growth factor and other neurotrophic factors

1994 • 133 citations

Role of insulin-like growth factors in peripheral nerve regeneration

1994 • 130 citations

Expression of neuropeptides in experimental diabetes; effects of treatment with nerve growth factor or brain-derived neurotrophic factor

1994 • 125 citations

Effects of brain‐derived neurotrophic factor on motor dysfunction in wobbler mouse motor neuron disease

1995 • 125 citations

Nerve growth factor and the neurotrophic factor hypothesis

1996 • 113 citations

Biological studies of a putative avian muscle‐derived neurotrophic factor that prevents naturally occurring motoneuron death in vivo

1993 • 112 citations

IGF-I deficient mice show reduced peripheral nerve conduction velocities and decreased axonal diameters and respond to exogenous IGF-I treatment

1999 • 94 citations

Elevated insulin-like growth factor (IGF) gene expression in sciatic nerves during IGF-supported nerve regeneration

1994 • 80 citations

Expression of Insulin-like Growth Factor-I and Related Peptides during Motoneuron Regeneration

1994 • 64 citations

Activity‐Sensitive Signaling by Muscle‐Derived Insulin‐like Growth Factors in the Developing and Regenerating Neuromuscular System

1993 • 55 citations

Insulin-Like Growth Factor I Promotes Nerve Regeneration: An Experimental Study on Rat Sciatic Nerve

1990 • 45 citations

Increased nerve growth factor mRNA in lateral calf skin biopsies from diabetic patients

1999 • 35 citations

The Potential of Insulin‐like Growth Factor‐I as a Therapeutic for the Treatment of Neuromuscular Disorders

1993 • 26 citations

Effects of insulin-like growth factors on organotypic cocultures of embryonic rat brainstem slices and skeletal muscle fibres

1994 • 17 citations

Effects of Multiple Subcutaneous Doses of rhIGF‐1 on Total and Free IGF‐1 Levels and Blood Glucose in Humans

1993 • 12 citations

rhIGF‐I Enhances Functional Recovery from Sciatic Crush Time‐Course and Dose‐Response Study

1993 • 12 citations