In vivo evidence that erythropoietin protects neurons from ischemic damage

Glutamate neurotoxicity and diseases of the nervous system

1988 • 7,257 citations

Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme.

1990 • 3,304 citations

The Role of Glutamate Neurotoxicity in Hypoxic-Ischemic Neuronal Death

1990 • 2,204 citations

Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures.

1991 • 2,173 citations

Ionic dependence of glutamate neurotoxicity

1987 • 1,811 citations

Effects of Cerebral Ischemia in Mice Deficient in Neuronal Nitric Oxide Synthase

1994 • 1,578 citations

Oxygen sensing and molecular adaptation to hypoxia

1996 • 1,187 citations

Erythropoietin: structure, control of production, and function

1992 • 1,158 citations

Generation of committed erythroid BFU-E and CFU-E progenitors does not require erythropoietin or the erythropoietin receptor

1995 • 1,027 citations

Erythropoietin

1991 • 852 citations

Glutamate neurotoxicity in cortical cell culture is calcium dependent

1985 • 818 citations

Basic fibroblast growth factor supports the survival of cerebral cortical neurons in primary culture.

1986 • 696 citations

Erythropoietin receptor is expressed in rat hippocampal and cerebral cortical neurons, and erythropoietin prevents in vitro glutamate-induced neuronal death

1996 • 658 citations

Erythropoietin Gene Expression in Human, Monkey and Murine Brain

1996 • 562 citations

Localization of specific erythropoietin binding sites in defined areas of the mouse brain.

1995 • 481 citations

A novel site of erythropoietin production. Oxygen-dependent production in cultured rat astrocytes.

1994 • 476 citations

Differential effects of an erythropoietin receptor gene disruption on primitive and definitive erythropoiesis.

1996 • 439 citations

Historical Overview

1988 • 428 citations

Functional erythropoietin receptor of the cells with neural characteristics. Comparison with receptor properties of erythroid cells

1993 • 424 citations

Structure, function, and activation of the erythropoietin receptor

1993 • 360 citations

Trophic effects of interleukin-4, -7 and -8 on hippocampal neuronal cultures: potential involvement of glial-derived factors

1993 • 244 citations

Feedback modulation of renal and hepatic erythropoietin mRNA in response to graded anemia and hypoxia

1992 • 243 citations

Potent and selective inhibition of human nitric oxide synthases. Selective inhibition of neuronal nitric oxide synthase by S-methyl-L-thiocitrulline and S-ethyl-L-thiocitrulline.

1994 • 220 citations

Protection of ischemic hippocampal neurons by ginsenoside Rb1, a main ingredient of ginseng root

1997 • 189 citations

Mechanisms Involved in the Neuroprotective Activity of a Nitric Oxide Synthase Inhibitor During Focal Cerebral Ischemia

1993 • 171 citations

Ginseng root prevents learning disability and neuronal loss in gerbils with 5-minute forebrain ischemia

1995 • 126 citations

Interleukin-6 prevents ischemia-induced learning disability and neuronal and synaptic loss in gerbils

1996 • 113 citations

PDGFs protect hippocampal neurons against energy deprivation and oxidative injury: evidence for induction of antioxidant pathways

1995 • 110 citations

Chromaffin cell calcium channel kinetics measured isotopically through fast calcium, strontium, and barium fluxes.

1987 • 108 citations

Prosaposin Facilitates Sciatic Nerve Regeneration In Vivo

1996 • 102 citations

Insulin-like growth factors and insulin stimulate erythropoietin production in primary cultured astrocytes

1997 • 99 citations

Protection by Prosaposin Against Ischemia-Induced Learning Disability and Neuronal Loss

1994 • 99 citations

A Hydrophilic Peptide Comprising 18 Amino Acid Residues of the Prosaposin Sequence Has Neurotrophic Activity In Vitro and In Vivo

1996 • 98 citations

Rat mesencephalic neurons in culture exhibit different morphological traits in the presence of media conditioned on mesencephalic or striatal astroglia

1988 • 98 citations

Characterization of the signal transduction of prostaglandin E receptor EP1 subtype in cDNA-transfected Chinese hamster ovary cells

1995 • 85 citations

Insulin-like growth factors decrease oxygen-regulated erythropoietin production by human hepatoma cells (Hep G2)

1992 • 82 citations

Behavioral, electroencephalographic and histopathological studies on mongolian gerbils with occluded common carotid arteries

1986 • 63 citations

Transient forebrain ischemia of three-minute duration consistently induces severe neuronal damage in field CA1 of the hippocampus in the normothermic gerbil

1991 • 61 citations

Ciliary neurotrophic factor prevents ischemia-induced learning disability and neuronal loss in gerbils

1995 • 59 citations

Production and ligand-binding characteristics of the soluble form of murine erythropoietin receptor

1992 • 59 citations

Anti-erythropoietin receptor monoclonal antibody: epitope mapping, quantification of the soluble receptor, and detection of the solubilized transmembrane receptor and the receptor-expressing cells

1996 • 57 citations

Protective effect of basic fibroblast growth factor-heparin and neurotoxic effect of platelet factor 4 on ischemic neuronal loss and learning disability in gerbils

1995 • 46 citations

protects against ischaemia-induced increases in nitric oxide and hippocampal neuro-degeneration in the gerbil

1994 • 44 citations

Nitric oxide synthase inhibitor reduces delayed neuronal death in gerbil hippocampal CA1 neurons after transient global ischemia without reduction of brain temperature or extracellular glutamate concentration

1996 • 24 citations

Erythropoietin processing in erythropoietic system and central nervous system

1995 • 6 citations