Effect of Mutations at Serines 1280–1283 on the Mitogenic and Transforming Activities of the Insulin-like Growth Factor I Receptor

Jak-STAT Pathways and Transcriptional Activation in Response to IFNs and Other Extracellular Signaling Proteins

1994 • 5,932 citations

Signal transduction by receptors with tyrosine kinase activity

1990 • 5,528 citations

Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r)

1993 • 2,880 citations

Role of insulin-like growth factors in embryonic and postnatal growth

1993 • 2,349 citations

Insulin-like growth factor I receptor primary structure: comparison with insulin receptor suggests structural determinants that define functional specificity.

1986 • 1,866 citations

The insulin signaling system.

1994 • 1,733 citations

Dual control of cell growth by somatomedins and platelet-derived growth factor.

1979 • 926 citations

Expression of a Bacterial Gene in Mammalian Cells

1980 • 788 citations

Direct stimulation of Jak/STAT pathway by the angiotensin II AT1 receptor

1995 • 737 citations

Signaling by the cytokine receptor superfamily: JAKs and STATs

1994 • 659 citations

Simian virus 40 large tumor antigen is unable to transform mouse embryonic fibroblasts lacking type 1 insulin-like growth factor receptor.

1993 • 554 citations

Requirement for MAP Kinase (ERK2) Activity in Interferon α- and Interferon β-Stimulated Gene Expression Through STAT Proteins

1995 • 549 citations

The insulin-like growth factor I receptor: a key to tumor growth?

1995 • 549 citations

Effect of a null mutation of the insulin-like growth factor I receptor gene on growth and transformation of mouse embryo fibroblasts.

1994 • 527 citations

Polypeptide signalling to the nucleus through tyrosine phosphorylation of Jak and Stat proteins

1993 • 504 citations

Overexpression of the human insulinlike growth factor I receptor promotes ligand-dependent neoplastic transformation.

1990 • 404 citations

A second signal supplied by insulin-like growth factor II in oncogene-induced tumorigenesis

1994 • 391 citations

The insulin-like growth factor I receptor protects tumor cells from apoptosis in vivo.

1995 • 385 citations

Platelet-derived growth factor and the regulation of the mammalian fibroblast cell cycle

1979 • 374 citations

RapV12 antagonizes Ras-dependent activation of ERK1 and ERK2 by LPA and EGF in Rat-1 fibroblasts.

1993 • 356 citations

Ras-Independent Growth Factor Signaling by Transcription Factor Tyrosine Phosphorylation

1993 • 345 citations

Treatment and Prevention of Rat Glioblastoma by Immunogenic C6 Cells Expressing Antisense Insulin-Like Growth Factor I RNA

1993 • 328 citations

Rat glioblastoma cells expressing an antisense RNA to the insulin-like growth factor-1 (IGF-1) receptor are nontumorigenic and induce regression of wild-type tumors.

1994 • 310 citations

Transcription factor p91 interacts with the epidermal growth factor receptor and mediates activation of the c-fos gene promoter

1993 • 306 citations

A functional insulin-like growth factor I receptor is required for the mitogenic and transforming activities of the epidermal growth factor receptor.

1994 • 282 citations

Altered body composition and increased frequency of diverse malignancies in insulin-like growth factor-II transgenic mice.

1994 • 274 citations

Role of tyrosine kinase activity in signal transduction by the insulin-like growth factor-I (IGF-I) receptor. Characterization of kinase-deficient IGF-I receptors and the action of an IGF-I-mimetic antibody (alpha IR-3).

1993 • 247 citations

Growth Hormone, Interferon-γ, and Leukemia Inhibitory Factor Promoted Tyrosyl Phosphorylation of Insulin Receptor Substrate-1

1995 • 246 citations

Differential signalling potential of insulin- and IGF-1-receptor cytoplasmic domains.

1989 • 225 citations

Dominant negative inhibition of tumorigenesis in vivo by human insulin-like growth factor I receptor mutant.

1994 • 195 citations

In vivo treatment with antibody against IGF-1 receptor suppresses growth of human rhabdomyosarcoma and down-regulates p34cdc2.

1994 • 186 citations

Ras-Dependent and -Independent Pathways Target the Mitogen-Activated Protein Kinase Network in Macrophages

1995 • 179 citations

Correlation between apoptosis, tumorigenesis, and levels of insulin-like growth factor I receptors.

1995 • 172 citations

Antisense-mediated reduction in insulin-like growth factor-I receptor expression suppresses the malignant phenotype of a human alveolar rhabdomyosarcoma.

1994 • 170 citations

Constitutive expression of insulin-like growth factor 1 and insulin-like growth factor 1 receptor abrogates all requirements for exogenous growth factors.

1992 • 159 citations

Competition for Overlapping Sites in the Regulatory Region of the Drosophila Gene Krüppel

1992 • 145 citations

Loss of the metastatic phenotype in murine carcinoma cells expressing an antisense RNA to the insulin-like growth factor receptor.

1995 • 141 citations

Insulin receptor substrate 1 is required for insulin-mediated mitogenic signal transduction.

1994 • 126 citations

Different Effects on Mitogenesis and Transformation of a Mutation at Tyrosine 1251 of the Insulin-like Growth Factor I Receptor

1995 • 119 citations

Evidence for a Differential Interaction of SHC and the Insulin Receptor Substrate-1 (IRS-1) with the Insulin-like Growth Factor-I (IGF-I) Receptor in the Yeast Two-hybrid System

1995 • 117 citations

Functional expression of insulin receptor substrate-1 is required for insulin-stimulated mitogenic signaling.

1993 • 116 citations

Growth-promoting effects of insulin-like growth factor-1 (IGF-1) on hematopoietic cells: overexpression of introduced IGF-1 receptor abrogates interleukin-3 dependency of murine factor-dependent cells by a ligand-dependent mechanism

1991 • 112 citations

Structure-function relationship of the insulin-like growth factor-I receptor tyrosine kinase.

1993 • 111 citations

Roles of insulinlike growth factor 1 (IGF-1) and the IGF-1 receptor in epidermal growth factor-stimulated growth of 3T3 cells.

1992 • 110 citations

Relationship between alpha subunit ligand occupancy and beta subunit autophosphorylation in insulin/insulin-like growth factor-1 hybrid receptors.

1993 • 105 citations

Mutational analysis of the mitogenic and transforming activities of the insulin-like growth factor I receptor.

1996 • 104 citations

Mitogenicity and transforming activity of the insulin-like growth factor-I receptor with mutations in the tyrosine kinase domain.

1994 • 101 citations

Interference of the IGF system as a strategy to inhibit breast cancer growth

1992 • 100 citations

Insulin-sensitive phosphorylation of serine 1293/1294 on the human insulin receptor by a tightly associated serine kinase.

1990 • 93 citations

Insulin‐like growth factor I receptor is required for the mitogenic and transforming activities of the platelet‐derived growth factor receptor

1995 • 93 citations

Transphosphorylation as a possible mechanism for insulin and epidermal growth factor receptor activation.

1990 • 80 citations

Mutational analysis of insulin receptor function

1993 • 79 citations

Dissociation of Mitogenesis and Transforming Activity by C-Terminal Truncation of the Insulin-like Growth Factor-I Receptor

1995 • 75 citations

The Kinase Domain and Membrane Localization Determine Intracellular Interactions between Epidermal Growth Factor Receptors

1995 • 73 citations

Failure of the bovine papillomavirus to transform mouse embryo fibroblasts with a targeted disruption of the insulin-like growth factor I receptor genes

1995 • 73 citations

Intracellular Transactivation of the Insulin-like Growth Factor I Receptor by an Epidermal Growth Factor Receptor

1996 • 64 citations

Intermolecular transphosphorylation between insulin receptors and EGF-insulin receptor chimerae.

1989 • 64 citations

Role of the carboxyl-terminal domains of the insulin and insulin-like growth factor I receptors in receptor function.

1994 • 60 citations

Hydrolysis of Phosphatidylcholine Is Stimulated by Ras Proteins during Mitogenic Signal Transduction

1992 • 59 citations

Mutant IGF-I Receptors as Dominant Negatives for Growth and Transformation

1995 • 57 citations

A Dominant-Negative Mutant of mSOS1 Inhibits Insulin-Induced Ras Activation and Reveals Ras-Dependent and -Independent Insulin Signaling Pathways

1995 • 55 citations

Interactions of growth factors and retroviral oncogenes with mitogenic signal transduction pathways of Balb/MK keratinocytes.

1988 • 49 citations

Enhancement or Inhibition of Insulin Signaling by Insulin Receptor Substrate 1 Is Cell Context Dependent

1994 • 48 citations

Effect of a mutation at tyrosine 950 of the insulin-like growth factor I receptor on the growth and transformation of cells.

1995 • 47 citations

Human insulin-like growth factor I receptor 950tyrosine is required for somatotroph growth factor signal transduction.

1992 • 45 citations

Distinctive effects of the carboxyl-terminal sequence of the insulin-like growth factor I receptor on its signaling functions

1993 • 39 citations

Functional characterization of hybrid receptors composed of a truncated insulin receptor and wild type insulin-like growth factor 1 or insulin receptors.

1995 • 38 citations

Rescue and activation of a binding-deficient insulin receptor. Evidence for intermolecular transphosphorylation.

1994 • 12 citations