Insulin-like growth factor-I is an osmoprotectant in human neuroblastoma cells

Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation

1980 • 4,591 citations

Specific proteolytic cleavage of poly(ADP-ribose) polymerase: an early marker of chemotherapy-induced apoptosis.

1993 • 1,888 citations

Induction of apoptosis in cerebellar granule neurons by low potassium: inhibition of death by insulin-like growth factor I and cAMP.

1993 • 886 citations

c-Myc-induced apoptosis in fibroblasts is inhibited by specific cytokines.

1994 • 747 citations

Igf1 gene disruption results in reduced brain size, CNS hypomyelination, and loss of hippocampal granule and striatal parvalbumin-containing neurons

1995 • 629 citations

Endogenous endonuclease-induced DNA fragmentation: an early event in cell-mediated cytolysis.

1983 • 616 citations

Temporal analysis of events associated with programmed cell death (apoptosis) of sympathetic neurons deprived of nerve growth factor.

1993 • 535 citations

Studies of the lamin proteinase reveal multiple parallel biochemical pathways during apoptotic execution.

1995 • 524 citations

Purification of three cytotoxic lymphocyte granule serine proteases that induce apoptosis through distinct substrate and target cell interactions.

1992 • 447 citations

Calpain activation in apoptosis

1994 • 445 citations

Large-scale normal cell death in the developing rat kidney and its reduction by epidermal growth factor

1993 • 433 citations

Specific cleavage of the 70-kDa protein component of the U1 small nuclear ribonucleoprotein is a characteristic biochemical feature of apoptotic cell death.

1994 • 424 citations

Apoptosis in cerebellar granule cells is blocked by high KCl, forskolin, and IGF-1 through distinct mechanisms of action: the involvement of intracellular calcium and RNA synthesis

1995 • 403 citations

Peptide inhibitors of the ice protease family arrest programmed cell death of motoneurons in vivo and in vitro

1995 • 324 citations

Identification, purification, and characterization of a calcium-dependent endonuclease (NUC18) from apoptotic rat thymocytes. NUC18 is not histone H2B.

1991 • 301 citations

Macromolecular synthesis inhibitors prevent oxidative stress-induced apoptosis in embryonic cortical neurons by shunting cysteine from protein synthesis to glutathione

1994 • 268 citations

A system for characterizing cellular and molecular events in programmed neuronal cell death

1993 • 267 citations

IGF-I and IGF-II protect cultured hippocampal and septal neurons against calcium-mediated hypoglycemic damage

1992 • 253 citations

Programmed Cell Death in Terminally Differentiating Keratinocytes: Role of Endogenous Endonuclease

1991 • 248 citations

Degradation of lamin B1 precedes oligonucleosomal DNA fragmentation in apoptotic thymocytes and isolated thymocyte nuclei.

1995 • 242 citations

Insulin-like growth factor I (IGF I) stimulates DNA synthesis in fetal rat brain cell cultures

1983 • 230 citations

Detection of the initial stages of DNA fragmentation in apoptosis.

1993 • 228 citations

Insulin‐like growth factors: Putative muscle‐derived trophic agents that promote motoneuron survival

1993 • 225 citations

Insulin-like growth factor I gene expression is induced in astrocytes during experimental demyelination.

1992 • 223 citations

Evidence indicating trophic importance of IGF‐1 in regenerating peripheral nerves

1986 • 223 citations

Human cathepsin H

1980 • 193 citations

CrmA-inhibitable Cleavage of the 70-kDa Protein Component of the U1 Small Nuclear Ribonucleoprotein during Fas- and Tumor Necrosis Factor-induced Apoptosis

1995 • 179 citations

Insulin-like growth factor I rescues SH-SY5Y human neuroblastoma cells from hyperosmotic induced programmed cell death

1996 • 169 citations

Attenuation of ceramide-induced apoptosis by diglyceride in human myeloid leukemia cells.

1994 • 169 citations

Insulin-like Growth Factor-I: Potential for Treatment of Motor Neuronal Disorders

1993 • 166 citations

Abnormalities of cell volume regulation and their functional consequences

1980 • 145 citations

DNA fragmentation indicative of apoptosis following unilateral cerebral hypoxia-ischemia in the neonatal rat

1995 • 135 citations

Inhibition of activation-induced programmed cell death and restoration of defective immune responses of HIV+ donors by cysteine protease inhibitors.

1994 • 131 citations

Activation of intracellular proteases is an early event in TNF-induced apoptosis.

1995 • 129 citations

Patterns of Insulin‐like Growth Factor and IGF Receptor Gene Expression in the Brain: Functional Implications

1993 • 129 citations

Methods for the Detection of Apoptosis

1994 • 125 citations

Evidence for hypoxia‐induced, programmed cell death of cultured neurons

1994 • 120 citations

Insulin-like growth factors in the response to cerebral ischemia

1992 • 116 citations

Role of proteolysis in apoptosis: involvement of serine proteases in internucleosomal DNA fragmentation in immature thymocytes

1993 • 109 citations

Tissue platelet derived-growth factor (PDGF) predicts for shortened survival and treatment failure in advanced breast cancer

1993 • 101 citations

Ca2+ ionophore-induced apoptosis on cultured embryonic rat cortical neurons

1994 • 92 citations

Osmoregulation of Na(+)-inositol cotransporter activity and mRNA levels in brain glial cells

1992 • 89 citations

Inhibitors of proteases prevent endonucleolysis accompanying apoptotic death of HL-60 leukemic cells and normal thymocytes.

1992 • 86 citations

Reevaluation of the Role of de Novo Protein Synthesis in Rat Thymocyte Apoptosis

1995 • 82 citations

Observations on exsudation of fibronectin, fibrinogen and albumin in the brain after carotid infusion of hyperosmolar solutions

1988 • 77 citations

Inhibition of apoptosis in human tumour cells by okadaic acid

1992 • 75 citations

The Na⁺/H⁺ exchange system in glial cell lines

1986 • 74 citations

Volume regulatory influx of electrolytes from plasma to brain during acute hyperosmolality

1987 • 72 citations

Vasoactive intestinal peptide-mediated suppression of apoptosis in the ovary: potential mechanisms of action and evidence of a conserved antiatretogenic role through evolution.

1995 • 67 citations

Volume regulation during recovery from chronic hypertonicity in brain glial cells

1992 • 62 citations

Protease inhibitors differentially regulate tumor necrosis factor- induced apoptosis, nuclear factor-kappa B activation, cytotoxicity, and differentiation

1995 • 61 citations

TrkA neurogenic receptor regulates differentiation of neuroblastoma cells.

1995 • 60 citations

Cell Volume Regulation in the Nervous System

1988 • 58 citations

Skeletal muscle-derived trophic factors prevent motoneurons from entering an active cell death program in vitro

1994 • 56 citations

Mechanism of tissue-specific induction of internucleosomal deoxyribonucleic acid cleavage activity and apoptosis by glucocorticoids.

1993 • 54 citations

Insulin-like growth factor I regulates c-myc and GAP-43 messenger ribonucleic acid expression in SH-SY5Y human neuroblastoma cells.

1993 • 47 citations

Apoptosis: Breaking the ICE

1994 • 46 citations

The effects of hyperosmolarity on the blood-brain barrier. A morphological and physiological correlation

1974 • 45 citations

Regulation of insulin‐like growth factor‐II expression and its role in autocrine growth of human neuroblastoma cells

1993 • 44 citations

Steady-state polypeptide modulations associated with nerve growth factor (NGF)-induced terminal differentiation and NGF deprivation-induced apoptosis in human neuroblastoma cells.

1992 • 41 citations

Types of nuclear endonuclease activity capable of inducing internucleosomal DNA fragmentation are completely different between human CD34+ cells and their granulocytic descendants

1995 • 41 citations

Transcription factor DNA binding activity in PC12 cells undergoing apoptosis after glucose deprivation

1995 • 37 citations

Multi-Step Chromatin Degradation in Apoptosis

1994 • 36 citations

Interferon‐γ inhibits DNA synthesis and insulin‐like growth factor‐II expression in human neuroblastoma cells

1993 • 34 citations

Transient increase in insulin-like growth factor I immunoreactivity in rat peripheral nerves exposed to vibrations

1988 • 30 citations

Vasoactive intestinal peptide-mediated suppression of apoptosis in the ovary: potential mechanisms of action and evidence of a conserved antiatretogenic role through evolution

1995 • 30 citations

Synthesis of Specific Proteins in Trophic Factor‐Deprived Neurons Undergoing Apoptosis

1994 • 28 citations

Changes in the nuclei of dying neurons as studied with thymidine autoradiography

1989 • 27 citations

Mechanism of tissue-specific induction of internucleosomal deoxyribonucleic acid cleavage activity and apoptosis by glucocorticoids

1993 • 27 citations

Induction of Apoptotic Cell Death in Differentiating Neuroblastoma SH-SY5Y Cells by Colchicine

1994 • 22 citations

Co‐activation of insulin‐like growth factor‐I receptors and protein kinase C results in parasympathetic neuronal survival

1991 • 18 citations

DNA cleavage in rat liver nuclei activated by Mg²⁺ or Ca²⁺ + Mg²⁺ is inhibited by a variety of structurally unrelated inhibitors

1994 • 17 citations

Morphological differentiation of human SH-SY5Y neuroblastoma cells inhibits human immunodeficiency virus type 1 infection

1994 • 15 citations

Insulin-like growth factor I regulates c-myc and GAP-43 messenger ribonucleic acid expression in SH-SY5Y human neuroblastoma cells

1993 • 12 citations

Neurologic manifestations of osmolar disorders.

1980 • 11 citations