Insulin-like Growth Factor-I Extends in VitroReplicative Life Span of Skeletal Muscle Satellite Cells by Enhancing G1/S Cell Cycle Progression via the Activation of Phosphatidylinositol 3′-Kinase/Akt Signaling Pathway

The serial cultivation of human diploid cell strains

1961 • 7,886 citations

Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery

1997 • 5,665 citations

Extension of Life-Span by Introduction of Telomerase into Normal Human Cells

1998 • 4,845 citations

Inhibitors of mammalian G1 cyclin-dependent kinases.

1995 • 3,258 citations

A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002).

1994 • 3,249 citations

A synthetic inhibitor of the mitogen-activated protein kinase cascade.

1995 • 2,723 citations

G ₁ Events and Regulation of Cell Proliferation

1989 • 2,203 citations

Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals

1994 • 2,154 citations

p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21

1994 • 2,071 citations

Mice Lacking p27 Display Increased Body Size, Multiple Organ Hyperplasia, Retinal Dysplasia, and Pituitary Tumors

1996 • 1,583 citations

E2F: a Link Between the Rb Tumor Suppressor Protein and Viral Oncoproteins

1992 • 1,552 citations

A Syndrome of Multiorgan Hyperplasia with Features of Gigantism, Tumorigenesis, and Female Sterility in p27 -Deficient Mice

1996 • 1,488 citations

Enhanced Growth of Mice Lacking the Cyclin-Dependent Kinase Inhibitor Function of p27

1996 • 1,283 citations

Growth Hormone and the Insulin-Like Growth Factor System in Myogenesis*

1996 • 1,078 citations

Epidermal growth factor and the multiplication of cultured human epidermal keratinocytes

1977 • 1,063 citations

Immunochemical analysis of myosin heavy chain during avian myogenesis in vivo and in vitro.

1982 • 932 citations

The Regulation and Activities of the Multifunctional Serine/Threonine Kinase Akt/PKB

1999 • 882 citations

Cyclin-Dependent Regulation of G ₁ in Mammalian Fibroblasts

1993 • 767 citations

The retinoblastoma gene product regulates progression through the G1 phase of the cell cycle

1991 • 708 citations

Viral mediated expression of insulin-like growth factor I blocks the aging-related loss of skeletal muscle function

1998 • 700 citations

The Mitogenic and Myogenic Actions of Insulin-like Growth Factors Utilize Distinct Signaling Pathways

1997 • 654 citations

The Insulin-Like Growth Factors

1993 • 647 citations

Myogenic Vector Expression of Insulin-like Growth Factor I Stimulates Muscle Cell Differentiation and Myofiber Hypertrophy in Transgenic Mice

1995 • 634 citations

DNA synthesis and myogenesis

1961 • 557 citations

Replicative Senescence: Implications for in Vivo Aging and Tumor Suppression

1996 • 549 citations

Transduction of interleukin-2 antiapoptotic and proliferative signals via Akt protein kinase

1997 • 534 citations

PTEN/MMAC1/TEP1 suppresses the tumorigenicity and induces G ₁ cell cycle arrest in human glioblastoma cells

1998 • 480 citations

Phosphatidylinositol 3-Kinase Couples the Interleukin-2 Receptor to the Cell Cycle Regulator E2F

1997 • 411 citations

Localized infusion of IGF-I results in skeletal muscle hypertrophy in rats

1998 • 392 citations

Failure to Phosphorylate the Retinoblastoma Gene Product in Senescent Human Fibroblasts

1990 • 367 citations

Replicative Potential and Telomere Length in Human Skeletal Muscle: Implications for Satellite Cell-Mediated Gene Therapy

1997 • 297 citations

Cyclin dependent kinase regulation

1995 • 286 citations

Altered regulation of G1 cyclins in senescent human diploid fibroblasts: accumulation of inactive cyclin E-Cdk2 and cyclin D1-Cdk2 complexes.

1993 • 277 citations

Inhibition of the Phosphoinositide 3-Kinase Pathway Induces a Senescence-like Arrest Mediated by p27Kip1

2000 • 273 citations

IGF-I restores satellite cell proliferative potential in immobilized old skeletal muscle

2000 • 271 citations

The phosphatidylinositol 3-kinase alpha is required for DNA synthesis induced by some, but not all, growth factors.

1994 • 270 citations

Activation of Phosphatidylinositol 3-Kinase Is Sufficient for Cell Cycle Entry and Promotes Cellular Changes Characteristic of Oncogenic Transformation

1998 • 266 citations

Mitogenic Signaling of Insulin-like Growth Factor I in MCF-7 Human Breast Cancer Cells Requires Phosphatidylinositol 3-Kinase and Is Independent of Mitogen-activated Protein Kinase

1997 • 262 citations

Insulin-like growth factor-I receptor signal transduction: at the interface between physiology and cell biology

1998 • 253 citations

Expression of cell cycle-dependent genes in young and senescent WI-38 fibroblasts.

1986 • 247 citations

Phosphorylation of the retinoblastoma protein by cdk2.

1992 • 217 citations

Reversible G1 Arrest Induced by Inhibition of the Epidermal Growth Factor Receptor Tyrosine Kinase Requires Up-regulation of p27KIP1 Independent of MAPK Activity

2000 • 209 citations

Replicating myoblasts express a muscle-specific phenotype.

1988 • 206 citations

Downregulation of cyclin-dependent kinase 2 activity and cyclin A promoter activity in vascular smooth muscle cells by p27(KIP1), an inhibitor of neointima formation in the rat carotid artery.

1997 • 192 citations

Vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) delays and induces escape from senescence in human dermal microvascular endothelial cells

1997 • 139 citations

Anchorage-Dependent Transcription of the Cyclin A Gene

1996 • 136 citations

Conditional Knockout of Mouse Insulin-Like Growth Factor-1 Gene Using the Cre/loxP System

2000 • 129 citations

Stimulation of C2C12 Myoblast Growth by Basic Fibroblast Growth Factor and Insulin-Like Growth Factor 1 Can Occur via Mitogen-Activated Protein Kinase-Dependent and -Independent Pathways

1996 • 120 citations

Immunocytochemical analysis of intermediate filaments in embryonic heart cells with monoclonal antibodies to desmin.

1984 • 99 citations

Differential CDK-inhibitor gene expression in aging human diploid fibroblasts

1996 • 98 citations

Tumor suppression and inhibition of aneuploid cell accumulation in human brain tumor cells by ectopic overexpression of the cyclin-dependent kinase inhibitor p27KIP1.

1996 • 75 citations

Accumulation of insulin‐like growth factor binding protein‐3 in conditioned medium of human fibroblasts increases with chronologic age of donor and senescence in vitro

1993 • 53 citations

Myoblast senescence in muscular dystrophy

1985 • 42 citations

Effect of insulin‐like growth factor 1 on PHA‐stimulated cord blood mononuclear cell telomerase activity

1999 • 40 citations

A general method for determining the replicative age of normal animal cell cultures

1980 • 21 citations

Replicative potential and the duration of the cell cycle in human fibroblasts: Coordinate stimulation by epidermal growth factor

1992 • 7 citations