IGFs and the Nervous System

Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery

1997 • 5,665 citations

Cell Migration: A Physically Integrated Molecular Process

1996 • 3,909 citations

Apoptosis, oncosis, and necrosis. An overview of cell death.

1995 • 3,325 citations

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα

1997 • 2,747 citations

Regulation of Neuronal Survival by the Serine-Threonine Protein Kinase Akt

1997 • 2,442 citations

Bcl-2 and the regulation of programmed cell death

1994 • 2,346 citations

Insulin-Like Growth Factors I and II. Peptide, Messenger Ribonucleic Acid and Gene Structures, Serum, and Tissue Concentrations*

1989 • 1,796 citations

Direct Regulation of the Akt Proto-Oncogene Product by Phosphatidylinositol-3,4-bisphosphate

1997 • 1,448 citations

Requirement for Phosphatidylinositol-3 Kinase in the Prevention of Apoptosis by Nerve Growth Factor

1995 • 1,400 citations

Molecular and Cellular Aspects of the Insulin-Like Growth Factor I Receptor

1995 • 1,361 citations

Integrin function: molecular hierarchies of cytoskeletal and signaling molecules.

1995 • 1,202 citations

Insulin-like growth factors and their binding proteins

1990 • 929 citations

Inhibition of MAP Kinase Kinase Blocks the Differentiation of PC-12 Cells Induced by Nerve Growth Factor

1995 • 906 citations

Induction of apoptosis in cerebellar granule neurons by low potassium: inhibition of death by insulin-like growth factor I and cAMP.

1993 • 886 citations

Role of Substrates and Products of PI 3-kinase in Regulating Activation of Rac-Related Guanosine Triphosphatases by Vav

1998 • 798 citations

Astrocyte Responses to CNS Injury

1994 • 596 citations

Insulin-like growth factor binding proteins and their role in controlling IGF actions

1997 • 510 citations

A Specific Product of Phosphatidylinositol 3-Kinase Directly Activates the Protein Kinase Akt through Its Pleckstrin Homology Domain

1997 • 481 citations

Differential expression of insulin-like growth factor genes in rat central nervous system.

1988 • 477 citations

Insulin-like growth factor I increases brain growth and central nervous system myelination in tTransgenic mice

1993 • 468 citations

Coupling of Ras and Rac Guanosine Triphosphatases Through the Ras Exchanger Sos

1998 • 452 citations

Nerve sprouting in innervated adult skeletal muscle induced by exposure to elevated levels of insulin-like growth factors.

1990 • 441 citations

Activation of the small GTP-binding proteins rho and rac by growth factor receptors

1995 • 437 citations

Apoptosis in cerebellar granule cells is blocked by high KCl, forskolin, and IGF-1 through distinct mechanisms of action: the involvement of intracellular calcium and RNA synthesis

1995 • 403 citations

A role for IGF-1 in the rescue of CNS neurons following hypoxic-ischemic injury

1992 • 381 citations

Disoriented pathfinding by pioneer neurone growth cones deprived of filopodia by cytochalasin treatment

1986 • 378 citations

Interleukin 3-dependent survival by the Akt protein kinase

1997 • 374 citations

Cellular pattern of type-I insulin-like growth factor receptor gene expression during maturation of the rat brain: Comparison with insulin-like growth factors I and II

1992 • 370 citations

Involvement of phosphoinositide 3-kinase in insulin- or IGF-1-induced membrane ruffling.

1994 • 360 citations

Effect of recombinant human insulin-like growth factor-I on progression of ALS

1997 • 359 citations

Multiple agents rescue PC12 cells from serum-free cell death by translation- and transcription-independent mechanisms

1991 • 337 citations

The Insulin-Like Growth Factor-I Receptor

1994 • 325 citations

Insulin-like growth factor I protects and rescues hippocampal neurons against β-amyloid- and human amylin-induced toxicity

1997 • 325 citations

Essential role of filopodia in chemotropic turning of nerve growth cone induced by a glutamate gradient

1996 • 323 citations

Cellular Pattern of Insulin-Like Growth Factor-I (IGF-I) and Type I IGF Receptor Gene Expression in Early Organogenesis: Comparison with IGF-II Gene Expression

1990 • 320 citations

Insulin-like growth factor I (IGF-I) stimulates regeneration of the rat sciatic nerve

1989 • 280 citations

A system for characterizing cellular and molecular events in programmed neuronal cell death

1993 • 267 citations

Navigational errors made by growth cones without filopodia in the embryonic xenopus brain

1993 • 264 citations

The organization of F-actin and microtubules in growth cones exposed to a brain-derived collapsing factor.

1993 • 262 citations

Expression of the insulin-like growth factor II gene in the choroid plexus and the leptomeninges of the adult rat central nervous system.

1988 • 262 citations

In vivo actions of insulin-like growth factor-I (IGF-I) on brain myelination: studies of IGF-I and IGF binding protein-1 (IGFBP-1) transgenic mice

1995 • 257 citations

Studies on cultured rat Schwann cells

1979 • 250 citations

Brain neurons develop in a serum and glial free environment: effects of transferrin, insulin- insulin-like growth factor-I and thyroid hormone on neuronal survival, growth and differentiation

1987 • 249 citations

Inhibition of Phosphatidylinositol 3-Kinase Activity Blocks Depolarization- and Insulin-like Growth Factor I-mediated Survival of Cerebellar Granule Cells

1997 • 246 citations

THE ROLE OF THE INSULIN-LIKE GROWTH FACTOR BINDING PROTEINS AND THE IGFBP PROTEASES IN MODULATING IGF ACTION

1996 • 227 citations

Progress in Brain Research

1995 • 226 citations

Insulin‐like growth factors: Putative muscle‐derived trophic agents that promote motoneuron survival

1993 • 225 citations

Insulin-like growth factor I gene expression is induced in astrocytes during experimental demyelination.

1992 • 223 citations

A sensory role for neuronal growth cone filopodia

1993 • 223 citations

The Neuronal Growth-Associated Protein GAP-43 Induces Filopodia in Non-Neuronal Cells

1989 • 216 citations

Evidence that calcium may control neurite outgrowth by regulating the stability of actin filaments.

1989 • 214 citations

Insulin-like growth factor I treatment reduces demyelination and up-regulates gene expression of myelin-related proteins in experimental autoimmune encephalomyelitis.

1995 • 207 citations

Quantitative autoradiographic localization of [¹²⁵I]insulin‐like growth factor I, [¹²⁵I]insulin‐like growth factor II, and [¹²⁵I]insulin receptor binding sites in developing and adult rat brain

1993 • 207 citations

The Effects of IGF-1 Treatment after Hypoxic-Ischemic Brain Injury in Adult Rats

1993 • 202 citations

Immunocytochemical localization of P0 protein in Golgi complex membranes and myelin of developing rat Schwann cells.

1981 • 184 citations

Absence of persistent spreading, branching, and adhesion in GAP-43-depleted growth cones.

1995 • 183 citations

Autocrine—paracrine Regulation of Hippocampal Neuron Survival by IGF‐1 and the Neurotrophins BDNF, NT‐3 and NT‐4

1996 • 182 citations

Insulin-like growth factor-1 is a potent neuronal rescue agent after hypoxic-ischemic injury in fetal lambs.

1996 • 182 citations

Insulin-like Growth Factor-1 (IGF-1) Improves both Neurological Motor and Cognitive Outcome Following Experimental Brain Injury

1997 • 182 citations

Immunohistochemical localization of insulin-like growth factor I in the adult rat

1988 • 177 citations

Implication of insulin-like growth factors in the pathogenesis of diabetic neuropathy

1995 • 177 citations

Localization of insulin-like growth factor I (IGF-I)-like immunoreactivity in the developing and adult rat brain

1991 • 176 citations

Human neuroblastoma cells in culture: a model for neuronal cell differentiation and function.

1990 • 175 citations

Myelination determines the caliber of dorsal root ganglion neurons in culture

1985 • 170 citations

Insulin-like growth factor I rescues SH-SY5Y human neuroblastoma cells from hyperosmotic induced programmed cell death

1996 • 169 citations

Insulin‐like growth factor I stimulates oligodendrocyte development and myelination in rat brain aggregate cultures

1991 • 169 citations

Neuronal Apoptosis: Current Understanding of Molecular Mechanisms and Potential Role in Ischemic Brain Injury

1995 • 168 citations

Insulin-like Growth Factor-I: Potential for Treatment of Motor Neuronal Disorders

1993 • 166 citations

Type I Insulin-like Growth Factor Receptor Activation Regulates Apoptotic Proteins

1996 • 162 citations

The insulin and insulin-like growth factor-I receptor substrate IRS-1 associates with and activates phosphatidylinositol 3-kinase in vitro.

1993 • 161 citations

Insulin-like Growth Factor-I-mediated Neurite Outgrowth in Vitro Requires Mitogen-activated Protein Kinase Activation

1997 • 157 citations

Motor Neuron Disease (Amyotrophic Lateral Sclerosis)

1991 • 151 citations

Coordinate expression of insulin-like growth factor system components by neurons and neuroglia during retinal and cerebellar development

1992 • 150 citations

Expression of IGF-I and -II mRNA in the brain and craniofacial region of the rat fetus

1991 • 146 citations

Actin dynamics in growth cones

1991 • 145 citations

Studies on cultured rat Schwann cells. III. Assays for peripheral myelin proteins

1980 • 144 citations

Tyrosine Phosphorylation of Paxillin and Focal Adhesion Kinase during Insulin-like Growth Factor-I-stimulated Lamellipodial Advance

1997 • 144 citations

Regenerating skeletal muscle cells express insulin‐like growth factor I

1987 • 143 citations

Relationship of insulin-like growth factor II gene expression in muscle to synaptogenesis.

1989 • 143 citations

Correlation between insulin-like growth factor (IGF)-binding protein 5 and IGF-I gene expression during brain development

1993 • 138 citations

Insulin-like growth factors, insulin, and epidermal growth factor cause rapid cytoskeletal reorganization in KB cells. Clarification of the roles of type I insulin-like growth factor receptors and insulin receptors.

1986 • 136 citations

Localization of insulin-like growth factor binding protein-2 messenger RNA during postnatal brain development: Correlation with insulin-like growth factors I and II

1993 • 133 citations

Role of insulin-like growth factors in peripheral nerve regeneration

1994 • 130 citations

Initiation and maintenance of NGF-stimulated neurite outgrowth requires activation of a phosphoinositide 3-kinase

1996 • 130 citations

Patterns of Insulin‐like Growth Factor and IGF Receptor Gene Expression in the Brain: Functional Implications

1993 • 129 citations

Oligodendrocytes and their precursors require phosphatidylinositol 3-kinase signaling for survival

1996 • 127 citations

Filopodia initiate choices made by sensory neuron growth cones at laminin/fibronectin borders in vitro

1994 • 126 citations

The effects of insulin-like growth factor (IGF)-1, IGF-2, and des-IGF-1 on neuronal loss after hypoxic-ischemic brain injury in adult rats: evidence for a role for IGF binding proteins.

1996 • 122 citations

Localization of Type I Insulin-Like Growth Factor Receptor Messenger RNA in the Adult Rat Brain byin SituHybridization

1991 • 122 citations

Expression of IGF‐I and insulin receptor genes in the rat central nervous system: A developmental, regional, and cellular analysis

1991 • 121 citations

Insulin-like growth factor-I prevents apoptosis in neurons after nerve growth factor withdrawal

1998 • 121 citations

Evidence for an important role of IGF-I and IGF-II for the early development of chick sympathetic neurons

1995 • 119 citations

Phosphoinositide 3-kinase and the regulation of cell growth

1996 • 117 citations

Role of muscle insulin-like growth factors in nerve sprouting: suppression of terminal sprouting in paralyzed muscle by IGF-binding protein 4.

1994 • 116 citations

Insulin‐like growth factor‐1 mRNA is increased in deafferented hippocampus: Spatiotemporal correspondence of a trophic event with axon sprouting

1995 • 114 citations

Insulin‐like growth factors protect against diabetic neuropathy: Effects on sensory nerve regeneration in rats

1995 • 113 citations

Intraventricular Administration of Insulin and IGF-1 in Transient Forebrain Ischemia

1994 • 112 citations

The insulin‐like growth factor I system in the rat cerebellum: Developmental regulation and role in neuronal survival and differentiation

1994 • 112 citations

Insulin-like growth factor II increases the rate of sciatic nerve regeneration in rats

1993 • 111 citations

Participation of Acetylpseudouridine in the Synthesis of a Peptide Bond in Vitro

1995 • 111 citations

Differing expression of insulin‐like growth factor I in the developing and in the adult rat cerebellum

1988 • 110 citations

Spatial and Temporal Changes in the Insulin-Like Growth Factor (IGF) Axis Indicate Autocrine/Paracrine Actions of IGF-I within Wounds of the Rat Brain*

1997 • 110 citations

Expression of insulin-like growth factor I by astrocytes in response to injury

1992 • 109 citations

Actin filament bundles are required for microtubule reorientation during growth cone turning to avoid an inhibitory guidance cue

1996 • 109 citations

Characterization of Insulin‐Like Growth Factor‐I and Its Receptor and Binding Proteins in Transected Nerves and Cultured Schwann Cells

1996 • 108 citations

Insulin and insulinlike growth factor receptors regulating neurite formation in cultured human neuroblastoma cells

1988 • 106 citations

Cryogenic spinal cord injury induces astrocytic gene expression of insulin‐like growth factor I and insulin‐like growth factor binding protein 2 during myelin regeneration

1995 • 106 citations

Distinct expression patterns of insulin-like growth factor binding proteins 2 and 5 during fetal and postnatal development.

1994 • 104 citations

Stabilization of tubulin mRNAs by insulin and insulin-like growth factor I during neurite formation

1989 • 103 citations

Insulin-like growth factor I treatment reduces clinical deficits and lesion severity in acute demyelinating experimental autoimmune encephalomyelitis

1995 • 102 citations

Insulin-like growth factors and insulin stimulate erythropoietin production in primary cultured astrocytes

1997 • 99 citations

Regulation of Rat Schwann Cell P_o Expression and DNA Synthesis by Insulin‐like Growth Factors In Vitro

1996 • 96 citations

The cytoskeleton in nerve growth cone motility and axonal pathfinding.

1996 • 95 citations

Increase of insulin-like growth factor (IGF)-1, IGF binding protein-2 and −4 mRNAs following cerebral contusion

1996 • 94 citations

Protein kinase C-epsilon is implicated in neurite outgrowth in differentiating human neuroblastoma cells.

1996 • 93 citations

Cultured Schwann Cells Constitutively Express the Myelin Protein P0

1996 • 91 citations

Insulin-like growth factor (IGF) gene expression is reduced in neural tissues and liver from rats with non-insulin-dependent diabetes mellitus, and IGF treatment ameliorates diabetic neuropathy.

1997 • 89 citations

Coordinated pattern of expression and localization of insulin-like growth factor-II (IGF-II) and IGF-binding protein-2 in the adult rat brain.

1994 • 89 citations

Peptide Growth Factors and Proto-oncogenes in Mammalian Conceptus Development1

1991 • 88 citations

Cytoskeletal movements and substrate interactions during initiation of neurite outgrowth by sympathetic neurons in vitro

1994 • 86 citations

A combination of insulin-like growth factor-I and platelet-derived growth factor enhances myelination but diminishes axonal regeneration into Schwann cell grafts in the adult rat spinal cord

1997 • 86 citations

Expression of the insulin-like growth factor-II/mannose-6-phosphate receptor in multiple human tissues during fetal life and early infancy.

1992 • 82 citations

Insulin-like growth factor-1 attenuates apoptosis in hippocampal neurons caused by cerebral ischemia and reperfusion in stroke-prone spontaneously hypertensive rats.

1997 • 81 citations

Elevated insulin-like growth factor (IGF) gene expression in sciatic nerves during IGF-supported nerve regeneration

1994 • 80 citations

The expression of insulin-like growth factor (IGF)-binding protein-2 and IGF-II genes in the tissues of the developing ovine fetus.

1993 • 79 citations

Mechanisms of astrocyte-directed neurite guidance

1997 • 79 citations

Fibroblast Growth Factors and Insulin Growth Factors Combine to Promote Survival of Rat Schwann Cell Precursors Without Induction of DNA Synthesis

1995 • 79 citations

Expression of insulin-like growth factor-1 (IGF-1) and IGF-binding protein 2 (IGF-BP2) in the hippocampus following cytotoxic lesion of the dentate gyrus

1996 • 78 citations

Insulin-like growth factor II is induced during wound repair following hypoxic-ischemic injury in the developing rat brain

1995 • 77 citations

Signalling through the insulin receptor and the insulin-like growth factor-I receptor

1994 • 74 citations

Insulin-like growth factor I (IGF-I) is a critical trophic factor for developing cerebellar granule cells

1997 • 73 citations

IGF-Binding Protein mRNAs in the Human Fetus: Tissue and Cellular Distribution of Developmental Expression

1996 • 73 citations

Insulin-like growth factor-I influences the initiation of myelination: studies of the anterior commissure of transgenic mice

1995 • 69 citations

Trophic effects of basic fibroblast growth factor on fetal rat hypothalamic cells: interactions with insulin-like growth factor I

1990 • 69 citations

Developing oligodendroglia express mRNA for insulin‐like growth factor‐I, a regulator of oligodendrocyte development

1995 • 67 citations

Naturally occurring and axotomy-induced motoneuron death and its prevention by neurotrophic agents: a comparison between chick and mouse

1994 • 64 citations

Insulin receptor substrate 1 and 2 (IRS1 and IRS2): what a tangled web we weave

1996 • 64 citations

Expression of Insulin-like Growth Factor-I and Related Peptides during Motoneuron Regeneration

1994 • 64 citations

Differential spatio-temporal expression of the insulin-like growth factor genes in regenerating sciatic nerve

1995 • 64 citations

Insulin-like growth factor-I given subcutaneously reduces clinical deficits, decreases lesion severity and upregulates synthesis of myelin proteins in experimental autoimmune encephalomyelitis

1996 • 64 citations

Insulin‐like growth factor‐I (IGF‐I) production by astroglial cells: Regulation and importance for epidermal growth factor‐induced cell replication

1993 • 62 citations

Signaling by insulin-like growth factors in paralyzed skeletal muscle: rapid induction of IGF1 expression in muscle fibers and prevention of interstitial cell proliferation by IGF-BP5 and IGF-BP4

1994 • 61 citations

Growth factors and myelin regeneration in multiple sclerosis

1997 • 61 citations

Expression of the insulin-like growth factor-II/mannose-6-phosphate receptor in multiple human tissues during fetal life and early infancy

1992 • 60 citations

Insulin-like growth factor-I is an osmoprotectant in human neuroblastoma cells

1997 • 60 citations

Insulin‐like Growth Factor‐I and IGF‐I Receptors in Diabetic Patients with Neuropathy

1995 • 60 citations

Expression of insulin-like growth factor-II (IGF-II) and IGF-II/mannose-6-phosphate receptor in the rat hippocampus: an in situ hybridization and immunocytochemical study.

1992 • 60 citations

Developmental Expression of Insulin-Like Growth Factor-II Receptor Immunoreactivity in the Rat Central Nervous System*

1990 • 58 citations

Basic fibroblast growth factor rescues CNS neurons from cell death caused by high oxygen atmosphere in culture

1992 • 57 citations

Concomitant induction of apoptosis and necrosis in cerebellar granule cells following serum and potassium withdrawal

1997 • 56 citations

Insulin-like growth factors prevent apoptosis in cortical neurons isolated from stroke-prone spontaneously hypertensive rats.

1997 • 56 citations

Cell death in perinatal hypoxic–ischaemic brain injury

1997 • 55 citations

Mitogenic activity of epidermal growth factor on newborn rat astroglia: interaction with insulin-like growth factors.

1992 • 55 citations

Systemic administration of rhIGF-I enhanced regeneration after sciatic nerve crush in mice.

1995 • 55 citations

Insulinlike growth factor gene expression in rat muscle during reinnervation

1995 • 54 citations

Insulin-like growth factor-I prevents development of a vincristine neuropathy in mice

1997 • 54 citations

Insulin-Like Growth Factor II (IGF-II) and the IGF-II/ Mannose-6-Phosphate Receptor: The Myth Continues

1994 • 54 citations

Immunohistochemical localization of insulin-like growth factor-II (IGF-II) and IGF-binding protein-2 during development in the rat brain.

1994 • 54 citations

Localization of insulin‐like growth factor binding protein‐4 expression in the developing and adult rat brain: Analysis by in situ hybridization

1993 • 53 citations

Insulin-like growth factor-1 receptors in human spinal cord: changes in amyotrophic lateral sclerosis

1994 • 53 citations

Selective Induction of α1 Isoform of (Na+ + K+)-ATPase by Insulin/Insulin-like Growth Factor-I in Cultured Rat Astrocytes

1993 • 53 citations

Tyrosine Phosphorylation and Enhanced Expression of Paxillin during Neuronal Differentiation in Vitro

1996 • 52 citations

The effects of insulin-like growth factor (IGF)-1, IGF-2, and des-IGF-1 on neuronal loss after hypoxic-ischemic brain injury in adult rats: evidence for a role for IGF binding proteins

1996 • 50 citations

Distribution of insulin-like growth factor-I receptor mRNA in rat brain. Regulation in the hypothalamo-neurohypophysial system

1993 • 49 citations

Insulin-like growth factor-I treatment reduces immune cell responses in acute non-demyelinative experimental autoimmune encephalomyelitis

1997 • 49 citations

Requirement for receptor-intrinsic tyrosine kinase activities during ligand-induced membrane ruffling of KB cells. Essential sites of src-related growth factor receptor kinases.

1988 • 48 citations

Inhibition of protein phosphatases induces IGF‐1‐blocked neurotrophin‐insensitive neuronal apoptosis

1996 • 48 citations

[Insulin like growth factor-I and II].

1999 • 47 citations

Insulin-like growth factor I regulates c-myc and GAP-43 messenger ribonucleic acid expression in SH-SY5Y human neuroblastoma cells.

1993 • 47 citations

Spatial and Temporal Changes in the Insulin-Like Growth Factor (IGF) Axis Indicate Autocrine/Paracrine Actions of IGF-I within Wounds of the Rat Brain

1997 • 47 citations

Involvement of protein kinase-C in the mitogenic effect of insulin-like growth factor-I on rat astrocytes.

1992 • 46 citations

Hypoxia and hypoxia/ischemia affect the expression of insulin-like growth factor binding protein 2 in the developing rat brain

1993 • 46 citations

Insulin-like growth factor II/cation-independent mannose 6-phosphate receptor and lysosomal enzyme recognition

1996 • 46 citations

Apoptosis: Breaking the ICE

1994 • 46 citations

Neurofilament phosphorylation is modulated by myelination

1996 • 43 citations

The expression of insulin-like growth factor (IGF)-binding protein-2 and IGF-II genes in the tissues of the developing ovine fetus

1993 • 42 citations

Changes in Insulin-like Growth Factor 1 Receptor Density after Transient Cerebral Ischemia in the Rat. Lack of Protection against Ischemic Brain Damage following Injection of Insulin-Like Growth Factor 1

1993 • 42 citations

Insulin-like growth factor I receptors of fetal brain are enriched in nerve growth cones and contain a beta-subunit variant.

1995 • 42 citations

Rapid growth cone translocation on laminin is supported by lamellipodial not filopodial structures

1989 • 40 citations

Insulin-like growth factor I increases myelination and inhibits demyelination in cultured organotypic nerve tissue

1995 • 39 citations

Developmental Regulation of Insulin-Like Growth Factor-I-Stimulated Glucose Transporter in Rat Brain Astrocytes*

1991 • 38 citations

Identification, localization, and regulation of insulin-like growth factor binding proteins and their messenger ribonucleic acids in the newborn rat olfactory bulb.

1994 • 38 citations

Neurotrophic Factors in the Treatment of Peripheral Neuropathy

2007 • 37 citations

Protein kinase C‐α and ‐ε are enriched in growth cones of differentiating SH‐SY5Y human neuroblastoma cells

1995 • 35 citations

Insulin-like Growth Factor I (IGF-I) Induces Unique Effects in the Cytoskeleton of Cultured Rat Glomerular Mesangial Cells

1997 • 35 citations

Differential regulation of astrocyte plasminogen activators by insulin-like growth factor-I and epidermal growth factor.

1994 • 35 citations

Activation of S6 kinase activity in astrocytes by insulin, somatomedin C and TPA

1986 • 34 citations

Expression of insulin-like growth factor-II (IGF-II) and IGF-II/mannose- 6-phosphate receptor in the rat hippocampus: an in situ hybridization and immunocytochemical study

1992 • 34 citations

Developmental expression of rat insulin-like growth factor-II/mannose 6-phosphate receptor messenger ribonucleic acid.

1992 • 33 citations

Immunohistochemical localization of insulin-like growth factor binding protein-5 in the developing rat nervous system

1996 • 33 citations

Coordinated pattern of expression and localization of insulin-like growth factor-II (IGF-II) and IGF-binding protein-2 in the adult rat brain

1994 • 32 citations

Brain Insulin‐Like Growth Factor‐II mRNA Content Is Reduced in Insulin‐Dependent and Non‐Insulin‐Dependent Diabetes Mellitus

1996 • 31 citations

Expression of insulin-like growth factor-binding protein messenger RNAs in developing rat oligodendrocytes and astrocytes

1997 • 31 citations

Effect of combined administration of insulin-like growth factor and platelet-derived growth factor on the regeneration of transected and anastomosed sciatic nerve in rats

1997 • 31 citations

Insulin-Like Growth Factor II Expression in the Developing Human Brain

1992 • 31 citations

Expression and Distribution of IGF-1 Receptors Containing a β-Subunit Variant (β_gc) in Developing Neurons

1997 • 30 citations

Insulin and IGF-II, but not IGF-I, stimulate the in vitro regeneration of adult frog sciatic sensory axons

1994 • 30 citations

Distinct expression patterns of insulin-like growth factor binding proteins 2 and 5 during fetal and postnatal development

1994 • 29 citations

The Potential of Insulin‐like Growth Factor‐I as a Therapeutic for the Treatment of Neuromuscular Disorders

1993 • 26 citations

Inhibition of formation of filopodia after axotomy by inhibitors of protein tyrosine kinases

1995 • 26 citations

Peripheral, but not Central, Nervous System Abnormalities are Reversed by Pancreatic Islet Transplantation in Diabetic Lewis Rats

1996 • 25 citations

Neuronal tyrosine phosphorylation in growth cone glycoproteins.

1990 • 24 citations

Motor Neuron Disease

1998 • 23 citations

Immunohistochemical localization of insulin-like growth factor-II (IGF- II) and IGF-binding protein-2 during development in the rat brain

1994 • 23 citations

Effects of growth factors on phosphatidylinositol‐3 kinase in astroglial cells

1995 • 23 citations

IGF-I enhances neurite regeneration but is not required for its survival in adult DRG explant

1997 • 23 citations

Immunohistochemical localization of insulin-like growth factor binding protein-1, -3 and -4 in human fetal tissues and their analysis in media from fetal tissue explants.

1996 • 20 citations

Filopodia and growth cones in the vertically migrating granule cells of the postnatal mouse cerebellum

1997 • 19 citations

Differential regulation of astrocyte plasminogen activators by insulin- like growth factor-I and epidermal growth factor

1994 • 17 citations

Nerve structural defects in diabetic neuropathy: do animals exhibit similar changes?

1997 • 17 citations

Developmental expression of rat insulin-like growth factor-II/mannose 6- phosphate receptor messenger ribonucleic acid

1992 • 17 citations

Laminin Promotes Differentiation, Adhesion and Proliferation of Cell Cultures Derived from Human Acoustic Nerve Schwannoma

1995 • 16 citations

The developmental pattern of rabbit brain insulin and insulin-like growth factor receptor expression

1993 • 16 citations

On the track of cell survival pharmaceuticals in the oligodendrocyte type-2 astrocyte lineage.

1996 • 16 citations

Potential Utility of rhIGF-1 in Neuromuscular and/or Degenerative Disease

2007 • 15 citations

Involvement of protein kinase-C in the mitogenic effect of insulin-like growth factor-I on rat astrocytes

1992 • 15 citations

Stimulation of myenteric plexus neurite outgrowth by insulin and insulin-like growth factors I and II

1992 • 14 citations

Mitogenic activity of epidermal growth factor on newborn rat astroglia: interaction with insulin-like growth factors

1992 • 14 citations

Identification, localization, and regulation of insulin-like growth factor binding proteins and their messenger ribonucleic acids in the newborn rat olfactory bulb

1994 • 14 citations

Insulin-like growth factor I regulates c-myc and GAP-43 messenger ribonucleic acid expression in SH-SY5Y human neuroblastoma cells

1993 • 12 citations

Regional distribution of messenger RNA encoding the insulin-like growth factor type 2 receptor in the rat lower brainstem

1995 • 11 citations

On the Therapeutic Potential for Insulin-like Growth Factor Use in Motor Neuron Disease

1993 • 9 citations

Expression of Insulin-Like Growth Factor Binding Protein-2 during Postnatal Development of the Rat Neurointermediate Pituitary

1997 • 8 citations

Inhibition of Neuroblastoma Cell Phosphatidylinositol 3‐Kinase by CDP‐Diacylglycerol and Phosphatidate

1996 • 7 citations

Expression of P0 protein mRNA along rat sciatic nerve during development

1994 • 6 citations

The tyrosine kinase inhibitor methyl 2,5-dihydroxycinnimate disrupts changes in the actin cytoskeleton required for neurite formation

1996 • 6 citations