Immunological relationships between receptors for insulin and insulin-like growth factor I. Evidence for structural heterogeneity of insulin-like growth factor I receptors involving hybrids with insulin receptors

Insulin-like growth factor I receptor primary structure: comparison with insulin receptor suggests structural determinants that define functional specificity.

1986 • 1,866 citations

The human insulin receptor cDNA: The structural basis for hormone-activated transmembrane signalling

1985 • 1,485 citations

Actions of Insulin-Like Growth Factors

1985 • 1,141 citations

Insulin-like growth factor II receptor as a multifunctional binding protein

1987 • 858 citations

Human insulin receptors mutated at the ATP-binding site lack protein tyrosine kinase activity and fail to mediate postreceptor effects of insulin.

1987 • 648 citations

The Nature and Regulation of the Receptors for Insulin-Like Growth Factors

1985 • 639 citations

The Molecular Mechanism of Insulin Action

1985 • 424 citations

Monoclonal antibodies to receptors for insulin and somatomedin-C.

1983 • 423 citations

Replacement of lysine residue 1030 in the putative ATP-binding region of the insulin receptor abolishes insulin- and antibody-stimulated glucose uptake and receptor kinase activity.

1987 • 399 citations

Cooperativity in ligand binding: A new graphic analysis

1975 • 369 citations

The Nature and Regulation of the Insulin Receptor: Structure and Function

1985 • 318 citations

Expression and characterization of a functional human insulin-like growth factor I receptor.

1988 • 313 citations

Alternative splicing of human insulin receptor messenger RNA

1989 • 312 citations

Purification of insulin receptor with full binding activity.

1983 • 273 citations

Monoclonal antibodies reacting with multiple epitopes on the human insulin receptor

1986 • 203 citations

Insulin receptors: binding kinetics and structure-function relationship of insulin

1984 • 200 citations

[16] Methods for assessing immunologic and biologic properties of iodinated peptide hormones

1975 • 196 citations

One-step purification of mouse monoclonal antibodies from ascites fluid by hydroxylapatite chromatography

1985 • 192 citations

Biochemical evidence that the type II insulin-like growth factor receptor is identical to the cation-independent mannose 6-phosphate receptor.

1988 • 190 citations

Monoclonal antibodies to the human insulin receptor block insulin binding and inhibit insulin action.

1982 • 122 citations

The insulin receptor. Structural basis for high affinity ligand binding.

1987 • 117 citations

Tyrosine A14 [125I]monoiodoinsulin: Preparation, Biologic Properties, and Long-term Stability

1981 • 105 citations

Phosphorylation of receptors for insulin and insulin-like growth factor I. Effects of hormones and phorbol esters.

1986 • 102 citations

Isolation of functional alpha beta heterodimers from the purified human placental alpha 2 beta 2 heterotetrameric insulin receptor complex. A structural basis for insulin binding heterogeneity.

1987 • 99 citations

Antireceptor antibodies as probes of insulinlike growth factor receptor structure.

1983 • 85 citations

Insulin receptors with defective tyrosine kinase inhibit normal receptor function at the level of substrate phosphorylation.

1988 • 82 citations

Mapping surface structures of the human insulin receptor with monoclonal antibodies: localization of main immunogenic regions to the receptor kinase domain

1986 • 81 citations

The human placenta contains two distinct binding and immunoreactive species of insulin-like growth factor-I receptors.

1985 • 78 citations

Interaction of the Monoclonal AntibodiesαlR-1 andαIR-3 with Insulin and Somatomedin-C Receptors

1986 • 78 citations

[24] Labeled antibodies and their use in the immunoradiometric assay

1980 • 76 citations

Dual regulation of glycogen metabolism by insulin and insulin-like growth factors in human hepatoma cells (HEP-G2). Analysis with an anti-receptor monoclonal antibody.

1984 • 73 citations

Insulin-like and insulin-inhibitory effects of monoclonal antibodies for different epitopes on the human insulin receptor

1987 • 68 citations

Subunit structure of the insulin receptor of the human lymphocyte

1980 • 61 citations

Evidence that insulin receptor from human placenta has a high affinity for only one molecule of insulin.

1984 • 57 citations

Insulin-dependent intermolecular subunit communication between isolated alpha beta heterodimeric insulin receptor complexes.

1987 • 57 citations

An atypical insulin receptor with high affinity for insulin-like growth factors copurified with placental insulin receptors.

1986 • 54 citations

Properties of the insulin receptor ectodomain.

1988 • 52 citations

Purification of insulin-like growth factor I receptor from human placental membranes.

1986 • 51 citations

Actions of insulin and insulinlike growth factors I and II in cultured microvessel endothelial cells from bovine adipose tissue

1988 • 48 citations

Identification of a monoclonal antibody which can distinguish between two distinct species of the type I receptor for insulin-like growth factor

1986 • 45 citations

Characterization of detergent-solubilized membrane proteins. Hydrodynamic and sedimentation equilibrium properties of the insulin receptor of the cultured human lymphoblastoid cell.

1981 • 43 citations

INTERACTIONS OF A MONOCLONAL ANTIBODY TO THE INSULIN RECEPTOR WITH RECEPTORS FOR INSULIN-LIKE GROWTH FACTORS

1983 • 42 citations

Functional properties of an isolated .alpha..beta. heterodimeric human placenta insulin-like growth factor 1 receptor complex

1988 • 42 citations

Structural differences between insulin and somatomedin-C/insulin-like growth factor-1 receptors revealed by autoantibodies to the insulin receptor

1982 • 39 citations

Delineation of atypical insulin receptors from classical insulin and type I insulin-like growth factor receptors in human placenta

1989 • 36 citations

Antibodies to deduced sequences of the insulin receptor distinguish conserved and nonconserved regions in the IGF-I receptor.

1986 • 35 citations

Disulphide reduction alters the immunoreactivity and increases the affinity of insulin-like growth-factor-I receptors in human placenta

1986 • 20 citations

Purification of the type I insulin-like growth factor receptor from human placenta

1986 • 16 citations

Characterization of two insulin-binding components of rat-liver plasma membranes

1982 • 11 citations