Wild-type and mutant p53 differentially regulate transcription of the insulin-like growth factor I receptor gene.

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

1979 • 22,482 citations

WAF1, a potential mediator of p53 tumor suppression

1993 • 8,360 citations

p53 Mutations in Human Cancers

1991 • 8,133 citations

High-efficiency transformation of mammalian cells by plasmid DNA.

1987 • 5,377 citations

Insulin-Like Growth Factors and Their Binding Proteins: Biological Actions*

1995 • 4,419 citations

Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r)

1993 • 2,880 citations

Role of insulin-like growth factors in embryonic and postnatal growth

1993 • 2,349 citations

Definition of a consensus binding site for p53

1992 • 2,000 citations

Suppression of Human Colorectal Carcinoma Cell Growth by Wild-Type p53

1990 • 1,796 citations

Insulin-Like Growth Factors I and II. Peptide, Messenger Ribonucleic Acid and Gene Structures, Serum, and Tissue Concentrations*

1989 • 1,796 citations

The “initiator” as a transcription control element

1989 • 1,597 citations

Molecular and Cellular Aspects of the Insulin-Like Growth Factor I Receptor

1995 • 1,361 citations

Clinical Implications of the p53 Tumor-Suppressor Gene

1993 • 1,341 citations

DNA-dependent transcription of adenovirus genes in a soluble whole-cell extract.

1980 • 1,285 citations

Identification of p53 as a Sequence-Specific DNA-Binding Protein

1991 • 1,109 citations

Induction of the growth inhibitor IGF-binding protein 3 by p53

1995 • 884 citations

Modulation of Activity of the Promoter of the Human MDR 1 Gene by Ras and p53

1992 • 735 citations

Absence of HeLa Cell Contamination in 169 Cell Lines Derived From Human Tumors2

1977 • 648 citations

Wild-type p53 activates transcription in vitro

1992 • 609 citations

Simian virus 40 large tumor antigen is unable to transform mouse embryonic fibroblasts lacking type 1 insulin-like growth factor receptor.

1993 • 554 citations

The insulin-like growth factor I receptor: a key to tumor growth?

1995 • 549 citations

Effect of a null mutation of the insulin-like growth factor I receptor gene on growth and transformation of mouse embryo fibroblasts.

1994 • 527 citations

Wild-type p53 binds to the TATA-binding protein and represses transcription.

1992 • 527 citations

Sequence-specific transcriptional activation is essential for growth suppression by p53.

1994 • 412 citations

The insulin-like growth factor I receptor protects tumor cells from apoptosis in vivo.

1995 • 385 citations

Developmental regulation of the rat insulin-like growth factor I receptor gene.

1989 • 338 citations

Specific repression of TATA-mediated but not initiator-mediated transcription by wild-type p53

1993 • 329 citations

The Role of the Insulin-like Growth Factor System in Human Cancer

1996 • 295 citations

Insulin-like growth factor I (IGF-I) and the IGF-I receptor prevent etoposide-induced apoptosis.

1995 • 286 citations

Increased expression of the insulin-like growth factor I receptor gene, IGF1R, in Wilms tumor is correlated with modulation of IGF1R promoter activity by the WT1 Wilms tumor gene product.

1993 • 268 citations

Oncogenes and the strategy of growth factors

1994 • 232 citations

EGR3, a novel member of the Egr family of genes encoding immediate-early transcription factors.

1991 • 218 citations

Direct interaction between the transcriptional activation domain of human p53 and the TATA box-binding protein.

1993 • 209 citations

p53: the ultimate tumor suppressor gene?

1992 • 209 citations

Frequency and diversity of p53 mutations in childhood rhabdomyosarcoma.

1992 • 176 citations

Effect of a Null Mutation of the Insulin-Like Growth Factor I Receptor Gene on Growth and Transformation of Mouse Embryo Fibroblasts

1994 • 162 citations

Constitutive expression of insulin-like growth factor 1 and insulin-like growth factor 1 receptor abrogates all requirements for exogenous growth factors.

1992 • 159 citations

Transcriptional repression of the insulin-like growth factor I receptor (IGF-I-R) gene by the tumor suppressor WT1 involves binding to sequences both upstream and downstream of the IGF-I-R gene transcription start site.

1994 • 154 citations

Transcriptional regulation of basic fibroblast growth factor gene by p53 in human glioblastoma and hepatocellular carcinoma cells.

1994 • 145 citations

Analysis of human p53 proteins and mRNA levels in normal and transformed cells

1986 • 143 citations

Insulin-like Growth Factors: Molecular and Cellular Aspects

1991 • 143 citations

Inhibition of Cellular Proliferation by the Wilms’ Tumor Suppressor WT1 Is Associated with Suppression of Insulin-Like Growth Factor I Receptor Gene Expression

1995 • 110 citations

Mechanism of Initiator-Mediated Transcription: Evidence for a Functional Interaction between the TATA-Binding Protein and DNA in the Absence of a Specific Recognition Sequence

1993 • 104 citations

Regulation of insulin-like growth factor II P3 promotor by p53: a potential mechanism for tumorigenesis.

1996 • 99 citations

Structural and functional analysis of the insulin-like growth factor I receptor gene promoter.

1992 • 98 citations

Analysis of Tat transactivation of human immunodeficiency virus transcription in vitro.

1992 • 94 citations

Analysis of the human type I insulin-like growth factor receptor promoter region

1991 • 90 citations

Molecular and Cellular Aspects of Insulin-like Growth Factor Action

1994 • 84 citations

Cloning and characterization of the proximal promoter region of the rat insulin-like growth factor I (IGF-I) receptor gene

1990 • 84 citations

Cloning and Characterization of the Human Insulin-Like Growth Factor-I Receptor Gene 5′-Flanking Region

1992 • 44 citations