Antiproliferative and apoptotic effect of ascorbyl stearate in human glioblastoma multiforme cells: modulation of insulin-like growth factor-I receptor (IGF-IR) expression.

Cancer statistics, 2000

2000 • 3,907 citations

Pathology of Tumours of the Nervous System

1990 • 3,462 citations

G ₁ Events and Regulation of Cell Proliferation

1989 • 2,203 citations

Pathology of Tumors of the Nervous System.

1964 • 1,494 citations

Molecular and Cellular Aspects of the Insulin-Like Growth Factor I Receptor

1995 • 1,361 citations

Effect of a null mutation of the insulin-like growth factor I receptor gene on growth and transformation of mouse embryo fibroblasts.

1994 • 527 citations

Vitamin C and cancer prevention: the epidemiologic evidence

1991 • 470 citations

The IGF-I receptor in cell growth, transformation and apoptosis

1997 • 446 citations

Insulin and insulin-like growth factors in the CNS

1988 • 334 citations

Treatment and Prevention of Rat Glioblastoma by Immunogenic C6 Cells Expressing Antisense Insulin-Like Growth Factor I RNA

1993 • 328 citations

Rat glioblastoma cells expressing an antisense RNA to the insulin-like growth factor-1 (IGF-1) receptor are nontumorigenic and induce regression of wild-type tumors.

1994 • 310 citations

Peptides and the blood-brain barrier: Lipophilicity as a predictor of permeability

1985 • 297 citations

A functional insulin-like growth factor I receptor is required for the mitogenic and transforming activities of the epidermal growth factor receptor.

1994 • 282 citations

Insulin-like growth factor-I receptor signal transduction: at the interface between physiology and cell biology

1998 • 253 citations

Brain Tumors

1991 • 224 citations

Correlation between apoptosis, tumorigenesis, and levels of insulin-like growth factor I receptors.

1995 • 172 citations

Effect of a Null Mutation of the Insulin-Like Growth Factor I Receptor Gene on Growth and Transformation of Mouse Embryo Fibroblasts

1994 • 162 citations

Ascorbic acid may protect against human gastric cancer by scavenging mucosal oxygen radicals

1996 • 137 citations

Growth and Differentiation Signals by the Insulin-like Growth Factor 1 Receptor in Hemopoietic Cells Are Mediated through Different Pathways

1999 • 126 citations

The expression of insulin-like growth factor I and insulin-like growth factor II genes in the human fetal and adult brain and in glioma

1988 • 123 citations

Variation Among Cell Types in the Signaling Pathways by which IGF-I Stimulates Specific Cellular Responses*

1999 • 122 citations

Apoptosis-inducing activity of vitamin C and vitamin K.

2000 • 112 citations

Expression of two types of receptor for insulin-like growth factors in human malignant glioma.

1988 • 108 citations

Suppression of insulin-like growth factor type I receptor by a triple-helix strategy inhibits IGF-I transcription and tumorigenic potential of rat C6 glioblastoma cells

1997 • 98 citations

Insulin‐like growth factor I receptor is required for the mitogenic and transforming activities of the platelet‐derived growth factor receptor

1995 • 93 citations

Cytotoxic effect of ascorbate and its derivatives on cultured malignant and nonmalignant cell lines.

1993 • 92 citations

Insulin and Insulin-Like Growth Factor I in Brain Tumors: Binding and in Vitro Effects

1989 • 87 citations

Stearic acid and carcinogenesis

1987 • 87 citations

The role of the insulin-like growth factors in the regulation of brain development

1988 • 84 citations

Growth suppression of human leukemic cells in vitro by L-ascorbic acid.

1980 • 80 citations

A Functional Insulin-Like Growth Factor I Receptor Is Required for the Mitogenic and Transforming Activities of the Epidermal Growth Factor Receptor

1994 • 69 citations

Neuro-oncology index and review (adult primary brain tumors)

1991 • 65 citations

Relationship between ascorbyl radical intensity and apoptosis-inducing activity.

1996 • 60 citations

Insulin-Like Growth Factor-I Receptors in Human Glial Tumors

1990 • 59 citations

Inhibition of rat C6 glioblastoma tumor growth by expression of insulin-like growth factor I receptor antisense mRNA

1996 • 55 citations

Growth regulation of human glioblastoma t98g cells by insulin‐like growth factor‐1 and its receptor

1994 • 53 citations

Ascorbic acid-dehydroascorbate induces cell cycle arrest at G2/M DNA damage checkpoint during oxidative stress

1999 • 49 citations

Effect of ascorbic acid on incidence of spontaneous mammary tumors and UV-light-induced skin tumors in mice

1991 • 49 citations

Characterization of insulin-like growth factor 1 in human primary brain tumors.

1993 • 44 citations

Growth suppression of malignant leukemia cell line in vitro by ascorbic acid (vitamin C) and its derivatives

1998 • 40 citations

Vitamin C reduces the Incidence and severity of renal tumors induced by estradiol or diethylstilbestrol

1991 • 38 citations

Induction of cell death by ascorbic acid derivatives in human renal carcinoma and glioblastoma cell lines.

2000 • 32 citations

Protective Effect of Lipophilic Derivatives of Ascorbic Acid on Lipid Peroxide-Induced Endothelial Injury

1993 • 32 citations

Inhibition of human term placental and fetal liver glutathione-S-transferases by fatty acids and fatty acid esters

1992 • 25 citations

Inhibiting effect of ascorbic acid on the growth of human mammary tumor xenografts

1991 • 24 citations

Inhibition of cell proliferation and glutathione S-transferase by ascorbyl esters and interferon in mouse glioma

1993 • 22 citations

Inhibition of human glioma cell proliferation and glutathione S-transferase by ascorbyl esters and interferon.

1993 • 16 citations

Mechanisms of ascorbic acid-induced inhibition of chemical transformation in C3H/10T1/2 cells

1991 • 15 citations

Ascorbic acid is cytotoxic for pediatric tumor cells cultured in vitro.

1994 • 14 citations

Inhibition of hepatic glutathione-S-transferases by fatty acids and fatty acid esters

1991 • 13 citations

Expression and synthesis of insulin-like growth factor (IGF)-I, -II and their receptors in human glioma cell lines

1996 • 9 citations

Comparative study of the antitumor action between sodium 5,6-benzylidene-L-ascorbate and sodium ascorbate (minireview).

1998 • 8 citations

Cytotoxic effect of substitution at 2-, 6-, and 2,6-positions in ascorbic acid on malignant cell line.

1998 • 5 citations