Insulin-like growth factor-I, cognition and brain aging

The Endocrinology of Aging

1997 • 957 citations

Peripheral Infusion of IGF-I Selectively Induces Neurogenesis in the Adult Rat Hippocampus

2000 • 838 citations

Growth Hormone Replacement in Healthy Older Men Improves Body Composition but Not Functional Ability

1996 • 474 citations

Intracerebroventricular infusion of insulin-like growth factor-I ameliorates the age-related decline in hippocampal neurogenesis

2001 • 430 citations

Insulin-like growth factor I/somatomedin C: a potent inducer of oligodendrocyte development.

1986 • 383 citations

Insulin-like growth factor I protects and rescues hippocampal neurons against β-amyloid- and human amylin-induced toxicity

1997 • 325 citations

Signaling by insulin-like growth factor 1 in brain

2004 • 322 citations

Potentially predictive and manipulable blood serum correlates of aging in the healthy human male: Progressive decreases in bioavailable testosterone, dehydroepiandrosterone sulfate, and the ratio of insulin-like growth factor 1 to growth hormone

1997 • 291 citations

Insulin-like growth factor-1 ameliorates age-related behavioral deficits

1998 • 271 citations

The neurobiology of memory changes in normal aging

2003 • 260 citations

Cognitive changes during growth hormone replacement in adult men

1998 • 205 citations

Cognitive impairments and mood disturbances in growth hormone deficient men

1996 • 205 citations

Treatment of Growth Hormone-Deficient Adults with Recombinant Human Growth Hormone Increases the Concentration of Growth Hormone in the Cerebrospinal Fluid and Affects Neurotransmitters

1995 • 204 citations

Insulin-Like Growth Factor-I and Cognitive Function in Healthy Older Men

1999 • 198 citations

Aging and Neuropsychological Assessment

1992 • 195 citations

Effects of Physiological Growth Hormone (GH) Therapy on Cognition and Quality of Life in Patients with Adult-Onset GH Deficiency1

1998 • 178 citations

Growth hormone as a neuronal rescue factor during recovery from CNS injury

2001 • 176 citations

Serum Levels of Insulin-Like Growth Factor-I (IGF-I) and IGF-Binding Protein-3 in Healthy Centenarians: Relationship with Plasma Leptin and Lipid Concentrations, Insulin Action, and Cognitive Function

1997 • 175 citations

The Little Women of Loja — Growth Hormone–Receptor Deficiency in an Inbred Population of Southern Ecuador

1990 • 158 citations

Insulin-like growth factor-1 (somatomedin-C) receptors in the rat brain: distribution and interaction with the hippocampal cholinergic system

1989 • 148 citations

Age-related reduction of human growth hormone-binding sites in the human brain

1993 • 147 citations

Characterization of putative growth hormone receptors in human choroid plexus

1991 • 145 citations

The effects of growth hormone and IGF‐1 deficiency on cerebrovascular and brain ageing

2000 • 145 citations

Age and insulin-like growth factor-1 modulate N-methyl-D-aspartate receptor subtype expression in rats

2000 • 138 citations

Physical and psychological capabilities during substitution therapy with recombinant growth hormone in adults with growth hormone deficiency

1990 • 138 citations

Relationship between Cognitive Function, Growth Hormone and Insulin-Like Growth Factor I Plasma Levels in Aged Subjects

1998 • 133 citations

A Prospective Study on Circulating Insulin-Like Growth Factor I (IGF-I), IGF-Binding Proteins, and Cognitive Function in the Elderly

2000 • 131 citations

Growth hormone, insulin-like growthfactor I and cognitive function in adults

2000 • 126 citations

Growth hormone treatment affects brain neurotransmitters and thyroxine

1996 • 126 citations

Alterations in insulin-like growth factor-1 gene and protein expression and type 1 insulin-like growth factor receptors in the brains of ageing rats

1999 • 124 citations

Insulin-like growth factor 1 (IGF-1) receptors in the human brain: quantitative autoradiographic localization

1989 • 122 citations

Insulin-like growth factor I (IGF-I) and cognitive decline in older persons

2003 • 118 citations

Growth hormone induces age-dependent alteration in the expression of hippocampal growth hormone receptor and N -methyl- <scp>d</scp> -aspartate receptor subunits gene transcripts in male rats

2002 • 116 citations

One Year of Insulin-Like Growth Factor I Treatment Does Not Affect Bone Density, Body Composition, or Psychological Measures in Postmenopausal Women1

2001 • 112 citations

The effects of growth hormone and IGF-1 deficiency on cerebrovascular and brain ageing

2000 • 109 citations

Effects of growth hormone substitution on mental performance in adults with growth hormone deficiency: a pilot study

1986 • 108 citations

Insulin‐like Growth Factor 1 and Functional Status in Healthy Older Men

1995 • 108 citations

Central effects of the somatotropic system

2003 • 99 citations

Insulin-like growth factor 1 stimulates the release of acetylcholine from rat cortical slices

1988 • 90 citations

The effect of growth hormone substitution on cognitive performance in adult patients with hypopituitarism

2003 • 90 citations

Cognitive dysfunction in patients with pituitary tumour who have been treated with transfrontal or transsphenoidal surgery or medication

1998 • 89 citations

High incidence of mental disorders, reduced mental well‐being and cognitive function in hypopituitary women with GH deficiency treated for pituitary disease

2002 • 81 citations

Growth Hormone Treatment in Adults with Childhood Onset Growth Hormone Deficiency: Effects on Psychological Capabilities

1995 • 79 citations

Age-Sensitive Cognitive Function, Growth Hormone and Insulin-Like Growth Factor 1 Plasma Levels in Healthy Older Men

2000 • 75 citations

Effects of Physiological Growth Hormone (GH) Therapy on Cognition and Quality of Life in Patients with Adult-Onset GH Deficiency

1998 • 75 citations

Impact of recombinant human growth hormone (rh-GH) treatment on psychiatric, neuropsychological and clinical profiles of GH deficient adults: a placebo - controlled trial

1999 • 74 citations

Insulin-Like Growth Factor-I and Cognitive Function in Healthy Older Men

1999 • 71 citations

Characterization of growth hormone binding sites in rat brain

1994 • 71 citations

Uptake of Circulating Insulin-Like Growth Factors (IGFs) into Cerebrospinal Fluid Appears to Be Independent of the IGF Receptors as Well as IGF-Binding Proteins**This work was supported by Centers for Disease Control and Prevention Grant R49/CCR811509.

2001 • 69 citations

Insulin-Like Growth Factor-1 Selectively Increases Glucose Utilization in Brains of Aged Animals

2001 • 66 citations

Normal Intelligence with Severe Insulin-Like Growth Factor I Deficiency due to Growth Hormone Receptor Deficiency: A Controlled Study in a Genetically Homogeneous Population1

1998 • 65 citations

One Year of Insulin-Like Growth Factor I Treatment Does Not Affect Bone Density, Body Composition, or Psychological Measures in Postmenopausal Women

2001 • 60 citations

Cognitive and Emotional Functioning in Hypopituitary Short-statured Children

1982 • 58 citations

Growth, Growth Hormone and Cognitive Functions

1996 • 58 citations

Serum Levels of Insulin-Like Growth Factor-I (IGF-I) and IGF-Binding Protein-3 in Healthy Centenarians: Relationship with Plasma Leptin and Lipid Concentrations, Insulin Action, and Cognitive Function

1997 • 56 citations

Relationship between testosterone supplementation and insulin-like growth factor-I levels and cognition in healthy older men

2003 • 54 citations

Normal Values of Insulin-Like Growth Factor I and Their Clinical Utility in Adults

2001 • 51 citations

Increased expression of type 1 insulin-like growth factor receptor messenger rna in rat hippocampal formation is associated with aging and behavioral impairment

1996 • 51 citations

Long-Term Growth Hormone Replacement Therapy in Hypopituitary Adults

2002 • 50 citations

Relationship Between Circulating Levels of Sex Hormones and Insulin-Like Growth Factor-1 and Fluid Intelligence in Older Men

2001 • 49 citations

Effects of age and insulin-like growth factor-1 on neuron and synapse numbers in area CA3 of hippocampus

2001 • 47 citations

Region-specific alterations in insulin-like growth factor receptor type I in the cerebral cortex and hippocampus of aged rats

2002 • 41 citations

Somatotropic-axis deficiency affects brain substrates of selective attention in childhood-onset growth hormone deficient patients

2003 • 41 citations

Aging effects on growth hormone receptor binding in the brain

1997 • 40 citations

Insulin-like growth factor-I receptor densities in human frontal cortex and white matter during aging, in Alzheimer's disease, and in Huntington's disease

1994 • 40 citations

Insulin-like growth factor-1 stimulation of protein synthesis is attenuated in cerebral cortex of aging rats

1995 • 40 citations

Normal Intelligence with Severe Insulin-Like Growth Factor I Deficiency due to Growth Hormone Receptor Deficiency: A Controlled Study in a Genetically Homogeneous Population

1998 • 37 citations

Insulin-Like Growth Factor-1 Selectively Increases Glucose Utilization in Brains of Aged Animals

2001 • 36 citations

A Prospective Study on Circulating Insulin-Like Growth Factor I (IGF-I), IGF-Binding Proteins, and Cognitive Function in the Elderly

2000 • 33 citations

Peripherally Administered Insulin-like Growth Factor-I Preserves Hindlimb Reflex and Spinal Cord Noradrenergic Circuitry Following a Central Nervous System Lesion in Rats

1999 • 32 citations

Is the central nervous system a target for growth hormone and insulin‐like growth factors?

1995 • 27 citations

Uptake of Circulating Insulin-Like Growth Factors (IGFs) into Cerebrospinal Fluid Appears to Be Independent of the IGF Receptors as Well as IGF-Binding Proteins

2001 • 27 citations

Cognitive problems in the elderly

1995 • 22 citations

Growth Hormone Deficiency in Children Has Psychological and Educational Co-Morbidity

1991 • 13 citations

The Central Nervous System as a Direct Target for Growth Hormone Action

2000 • 3 citations

Lessons from Laron syndrome

2023 • 2 citations