Endogenous IGF-1 regulates the neuronal differentiation of adult stem cells

Generation of Neurons and Astrocytes from Isolated Cells of the Adult Mammalian Central Nervous System

1992 • 5,296 citations

Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r)

1993 • 2,880 citations

Long-Distance Neuronal Migration in the Adult Mammalian Brain

1994 • 2,291 citations

Restricted proliferation and migration of postnatally generated neurons derived from the forebrain subventricular zone

1993 • 1,799 citations

Autoradiographic and histological studies of postnatal neurogenesis. IV. Cell proliferation and migration in the anterior forebrain, with special reference to persisting neurogenesis in the olfactory bulb

1969 • 1,471 citations

Proliferating subventricular zone cells in the adult mammalian forebrain can differentiate into neurons and glia.

1993 • 1,319 citations

Multipotential stem cells from the adult mouse brain proliferate and self-renew in response to basic fibroblast growth factor

1996 • 1,027 citations

bFGF regulates the proliferative fate of unipotent (neuronal) and bipotent (neuronal/astroglial) EGF-generated CNS progenitor cells

1993 • 651 citations

Extracellular matrix contains insulin-like growth factor binding protein-5: potentiation of the effects of IGF-I.

1993 • 543 citations

De novo generation of neuronal cells from the adult mouse brain.

1992 • 535 citations

Epidermal and Fibroblast Growth Factors Behave as Mitogenic Regulators for a Single Multipotent Stem Cell-Like Population from the Subventricular Region of the Adult Mouse Forebrain

1999 • 534 citations

Intraventricular Administration of BDNF Increases the Number of Newly Generated Neurons in the Adult Olfactory Bulb

1998 • 528 citations

Distinct roles for bFGF and NT-3 in the regulation of cortical neurogenesis

1995 • 476 citations

FGF2 Concentration Regulates the Generation of Neurons and Glia from Multipotent Cortical Stem Cells

1997 • 455 citations

Changes in cerebral cortex size are governed by fibroblast growth factor during embryogenesis

1999 • 397 citations

Endothelial Trophic Support of Neuronal Production and Recruitment from the Adult Mammalian Subependyma

1999 • 384 citations

Cloning and growth of multipotential neural precursors: Requirements for proliferation and differentiation

1993 • 381 citations

Presence of brain-derived neurotrophic factor in brain and human and rat but not mouse serum detected by a sensitive and specific immunoassay

1996 • 334 citations

Brain-derived neurotrophic factor promotes the survival of neurons arising from the adult rat forebrain subependymal zone.

1995 • 309 citations

Transient IGF-I gene expression during the maturation of functionally related central projection neurons

1991 • 287 citations

Sensitive visualization of antigen-antibody reactions in dot and blot immune overlay assays with immunogold and immunogold/silver staining

1984 • 274 citations

Neurogenesis persists in the subependymal layer of the adult mouse brain

1993 • 262 citations

Fibroblast growth factor stimulates the proliferation and differentiation of neural precursor cells in vitro

1990 • 257 citations

Insulin-Like Growth Factor-I Is a Differentiation Factor for Postmitotic CNS Stem Cell-Derived Neuronal Precursors: Distinct Actions from Those of Brain-Derived Neurotrophic Factor

1998 • 245 citations

Fibroblast growth factor-mediated proliferation of central nervous system precursors depends on endogenous production of insulin-like growth factor I.

1991 • 245 citations

Cloned multipotential precursors from the mouse cerebrum require FGF-2, whereas glial restricted precursors are stimulated with either FGF-2 or EGF

1995 • 238 citations

Expression of polysialylated neural cell adhesion molecule by proliferating cells in the subependymal layer of the adult rat, in its rostral extension and in the olfactory bulb

1994 • 215 citations

Early patterns of migration, morphogenesis, and intermediate filament expression of subventricular zone cells in the postnatal rat forebrain

1995 • 189 citations

Neuronal Progenitor Cells Derived from the Anterior Subventricular Zone of the Neonatal Rat Forebrain Continue to Proliferatein Vitroand Express a Neuronal Phenotype

1997 • 181 citations

Separate Progenitor Cells Give Rise to Pyramidal and Nonpyramidal Neurons in the Rat Telencephalon

1991 • 165 citations

Heparin, heparan sulfate, and dermatan sulfate regulate formation of the insulin-like growth factor-I and insulin-like growth factor-binding protein complexes.

1994 • 165 citations

In vivo actions of insulin-like growth factor-I (IGF-I) on cerebellum development in transgenic mice: evidence that IGF-I increases proliferation of granule cell progenitors

1996 • 163 citations

Coordinate expression of insulin-like growth factor system components by neurons and neuroglia during retinal and cerebellar development

1992 • 150 citations

Dopaminergic and gabaergic interneurons of the olfactory bulb are derived from the neonatal subventricular zone

1996 • 144 citations

Lineage analysis reveals neurotransmitter (GABA or glutamate) but not calcium-binding protein homogeneity in clonally related cortical neurons

1994 • 142 citations

Binding of insulin-like growth factor (IGF) I or II to IGF-binding protein-2 enables it to bind to heparin and extracellular matrix.

1996 • 139 citations

Correlation between insulin-like growth factor (IGF)-binding protein 5 and IGF-I gene expression during brain development

1993 • 138 citations

Rate and pattern of migration of lineally-related olfactory bulb interneurons generated postnatally in the subventricular zone of the rat

1994 • 132 citations

Embryonic Precursor Cells That Express Trk Receptors: Induction of Different Cell Fates by NGF, BDNF, NT-3, and CNTF

1997 • 127 citations

Insulin-Like Growth Factor Binding Protein-2 Binds to Cell Surface Proteoglycans in the Rat Brain Olfactory Bulb*

1997 • 118 citations

A Comparison of the Patterns of Migration and the Destinations of Homotopically Transplanted Neonatal Subventricular Zone Cells and Heterotopically Transplanted Telencephalic Ventricular Zone Cells

1996 • 99 citations

Postnatal mouse subventricular zone neuronal precursors can migrate and differentiate within multiple levels of the developing neuraxis

1997 • 99 citations

Leukaemia Inhibitory Factor or Related Factors Promote the Differentiation of Neuronal and Astrocytic Precursors within the Developing Murine Spinal Cord

1996 • 77 citations

Neuronal Progenitor Cells of the Neonatal Subventricular Zone Differentiate and Disperse Following Transplantation Into the Adult Rat Striatum

1998 • 72 citations

Regulation of neural stem cell differentiation in the forebrain

1998 • 63 citations

Differentiation of Transmitter Phenotypes in Rat Cerebral Cortex

1994 • 61 citations

Expression of Insulin‐like Growth Factor‐I in Transgenic Mice^a

1993 • 55 citations

Adenovirus-mediated gene delivery into neuronal precursors of the adult mouse brain.

1996 • 55 citations

Expression of IGF-1 mRNA in the murine subventricular zone during postnatal development

1992 • 54 citations

Glial cell line-derived neurotrophic factor promotes the development of adrenergic neurons in mouse neural crest cultures

1996 • 53 citations

Regulation of Insulin-Like Growth Factor I (IGF-I) Gene Expression in Brain of Transgenic Mice Expressing an IGF-I-Luciferase Fusion Gene*

1997 • 50 citations

Insulin-like growth factor-1 is a radial cell-associated neurotrophin that promotes neuronal recruitment from the adult songbird ependyma/subependyma

1998 • 48 citations

Neuronal Progenitor Cells of the Neonatal Subventricular Zone Differentiate and Disperse following Transplantation into the Adult Rat Striatum

1998 • 42 citations

Identification, localization, and regulation of insulin-like growth factor binding proteins and their messenger ribonucleic acids in the newborn rat olfactory bulb.

1994 • 38 citations

Retrograde axonal transport of neurotrophins: Differences between neuronal populations and implications for motor neuron disease

1998 • 30 citations

Fate of adult neural precursors grafted to adult cortex monitored with a Y-chromosome marker

1997 • 14 citations

Factors Regulating the Differentiation of Neural Precursors in the Forebrain

2007 • 12 citations

Expression of a TGFβ regulated, brain-specific mRNA in serum-free mouse embryo (SFME) cells

1993 • 8 citations

The Cel Lineage of Neuronal Subtypes in the Mammalian Cerebral Cortex

2007 • 7 citations