Liver-derived insulin-like growth factor I (IGF-I) is the principal source of IGF-I in blood but is not required for postnatal body growth in mice

Insulin-Like Growth Factors and Their Binding Proteins: Biological Actions*

1995 • 4,419 citations

Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r)

1993 • 2,880 citations

Role of insulin-like growth factors in embryonic and postnatal growth

1993 • 2,349 citations

Inducible Gene Targeting in Mice

1995 • 1,897 citations

Insulin-Like Growth Factors I and II. Peptide, Messenger Ribonucleic Acid and Gene Structures, Serum, and Tissue Concentrations*

1989 • 1,796 citations

Deletion of a DNA Polymerase β Gene Segment in T Cells Using Cell Type-Specific Gene Targeting

1994 • 1,396 citations

Tissue concentrations of somatomedin C: further evidence for multiple sites of synthesis and paracrine or autocrine mechanisms of action.

1984 • 1,171 citations

Analysis of serum insulin-like growth factor binding proteins using Western blotting: Use of the method for titration of the binding proteins and competitive binding studies

1986 • 1,158 citations

Actions of Insulin-Like Growth Factors

1985 • 1,141 citations

Intrauterine Growth Retardation and Postnatal Growth Failure Associated with Deletion of the Insulin-Like Growth Factor I Gene

1996 • 1,094 citations

IGF-I is required for normal embryonic growth in mice.

1993 • 810 citations

Growth Hormone and Bone*

1998 • 807 citations

Growth, differentiation, and survival: multiple physiological functions for insulin-like growth factors

1996 • 783 citations

Inducible Gene Targeting in Mice Using the Cre/loxSystem

1998 • 756 citations

Sexual Dimorphism in the Control of Growth Hormone Secretion*

1985 • 749 citations

Mechanism of the Stimulatory Effect of Growth Hormone on Longitudinal Bone Growth*

1987 • 580 citations

Growth Hormone Stimulates Longitudinal Bone Growth Directly

1982 • 524 citations

Inducible inactivation of hepatic LRP gene by cre-mediated recombination confirms role of LRP in clearance of chylomicron remnants.

1998 • 454 citations

Preparation of rat liver cells

1972 • 448 citations

Growth Hormone-Releasing Hormone*

1986 • 427 citations

Recombinant human insulin-like growth factor I stimulates growth and has distinct effects on organ size in hypophysectomized rats.

1988 • 424 citations

Radioimmunoassays for IGFs and IGFBPs.

1994 • 367 citations

Evidence suggesting that the direct growth-promoting effect of growth hormone on cartilage in vivo is mediated by local production of somatomedin.

1986 • 310 citations

Effects of insulin-like growth factor on linear growth, head circumference, and body fat in patients with Laron-type dwarfism

1992 • 206 citations

Expression of Insulin-Like Growth Factor I Stimulates Normal Somatic Growth in Growth Hormone-Deficient Transgenic Mice

1990 • 195 citations

Insulin-Like Growth Factor-I Affects Perinatal Lethality and Postnatal Development in a Gene Dosage-Dependent Manner: Manipulation Using the Cre/loxP System in Transgenic Mice

1998 • 185 citations

Influence of Gonadal Steroids on Age- and Sex-Related Secretory Patterns of Growth Hormone in the Rat^*

1984 • 184 citations

Effects of the Infusion of Insulin-like Growth Factor I in a Child with Growth Hormone Insensitivity Syndrome (Laron Dwarfism)

1991 • 141 citations

Growth Allometry of the Organs in Giant Transgenic Mice*

1987 • 136 citations

Prolonged treatment with recombinant insulin-like growth factor-I in children with growth hormone insensitivity syndrome--a clinical research center study. GHIS Collaborative Group.

1996 • 112 citations

EFFECT OF BOVINE GROWTH HORMONE AND A PARTIALLY PURE PREPARATION OF SOMATOMEDIN ON VARIOUS GROWTH PARAMETERS IN HYPOPITUITARY DWARF MICE

1981 • 57 citations

Pituitary and hypothalamic insulin-like growth factor-I (IGF-I) and IGF-I receptor expression in food-deprived rats

1993 • 30 citations

Adaptive responses of rat liver to the gestagen and anti-androgen cyproterone acetate and other inducers. III. Cytological changes

1980 • 29 citations