Characterization of somatomedin/insulin-like growth factor receptors and correlation with biologic action in cultured neonatal rat astroglial cells

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

THE ATTRACTIONS OF PROTEINS FOR SMALL MOLECULES AND IONS

1949 • 19,979 citations

Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue.

1980 • 3,822 citations

A graphic method for the determination and presentation of binding parameters in a complex system

1967 • 1,524 citations

Estimation of Somatomedin-C Levels in Normals and Patients with Pituitary Disease by Radioimmunoassay

1977 • 858 citations

Primary structure of human insulin‐like growth factor II

1978 • 776 citations

Interaction of cross-linking agents with the insulin effector system of isolated fat cells. Covalent linkage of 125I-insulin to a plasma membrane receptor protein of 140,000 daltons.

1979 • 422 citations

Epidermal growth factor: morphological demonstration of binding, internalization, and lysosomal association in human fibroblasts.

1978 • 358 citations

Demonstration of two subtypes of insulin-like growth factor receptors by affinity cross-linking.

1981 • 332 citations

Purification and primary structure of a polypeptide with multiplication-stimulating activity from rat liver cell cultures. Homology with human insulin-like growth factor II.

1981 • 298 citations

SEQUENCE ANALYSIS OF SOMATOMEDIN-C: CONFIRMATION OF IDENTITY WITH INSULIN-LIKE GROWTH FACTOR I

1983 • 297 citations

1 Biological and immunological properties of insulin-like growth factors (IGF) I and II

1984 • 279 citations

Purification of somatomedin-C from human plasma: chemical and biological properties, partial sequence analysis, and relationship to other somatomedins

1980 • 250 citations

Insulin-like growth factor I (IGF I) stimulates DNA synthesis in fetal rat brain cell cultures

1983 • 230 citations

Insulin-like growth factor II (IGF II) in human brain: regional distribution of IGF II and of higher molecular mass forms.

1985 • 205 citations

Ontogenesis of somatomedin and insulin receptors in the human fetus.

1983 • 197 citations

Structural similarities between human receptors for somatomedin C and insulin: analysis by affinity labeling

1981 • 187 citations

Multiplication‐stimulating activity for chicken embryo fibroblasts from rat liver cell conditioned medium: A family of small polypeptides

1973 • 181 citations

Purification and Characterization of Multiplication‐Stimulating Activity

1980 • 171 citations

EVIDENCE FOR TWO SPECIES OF INSULIN-LIKE GROWTH FACTOR II (IGF II AND “BIG” IGF II) IN HUMAN SPINAL FLUID

1982 • 158 citations

EVIDENCE FROM RADIOLIGAND ASSAYS THAT SOMATOMEDIN-C AND INSULIN-LIKE GROWTH FACTOR-I ARE SIMILAR TO EACH OTHER AND DIFFERENT FROM OTHER SOMATOMEDINS1

1980 • 157 citations

Structural and functional homologies in the receptors for insulin and the insulin-like growth factors

1982 • 154 citations

Inhibition of the mitogenic effects of plasma by a monoclonal antibody to somatomedin C.

1984 • 142 citations

Somatomedin receptor of human placenta: solubilization, photolabeling, partial purification, and comparison with insulin receptor.

1981 • 136 citations

Production of insulin‐like growth factors and their carrier by rat pituitary gland and brain explants in culture

1981 • 132 citations

Affinity labeling of multiplication stimulating activity receptors in membranes from rat and human tissues.

1981 • 124 citations

Affinity-labeled plasma somatomedin-C/insulinlike growth factor I binding proteins. Evidence of growth hormone dependence and subunit structure.

1985 • 113 citations

4 Insulin and insulin-like growth factors/ somatomedins in fetal and neonatal development

1984 • 108 citations

Insulin-like growth factor II binding to the type I somatomedin receptor. Evidence for two high affinity binding sites.

1986 • 104 citations

The Response of Cultured Human Normal Glial Cells to Growth Factors

1975 • 92 citations

Isolation and Partial Sequence Analysis of Rat Basic Somatomedin*

1982 • 87 citations

Interaction of multiplication-stimulating activity with chick embryo fibroblasts demonstrates a growth receptor

1976 • 86 citations

Human embryonic somatomedin.

1981 • 81 citations

An autoradiographic analysis of beta adrenergic receptors on immunocytochemically defined astroglia.

1983 • 68 citations

Receptors for Insulin-Like Growth Factors and Growth Effects of Multiplication-Stimulating Activity (Rat Insulin-Like Growth Factor II) in Rat Embryo Fibroblasts*

1983 • 64 citations

A calculator for finding binding parameters from a scatchard plot

1973 • 58 citations

Optimization of tyrosine hydroxylase immunocytochemistry in paraffin sections using pretreatment with proteolytic enzymes.

1984 • 57 citations

Proinsulin‐like material in mouse foetal brain cell cultures

1984 • 44 citations

Insulin-Like Growth Factor Receptors in Rat Placental Membranes*

1984 • 39 citations

Combination of immunocytochemistry and radioligand receptor assay to identify beta-adrenergic receptor subtypes on astroglia in vitro

1984 • 34 citations

Binding, membrane redistribution, internalization and lysosomal association of [125I]anti-insulin receptor antibody in IM-9-cultured human lymphocyte

1981 • 16 citations

Light and electron microscopic analysis of insulin binding sites on neurons in dissociated brain cell cultures

1985 • 11 citations

Affinity-labeled plasma somatomedin-C/insulinlike growth factor I binding proteins. Evidence of growth hormone dependence and subunit structure.

1985 • 6 citations