Advances in the Signal Transduction of Ceramide and Related Sphingolipids

Mitochondria and Apoptosis

1998 • 8,909 citations

Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade

1997 • 7,177 citations

Death Receptors: Signaling and Modulation

1998 • 5,873 citations

Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis

1995 • 5,334 citations

Apoptosis by Death Factor

1997 • 5,038 citations

The retinoblastoma protein and cell cycle control

1995 • 4,873 citations

The Release of Cytochrome c from Mitochondria: A Primary Site for Bcl-2 Regulation of Apoptosis

1997 • 4,728 citations

Function and Activation of NF-kappaB in the Immune System

1994 • 4,698 citations

Cleavage of BID by Caspase 8 Mediates the Mitochondrial Damage in the Fas Pathway of Apoptosis

1998 • 4,383 citations

The Fas Death Factor

1995 • 4,070 citations

Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

1995 • 4,003 citations

Bid, a Bcl2 Interacting Protein, Mediates Cytochrome c Release from Mitochondria in Response to Activation of Cell Surface Death Receptors

1998 • 3,603 citations

JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

1994 • 3,219 citations

Apaf-1, a Human Protein Homologous to C. elegans CED-4, Participates in Cytochrome c–Dependent Activation of Caspase-3

1997 • 3,130 citations

An Essential Role for NF-κB in Preventing TNF-α-Induced Cell Death

1996 • 3,094 citations

FLICE, A Novel FADD-Homologous ICE/CED-3–like Protease, Is Recruited to the CD95 (Fas/APO-1) Death-Inducing Signaling Complex

1996 • 3,065 citations

Serine Phosphorylation of Death Agonist BAD in Response to Survival Factor Results in Binding to 14-3-3 Not BCL-XL

1996 • 2,627 citations

Suppression of TNF-α-Induced Apoptosis by NF-κB

1996 • 2,623 citations

The stress-activated protein kinase subfamily of c-Jun kinases

1994 • 2,616 citations

Mitogen-activated protein kinase pathways

1997 • 2,513 citations

Caspases: killer proteases

1997 • 2,440 citations

FADD, a novel death domain-containing protein, interacts with the death domain of fas and initiates apoptosis

1995 • 2,436 citations

Yama/CPP32β, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase

1995 • 2,402 citations

Involvement of MACH, a Novel MORT1/FADD-Interacting Protease, in Fas/APO-1- and TNF Receptor–Induced Cell Death

1996 • 2,306 citations

Induction of Apoptosis by ASK1, a Mammalian MAPKKK That Activates SAPK/JNK and p38 Signaling Pathways

1997 • 2,284 citations

The TNF receptor 1-associated protein TRADD signals cell death and NF-κB activation

1995 • 1,979 citations

TRADD–TRAF2 and TRADD–FADD Interactions Define Two Distinct TNF Receptor 1 Signal Transduction Pathways

1996 • 1,976 citations

Dissection of TNF Receptor 1 Effector Functions: JNK Activation Is Not Linked to Apoptosis While NF-κB Activation Prevents Cell Death

1996 • 1,962 citations

Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis

1996 • 1,784 citations

Programmed Cell Death Induced by Ceramide

1993 • 1,779 citations

Reduced Apoptosis and Cytochrome c–Mediated Caspase Activation in Mice Lacking Caspase 9

1998 • 1,642 citations

Caveolins, a Family of Scaffolding Proteins for Organizing “Preassembled Signaling Complexes” at the Plasma Membrane

1998 • 1,502 citations

Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate

1996 • 1,493 citations

Transcription Factor ATF2 Regulation by the JNK Signal Transduction Pathway

1995 • 1,453 citations

Mice deficient in IL-1β-converting enzyme are defective in production of mature IL-1β and resistant to endotoxic shock

1995 • 1,413 citations

Bcl-xL Regulates the Membrane Potential and Volume Homeostasis of Mitochondria

1997 • 1,389 citations

Identification of a Member of the MAPKKK Family as a Potential Mediator of TGF-β Signal Transduction

1995 • 1,318 citations

A novel domain within the 55 kd TNF receptor signals cell death

1993 • 1,302 citations

Differential Requirement for Caspase 9 in Apoptotic Pathways In Vivo

1998 • 1,292 citations

The sphingomyelin cycle and the second messenger function of ceramide.

1994 • 1,255 citations

Functions of Sphingolipids and Sphingolipid Breakdown Products in Cellular Regulation

1989 • 1,251 citations

CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1 beta-converting enzyme.

1994 • 1,239 citations

The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins

1995 • 1,237 citations

Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene

1997 • 1,229 citations

Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD-specific caspase activation and independently of mitochondrial transmembrane depolarization

1998 • 1,226 citations

FLICE is activated by association with the CD95 death-inducing signaling complex (DISC)

1997 • 1,207 citations

Sphingosine inhibition of protein kinase C activity and of phorbol dibutyrate binding in vitro and in human platelets.

1986 • 1,150 citations

Fatty acid-induced β cell apoptosis: A link between obesity and diabetes

1998 • 1,142 citations

Increasing complexity of Ras signaling

1998 • 1,069 citations

The Death Domain Kinase RIP Mediates the TNF-Induced NF-κB Signal

1998 • 1,062 citations

TNF activates NF-κB by phosphatidylcholine-specific phospholipase C-induced “Acidic” sphingomyelin breakdown

1992 • 1,058 citations

Bcl-2 family proteins

1998 • 1,055 citations

Caspases: the proteases of the apoptotic pathway

1998 • 1,048 citations

Two TNF receptors

1992 • 1,048 citations

A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor

1994 • 1,043 citations

A Novel Protein That Interacts with the Death Domain of Fas/APO1 Contains a Sequence Motif Related to the Death Domain

1995 • 1,007 citations

Sphingosine-1-Phosphate as a Ligand for the G Protein-Coupled Receptor EDG-1

1998 • 1,003 citations

The sphingomyelin pathway in tumor necrosis factor and interleukin-1 signaling

1994 • 934 citations

Apaf1 (CED-4 Homolog) Regulates Programmed Cell Death in Mammalian Development

1998 • 894 citations

FADD: Essential for Embryo Development and Signaling from Some, But Not All, Inducers of Apoptosis

1998 • 893 citations

Ionizing radiation acts on cellular membranes to generate ceramide and initiate apoptosis.

1994 • 890 citations

Bcl-2 prolongs cell survival after Bax-induced release of cytochrome c

1998 • 872 citations

A novel protein domain required for apoptosis. Mutational analysis of human Fas antigen

1993 • 857 citations

Ceramide synthase mediates daunorubicin-induced apoptosis: An alternative mechanism for generating death signals

1995 • 835 citations

REGULATION OF CERAMIDE PRODUCTION AND APOPTOSIS

1998 • 804 citations

Direct Effect of Ceramide on the Mitochondrial Electron Transport Chain Leads to Generation of Reactive Oxygen Species

1997 • 801 citations

A c-jun dominant negative mutant protects sympathetic neurons against programmed cell death

1995 • 800 citations

Acid Sphingomyelinase–Deficient Human Lymphoblasts and Mice Are Defective in Radiation-Induced Apoptosis

1996 • 795 citations

Early Lethality, Functional NF-κB Activation, and Increased Sensitivity to TNF-Induced Cell Death in TRAF2-Deficient Mice

1997 • 791 citations

Bcl-2 Targets the Protein Kinase Raf-1 to Mitochondria

1996 • 785 citations

FADD/MORT1 Is a Common Mediator of CD95 (Fas/APO-1) and Tumor Necrosis Factor Receptor-induced Apoptosis

1996 • 780 citations

Death of oligodendrocytes mediated by the interaction of nerve growth factor with its receptor p75

1996 • 768 citations

Potocytosis: Sequestration and Transport of Small Molecules by Caveolae

1992 • 751 citations

Induction of cell death by endogenous nerve growth factor through its p75 receptor

1996 • 750 citations

Tumor necrosis factor alpha-induced apoptosis in cardiac myocytes. Involvement of the sphingolipid signaling cascade in cardiac cell death.

1996 • 742 citations

In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains.

1996 • 731 citations

Functional dichotomy of neutral and acidic sphingomyelinases in tumor necrosis factor signaling

1994 • 726 citations

Fas-mediated apoptosis and activation-induced T-cell proliferation are defective in mice lacking FADD/Mort1

1998 • 704 citations

The Permeability Transition Pore Complex: A Target for Apoptosis Regulation by Caspases and Bcl-2–related Proteins

1998 • 700 citations

Signal transduction of stress via ceramide

1998 • 687 citations

Ceramide activates heterotrimeric protein phosphatase 2A

1993 • 657 citations

ASK1 Is Essential for JNK/SAPK Activation by TRAF2

1998 • 641 citations

Sphingolipids—The Enigmatic Lipid Class: Biochemistry, Physiology, and Pathophysiology

1997 • 640 citations

Sphingosine-1-phosphate, a novel lipid, involved in cellular proliferation.

1991 • 627 citations

The Central Executioner of Apoptosis: Multiple Connections between Protease Activation and Mitochondria in Fas/APO-1/CD95- and Ceramide-induced Apoptosis

1997 • 625 citations

Ceramide: an intracellular signal for apoptosis

1995 • 604 citations

Inhibition of NF-kappaB/Rel induces apoptosis of murine B cells.

1996 • 604 citations

Lysosphingolipids Inhibit Protein Kinase C: Implications for the Sphingolipidoses

1987 • 593 citations

Apoptotic signaling through CD95 (Fas/Apo-1) activates an acidic sphingomyelinase.

1994 • 582 citations

RAIDD is a new 'death' adaptor molecule

1997 • 547 citations

Modulation of life and death by the TNF receptor superfamily

1998 • 543 citations

Bcl-X _L interacts with Apaf-1 and inhibits Apaf-1-dependent caspase-9 activation

1998 • 534 citations

Molecular Cloning and Functional Characterization of Murine Sphingosine Kinase

1998 • 528 citations

Caspase-9, Bcl-XL, and Apaf-1 Form a Ternary Complex

1998 • 523 citations

Molecular ordering of the Fas-apoptotic pathway: The Fas/APO-1 protease Mch5 is a CrmA-inhibitable protease that activates multiple Ced-3/ICE-like cysteine proteases

1996 • 519 citations

Target Protease Specificity of the Viral Serpin CrmA

1997 • 517 citations

PKC zeta is a molecular switch in signal transduction of TNF-alpha, bifunctionally regulated by ceramide and arachidonic acid.

1995 • 506 citations

Role for Ceramide in Cell Cycle Arrest

1995 • 488 citations

Implication of Mitochondrial Hydrogen Peroxide Generation in Ceramide-induced Apoptosis

1997 • 485 citations

Tumor necrosis factors: developments during the last decade.

1996 • 473 citations

Protein kinase C zeta isoform is critical for kappa B-dependent promoter activation by sphingomyelinase.

1994 • 473 citations

The CED-3/ICE-like Protease Mch2 Is Activated during Apoptosis and Cleaves the Death Substrate Lamin A

1996 • 466 citations

Induction of apoptotic DNA damage and cell death by activation of the sphingomyelin pathway.

1994 • 459 citations

The stress-activated protein kinase pathway mediates cell death following injury induced by cis-platinum, UV irradiation or heat

1996 • 457 citations

Activation of SAPK/JNK by TNF Receptor 1 Through a Noncytotoxic TRAF2-Dependent Pathway

1997 • 454 citations

Role of Ceramide in Cellular Senescence

1995 • 453 citations

TRAF2 Is Essential for JNK but Not NF-κB Activation and Regulates Lymphocyte Proliferation and Survival

1997 • 449 citations

Kinase Suppressor of Ras Is Ceramide-Activated Protein Kinase

1997 • 440 citations

Sphingosine-1-phosphate: a platelet-activating sphingolipid released from agonist-stimulated human platelets

1995 • 435 citations

Activation of the Sphingomyelin Signaling Pathway in Intact EL4 Cells and in a Cell-Free System By IL-1β

1993 • 433 citations

The tumor necrosis factor receptor 2 signal transducers TRAF2 and c-IAP1 are components of the tumor necrosis factor receptor 1 signaling complex

1996 • 415 citations

The tumor necrosis factor-inducible zinc finger protein A20 interacts with TRAF1/TRAF2 and inhibits NF-kappaB activation.

1996 • 414 citations

FAS-induced apoptosis is mediated via a ceramide-initiated RAS signaling pathway

1995 • 411 citations

Ceramide stimulates a cytosolic protein phosphatase.

1992 • 406 citations

FLICE Is Predominantly Expressed as Two Functionally Active Isoforms, Caspase-8/a and Caspase-8/b

1997 • 405 citations

Mch3, a novel human apoptotic cysteine protease highly related to CPP32.

1995 • 391 citations

FAN, a Novel WD-Repeat Protein, Couples the p55 TNF-Receptor to Neutral Sphingomyelinase

1996 • 390 citations

Tumor necrosis factor receptor-mediated signaling pathways.

1994 • 389 citations

Apoptosis Induction by Caspase-8 Is Amplified through the Mitochondrial Release of Cytochrome c

1998 • 380 citations

Characterization of a ceramide-activated protein kinase: stimulation by tumor necrosis factor alpha.

1991 • 376 citations

Daunorubicin-induced apoptosis: triggering of ceramide generation through sphingomyelin hydrolysis.

1996 • 371 citations

Ceramide Activates the Stress-activated Protein Kinases

1995 • 367 citations

Compartmentalized Production of Ceramide at the Cell Surface

1995 • 352 citations

Inhibition of Carnitine Palmitoyltransferase I Augments Sphingolipid Synthesis and Palmitate-induced Apoptosis

1997 • 349 citations

Signal Transduction Pathways Regulated by Mitogen-activated/Extracellular Response Kinase Kinase Kinase Induce Cell Death

1996 • 346 citations

Glutathione Regulation of Neutral Sphingomyelinase in Tumor Necrosis Factor-α-induced Cell Death

1998 • 345 citations

TAK1 Mediates the Ceramide Signaling to Stress-activated Protein Kinase/c-Jun N-terminal Kinase

1997 • 336 citations

Phosphorylation of Raf by ceramide-activated protein kinase

1995 • 332 citations

Rabbit aorta and human atherosclerotic lesions hydrolyze the sphingomyelin of retained low-density lipoprotein. Proposed role for arterial-wall sphingomyelinase in subendothelial retention and aggregation of atherogenic lipoproteins.

1996 • 326 citations

Role for ceramide as an endogenous mediator of Fas-induced cytotoxicity.

1995 • 323 citations

Bcr-Abl Exerts Its Antiapoptotic Effect Against Diverse Apoptotic Stimuli Through Blockage of Mitochondrial Release of Cytochrome C and Activation of Caspase-3

1998 • 319 citations

New Developments in Phospholipase D

1997 • 313 citations

Inhibition of the Neutral Magnesium-dependent Sphingomyelinase by Glutathione

1997 • 306 citations

Fas- or Ceramide-induced Apoptosis Is Mediated by a Rac1-regulated Activation of Jun N-terminal Kinase/p38 Kinases and GADD153

1997 • 302 citations

Bcl-2 interrupts the ceramide-mediated pathway of cell death.

1996 • 302 citations

Characterization of Ceramide Synthesis

1997 • 297 citations

Multiple pathways originate at the Fas/APO-1 (CD95) receptor: sequential involvement of phosphatidylcholine-specific phospholipase C and acidic sphingomyelinase in the propagation of the apoptotic signal.

1995 • 295 citations

Tumor necrosis factor alpha stimulates AP-1 activity through prolonged activation of the c-Jun kinase

1994 • 294 citations

Signaling by dual specificity kinases

1998 • 291 citations

Sphingomyelin Synthase, a Potential Regulator of Intracellular Levels of Ceramide and Diacylglycerol during SV40 Transformation

1998 • 290 citations

Role of ceramide-activated protein phosphatase in ceramide-mediated signal transduction.

1994 • 288 citations

Activation of CD95 (APO-1/Fas) signaling by ceramide mediates cancer therapy-induced apoptosis

1997 • 286 citations

TANK, a co-inducer with TRAF2 of TNF- and CD 40L-mediated NF-kappaB activation.

1996 • 283 citations

Sphingosine-1-phosphate rapidly induces Rho-dependent neurite retraction: action through a specific cell surface receptor.

1996 • 280 citations

Tumor necrosis factor alpha -induced activation of c-jun N-terminal kinase is mediated by TRAF2

1997 • 273 citations

Sphingosine-1-phosphate, a putative second messenger, mobilizes calcium from internal stores via an inositol trisphosphate-independent pathway.

1994 • 273 citations

Ceramide Induces Cytochrome c Release from Isolated Mitochondria

1999 • 273 citations

Mitogen-activated protein kinase-mediated Fas apoptotic signaling pathway

1997 • 268 citations

The Cytotoxicity of Tumor Necrosis Factor Depends on Induction of the Mitochondrial Permeability Transition

1996 • 266 citations

Cell growth control by G protein-coupled receptors: from signal transduction to signal integration

1998 • 265 citations

Sphingosine 1-Phosphate Inhibits Activation of Caspases that Cleave Poly(ADP-ribose) Polymerase and Lamins during Fas- and Ceramide-mediated Apoptosis in Jurkat T Lymphocytes

1998 • 265 citations

Sphingomyelinase and ceramide activate mitogen-activated protein kinase in myeloid HL-60 cells

1993 • 262 citations

Requirement of an ICE-Like Protease for Induction of Apoptosis and Ceramide Generation by REAPER

1996 • 262 citations

Oxidized Low Density Lipoprotein Induces Apoptosis in Cultured Human Umbilical Vein Endothelial Cells by Common and Unique Mechanisms

1998 • 258 citations

Ceramide signalling and the immune response

1996 • 257 citations

Fas-associated Death Domain Protein Interleukin-1β-converting Enzyme 2 (FLICE2), an ICE/Ced-3 Homologue, Is Proximally Involved in CD95- and p55-mediated Death Signaling

1997 • 256 citations

Sphingosine 1-phosphate generated in the endoplasmic reticulum membrane activates release of stored calcium.

1994 • 253 citations

The Transcription Factor NF‐κB Mediates Increases in Calcium Currents and Decreases in NMDA‐ and AMPA/Kainate‐Induced Currents Induced by Tumor Necrosis Factor‐α in Hippocampal Neurons

1998 • 252 citations

CRADD, a novel human apoptotic adaptor molecule for caspase-2, and FasL/tumor necrosis factor receptor-interacting protein RIP.

1997 • 252 citations

Ceramide Inactivates Cellular Protein Kinase Cα

1996 • 251 citations

Structural requirements for long-chain (sphingoid) base inhibition of protein kinase C in vitro and for the cellular effects of these compounds

1989 • 247 citations

The Tricyclic Antidepressant Desipramine Causes Proteolytic Degradation of Lysosomal Sphingomyelinase in Human Fibroblasts

1994 • 245 citations

Neurotrophins Induce Sphingomyelin Hydrolysis

1995 • 245 citations

Sphingoid base 1-phosphate phosphatase: A key regulator of sphingolipid metabolism and stress response

1998 • 244 citations

TNF-Induced Activation of NF-κB

1995 • 240 citations

The Cellular Trafficking and Zinc Dependence of Secretory and Lysosomal Sphingomyelinase, Two Products of the Acid Sphingomyelinase Gene

1998 • 240 citations

Association of the p75 Neurotrophin Receptor with TRAF6

1999 • 237 citations

Stress-induced apoptosis and the sphingomyelin pathway

1997 • 234 citations

Endothelial Cell Inflammatory Responses to Tumor Necrosis Factor α

1996 • 232 citations

zeta PKC induces phosphorylation and inactivation of I kappa B-alpha in vitro.

1994 • 231 citations

N,N-Dimethylsphingosine Is a Potent Competitive Inhibitor of Sphingosine Kinase but Not of Protein Kinase C: Modulation of Cellular Levels of Sphingosine 1-Phosphate and Ceramide

1998 • 229 citations

Retinoblastoma gene product as a downstream target for a ceramide-dependent pathway of growth arrest.

1995 • 226 citations

Differential Regulation of Sphingomyelinase and Ceramidase Activities by Growth Factors and Cytokines

1995 • 222 citations

Tumor necrosis factor-alpha (TNF-alpha) signal transduction through ceramide. Dissociation of growth inhibitory effects of TNF-alpha from activation of nuclear factor-kappa B.

1993 • 217 citations

(1S,2R)-D-erythro-2-(N-Myristoylamino)-1-phenyl-1-propanol as an Inhibitor of Ceramidase

1996 • 216 citations

Fibroblast Growth Factor-2 Suppression of Tumor Necrosis Factor α-Mediated Apoptosis Requires Ras and the Activation of Mitogen-activated Protein Kinase

1996 • 213 citations

Stress signals for apoptosis: ceramide and c-Jun kinase

1998 • 211 citations

I-TRAF is a novel TRAF-interacting protein that regulates TRAF-mediated signal transduction.

1996 • 210 citations

Cytokine Response Modifier A (CrmA) Inhibits Ceramide Formation in Response to Tumor Necrosis Factor (TNF)-α: CrmA and Bcl-2 Target Distinct Components in the Apoptotic Pathway

1997 • 210 citations

Enhancement of Fibroblast Collagenase (Matrix Metalloproteinase-1)Gene Expression by Ceramide Is Mediated by Extracellular Signal-regulated and Stress-activated Protein Kinase Pathways

1998 • 209 citations

The role of diacylglycerol and ceramide in tumor necrosis factor and interleukin-1 signal transduction

1994 • 207 citations

Ceramide Formation Leads to Caspase-3 Activation during Hypoxic PC12 Cell Death

1998 • 207 citations

A ceramide-activated protein phosphatase mediates ceramide-induced G1 arrest of Saccharomyces cerevisiae.

1996 • 206 citations

Renaturation and tumor necrosis factor-alpha stimulation of a 97-kDa ceramide-activated protein kinase.

1994 • 205 citations

prICE: a downstream target for ceramide-induced apoptosis and for the inhibitory action of Bcl-2

1996 • 203 citations

Forced degradation of Fas inhibits apoptosis in adenovirus-infected cells

1998 • 203 citations

Ceramide Regulates the Transcription of Cyclooxygenase-2

1998 • 203 citations

Sphingosine‐1‐Phosphate in Cell Growth and Cell Death^a

1998 • 202 citations

Sphingosine 1-Phosphate Induces Platelet Activation through an Extracellular Action and Shares a Platelet Surface Receptor with Lysophosphatidic Acid

1997 • 200 citations

Induction of apoptosis by sphingosine in human leukemic HL-60 cells: a possible endogenous modulator of apoptotic DNA fragmentation occurring during phorbol ester-induced differentiation.

1995 • 197 citations

Activation of a High Affinity Gi Protein-coupled Plasma Membrane Receptor by Sphingosine-1-phosphate

1996 • 197 citations

Ceramide-binding and activation defines protein kinase c-Raf as a ceramide-activated protein kinase.

1996 • 193 citations

Ceramide Induces Apoptosis in Cultured Mesencephalic Neurons

1996 • 191 citations

Cell-permeable ceramides inhibit the stimulation of DNA synthesis and phospholipase D activity by phosphatidate and lysophosphatidate in rat fibroblasts.

1994 • 188 citations

Requirement of AP-1 for Ceramide-induced Apoptosis in Human Leukemia HL-60 Cells

1995 • 186 citations

BAD Enables Ceramide to Signal Apoptosis via Ras and Raf-1

1998 • 186 citations

EGF-Receptor Phosphorylation and Signaling Are Targeted by H₂O₂ Redox Stress

1998 • 183 citations

Involvement of de NovoCeramide Biosynthesis in Tumor Necrosis Factor-α/Cycloheximide-induced Cerebral Endothelial Cell Death

1998 • 182 citations

3pK, a Novel Mitogen-Activated Protein (MAP) Kinase-Activated Protein Kinase, Is Targeted by Three MAP Kinase Pathways

1996 • 180 citations

The long-chain sphingoid base of sphingolipids is acylated at the cytosolic surface of the endoplasmic reticulum in rat liver

1993 • 180 citations

Tumor necrosis factor activation of the sphingomyelin pathway signals nuclear factor kappa B translocation in intact HL-60 cells.

1993 • 179 citations

Ceramide-induced Translocation of Protein Kinase C-δ and -ϵ to the Cytosol

1997 • 178 citations

Disruption of Fas Receptor Signaling by Nitric Oxide in Eosinophils

1998 • 176 citations

Both TNF receptors are required for TNF-mediated induction of apoptosis in PC60 cells.

1995 • 175 citations

Staurosporine Induces Programmed Cell Death in Embryonic Neurons and Activation of the Ceramide Pathway

1996 • 174 citations

Bcl-2 and the Outer Mitochondrial Membrane in the Inactivation of Cytochrome c during Fas-mediated Apoptosis

1997 • 174 citations

Selective Activation of c-Jun Kinase Mitogen-activated Protein Kinase by CD40 on Human B Cells

1995 • 172 citations

TNF Receptor Death Domain-associated Proteins TRADD and FADD Signal Activation of Acid Sphingomyelinase

1998 • 171 citations

Tumor necrosis factor-alpha stimulates aromatase gene expression in human adipose stromal cells through use of an activating protein-1 binding site upstream of promoter 1.4.

1996 • 171 citations

Hormonal regulation of caveolae internalization.

1995 • 170 citations

Association of p75 with Caveolin and Localization of Neurotrophin-induced Sphingomyelin Hydrolysis to Caveolae

1997 • 169 citations

A possible role of sphingosine in induction of apoptosis by tumor necrosis factor‐α, in human neutrophils

1994 • 168 citations

1-beta-D-Arabinofuranosylcytosine stimulates ceramide and diglyceride formation in HL-60 cells.

1994 • 166 citations

Ceramide induces hepatocyte cell death through disruption of mitochondrial function in the rat

1997 • 164 citations

Role of the ceramide-signaling pathway in cytokine responses to P-fimbriated Escherichia coli.

1996 • 163 citations

Sphingomyelinase and Ceramide Stimulate the Expression of Inducible Nitric-oxide Synthase in Rat Primary Astrocytes

1998 • 162 citations

Phospholipase A2 Is Necessary for Tumor Necrosis Factor α-induced Ceramide Generation in L929 Cells

1997 • 161 citations

Expression of Neutral Sphingomyelinase Identifies a Distinct Pool of Sphingomyelin Involved in Apoptosis

1997 • 159 citations

Fas Induces Cytoplasmic Apoptotic Responses and Activation of the MKK7-JNK/SAPK and MKK6-p38 Pathways Independent of CPP32-like Proteases

1997 • 154 citations

Interaction of Ceramides, Sphingosine, and Sphingosine 1-Phosphate in Regulating DNA Synthesis and Phospholipase D Activity

1995 • 153 citations

Sphingomyelinase and Ceramide Suppress Insulin-induced Tyrosine Phosphorylation of the Insulin Receptor Substrate-1

1996 • 153 citations

c-Jun NH2-terminal Kinase Regulation of the Apoptotic Response of Small Cell Lung Cancer Cells to Ultraviolet Radiation

1997 • 151 citations

Regulation of cell proliferation by G proteins

1998 • 151 citations

A Novel Cytoplasmic Domain of the p55 Tumor Necrosis Factor Receptor Initiates the Neutral Sphingomyelinase Pathway

1996 • 150 citations

Activation of Jun kinase is an early event in hepatic regeneration.

1995 • 150 citations

Ceramide-mediated growth inhibition and CAPP are conserved in Saccharomyces cerevisiae

1993 • 149 citations

Choline deficiency‐induced apoptosis in PC12 cells is associated with diminished membrane phosphatidylcholine and sphingomyelin, accumulation of ceramide and diacylglycerol, and activation of a caspase

1999 • 149 citations

Disruption of sphingolipid metabolism and stimulation of DNA synthesis by fumonisin B1. A molecular mechanism for carcinogenesis associated with Fusarium moniliforme.

1994 • 147 citations

Acylation of Naturally Occurring and Synthetic 1-Deoxysphinganines by Ceramide Synthase

1998 • 144 citations

Tumor necrosis factor alpha rapidly activates the mitogen-activated protein kinase (MAPK) cascade in a MAPK kinase kinase-dependent, c-Raf-1-independent fashion in mouse macrophages.

1995 • 144 citations

12-O-tetradecanoylphorbol-13-acetate-induced apoptosis in LNCaP cells is mediated through ceramide synthase.

1998 • 139 citations

Evidence That Ceramide Selectively Inhibits Protein Kinase C-α Translocation and Modulates Bradykinin Activation of Phospholipase D

1995 • 139 citations

TNFR80-Dependent Enhancement of TNFR60-Induced Cell Death Is Mediated by TNFR-Associated Factor 2 and Is Specific for TNFR60

1998 • 136 citations

Induction of Apoptosis and Potentiation of Ceramide-mediated Cytotoxicity by Sphingoid Bases in Human Myeloid Leukemia Cells

1996 • 136 citations

Lipid biochemistry: functions of glycerolipids and sphingolipids in cellular signaling

1997 • 136 citations

Atypical PKC ζ is activated by ceramide, resulting in coactivation of NF-κb/JNK kinase and cell survival

1999 • 135 citations

Ceramide stimulates epidermal growth factor receptor phosphorylation in A431 human epidermoid carcinoma cells. Evidence that ceramide may mediate sphingosine action

1991 • 134 citations

A potential mechanism of "cross-talk" between the p55 tumor necrosis factor receptor and Fas/APO1: proteins binding to the death domains of the two receptors also bind to each other.

1996 • 134 citations

Granulysin-Induced Apoptosis. I. Involvement of at Least Two Distinct Pathways

1998 • 133 citations

A Novel Sphingosine-dependent Protein Kinase (SDK1) Specifically Phosphorylates Certain Isoforms of 14-3-3 Protein

1998 • 130 citations

Ceramide Inhibits Phospholipase D in a Cell-free System

1996 • 129 citations

Tissue Transglutaminase-Dependent Posttranslational Modification of the Retinoblastoma Gene Product in Promonocytic Cells Undergoing Apoptosis

1997 • 129 citations

Sphingomyelinases in cell regulation

1997 • 127 citations

Sphingomyelin‐Derived Lipids Differentially Regulate the Extracellular Signal‐Regulated Kinase 2 (ERK‐2) and c‐Jun N‐Terminal Kinase (JNK) Signal Cascades in Airway Smooth Muscle

1996 • 126 citations

1,2-Diacylglycerols and phorbol esters stimulate phosphatidylcholine metabolism in GH3 pituitary cells. Evidence for separate mechanisms of action.

1987 • 124 citations

Substrate recognition by ceramide-activated protein kinase. Evidence that kinase activity is proline-directed.

1993 • 124 citations

Protein-tyrosine Phosphatase Inhibitors Block Tumor Necrosis Factor-dependent Activation of the Nuclear Transcription Factor NF-kB

1995 • 123 citations

Stimulation of DNA synthesis by natural ceramide 1-phosphate

1997 • 121 citations

1,2-Diacylglycerols, but not phorbol esters, activate a potential inhibitory pathway for protein kinase C in GH3 pituitary cells. Evidence for involvement of a sphingomyelinase.

1988 • 120 citations

Daunorubicin Activates NFκB and Induces κB-dependent Gene Expression in HL-60 Promyelocytic and Jurkat T Lymphoma Cells

1997 • 118 citations

Sphingolipid Biosynthesis de Novo by Rat Hepatocytes in Culture.

1995 • 117 citations

Identification of a defect in the phospholipase D/diacylglycerol pathway in cellular senescence

1994 • 117 citations

Modulation of cell signalling by ceramides

1998 • 115 citations

Anti-immunoglobulin-induced Apoptosis in WEHI 231 Cells Involves the Slow Formation of Ceramide from Sphingomyelin and Is Blocked by bcl-xL

1997 • 114 citations

Interleukin-1β-induced Ceramide and Diacylglycerol Generation 5 Lead to Activation of the c-Jun NH2-terminal Kinase and the Transcription Factor ATF2 in the Insulin-producing Cell Line RINm5F

1996 • 113 citations

Calcium Release-activated Calcium Current (I CRAC) Is a Direct Target for Sphingosine

1998 • 113 citations

Ceramide Induces Structural Defects into Phosphatidylcholine Bilayers and Activates Phospholipase A2

1996 • 113 citations

Regulation of Raf-1 kinase by TNF via its second messenger ceramide and cross-talk with mitogenic signalling

1998 • 112 citations

Autocrine Nitric Oxide Modulates CD95-induced Apoptosis in γδ T Lymphocytes

1997 • 111 citations

Role of an acidic compartment in tumor‐necrosis‐factor‐α−induced production of ceramide, activation of caspase‐3 and apoptosis

1998 • 109 citations

1Alpha,25-dihydroxyvitamin D3 inhibits programmed cell death in HL-60 cells by activation of sphingosine kinase.

1998 • 107 citations

Purification and Characterization of a Novel Ceramidase fromPseudomonas aeruginosa

1998 • 107 citations

c-Jun N-terminal Kinase but Not Mitogen-activated Protein Kinase Is Sensitive to cAMP Inhibition in T Lymphocytes

1995 • 106 citations

Cell-permeable Ceramides Prevent the Activation of Phospholipase D by ADP-ribosylation Factor and RhoA

1997 • 106 citations

Sphingolipid metabolites differentially regulate extracellular signal-regulated kinase and stress-activated protein kinase cascades

1996 • 106 citations

Decreasing the apoptotic threshold of tumor cells through protein kinase C inhibition and sphingomyelinase activation increases tumor killing by ionizing radiation.

1997 • 103 citations

Conversion of diacylglycerol to phosphatidylcholine on the basolateral surface of epithelial (Madin-Darby canine kidney) cells. Evidence for the reverse action of a sphingomyelin synthase.

1994 • 102 citations

Ceramide induces apoptosis in PC12 cells

1997 • 101 citations

Partial purification and characterization of sphingosine N‐acyltransferase (ceramide synthase) from bovine liver mitochondrion‐rich fraction

1998 • 100 citations

Sphingomyelinase activates proteolytic I kappa B-alpha degradation in a cell-free system.

1994 • 100 citations

Inhibition of sphingolipid induced apoptosis by caspase inhibitors indicates that sphingosine acts in an earlier part of the apoptotic pathway than ceramide

1998 • 98 citations

Rho-regulated signals induce apoptosis in vitro and in vivo by a p53-independent, but Bcl2 dependent pathway

1998 • 98 citations

Purification and Characterization of 1-O-Acylceramide Synthase, a Novel Phospholipase A2 with Transacylase Activity

1998 • 97 citations

Tumor necrosis factor (TNF)-alpha activates c-raf-1 kinase via the p55 TNF receptor engaging neutral sphingomyelinase.

1995 • 96 citations

Fas-induced Apoptosis Is Mediated by Activation of a Ras and Rac Protein-regulated Signaling Pathway

1996 • 96 citations

Intracellular Signaling Events in CD77-Mediated Apoptosis of Burkitt's Lymphoma Cells

1997 • 95 citations

A Novel Enzyme That Catalyzes the Esterification of -Acetylsphingosine

1996 • 94 citations

Glucose Stimulates the Activity of the Guanine Nucleotide-exchange Factor eIF-2B in Isolated Rat Islets of Langerhans

1996 • 93 citations

The role of the stress-activated protein kinase (SAPK/JNK) signaling pathway in radiation-induced apoptosis

1998 • 91 citations

Role of Ceramide in Stimulation of the Transcription of Cytosolic Phospholipase A2and Cyclooxygenase 2

1996 • 90 citations

Regulation of Cytochrome P450 2C11 (CYP2C11) Gene Expression by Interleukin-1, Sphingomyelin Hydrolysis, and Ceramides in Rat Hepatocytes

1995 • 90 citations

Keratinocyte differentiation is induced by cell-permeant ceramides and its proliferation is promoted by sphingosine

1994 • 86 citations

Evidence against involvement of the acid lysosomal sphingomyelinase in the tumor-necrosis-factor- and interleukin-1-induced sphingomyelin cycle and cell proliferation in human fibroblasts

1994 • 84 citations

Control of cardiac Ca2+ levels. Inhibitory actions of sphingosine on Ca2+ transients and L-type Ca2+ channel conductance.

1994 • 83 citations

Sphingolipid Transport to the Apical Plasma Membrane Domain in Human Hepatoma Cells Is Controlled by PKC and PKA Activity: A Correlation with Cell Polarity in HepG2 Cells

1997 • 83 citations

Acidic sphingomyelinase-generated ceramide is needed but not sufficient for TNF-induced apoptosis and nuclear factor-kappa B activation.

1996 • 81 citations

Activation of C-jun N-terminal kinase/stress-activated protein kinase in primary glial cultures

1996 • 81 citations

Ceramide 1‐Phosphate Phosphatase Activity in Brain

1993 • 80 citations

Protein kinase C inhibition induces apoptosis and ceramide production through activation of a neutral sphingomyelinase.

1996 • 79 citations

Sphingosine 1-Phosphate Regulates Melanoma Cell Motility through a Receptor-Coupled Extracellular Action and in a Pertussis Toxin-Insensitive Manner

1997 • 78 citations

Ceramide regulates oxidant release in adherent human neutrophils

1994 • 77 citations

Differential responses of oligodendrocytes to tumor necrosis factor and other pro-apoptotic agents: Role of ceramide in apoptosis

1999 • 77 citations

Sphingosine-mediated phosphatidylinositol metabolism and calcium mobilization.

1994 • 77 citations

Stereospecificity of sphingosine-induced intracellular calcium mobilization and cellular proliferation.

1994 • 76 citations

Radiation-induced apoptosis mediated by retinoblastoma protein.

1998 • 75 citations

Dihydroceramide Biology

1997 • 74 citations

A Cytofluorometric Assay of Nuclear Apoptosis Induced in a Cell-Free System: Application to Ceramide-Induced Apoptosis

1997 • 73 citations

Requirement of Caveolae Microdomains in Extracellular Signal‐Regulated Kinase and Focal Adhesion Kinase Activation Induced by Endothelin‐1 in Primary Astrocytes

1999 • 72 citations

Purification and Characterization of Ceramide-Activated Protein Phosphatases

1998 • 72 citations

Ceramide inhibits pancreatic β‐cell insulin production and mitogenesis and mimics the actions of interleukin‐1β

1995 • 72 citations

c-Jun Is a Downstream Target for Ceramide-activated Protein Phosphatase in A431 Cells

1996 • 70 citations

Purification and Biochemical Characterization of Membrane-bound Epidermal Ceramidases from Guinea Pig Skin

1995 • 70 citations

Central glial and neuronal populations display differential sensitivity to ceramide-dependent cell death

1996 • 69 citations

Ceramide is a competitive inhibitor of diacylglycerol kinase in vitro and in intact human leukemia (HL-60) cells.

1992 • 69 citations

Caspase-mediated Cleavage of the Ubiquitin-protein Ligase Nedd4 during Apoptosis

1998 • 68 citations

N-Acetylsphingosine (C2--ceramide) Inhibited Neutrophil Superoxide Formation and Calcium Influx

1995 • 68 citations

25-Hydroxycholesterol stimulates sphingomyelin synthesis in Chinese hamster ovary cells.

1995 • 68 citations

Dissociation of endogenous cellular ceramide from NF-kappa B activation.

1994 • 67 citations

Coupling of the p75 Neurotrophin Receptor to Sphingolipid Signaling^a

1998 • 67 citations

Caspase-dependent Ceramide Production in Fas- and HLA Class I-mediated Peripheral T Cell Apoptosis

1998 • 67 citations

Cell-cycle-dependent changes in ceramide levels preceding retinoblastoma protein dephosphorylation in G2/M

1998 • 66 citations

Arachidonic acid mediates interleukin-1 and tumor necrosis factor-alpha- induced activation of the c-jun amino-terminal kinases in stromal cells

1996 • 65 citations

The Signal Modulator Protein-14-3-3 Ts a Target of Sphingosine-Dependent or N,N-Dimethylsphingosine-Dependent Kinase in 3T3(A31) Cells

1995 • 65 citations

Association of Ceramide Accumulation with Photodynamic Treatment‐Induced Cell Death

1998 • 65 citations

Ceramide inhibits IgE-mediated activation of phospholipase D, but not of phospholipase C, in rat basophilic leukemia (RBL-2H3) cells.

1996 • 64 citations

Tumor Necrosis Factor α Activates NF-κB in Acid Sphingomyelinase-deficient Mouse Embryonic Fibroblasts

1997 • 64 citations

Role of enhanced ceramide generation in DNA damage and cell death in chemical hypoxic injury to LLC-PK1 cells

1998 • 63 citations

Regulation of proliferation and apoptosis by Ras and Rho GTPases through specific phospholipid‐dependent signaling

1997 • 62 citations

The vitamin D₃ analogue, calcipotriol, induces sphingomyelin hydrolysis in human keratinocytes

1996 • 62 citations

Synergy between Tumor Necrosis Factor α and Interleukin 1β in Inducing Transcriptional Down-regulation of Muscarinic M2 Receptor Gene Expression

1996 • 62 citations

Changes in the Activity and mRNA Levels of Phospholipase D During Ceramide‐Induced Apoptosis in Rat C6 Glial Cells

1997 • 61 citations

Mitogen-activated protein kinase activation during IgG-dependent phagocytosis in human neutrophils: inhibition by ceramide.

1997 • 56 citations

Role of ceramide in mitogenesis induced by exogenous sphingoid bases.

1994 • 56 citations

"Cross talk" between the bioactive glycerolipids and sphingolipids in signal transduction

1996 • 55 citations

Nitroxides Tempol and Tempo Induce Divergent Signal Transduction Pathways in MDA-MB 231 Breast Cancer Cells

1998 • 55 citations

Evidence against an early signalling role for ceramide in Fas-mediated apoptosis

1997 • 55 citations

The multidrug resistance modulator SDZ PSC 833 is a potent activator of cellular ceramide formation

1998 • 55 citations

Early fumonisin B1 toxicity in relation to disrupted sphingolipid metabolism in male BALB/c mice

1998 • 54 citations

Caveolar Internalization of Growth Hormone

1999 • 54 citations

Acid sphingomyelinase is not essential for the IL-1 and tumor necrosis factor receptor signaling pathway leading to NFkB activation

1994 • 54 citations

Caspase Activation Is an Early Event in Anthracycline-Induced Apoptosis and Allows Detection of Apoptotic Cells before They Are Ingested by Phagocytes

1998 • 53 citations

Distinct sites of action of Bcl-2 and Bcl-xL in the ceramide pathway of apoptosis

1998 • 53 citations

Apoptosis in B lymphocytes: The WEHI‐231 perspective

1995 • 53 citations

Induction of intracellular ceramide by interleukin-1β in oligodendrocytes

1997 • 51 citations

Sphingolipids as mediators of effects of platelet-derived growth factor in vascular smooth muscle cells

1993 • 51 citations

Distinctive inhibitory activity of docosahexaenoic acid against sphingosine-induced apoptosis

1998 • 50 citations

Ceramide and Cyclic Adenosine Monophosphate (cAMP) Induce cAMP Response Element Binding Protein Phosphorylation via Distinct Signaling Pathways While Having Opposite Effects on Myeloid Cell Survival

1999 • 49 citations

Ceramides perturb the structure of phosphatidylcholine bilayers and modulate the activity of phospholipase A 2

1998 • 48 citations

Ceramide Generation by the Reaper Protein Is Not Blocked by the Caspase Inhibitor, p35

1998 • 48 citations

Inhibition of ceramide pathway does not affect ability of TNF-alpha to activate nuclear factor-kappa B.

1994 • 47 citations

Ceramide Is Not a Signal for Tumor Necrosis Factor–Induced Gene Expression but Does Cause Programmed Cell Death in Human Vascular Endothelial Cells

1996 • 46 citations

Activation of Phospholipase D and Phosphatidylinositol 4-Phosphate 5-Kinase in HL60 Membranes Is Mediated by Endogenous Arf but Not Rho

1996 • 46 citations

Modified low density lipoprotein delivers substrate for ceramide formation and stimulates the sphingomyelin‐ceramide pathway in human macrophages

1997 • 45 citations

Phospholipid localization in the plasma membrane of Friend erythroleukemic cells and mouse erythrocytes

1985 • 45 citations

Ca2+ Mobilizing Action of Sphingosine in Jurkat Human Leukemia T Cells

1996 • 44 citations

Arachidonic Acid Mediates Interferon-γ–Induced Sphingomyelin Hydrolysis and Monocytic Marker Expression in HL-60 Cell Line

1997 • 44 citations

Effect of Tumor Necrosis Factor‐α on Insulin‐Stimulated Mitogen‐Activated Protein Kinase Cascade in Cultured Rat Skeletal Muscle Cells

1996 • 43 citations

Daunorubicin- and Mitoxantrone-Triggered Phosphatidylcholine Hydrolysis: Implication in Drug-Induced Ceramide Generation and Apoptosis

1999 • 42 citations

Granulocyte-Macrophage Colony-Stimulating Factor Rescues TF-1 Leukemia Cells From Ionizing Radiation-Induced Apoptosis Through a Pathway Mediated by Protein Kinase Cα

1998 • 40 citations

Ceramide‐induced translocation of protein kinase C ζ in primary cultures of astrocytes

1997 • 40 citations

On the complexities of ceramide changes in cells undergoing apoptosis: lack of evidence for a second messenger function in apoptotic induction

1999 • 39 citations

Mutual modulation of sphingomyelinase and phospholipase A₂activities against mixed lipid monolayers by their lipid intermediates and glycosphingolipids

1997 • 38 citations

Induction of apoptosis by rho in NIH 3T3 cells requires two complementary signals. Ceramides function as a progression factor for apoptosis.

1995 • 34 citations

Ceramide does not mediate the effect of tumour necrosis factor α on superoxide generation in human neutrophils

1994 • 34 citations

Molecular species of sphingomyelin in sphingomyelinase-sensitive and sphingomyelinase-resistant pools of HL-60 cells

1995 • 33 citations

Differential effects of sphingomyelinase and cell-permeable ceramide analogs on proliferation of Swiss 3T3 fibroblasts

1997 • 32 citations

Involvement of a ceramide activated protein phosphatase in the differentiation of neuroblastoma Neuro2a cells

1997 • 32 citations

Growth-dependent regulation of cellular ceramides in human T-cells

1994 • 32 citations

Sphingosine Effects on the Contractile Behavior of Skinned Cardiac Myocytes

1994 • 32 citations

Morphological Differentiation of N1E-115 Neuroblastoma Cells by Dimethyl Sulfoxide Activation of Lipid Second Messengers

1996 • 31 citations

Permissive effect of ceramide on growth factor-induced cell proliferation

1995 • 31 citations

Lipid second messengers derived from glycerolipids and sphingolipids, and their role in smooth muscle function*

1998 • 31 citations

L-Selectin Stimulates the Neutral Sphingomyelinase and Induces Release of Ceramide

1998 • 31 citations

Monensin inhibits synthesis of plasma membrane sphingomyelin by blocking transport of ceramide through the Golgi: Evidence for two sites of sphingomyelin synthesis in BHK cells

1993 • 31 citations

Ceramide Promotes Calpain-Mediated Proteolysis of Protein Kinase C β in Murine Polymorphonuclear Leukocytes

1998 • 31 citations

Inhibition of Tumor-Necrosis-Factor α- and Ceramide-Induced Internucleosomal DNA Fragmentation by Herbimycin a in U937 Cells

1995 • 30 citations

Increases in Neutral, Mg2+-Dependent and Acidic, Mg2+-Independent Sphingomyelinase Activities Precede Commitment to Apoptosis and Are Not a Consequence of Caspase 3–Like Activity in Molt-4 Cells in Response to Thymidylate Synthase Inhibition by GW1843

1998 • 30 citations

The human retinoblastoma gene product suppresses ceramide-induced apoptosis in human bladder tumor cells.

1996 • 30 citations

Fluorinated anesthetic exposure “activates” the renal cortical sphingomyelinase cascade

1998 • 30 citations

Involvement of sphingolipids metabolites in cellular proliferation modulated by ganglioside GM1

1996 • 30 citations

Characterization of a Sphingomyelinase Activity inSaccharomyces cerevisiae

1997 • 29 citations

Reactive oxygen species enhances the induction of inducible nitric oxide synthase by sphingomyelinase in RAW264.7 cells

1998 • 29 citations

Stimulation by Ceramide of Phospholipase A2 Activation through a Mechanism Related to the Phospholipase C-Initiated Signaling Pathway in Rabbit Platelets

1999 • 29 citations

The Mitogen-Activated Protein Kinase Pathway Inhibits Ceramide-Induced Terminal Differentiation of a Human Monoblastic Leukemia Cell Line, U937

1998 • 28 citations

Release of ceramide after membrane sphingomyelin hydrolysis decreases the basolateral secretion of triacylglycerol and apolipoprotein B in cultured human intestinal cells.

1993 • 27 citations

Sphingosine stimulates calcium mobilization in rat parotid acinar cells

1991 • 27 citations

Sphingomyelinase Activity in Human Platelets

1998 • 27 citations

Phospholipid organization in H,K-ATPase-containing membranes from pig gastric mucosa.

1985 • 26 citations

Sphingosine mobilizes intracellular calcium in human neutrophils

1993 • 26 citations

Ceramide-Induced Apoptosis Is Mediated by Caspase Activation Independently from Retinoblastoma Protein Post-Translational Modification

1998 • 26 citations

Bombesin-stimulated ceramide production and MAP kinase activation in rabbit rectosigmoid smooth muscle cells

1997 • 26 citations

Two separate pools of sphingomyelin in BHK cells

1992 • 25 citations

Relationships of apoptotic signaling mediated by ceramide and TNF-α in U937 cells

1999 • 25 citations

Growth inhibition of human pancreatic cancer cells by sphingosylphosphorylcholine and influence of culture conditions

1997 • 25 citations

Clear differences in ceramide metabolism between glycosphingolipids and sphingomyelin in a human promyelocytic leukemia cell line HL‐60 stimulated by a differentiation inducer

1995 • 24 citations

Activation of the sphingomyelin cycle by brefeldin A: effects of brefeldin A on differentiation and implications for a role for ceramide in regulation of protein trafficking.

1996 • 24 citations

Sphingosine, W‐7, and Trifluoperazine Inhibit the Elevation in Cytosolic Calcium Induced by High K⁺Depolarization in Synaptosomes

1993 • 23 citations

Effect of endothelin-1 induced ischemia on peroxidative damage and membrane properties in rat striatum synaptosomes

1995 • 23 citations

Exogenous C2-ceramide activates c-fos serum response element via Rac-dependent signalling pathway

1998 • 23 citations

Activation of phospholipase D by growth factors and oncogenes in murine fibroblasts follow alternative but cross-talking pathways

1997 • 23 citations

Distinct Pathways for Tumor Necrosis Factor Alpha and Ceramides in Human Cytomegalovirus Infection

1998 • 23 citations

An accessory role for ceramide in interleukin-1beta induced prostaglandin synthesis.

1998 • 22 citations

Induction of stress-activated protein kinases/c-Jun N-terminal kinases by the p55 tumour necrosis factor receptor does not require sphingomyelinases

1998 • 21 citations

Different effects of cell‐permeable ceramide analogs on platelet activation

1998 • 21 citations

Characterization and localization of neutral sphingomyelinase in bovine adrenal medulla.

1986 • 20 citations

Bradykinin Increases Ceramide and Sphingosine Content in Human Fibroblasts: Possible Involvement of Glycosphingolipids

1996 • 19 citations

Sphingosine‐1‐Phosphate as an Intercellular Signaling Molecule^a

1998 • 19 citations

Sphingosine derivatives inhibit depolarization-evoked calcium entry in rat GH4C1 cells.

1995 • 18 citations

Alteration of glycerolipid and sphingolipid-derived second messenger kinetics in ras transformed 3T3 cells

1996 • 18 citations

Synovial fibroblasts and the sphingomyelinase pathway: sphingomyelin turnover and ceramide generation are not signaling mechanisms for the actions of tumor necrosis factor-alpha.

1998 • 17 citations

Involvement of sphingolipids in the endothelin-1 signal transduction mechanism in rat brain

1996 • 17 citations

Prostacyclin Formation Elicited by Endothelin-1 in Rat Aorta Is Mediated via Phospholipase D Activation and Not Phospholipase C or A ₂

1996 • 16 citations

Th2 Suppressor Cells Are More Susceptible to Sphingosine Than Th1 Cells in Murine Contact Photosensitivity

1996 • 15 citations

Fatty acyl chain composition in the determination of renal membrane order.

1986 • 15 citations

Bioactive Properties of Sphingosine and Structurally Related Compounds

1996 • 14 citations

Phosphorylated cis-4-Methylsphingosine Mimics the Mitogenic Effect of Sphingosine-1-phosphate in Swiss 3T3 Fibroblasts

1998 • 14 citations

Ceramide Selectively Inhibits Calcium-Mediated Potentiation of β-Adrenergic-Stimulated Cyclic Nucleotide Accumulation in Rat Pinealocytes

1998 • 12 citations

Conversion of short‐chain ceramides to short‐chain ceramide GM3 in B16 melanoma cells

1995 • 12 citations

Defects in Signal Transduction Pathways in Chronic B Lymphocytic Leukemia Cells

1995 • 12 citations

C2-ceramide primes specifically for the superoxide anion production induced by N-formylmethionylleucyl phenylalanine (fMLP) in human neutrophils

1996 • 11 citations

Evidence for the Lack of Involvement of Sphingomyelin Hydrolysis in the Tumor Necrosis Factor‐Induced Secretion of Nerve Growth Factor in Primary Astrocyte Cultures

1998 • 10 citations

Sphingosine Enhances Phosphatidylinositol 4-Kinase Activity in Rabbit Platelets

1996 • 8 citations

Peripheral Nerve Sphingomyelin and Cerebroside are Both Formed Via two Metabolically and Kinetically Distinct Pathways In vivo

1994 • 7 citations

Cerebroside formation in the peripheral nervous system of normal and Trembler mice

1995 • 7 citations

C6-ceramide maintains elevated cytosolic calcium levels in activated platelets

1996 • 5 citations

[Ceramide: a lipid mediator of apoptotic signal transduction].

1996 • 2 citations