Inhibition of the Neutral Magnesium-dependent Sphingomyelinase by Glutathione

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

1959 • 47,127 citations

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

1959 • 21,307 citations

Free radicals in biology and medicine

1991 • 17,840 citations

Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: Applications to mammalian blood and other tissues

1969 • 6,007 citations

Free Radicals in Biology and Medicine

1990 • 4,962 citations

Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine

1980 • 4,407 citations

Programmed Cell Death Induced by Ceramide

1993 • 1,779 citations

Bcl-2 inhibition of neural death: decreased generation of reactive oxygen species

1993 • 1,692 citations

Selective Modification of Glutathione Metabolism

1983 • 1,272 citations

The sphingomyelin cycle and the second messenger function of ceramide.

1994 • 1,255 citations

TNF activates NF-κB by phosphatidylcholine-specific phospholipase C-induced “Acidic” sphingomyelin breakdown

1992 • 1,058 citations

Ionizing radiation acts on cellular membranes to generate ceramide and initiate apoptosis.

1994 • 890 citations

Functional dichotomy of neutral and acidic sphingomyelinases in tumor necrosis factor signaling

1994 • 726 citations

Sphingomyelin turnover induced by vitamin D3 in HL-60 cells

1989 • 629 citations

Identification of sphingomyelin turnover as an effector mechanism for the action of tumor necrosis factor alpha and gamma-interferon. Specific role in cell differentiation.

1991 • 621 citations

Activation of the Sphingomyelin Cycle Through the Low-Affinity Neurotrophin Receptor

1994 • 583 citations

Apoptotic signaling through CD95 (Fas/Apo-1) activates an acidic sphingomyelinase.

1994 • 582 citations

Interaction of γ-Glutamyl Transpeptidase with Amino Acids, Dipeptides, and Derivatives and Analogs of Glutathione

1974 • 541 citations

Role for Ceramide in Cell Cycle Arrest

1995 • 488 citations

Role of Ceramide in Cellular Senescence

1995 • 453 citations

Activation of the Sphingomyelin Signaling Pathway in Intact EL4 Cells and in a Cell-Free System By IL-1β

1993 • 433 citations

Transport interaction of L-cystine and L-glutamate in human diploid fibroblasts in culture.

1980 • 409 citations

Ceramide stimulates a cytosolic protein phosphatase.

1992 • 406 citations

[1] Glutathione metabolism

1995 • 406 citations

Characterization of a ceramide-activated protein kinase: stimulation by tumor necrosis factor alpha.

1991 • 376 citations

Role for ceramide as an endogenous mediator of Fas-induced cytotoxicity.

1995 • 323 citations

Signalling mechanisms and oxidative stress in apoptosis

1995 • 306 citations

Bcl-2 interrupts the ceramide-mediated pathway of cell death.

1996 • 302 citations

Zn2+-stimulated Sphingomyelinase Is Secreted by Many Cell Types and Is a Product of the Acid Sphingomyelinase Gene

1996 • 274 citations

Interleukin-1-mediated PGE2 production and sphingomyelin metabolism. Evidence for the regulation of cyclooxygenase gene expression by sphingosine and ceramide.

1992 • 272 citations

Ceramide Inactivates Cellular Protein Kinase Cα

1996 • 251 citations

Retinoblastoma gene product as a downstream target for a ceramide-dependent pathway of growth arrest.

1995 • 226 citations

Characteristics and partial purification of a novel cytosolic, magnesium-independent, neutral sphingomyelinase activated in the early signal transduction of 1 alpha,25-dihydroxyvitamin D3-induced HL-60 cell differentiation.

1994 • 198 citations

Apoptosis or necrosis: Intracellular levels of glutathione influence mode of cell death

1994 • 197 citations

Non-oxidative Loss of Glutathione in Apoptosis via GSH Extrusion

1995 • 190 citations

Fas‐mediated apoptosis is modulated by intracellular glutathione in human T cells

1996 • 169 citations

1-beta-D-Arabinofuranosylcytosine stimulates ceramide and diglyceride formation in HL-60 cells.

1994 • 166 citations

Acid sphingomyelinase from human urine: purification and characterization

1987 • 131 citations

Ceramide Inhibits Phospholipase D in a Cell-free System

1996 • 129 citations

A decrease in intracellular glutathione concentration precedes the onset of apoptosis in murine thymocytes.

1995 • 125 citations

A New Zn2+-stimulated Sphingomyelinase in Fetal Bovine Serum

1989 • 111 citations

Insulin and glucocorticoid dependence of hepatic gamma-glutamylcysteine synthetase and glutathione synthesis in the rat. Studies in cultured hepatocytes and in vivo.

1992 • 95 citations

Identification of an alkaline sphingomyelinase activity in human bile

1996 • 79 citations

Acid Sphingomyelinase of Human Brain: Purification to Homogeneity

1982 • 75 citations

Glutathione and cysteine depletion in rats and mice following acute intoxication with diethylmaleate

1992 • 46 citations

Cardiac cell toxicity induced by 4-hydroperoxycyclophosphamide is modulated by glutathione

1993 • 32 citations

A Critical Role for Thiol, But Not ATP, Depletion in 95% O2-Mediated Injury of Preterm Pneumocytes in Vitro

1994 • 27 citations

Depletion of extracellular cysteine with hydroxocobalamin and ascorbate in experimental murine cancer chemotherapy.

1985 • 12 citations

An animal model of human acid sphingomyelinase deficiency (Niemannpick disease) and the study of its enzyme replacement

1987 • 6 citations