Sphingosine-1-phosphate: a platelet-activating sphingolipid released from agonist-stimulated human platelets

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

1959 • 47,127 citations

The role of protein kinase C in cell surface signal transduction and tumour promotion

1984 • 7,521 citations

Microdetermination of Phosphorus

1956 • 7,242 citations

Molecular mechanisms of platelet activation.

1989 • 903 citations

Bifunctional role of glycosphingolipids. Modulators for transmembrane signaling and mediators for cellular interactions.

1990 • 889 citations

Sphingosine-1-phosphate as second messenger in cell proliferation induced by PDGF and FCS mitogens

1993 • 879 citations

Lysophosphatidate-induced cell proliferation: Identification and dissection of signaling pathways mediated by G proteins

1989 • 846 citations

The bioactive phospholipid lysophosphatidic acid is released from activated platelets

1993 • 653 citations

Sphingosine-1-phosphate, a novel lipid, involved in cellular proliferation.

1991 • 627 citations

Cytochalasin D inhibits actin polymerization and induces depolymerization of actin filaments formed during platelet shape change

1981 • 460 citations

Sphingolipid breakdown products: anti-proliferative and tumor-suppressor lipids

1993 • 281 citations

Sphingosine-1-phosphate, a putative second messenger, mobilizes calcium from internal stores via an inositol trisphosphate-independent pathway.

1994 • 273 citations

Effect of chemically well-defined sphingosine and its N-methyl derivatives on protein kinase C and src kinase activities

1989 • 259 citations

Sphingosine 1-phosphate generated in the endoplasmic reticulum membrane activates release of stored calcium.

1994 • 253 citations

Sphingosine 1-phosphate, a specific endogenous signaling molecule controlling cell motility and tumor cell invasiveness.

1992 • 223 citations

The action of the protein kinase C inhibitor, staurosporine, on human platelets. Evidence against a regulatory role for protein kinase C in the formation of inositol trisphosphate by thrombin

1988 • 218 citations

Identification of a putative membrane receptor for the bioactive phospholipid, lysophosphatidic acid.

1992 • 199 citations

Inhibition of sphingosine kinase in vitro and in platelets. Implications for signal transduction pathways.

1992 • 193 citations

Increased platelet deposition on atherosclerotic coronary arteries.

1994 • 175 citations

Sphingosine-1-phosphate, a metabolite of sphingosine, increases phosphatidic acid levels by phospholipase D activation

1992 • 154 citations

Acetylation of the NH2-terminal serine of prostaglandin synthetase by aspirin.

1978 • 148 citations

Subcellular localization and membrane topology of sphingosine-1-phosphate lyase in rat liver

1991 • 142 citations

Gangliosides and glycosphingolipids as modulators of cell growth, adhesion, and transmembrane signaling.

1993 • 137 citations

Ceramide stimulates epidermal growth factor receptor phosphorylation in A431 human epidermoid carcinoma cells. Evidence that ceramide may mediate sphingosine action

1991 • 134 citations

Epinephrine potentiates human platelet activation but is not an aggregating agent

1988 • 132 citations

Receptors for ADP on human blood platelets

1994 • 130 citations

A specific enhancing effect of N,N-dimethylsphingosine on epidermal growth factor receptor autophosphorylation. Demonstration of its endogenous occurrence (and the virtual absence of unsubstituted sphingosine) in human epidermoid carcinoma A431 cells.

1990 • 115 citations

Responses to sphingosine-1-phosphate in X. laevis oocytes: similarities with lysophosphatidic acid signaling

1993 • 94 citations

A ceramide analog inhibits T cell proliferative response through inhibition of glycosphingolipid synthesis and enhancement of N,N-dimethylsphingosine synthesis

1990 • 92 citations

Possible Involvement of Cytoskeleton in Collagen-stimulated Activation of Phospholipases in Human Platelets

1989 • 87 citations

Are lysophosphatidic acids or phosphatidic acids involved in stimulus activation coupling in platelets?

1982 • 84 citations

[10] Platelet aggregation measured photometric method

1989 • 82 citations

Differential energy requirements for platelet responses. A simultaneous study of aggregation, three secretory processes, arachidonate liberation, phosphatidylinositol breakdown and phosphatidate production

1982 • 81 citations

Sphingosine-1-Phosphate Lyase 1

2020 • 80 citations

Sphingosine-mediated phosphatidylinositol metabolism and calcium mobilization.

1994 • 77 citations

Decanoyl lysophosphatidic acid induces platelet aggregation through an extracellular action. Evidence against a second messenger role for lysophosphatidic acid

1985 • 76 citations

Enzymatic synthesis of N,N-dimethyl-sphingosine: Demonstration of the sphingosine: N-methyltransferase in mouse brain

1989 • 73 citations

Sphinganine 1-phosphate metabolism in cultured skin fibroblasts: evidence for the existence of a sphingosine phosphatase

1994 • 68 citations

Platelet activation detected by turbidometric shape-change analysis. Differential influence of cytochalasin B and prostaglandin E1

1978 • 66 citations

Sphingosine Kinase in Blood Platelets

1973 • 66 citations

Identification and characterization of a lysophosphatidic acid receptor.

1994 • 64 citations

Properties and Specificities of Sphingosine Kinase from Blood Platelets

1973 • 58 citations

Metabolism of Sphingosine Bases, XIII. Enzymatic Synthesis of 1-Phosphate Esters of 4t-Sphingenine (Sphingosine), Sphinganine (Dihydrosphingosine), 4-Hydroxysphinganine (Phytosphingosine) and 3-Dehydrosphinganine by Erythrocytes

1970 • 57 citations

A facile enzymatic synthesis of sphingosine-1-phosphate and dihydrosphingosine-1-phosphate.

1989 • 55 citations

Suppression by wortmannin of platelet responses to stimuli due to inhibition of pleckstrin phosphorylation

1992 • 51 citations

Short chain ceramides as substrates for glucocerebroside synthetase. Differences between liver and brain enzymes

1979 • 50 citations

Quantification of energy consumption in platelets during thrombin-induced aggregation and secretion. Tight coupling between platelet responses and the increment in energy consumption

1984 • 47 citations

Sphingosine kinase: properties and cellular functions.

1993 • 46 citations

Effect of sphingosine and its N-methyl derivatives on oxidative burst, phagokinetic activity, and trans-endothelial migration of human neutrophils

1992 • 35 citations

Sphingomyelin synthesis is involved in adherence during macrophage differentiation of HL-60 cells

1991 • 33 citations

Multiple Signal-Transduction Pathways Synergize in Platelet Activation

1991 • 31 citations

Sphingosine‐1‐phosphate inhibits extracellular matrix protein‐induced haptotactic motility but not adhesion of B16 mouse melanoma cells

1994 • 28 citations

Quantification of Free Sphingosine in Cultured Cells by Acylation with Radioactive Acetic Anhydride

1994 • 26 citations

Use of <scp>d</scp>-erythro-sphingosine as a pharmacological inhibitor of protein kinase C in human platelets

1991 • 26 citations

Platelet membrane glycoprotein IIb-IIIa complex: Purification, characterization, and reconstitution into phospholipid vesicles

1992 • 22 citations

Synthesis of phosphatidylinositol 3,4-bisphosphate is regulated by protein-tyrosine phosphorylation but the p85α subunit of phosphatidylinositol 3-kinase may not be a target for tyrosine kinases in thrombin-stimulated human platelets

1994 • 15 citations