C2-ceramide primes specifically for the superoxide anion production induced by N-formylmethionylleucyl phenylalanine (fMLP) in human neutrophils

Calcium homeostasis in intact lymphocytes: cytoplasmic free calcium monitored with a new, intracellularly trapped fluorescent indicator.

1982 • 2,255 citations

Programmed Cell Death Induced by Ceramide

1993 • 1,779 citations

Signaling through phosphatidylcholine breakdown.

1990 • 1,362 citations

The sphingomyelin cycle and the second messenger function of ceramide.

1994 • 1,255 citations

The sphingomyelin pathway in tumor necrosis factor and interleukin-1 signaling

1994 • 934 citations

Laboratory Manual of Neutrophil Function

1986 • 443 citations

Lipid second messengers

1994 • 357 citations

Unsaturated fatty acids stimulate NADPH-dependent superoxide production by cell-free system derived from macrophages

1984 • 335 citations

Activation of the respiratory burst enzyme from human neutrophils in a cell-free system. Evidence for a soluble cofactor.

1985 • 334 citations

Activation of human neutrophil nicotinamide adenine dinucleotide phosphate, reduced (triphosphopyridine nucleotide, reduced) oxidase by arachidonic acid in a cell-free system.

1985 • 315 citations

Sphingolipid breakdown products: anti-proliferative and tumor-suppressor lipids

1993 • 281 citations

Interleukin-1-mediated PGE2 production and sphingomyelin metabolism. Evidence for the regulation of cyclooxygenase gene expression by sphingosine and ceramide.

1992 • 272 citations

Sphingomyelinase and ceramide activate mitogen-activated protein kinase in myeloid HL-60 cells

1993 • 262 citations

Neutrophil signal transduction and activation of the respiratory burst

1993 • 262 citations

Phorbol esters inhibit the fMet-Leu-Phe- and leukotriene B4-stimulated calcium mobilization and enzyme secretion in rabbit neutrophils.

1985 • 196 citations

Cell-permeable ceramides inhibit the stimulation of DNA synthesis and phospholipase D activity by phosphatidate and lysophosphatidate in rat fibroblasts.

1994 • 188 citations

Evidence That Ceramide Selectively Inhibits Protein Kinase C-α Translocation and Modulates Bradykinin Activation of Phospholipase D

1995 • 139 citations

Sphingomyelinase and cell-permeable ceramide analogs stimulate cellular proliferation in quiescent Swiss 3T3 fibroblasts.

1992 • 128 citations

Lipopolysaccharides prime whole human blood and isolated neutrophils for the increased synthesis of 5-lipoxygenase products by enhancing arachidonic acid availability: involvement of the CD14 antigen.

1993 • 101 citations

The immediate activator of the NADPH oxidase is arachidonate not phosphorylation

1993 • 82 citations

Involvement of a phospholipase D in the mechanism of action of granulocyte-macrophage colony-stimulating factor (GM-CSF): priming of human neutrophils in vitro with GM-CSF is associated with accumulation of phosphatidic acid and diradylglycerol.

1990 • 78 citations

Ceramide regulates oxidant release in adherent human neutrophils

1994 • 77 citations

N-Acetylsphingosine (C2--ceramide) Inhibited Neutrophil Superoxide Formation and Calcium Influx

1995 • 68 citations

Inhibition of neural phospholipase D activity by aminoglycoside antibiotics

1991 • 52 citations

Vasopressin-induced polyphosphoinositide and phosphatidylcholine degradation in fibroblasts. Temporal relationship for formation of phospholipase C and phospholipase D hydrolysis products.

1990 • 51 citations

Granulocyte-macrophage colony-stimulating factor primes phospholipase D activity in human nerutrophils in vitro: Role of calcium, G-proteins and tyrosine kinases

1992 • 46 citations

Ceramide: A New Lipid “Second Messenger”?

2009 • 39 citations

Ceramide does not mediate the effect of tumour necrosis factor α on superoxide generation in human neutrophils

1994 • 34 citations

Kinetics of 5-lipoxygenase activation, arachidonic acid release, and leukotriene synthesis in human neutrophils: Effects of granulocyte-macrophage colony-stimulating factor

1994 • 27 citations

Rapid priming of calcium mobilization and superoxide anion production in human neutrophils by substimulatory concentrations of phorbol esters: A novel role for protein kinase C and tyrosine phosphorylation in the up-modulation of signal transduction

1992 • 22 citations

Evaluation of synthetic sphingosine, lysosphingolipids and glycosphingolipids as inhibitors of functional responses of human neutrophils

1990 • 17 citations