zeta PKC induces phosphorylation and inactivation of I kappa B-alpha in vitro.

Intracellular Signaling by Hydrolysis of Phospholipids and Activation of Protein Kinase C

1992 • 4,480 citations

IκB: a Specific Inhibitor of the NF-κB Transcription Factor

1988 • 2,203 citations

The mitogen-activated protein kinase signal transduction pathway

1993 • 2,174 citations

NF-κB: A pleiotropic mediator of inducible and tissue-specific gene control

1989 • 1,622 citations

Raf-1 activates MAP kinase-kinase

1992 • 1,308 citations

Activation in vitro of NF-κB" by phosphorylation of its inhibitor IκB"

1990 • 1,202 citations

Activation of DNA-binding activity in an apparently cytoplasmic precursor of the NF-κB transcription factor

1988 • 1,200 citations

A Divergence in the MAP Kinase Regulatory Network Defined by MEK Kinase and Raf

1993 • 1,086 citations

TNF activates NF-κB by phosphatidylcholine-specific phospholipase C-induced “Acidic” sphingomyelin breakdown

1992 • 1,058 citations

Tumor necrosis factor and interleukin-1 lead to phosphorylation and loss of I kappa B alpha: a mechanism for NF-kappa B activation.

1993 • 1,047 citations

The Primary Structure of MEK, a Protein Kinase that Phosphorylates the ERK Gene Product

1992 • 931 citations

Activation of the MAP kinase pathway by the protein kinase raf

1992 • 816 citations

Activation of Mitogen-Activated Protein Kinase Kinase by v-Raf in NIH 3T3 Cells and in Vitro

1992 • 691 citations

NF-kappa B activation by ultraviolet light not dependent on a nuclear signal

1993 • 646 citations

Mutual regulation of the transcriptional activator NF-kappa B and its inhibitor, I kappa B-alpha.

1993 • 639 citations

A sensitive method for detection of calmodulin-dependent protein kinase II activity in sodium dodecyl sulfate-polyacrylamide gel

1989 • 466 citations

Mos stimulates MAP kinase in Xenopus oocytes and activates a MAP kinase kinase in vitro.

1993 • 420 citations

In Vitro Activation and Nuclear Translocation of NF-κB Catalyzed by Cyclic AMP-Dependent Protein Kinase and Protein Kinase C

1989 • 389 citations

Protein kinase C ζ isoform is critical for mitogenic signal transduction

1993 • 383 citations

Antisense inhibition of the p65 subunit of NF-kappa B blocks tumorigenicity and causes tumor regression.

1993 • 268 citations

A Dominant Negative Protein Kinase C ζ Subspecies Blocks NF-κ B Activation

1993 • 223 citations

Tumor Necrosis Factor and Interleukin-1 Lead to Phosphorylation and Loss of IκBα: a Mechanism for NF-κB Activation

1993 • 223 citations

Raf-1 protein kinase activates the NF-kappa B transcription factor by dissociating the cytoplasmic NF-kappa B-I kappa B complex.

1993 • 209 citations

Protein kinase C-independent activation of nuclear factor kappa B by tumor necrosis factor.

1990 • 193 citations

Kappa B site-dependent induction of gene expression by diverse inducers of nuclear factor kappa B requires Raf-1.

1993 • 189 citations

Induction of NF-kappa B DNA-binding activity during the G0-to-G1 transition in mouse fibroblasts.

1991 • 167 citations

Phospholipase C-mediated hydrolysis of phosphatidlycholine is an important step in PDGF-stimulated DNA synthesis

1990 • 163 citations

Evidence for a Role of Protein Kinase C ζ Subspecies in Maturation of Xenopus laevis Oocytes

1992 • 162 citations

Identification and characterization of a new mammalian mitogen-activated protein kinase kinase, MKK2.

1993 • 152 citations

Both p21ras and pp60v-src are required, but neither alone is sufficient, to activate the Raf-1 kinase.

1992 • 142 citations

Hydrolysis of phosphatidylcholine couples Ras to activation of Raf protein kinase during mitogenic signal transduction.

1993 • 135 citations

Oncogenic ras triggers the activation of 42-kDa mitogen-activated protein kinase in extracts of quiescent Xenopus oocytes.

1992 • 134 citations

Inhibition of Protein Kinase C ζ Subspecies Blocks the Activation of an NF-Kappa B-Like Activity in Xenopus laevis Oocytes

1993 • 131 citations

Raf-1 protein kinase is important for progesterone-induced Xenopus oocyte maturation and acts downstream of mos.

1993 • 120 citations

Mitogen regulation of c-Raf-1 protein kinase activity toward mitogen-activated protein kinase-kinase

1993 • 116 citations

Phosphatidylcholine hydrolysis activates NF-kappa B and increases human immunodeficiency virus replication in human monocytes and T lymphocytes

1993 • 103 citations

Mos Stimulates MAP Kinase in Xenopus Oocytes and Activates a MAP Kinase Kinase In Vitro

1993 • 82 citations

Requirement of phospholipase C-catalyzed hydrolysis of phosphatidylcholine for maturation of Xenopus laevis oocytes in response to insulin and ras p21.

1991 • 64 citations

NF-kappa B-dependent induction of the NF-kappa B p50 subunit gene promoter underlies self-perpetuation of human immunodeficiency virus transcription in monocytic cells.

1992 • 60 citations

Hydrolysis of Phosphatidylcholine Is Stimulated by Ras Proteins during Mitogenic Signal Transduction

1992 • 59 citations

The regulatory domain of protein kinase C-ε restricts the catalytic-domain-specificity

1991 • 53 citations

Identification and Characterization of a New Mammalian Mitogen-Activated Protein Kinase Kinase, MKK2

1993 • 38 citations

Induction of NF-κB DNA-Binding Activity during the G₀-to-G₁ Transition in Mouse Fibroblasts

1991 • 38 citations

Oncogene activation of HIV-LTR-driven expression via the NF-ϰB binding sites

1993 • 33 citations

Hydrolysis of Phosphatidylcholine Couples Ras to Activation of Raf Protein Kinase During Mitogenic Signal Transduction

1993 • 28 citations

Raf-1 Protein Kinase Is Important for Progesterone-Induced Xenopus Oocyte Maturation and Acts Downstream of mos

1993 • 22 citations