Ceramide Generation by the Reaper Protein Is Not Blocked by the Caspase Inhibitor, p35

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Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis

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Functions of Ceramide in Coordinating Cellular Responses to Stress

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Protease activation during apoptosis: Death by a thousand cuts?

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Bcl-2 inhibits the mitochondrial release of an apoptogenic protease.

1996 • 1,143 citations

Expression of baculovirus P35 prevents cell death in Drosophila

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Genetic Control of Programmed Cell Death in Drosophila

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Ceramide synthase mediates daunorubicin-induced apoptosis: An alternative mechanism for generating death signals

1995 • 835 citations

Acid Sphingomyelinase–Deficient Human Lymphoblasts and Mice Are Defective in Radiation-Induced Apoptosis

1996 • 795 citations

The head involution defective gene of Drosophila melanogaster functions in programmed cell death.

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Inhibition of ICE Family Proteases by Baculovirus Antiapoptotic Protein p35

1995 • 645 citations

Caspases and caspase inhibitors

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Protein kinase C zeta isoform is critical for kappa B-dependent promoter activation by sphingomyelinase.

1994 • 473 citations

Inhibition of the Caenorhabditis elegans cell-death protease CED-3 by a CED-3 cleavage site in baculovirus p35 protein

1995 • 467 citations

Kinase Suppressor of Ras Is Ceramide-Activated Protein Kinase

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grim, a novel cell death gene in Drosophila.

1996 • 414 citations

Ceramide stimulates a cytosolic protein phosphatase.

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Cell Killing by the Drosophila Gene reaper

1996 • 375 citations

Fumonisin B1 inhibits sphingosine (sphinganine) N-acyltransferase and de novo sphingolipid biosynthesis in cultured neurons in situ.

1993 • 363 citations

Compartmentalized Production of Ceramide at the Cell Surface

1995 • 352 citations

The Caenorhabditis elegans cell-death protein CED-3 is a cysteine protease with substrate specificities similar to those of the human CPP32 protease.

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DCP-1, a Drosophila Cell Death Protease Essential for Development

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Fas- or Ceramide-induced Apoptosis Is Mediated by a Rac1-regulated Activation of Jun N-terminal Kinase/p38 Kinases and GADD153

1997 • 302 citations

Sphingomyelinase and ceramide activate mitogen-activated protein kinase in myeloid HL-60 cells

1993 • 262 citations

Requirement of an ICE-Like Protease for Induction of Apoptosis and Ceramide Generation by REAPER

1996 • 262 citations

Substrate and Inhibitor Specificity of Interleukin-1β-converting Enzyme and Related Caspases

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Sphingolipids Are Potential Heat Stress Signals inSaccharomyces

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Stress-induced apoptosis and the sphingomyelin pathway

1997 • 234 citations

Cytokine Response Modifier A (CrmA) Inhibits Ceramide Formation in Response to Tumor Necrosis Factor (TNF)-α: CrmA and Bcl-2 Target Distinct Components in the Apoptotic Pathway

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Renaturation and tumor necrosis factor-alpha stimulation of a 97-kDa ceramide-activated protein kinase.

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prICE: a downstream target for ceramide-induced apoptosis and for the inhibitory action of Bcl-2

1996 • 203 citations

Identification of a Drosophila melanogaster ICE/CED-3-related protease, drICE

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Activation of CPP32 during apoptosis of neurons and astrocytes

1997 • 154 citations

Ceramide-mediated growth inhibition and CAPP are conserved in Saccharomyces cerevisiae

1993 • 149 citations

drICE is an essential caspase required for apoptotic activity in Drosophila cells

1997 • 143 citations

Ceramide induces apoptosis via CPP32 activation

1996 • 133 citations

Ceramide and the induction of apoptosis.

1996 • 128 citations

Heteronuclear Ribonucleoproteins C1 and C2, Components of the Spliceosome, Are Specific Targets of Interleukin 1β-converting Enzyme-like Proteases in Apoptosis

1996 • 127 citations

Fas-induced apoptosis of T cells occurs independently of ceramide generation

1997 • 123 citations

CD95/Fas-induced Ceramide Formation Proceeds with Slow Kinetics and Is Not Blocked by Caspase-3/CPP32 Inhibition

1997 • 115 citations

Regulation of Lipid Biosynthesis in Saccharomyces cerevisiae by Fumonisin B1

1995 • 111 citations

Activation of thereaperGene during Ectopic Cell Killing inDrosophila

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Induction of apoptotic cell death in hen granulosa cells by ceramide.

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Enzymatic quantification of sphingosine in the picomole range in cultured cells

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Sequential Operation of Ceramide Synthesis and ICE Cascade in CPT-11-Initiated Apoptotic Death Signaling

1997 • 74 citations

Ceramides induce a form of apoptosis in human acute lymphoblastic leukemia cells that is inhibited by Bcl‐2, but not by CrmA

1997 • 70 citations

Characterization of Reaper- and FADD-Induced Apoptosis in a Lepidopteran Cell Line

1997 • 69 citations

Apoptotic Activity of REAPER Is Distinct from Signaling by the Tumor Necrosis Factor Receptor 1 Death Domain

1996 • 48 citations

Temporal Phases in Apoptosis Defined by the Actions of Src Homology 2 Domains, Ceramide, Bcl-2, Interleukin-1β Converting Enzyme Family Proteases, and a Dense Membrane Fraction

1997 • 40 citations

Activation of distinct caspase-like proteases by Fas and reaper in Drosophila cells

1997 • 33 citations

Phospholipids of Semliki Forest virus grown in cultured mosquito cells

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Phospholipids inDrosophila heads: Effects of visual mutants and phototransduction manipulations

1993 • 15 citations