"Cross talk" between the bioactive glycerolipids and sphingolipids in signal transduction

Inositol trisphosphate and calcium signalling

1993 • 6,546 citations

IRS-1-Mediated Inhibition of Insulin Receptor Tyrosine Kinase Activity in TNF-α- and Obesity-Induced Insulin Resistance

1996 • 2,561 citations

Tumor Necrosis Factor α: A Key Component of the Obesity-Diabetes Link

1994 • 1,302 citations

The sphingomyelin cycle and the second messenger function of ceramide.

1994 • 1,255 citations

Tumor necrosis factor alpha inhibits signaling from the insulin receptor.

1994 • 1,173 citations

Inhibition by cAMP of Ras-Dependent Activation of Raf

1993 • 955 citations

The sphingomyelin pathway in tumor necrosis factor and interleukin-1 signaling

1994 • 934 citations

ADP-ribosylation factor, a small GTP-dependent regulatory protein, stimulates phospholipase D activity

1993 • 900 citations

Sphingosine-1-phosphate as second messenger in cell proliferation induced by PDGF and FCS mitogens

1993 • 879 citations

The regulation and cellular functions of phosphatidylcholine hydrolysis

1990 • 862 citations

Lysophosphatidate-induced cell proliferation: Identification and dissection of signaling pathways mediated by G proteins

1989 • 846 citations

The glyoxalase system: new developments towards functional characterization of a metabolic pathway fundamental to biological life

1990 • 792 citations

Phospholipase D: a Downstream Effector of ARF in Granulocytes

1994 • 636 citations

Lysophosphatidic Acid, a Multifunctional Phospholipid Messenger

1995 • 592 citations

Tumor necrosis factor-alpha suppresses insulin-induced tyrosine phosphorylation of insulin receptor and its substrates.

1993 • 543 citations

Secretory phospholipase A2 generates the novel lipid mediator lysophosphatidic acid in membrane microvesicles shed from activated cells

1995 • 523 citations

PKC zeta is a molecular switch in signal transduction of TNF-alpha, bifunctionally regulated by ceramide and arachidonic acid.

1995 • 506 citations

Protein kinase C zeta isoform is critical for kappa B-dependent promoter activation by sphingomyelinase.

1994 • 473 citations

Tumor Necrosis Factor α-induced Phosphorylation of Insulin Receptor Substrate-1 (IRS-1)

1995 • 426 citations

Tumor necrosis factor receptor-mediated signaling pathways.

1994 • 389 citations

Phosphatidic acid is a specific activator of phosphatidylinositol-4-phosphate kinase.

1992 • 368 citations

DNA Polymerase β Conducts the Gap-filling Step in Uracil-initiated Base Excision Repair in a Bovine Testis Nuclear Extract

1995 • 317 citations

Phosphatidic acid activation of protein kinase C-ζ overexpressed in COS cells: comparison with other protein kinase C isotypes and other acidic lipids

1994 • 308 citations

Modulation of protein kinase C and diverse cell functions by sphingosine — a pharmacologically interesting compound linking sphingolipids and signal transduction

1989 • 281 citations

Sphingosine-1-phosphate, a putative second messenger, mobilizes calcium from internal stores via an inositol trisphosphate-independent pathway.

1994 • 273 citations

Plasma membrane fractions from rat liver contain a phosphatidate phosphohydrolase distinct from that in the endoplasmic reticulum and cytosol.

1991 • 271 citations

Mitogenic action of lysophosphatidic acid and phosphatidic acid on fibroblasts. Dependence on acyl-chain length and inhibition by suramin

1992 • 266 citations

Activation of rat liver phospholipase D by the small GTP-binding protein RhoA

1994 • 265 citations

Neutrophil phospholipase D is activated by a membrane-associated Rho family small molecular weight GTP-binding protein.

1993 • 229 citations

Phosphatidic acid may stimulate membrane receptors mediating adenylate cyclase inhibition and phospholipid breakdown in 3T3 fibroblasts.

1987 • 219 citations

The role of sphingolipids in the process of signal transduction

1997 • 190 citations

Cell-permeable ceramides inhibit the stimulation of DNA synthesis and phospholipase D activity by phosphatidate and lysophosphatidate in rat fibroblasts.

1994 • 188 citations

The regulation of phospholipase C-gamma 1 by phosphatidic acid. Assessment of kinetic parameters.

1993 • 181 citations

Activation of actin polymerization by phosphatidic acid derived from phosphatidylcholine in IIC9 fibroblasts.

1993 • 175 citations

Antidiabetic thiazolidinediones block the inhibitory effect of tumor necrosis factor-alpha on differentiation, insulin-stimulated glucose uptake, and gene expression in 3T3-L1 cells.

1995 • 170 citations

cAMP abrogates the p21ras-mitogen-activated protein kinase pathway in fibroblasts.

1994 • 165 citations

Phosphatidic acid as a second messenger in human polymorphonuclear leukocytes. Effects on activation of NADPH oxidase.

1991 • 165 citations

Ceramide 1-phosphate, a novel phospholipid in human leukemia (HL-60) cells. Synthesis via ceramide from sphingomyelin.

1990 • 165 citations

Sphingosine-1-phosphate, a metabolite of sphingosine, increases phosphatidic acid levels by phospholipase D activation

1992 • 154 citations

A Cytoplasmic Protein Inhibits the GTPase Activity of H-Ras in a Phospholipid-Dependent Manner

1990 • 153 citations

Interaction of Ceramides, Sphingosine, and Sphingosine 1-Phosphate in Regulating DNA Synthesis and Phospholipase D Activity

1995 • 153 citations

Phosphatidic acid and not diacylglycerol generated by phospholipase D is functionally linked to the activation of the NADPH oxidase by FMLP in human neutrophils

1990 • 151 citations

Disruption of sphingolipid metabolism and stimulation of DNA synthesis by fumonisin B1. A molecular mechanism for carcinogenesis associated with Fusarium moniliforme.

1994 • 147 citations

Short-chain ceramide-1-phosphates are novel stimulators of DNA synthesis and cell division: antagonism by cell-permeable ceramides.

1995 • 145 citations

Phosphatidate Phosphohydrolase Catalyzes the Hydrolysis of Ceramide 1-Phosphate, Lysophosphatidate, and Sphingosine 1-Phosphate

1996 • 141 citations

Involvement of Glutamate 268 in the Active Site of Human Liver Mitochondrial (Class 2) Aldehyde Dehydrogenase As Probed by Site-Directed Mutagenesis

1995 • 138 citations

Activation of phospholipase D by sphingoid bases in NG108-15 neural-derived cells.

1990 • 134 citations

Different effects of sphingosine, R59022 and anionic amphiphiles on two diacylglycerol kinase isozymes purified from porcine thymus cytosol

1989 • 123 citations

Phosphatidate phosphohydrolase and signal transduction

1996 • 119 citations

Tumor Necrosis Factor Promotes Phosphorylation and Binding of Insulin Receptor Substrate 1 to Phosphatidylinositol 3-Kinase in 3T3-L1 Adipocytes

1996 • 117 citations

Cell-permeable Ceramides Prevent the Activation of Phospholipase D by ADP-ribosylation Factor and RhoA

1997 • 106 citations

ADP-ribosylation Factor Translocation Correlates with Potentiation of GTPγS-stimulated Phospholipase D Activity in Membrane Fractions of HL-60 Cells

1995 • 95 citations

Sphingosine 1-phosphate, a novel signaling molecule, stimulates DNA binding activity of AP-1 in quiescent Swiss 3T3 fibroblasts.

1994 • 86 citations

Detection and characterization of ceramide-1-phosphate phosphatase activity in rat liver plasma membrane.

1993 • 78 citations

Sphingosine-mediated phosphatidylinositol metabolism and calcium mobilization.

1994 • 77 citations

Purification and Characterization of a Novel Plasma Membrane Phosphatidate Phosphohydrolase from Rat Liver

1995 • 70 citations

Effects of sphingosine, albumin and unsaturated fatty acids on the activation and translocation of phosphatidate phosphohydrolases in rat hepatocytes

1992 • 69 citations

Insulin and dexamethasone regulate insulin receptors, insulin receptor substrate-1, and phosphatidylinositol 3-kinase in Fao hepatoma cells.

1995 • 49 citations

The role of sphingosine in cell growth regulation and transmembrane signaling.

1993 • 44 citations

Hepatic monoacylglycerol acyltransferase is regulated by sn-1,2-diacylglycerol and by specific lipids in Triton X-100/phospholipid-mixed micelles.

1994 • 35 citations

Sphingosine Inhibits Rat Hepatic Monoacylglycerol Acyltransferase in Triton X-100 Mixed Micelles and Isolated Hepatocytes

1995 • 16 citations