Ceramides perturb the structure of phosphatidylcholine bilayers and modulate the activity of phospholipase A 2

Quadrupolar echo deuteron magnetic resonance spectroscopy in ordered hydrocarbon chains

1976 • 1,301 citations

The sphingomyelin cycle and the second messenger function of ceramide.

1994 • 1,255 citations

Human stratum corneum lipids: characterization and regional variations

1983 • 664 citations

Ceramide activates heterotrimeric protein phosphatase 2A

1993 • 657 citations

Identification of sphingomyelin turnover as an effector mechanism for the action of tumor necrosis factor alpha and gamma-interferon. Specific role in cell differentiation.

1991 • 621 citations

The concept of lipid domains in membranes.

1982 • 466 citations

Activation of the Sphingomyelin Signaling Pathway in Intact EL4 Cells and in a Cell-Free System By IL-1β

1993 • 433 citations

Solute distributions and trapping efficiencies observed in freeze-thawed multilamellar vesicles

1985 • 429 citations

Characterization of a ceramide-activated protein kinase: stimulation by tumor necrosis factor alpha.

1991 • 376 citations

Phosphorylation of Raf by ceramide-activated protein kinase

1995 • 332 citations

Role of ceramide-activated protein phosphatase in ceramide-mediated signal transduction.

1994 • 288 citations

Lipid composition and metabolism in normal and diseased epidermis

1981 • 261 citations

Micrometer-scale domains in fibroblast plasma membranes.

1987 • 236 citations

Deuteron Quadrupole Coupling Constants in Three Solid Deuterated Paraffin Hydrocarbons: C2D6, C4D10, C6D14

1971 • 234 citations

Ceramide: A stress signal and mediator of growth suppression and apoptosis

1995 • 233 citations

Solute partitioning into lipid bilayer membranes

1988 • 223 citations

The role of diacylglycerol and ceramide in tumor necrosis factor and interleukin-1 signal transduction

1994 • 207 citations

A Mediator Role of Ceramide in the Regulation of Neuroblastoma Neuro2a Cell Differentiation

1995 • 165 citations

Characterization of a ceramide kinase activity from human leukemia (HL-60) cells. Separation from diacylglycerol kinase activity.

1990 • 131 citations

Ceramide Inhibits Phospholipase D in a Cell-free System

1996 • 129 citations

Modulation of the orientational order profile of the lipid acyl chain in the L? phase

1990 • 123 citations

The Sphingomyelin-Ceramide Signaling Pathway Is Involved in Oxidized Low Density Lipoprotein-induced Cell Proliferation

1996 • 119 citations

Ceramide Induces Structural Defects into Phosphatidylcholine Bilayers and Activates Phospholipase A2

1996 • 113 citations

Cell-permeable Ceramides Prevent the Activation of Phospholipase D by ADP-ribosylation Factor and RhoA

1997 • 106 citations

The spontaneous incorporation of proteins into preformed bilayers

1987 • 102 citations

Sphingomyelinase activates proteolytic I kappa B-alpha degradation in a cell-free system.

1994 • 100 citations

Conformational changes in oxidized phospholipids and their preferential hydrolysis by phospholipase A2: A monolayer study

1993 • 98 citations

Ceramide-activated protein phosphatase: partial purification and relationship to protein phosphatase 2A.

1993 • 93 citations

Lipid Regulation of CTP:Phosphocholine Cytidylyltransferase: Electrostatic, Hydrophobic, and Synergistic Interactions of Anionic Phospholipids and Diacylglycerol

1996 • 86 citations

Binding of phospholipase A2 to zwitterionic bilayers is promoted by lateral segregation of anionic amphiphiles

1989 • 85 citations

Hydrolysis of phosphatidylcholine in phosphatidylcholine-cholate mixtures by porcine pancreatic phospholipase A2.

1988 • 85 citations

Evidence for the release of arachidonic acid through the selective action of phospholipase A2 in thrombin-stimulated human platelets

1987 • 59 citations

Identification of domains of phosphatidylcholine in human erythrocyte plasma membranes. Differential action of acidic and basic phospholipases A2 from Agkistrodon halys blomhoffii.

1982 • 58 citations

Causes of nondiffusing lipid in the plasma membrane of mammalian spermatozoa

1988 • 55 citations

Differential scanning calorimetry and deuterium NMR studies of the phase behavior of gramicidin-phosphatidylcholine mixtures

1988 • 49 citations

Lipid Domains in Plasma Membrances from Rat Liver

1983 • 47 citations

Interactions of saturated diacylglycerols with phosphatidylcholine bilayers: a deuterium NMR study

1992 • 44 citations

Effects of dipalmitoylglycerol and fatty acids on membrane structure and protein kinase C activity

1997 • 42 citations

Ethanol-induced modifications to membrane lipid structure: Effect on phospholipase A2-membrane interactions

1988 • 42 citations

Effect of diacylglycerols on the activity of cobra venom, bee venom, and pig pancreatic phospholipases A2

1992 • 41 citations

Lateral heterogeneity in human platelet plasma membrane and lipids from the time-resolved fluorescence of trans-parinaric acid

1991 • 31 citations

Permissive effect of ceramide on growth factor-induced cell proliferation

1995 • 31 citations

Effects of Temperature and Glycerides on the Enhancement of Agkistrodon piscivorus piscivorus Phospholipase A2 Activity by Lysolecithin and Palmitic Acid

1995 • 24 citations

Chapter 7 Membrane Properties and the Activation of Protein Kinase C and Phospholipase A2

1997 • 24 citations

Intramolecular excimer kinetics of fluorescent dipyrenyl lipids: 2. DOPE/DOPC membranes

1994 • 13 citations

Different susceptibilities of platelet phospholipids to various phospholipases and modifications induced by thrombin. Possible evidence of rearrangement of lipid domains

1987 • 9 citations