Phosphorylated cis-4-Methylsphingosine Mimics the Mitogenic Effect of Sphingosine-1-phosphate in Swiss 3T3 Fibroblasts

Functions of Ceramide in Coordinating Cellular Responses to Stress

1996 • 1,620 citations

Sphingosine-1-Phosphate as a Ligand for the G Protein-Coupled Receptor EDG-1

1998 • 1,003 citations

Sphingosine-1-phosphate as second messenger in cell proliferation induced by PDGF and FCS mitogens

1993 • 879 citations

Sphingolipid metabolism and cell growth regulation

1996 • 709 citations

Sphingolipids—The Enigmatic Lipid Class: Biochemistry, Physiology, and Pathophysiology

1997 • 640 citations

Sphingosine-1-phosphate, a novel lipid, involved in cellular proliferation.

1991 • 627 citations

Signal transduction through lipid second messengers

1996 • 496 citations

Intracellular Calcium Release Mediated by Sphingosine Derivatives Generated in Cells

1990 • 391 citations

Sphingosine-1-phosphate, a putative second messenger, mobilizes calcium from internal stores via an inositol trisphosphate-independent pathway.

1994 • 273 citations

Sphingosine 1-phosphate signalling through the G-protein-coupled receptor Edg-1

1998 • 252 citations

Identification of cDNAs encoding two G protein‐coupled receptors for lysosphingolipids¹

1997 • 247 citations

Sphingosine stimulates cellular proliferation via a protein kinase C-independent pathway.

1990 • 230 citations

Activation of a High Affinity Gi Protein-coupled Plasma Membrane Receptor by Sphingosine-1-phosphate

1996 • 197 citations

Inhibition of sphingosine kinase in vitro and in platelets. Implications for signal transduction pathways.

1992 • 193 citations

Sphingosine 1-Phosphate Rapidly Activates the Mitogen-activated Protein Kinase Pathway by a G Protein-dependent Mechanism

1995 • 180 citations

Sphingosine-1-phosphate, a metabolite of sphingosine, increases phosphatidic acid levels by phospholipase D activation

1992 • 154 citations

Quantitative Measurement of Sphingosine 1-Phosphate in Biological Samples by Acylation with Radioactive Acetic Anhydride

1995 • 118 citations

Sphingosine 1-phosphate, a novel signaling molecule, stimulates DNA binding activity of AP-1 in quiescent Swiss 3T3 fibroblasts.

1994 • 86 citations

cis-4-Methylsphingosine Decreases Sphingolipid Biosynthesis by Specifically Interfering with Serine Palmitoyltransferase Activity in Primary Cultured Neurons

1997 • 76 citations

Stereospecificity of sphingosine-induced intracellular calcium mobilization and cellular proliferation.

1994 • 76 citations

Stereospecificities in the Metabolic Reactions of the four Isomeric Sphinganines (Dihydrosphingosines) in Rat Liver

1973 • 61 citations

Mitogenesis of 3T3 fibroblasts induced by endogenous ganglioside is not mediated by cAMP, protein kinase C, or phosphoinositides turnover

1988 • 59 citations

Calcium signalling by G protein-coupled sphingolipid receptors in bovine aortic endothelial cells

1996 • 58 citations

Metabolism of Sphingosine Bases, XV. Enzymatic Degradation of 4t-Sphingenine 1-phosphate (Sphingosine 1-phosphate) to 2t-Hexadecen-1-al and Ethanolamine phosphate

1970 • 56 citations

Sphingolipid-gated Ca2+ Release from Intracellular Stores of Endothelial Cells Is Mediated by a Novel Ca2+-permeable Channel

1995 • 41 citations

Induction of Apoptosis by Sphingosine-1-Phosphate in Human Hepatoma Cells Is Associated with Enhanced Expression of bax Gene Product

1996 • 38 citations

Involvement of sphingolipids metabolites in cellular proliferation modulated by ganglioside GM1

1996 • 30 citations