Granulocyte-Macrophage Colony-Stimulating Factor Rescues TF-1 Leukemia Cells From Ionizing Radiation-Induced Apoptosis Through a Pathway Mediated by Protein Kinase Cα

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

1959 • 47,127 citations

Studies and Perspectives of Protein Kinase C

1986 • 5,148 citations

Selective inhibition of protein kinase C isozymes by the indolocarbazole Gö 6976

1993 • 1,589 citations

Protein kinase C - a question of specificity

1994 • 958 citations

Ionizing radiation acts on cellular membranes to generate ceramide and initiate apoptosis.

1994 • 890 citations

The Complete Primary Structure of Protein Kinase C—the Major Phorbol Ester Receptor

1986 • 878 citations

Proteolytic activation of protein kinase C delta by an ICE-like protease in apoptotic cells.

1995 • 684 citations

Overexpression of protein kinase C-delta and -epsilon in NIH 3T3 cells induces opposite effects on growth, morphology, anchorage dependence, and tumorigenicity.

1993 • 546 citations

Signal transduction from membrane to cytoplasm: growth factors and membrane-bound oncogene products increase Raf-1 phosphorylation and associated protein kinase activity.

1988 • 458 citations

Chromatin condensation during apoptosis is accompanied by degradation of lamin A+B, without enhanced activation of cdc2 kinase.

1994 • 345 citations

The origins of human cancer: molecular mechanisms of carcinogenesis and their implications for cancer prevention and treatment--twenty-seventh G.H.A. Clowes memorial award lecture.

1988 • 326 citations

Cell division arrest induced by phorbol ester in CHO cells overexpressing protein kinase C-delta subspecies.

1992 • 300 citations

Protein kinase C mediates x-ray inducibility of nuclear signal transducers EGR1 and JUN.

1991 • 277 citations

The role of protein kinase C isoenzymes in the regulation of cell proliferation and differentiation

1992 • 265 citations

Protein kinase C mediates basic fibroblast growth factor protection of endothelial cells against radiation-induced apoptosis.

1994 • 255 citations

Phorbol ester-induced myeloid differentiation is mediated by protein kinase C-alpha and -delta and not by protein kinase C-beta II, -epsilon, -zeta, and -eta.

1993 • 251 citations

Ceramide Inactivates Cellular Protein Kinase Cα

1996 • 251 citations

X-irradiation, phorbol esters, and H2O2 stimulate mitogen-activated protein kinase activity in NIH-3T3 cells through the formation of reactive oxygen intermediates.

1994 • 247 citations

Interleukin-3 and bryostatin-1 mediate hyperphosphorylation of BCL2 alpha in association with suppression of apoptosis.

1994 • 222 citations

Type 3 protein kinase C localization to the nuclear envelope of phorbol ester-treated NIH 3T3 cells.

1989 • 221 citations

Regulation of the Sequence-specific DNA Binding Function of p53 by Protein Kinase C and Protein Phosphatases

1995 • 199 citations

Ceramide-induced Translocation of Protein Kinase C-δ and -ϵ to the Cytosol

1997 • 178 citations

Expression of protein kinase C genes in hemopoietic cells is cell-type- and B cell-differentiation stage specific.

1991 • 142 citations

Evidence That Ceramide Selectively Inhibits Protein Kinase C-α Translocation and Modulates Bradykinin Activation of Phospholipase D

1995 • 139 citations

Direction of p21ras-generated signals towards cell growth or apoptosis is determined by protein kinase C and Bcl-2.

1995 • 133 citations

Biology of the protein kinase C family

1989 • 120 citations

Cell-permeable Ceramides Prevent the Activation of Phospholipase D by ADP-ribosylation Factor and RhoA

1997 • 106 citations

Inhibition of Protein Kinases Sensitizes Human Tumor Cells to Ionizing Radiation

1992 • 91 citations

Human interleukin-3 receptor modulates bcl-2 mRNA and protein levels through protein kinase C in TF-1 cells

1995 • 77 citations

Correlation of Tumor Sensitivity to Low-Dose-Rate Irradiation with G 2 /M-Phase Block and Other Radiobiological Parameters

1993 • 74 citations

Differential Expression and Subcellular Localization of Protein Kinase C α, β, γ, δ, and ɛ Isoforms in SH‐SY5Y Neuroblastoma Cells: Modifications During Differentiation

1993 • 68 citations

Cell type-specific expression of the genes for the protein kinase C family: Down regulation of mRNAs for PKCα and nPKCε upon in vitro differentiation of a mouse neuroblastoma cell line Neuro 2a

1989 • 62 citations

PKC.epsilon. is involved in granulocyte-macrophage colony-stimulating factor signal transduction: Evidence from microphysiometry and antisense oligonucleotide experiments

1992 • 61 citations

Radiation signaling mediated by Jun activation following dissociation from a cell type-specific repressor.

1993 • 59 citations

Involvement of protein kinase C-_ɛ in glucocorticoid-induced apoptosis in thymocytes

1994 • 57 citations

The role of protein kinase C in insulin action

1992 • 53 citations

Role of Protein Kinase-C in Thymocyte Apoptosis Induced by Irradiation

1992 • 52 citations

Overexpressed protein kinase C-delta and -epsilon subtypes in NIH 3T3 cells exhibit differential subcellular localization and differential regulation of sodium-dependent phosphate uptake.

1994 • 50 citations

Antisense oligodeoxynucleotide inhibition of δ protein kinase C expression accelerates induced differentiation of murine erythroleukaemia cells

1995 • 46 citations

Nuclear protein synthesis and phosphorylation in Friend erythroleukemia cells stimulated with DMSO

1978 • 35 citations

Persistent, membrane-associated protein kinase C: From model membranes to synaptic long-term potentiation

1993 • 34 citations

Morphological Differentiation of N1E-115 Neuroblastoma Cells by Dimethyl Sulfoxide Activation of Lipid Second Messengers

1996 • 31 citations

Mechanism of Apoptosis Suppression by Phorbol Ester in IL-6-Starved Murine Plasmacytomas: Role of PKC Modulation and Cell Cycle

1996 • 31 citations

PKC Activity in Rat C6 Glioma Cells: Changes Associated with Cell Cycle and Simvastatin Treatment

1994 • 29 citations

Transmembrane signalling by interferon-α

1991 • 28 citations

Characterization and Distribution of Protein Kinase C Isoforms in Human Skin Fibroblasts

1994 • 27 citations

The role of protein kinase C in myeloid cell apoptosis

1994 • 25 citations

The Expression and Possible Roles of Protein Kinase C in Haematopoietic Cells

1992 • 23 citations

Phorbol Esters Can Protect Mouse Pre-T Cell Lines from Radiation-induced Rapid Interphase Apoptosis

1994 • 21 citations

The macrocyclic lactone protein kinase C activator, bryostatin 1, either alone, or in conjunction with recombinant murine granulocyte- macrophage colony-stimulating factor, protects Balb/c and C3H/HeN mice from the lethal in vivo effects of ionizing radiation

1994 • 21 citations

Human IL-3 receptor signaling: rapid induction of phosphatidylcholine hydrolysis is independent of protein kinase C but dependent on tyrosine phosphorylation in transfected NIH 3T3 cells.

1995 • 20 citations

Expression and Modulation of Protein Kinase C Isoforms in Differentiation-Competent and Differentiation-Resistant Erythroleukemic Cells

1995 • 18 citations

Effect of bryostatin 1 on the in vitro radioprotective capacity of recombinant granulocyte-macrophage colony-stimulating factor (rGM-CSF) toward committed human myeloid progenitor cells (CFU-GM).

1992 • 14 citations

Radiosensitization and Inhibition of Deoxyribonucleic Acid Repair in Rat Glioma Cells by Long-Term Treatment with 12-O-Tetradecanoylphorbol 13-Acetate

1993 • 13 citations

Evidence for involvement of the protein kinase C pathway in the activation of p37v-mos protein kinase.

1990 • 13 citations

Changes of Protein Kinase C Subspecies in Staphylococcal Enterotoxin B-Induced Thymocyte Apoptosis

1995 • 11 citations

Effects of increased expression of protein kinase C on radiation-induced cell transformation

1994 • 11 citations

Decrease in Phorbol Ester Receptors in Human Brain Tumors

1990 • 11 citations

Protein kinase C isotypes required for phorbol-ester induction of stromelysin-1 in rat fibroblasts

1996 • 10 citations