Ca2+ Mobilizing Action of Sphingosine in Jurkat Human Leukemia T Cells

A new generation of Ca2+ indicators with greatly improved fluorescence properties.

1985 • 21,873 citations

A model for receptor-regulated calcium entry

1986 • 2,535 citations

The sphingomyelin cycle and the second messenger function of ceramide.

1994 • 1,255 citations

Functions of Sphingolipids and Sphingolipid Breakdown Products in Cellular Regulation

1989 • 1,251 citations

Emptying of intracellular Ca2+ stores releases a novel small messenger that stimulates Ca2+ influx

1993 • 892 citations

Activation of Calcium Entry by the Tumor Promoter Thapsigargin in Parotid Acinar Cells

1989 • 887 citations

Mitogen-regulated Ca2+ current of T lymphocytes is activated by depletion of intracellular Ca2+ stores.

1993 • 752 citations

Sphingosine-1-phosphate, a novel lipid, involved in cellular proliferation.

1991 • 627 citations

Identification of sphingomyelin turnover as an effector mechanism for the action of tumor necrosis factor alpha and gamma-interferon. Specific role in cell differentiation.

1991 • 621 citations

Lysosphingolipids Inhibit Protein Kinase C: Implications for the Sphingolipidoses

1987 • 593 citations

An update of the enzymology and regulation of sphingomyelin metabolism

1990 • 460 citations

Intracellular Calcium Release Mediated by Sphingosine Derivatives Generated in Cells

1990 • 391 citations

Sphingosine-1-phosphate, a putative second messenger, mobilizes calcium from internal stores via an inositol trisphosphate-independent pathway.

1994 • 273 citations

The calcium current activated by T cell receptor and store depletion in human lymphocytes is absent in a primary immunodeficiency.

1994 • 256 citations

Sphingosine 1-phosphate generated in the endoplasmic reticulum membrane activates release of stored calcium.

1994 • 253 citations

Structural requirements for long-chain (sphingoid) base inhibition of protein kinase C in vitro and for the cellular effects of these compounds

1989 • 247 citations

The antigen receptor on a human T cell line initiates activation by increasing cytoplasmic free calcium.

1985 • 223 citations

Porcine diacylglycerol kinase sequence has zinc finger and E–F hand motifs

1990 • 218 citations

Tumor necrosis factor-alpha (TNF-alpha) signal transduction through ceramide. Dissociation of growth inhibitory effects of TNF-alpha from activation of nuclear factor-kappa B.

1993 • 217 citations

Sphingosine inhibits calmodulin-dependent enzymes.

1988 • 215 citations

Subcellular patterns of calcium release determined by G protein-specific residues of muscarinic receptors

1991 • 207 citations

Inhibition of Na,K-ATPase and sodium pump by protein kinase C regulators sphingosine, lysophosphatidylcholine, and oleic acid.

1990 • 159 citations

Sphingosine-1-phosphate, a metabolite of sphingosine, increases phosphatidic acid levels by phospholipase D activation

1992 • 154 citations

Polyunsaturated free fatty acids stimulate an increase in cytosolic Ca2+ by mobilizing the inositol 1,4,5-trisphosphate-sensitive Ca2+ pool in T cells through a mechanism independent of phosphoinositide turnover.

1990 • 144 citations

Porcine 80-kDa diacylglycerol kinase is a calcium-binding and calcium/phospholipid-dependent enzyme and undergoes calcium-dependent translocation.

1991 • 131 citations

Different effects of sphingosine, R59022 and anionic amphiphiles on two diacylglycerol kinase isozymes purified from porcine thymus cytosol

1989 • 123 citations

The effects of sphingosine on sarcoplasmic reticulum membrane calcium release.

1992 • 109 citations

Signal transduction by T-cell receptors: mobilization of Ca and regulation of Ca-dependent effector molecules

1992 • 105 citations

Intracellular Ca2+ pools in Jurkat T-lymphocytes

1993 • 104 citations

Regulation of protein kinase C by sphingosine and lysosphingolipids

1989 • 101 citations

Sphingosine inhibits phosphatidate phosphohydrolase in human neutrophils by a protein kinase C-independent mechanism

1991 • 97 citations

The T-cell antigen receptor regulates sustained increases in cytoplasmic free Ca2+ through extracellular Ca2+ influx and ongoing intracellular Ca2+ mobilization

1987 • 87 citations

Inhibition of phosphatidic acid phosphohydrolase activity by sphingosine

1990 • 87 citations

Sphingosine activation of protein kinases in Jurkat T cells. In vitro phosphorylation of endogenous protein substrates and specificity of action.

1992 • 80 citations

Sphingosine-mediated phosphatidylinositol metabolism and calcium mobilization.

1994 • 77 citations

Activation of endothelial cell phospholipase D by sphingosine and sphingosine-1-phosphate.

1994 • 76 citations

Activation of casein kinase II by sphingosine.

1991 • 70 citations

Inhibition of the insulin receptor tyrosine kinase by sphingosine

1991 • 62 citations

Sphingosine metabolism induces Ca2+ oscillations in rat pancreatic acinar cells

1993 • 57 citations

Excitatory amino acid‐induced slow biphasic responses of free intracellular calcium in human neuroblastoma cells

1993 • 56 citations

Distribution of distinct arachidonoyl-specific and non-specific isoenzymes of diacylglycerol kinase in baboon (Papio cynocephalus) tissues

1990 • 51 citations

Calcium influx in induced differentiation of murine erythroleukemia cells

1993 • 50 citations

Sphingosine activates cellular diacylglycerol kinase in intact Jurkat cells, a human T-cell line

1993 • 47 citations

Sphingosine Is Endogenous to Cardiac and Skeletal Muscle

1993 • 44 citations

Sphingolipid-gated Ca2+ Release from Intracellular Stores of Endothelial Cells Is Mediated by a Novel Ca2+-permeable Channel

1995 • 41 citations

Regulation by sphingomyelinase and sphingosine of Ca2+ signals elicited by CD3 monoclonal antibody, thapsigargin, or ionomycin in the Jurkat T cell line.

1994 • 41 citations

EFFECTS OF TRAUMA ON IMMUNE CELL FUNCTION

1994 • 38 citations

Regulation of phospholipase D by sphingosine involves both protein kinase C-dependent and -independent mechanisms in NIH 3T3 fibroblasts

1992 • 37 citations

Regulation of phospholipase Cδ activity by sphingomyelin and sphingosine

1992 • 36 citations

Intracellular Ca²⁺ stores of T lymphocytes: Changes induced by in vitro and in vivo activation

1994 • 35 citations

Effect of sphingosine derivatives on calcium fluxes in thyroid FRTL-5 cells

1994 • 33 citations

Ca2+ entry in T cells is activated by emptying the inositol 1,4,5-trisphosphate sensitive Ca2+ pool

1990 • 33 citations

Regulation of calcium influx across the plasma membrane of the human T-leukemic cell line, JURKAT: Dependence on a rise in cytosolic free calcium can be dissociated from formation of inositol phosphates

1990 • 28 citations

Sphingosine stimulates calcium mobilization in rat parotid acinar cells

1991 • 27 citations

Sphingosine mobilizes intracellular calcium in human neutrophils

1993 • 26 citations

Sphingosine enhances platelet aggregation through an increase in phospholipase C activity by a protein kinase C-independent mechanism

1992 • 22 citations

A phosphatidic acid-sensitive intracellular pool of calcium is released by anti-CD3 in Jurkat T cells.

1991 • 20 citations

Sphingosine increases inositol trisphosphate in rat parotid acinar cells by a mechanism that is independent of protein kinase C but dependent on extracellular calcium

1990 • 16 citations

β-Adrenergic receptor-mediated calcium mobilization in the human Jurkat T cell line

1995 • 11 citations

Regulation of phosphoinositide hydrolysis in cultured astrocytes by sphingosine and psychosine

1992 • 11 citations

Inventory of Exogenous Factors Affecting Platelet Aggregation Isolated from Plant Sources

1994 • 7 citations

The role of increased calcium influx rate in receptor mediated function of differentiating HL-60 cells

1990 • 6 citations