The Cellular Trafficking and Zinc Dependence of Secretory and Lysosomal Sphingomyelinase, Two Products of the Acid Sphingomyelinase Gene

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

1959 • 47,127 citations

The Metabolic Basis of Inherited Disease.

1983 • 2,885 citations

Zinc coordination, function, and structure of zinc enzymes and other proteins

1990 • 1,731 citations

The Response-to-Retention Hypothesis of Early Atherogenesis

1995 • 1,365 citations

Endocytosis

1997 • 1,263 citations

Functions of Sphingolipids and Sphingolipid Breakdown Products in Cellular Regulation

1989 • 1,251 citations

Acid Sphingomyelinase–Deficient Human Lymphoblasts and Mice Are Defective in Radiation-Induced Apoptosis

1996 • 795 citations

Functional dichotomy of neutral and acidic sphingomyelinases in tumor necrosis factor signaling

1994 • 726 citations

A critical physiological role of zinc in the structure and function of biomembranes

1981 • 635 citations

Apoptotic signaling through CD95 (Fas/Apo-1) activates an acidic sphingomyelinase.

1994 • 582 citations

Trafficking of lysosomal enzymes ¹

1987 • 497 citations

Acid sphingomyelinase deficient mice: a model of types A and B Niemann–Pick disease

1995 • 469 citations

An update of the enzymology and regulation of sphingomyelin metabolism

1990 • 460 citations

High-resolution (1.5 Å) crystal structure of phospholipase C from Bacillus cereus

1989 • 451 citations

Lipopolysaccharide Induces Disseminated Endothelial Apoptosis Requiring Ceramide Generation

1997 • 406 citations

Enhanced macrophage uptake of low density lipoprotein after self-aggregation.

1988 • 371 citations

Rabbit aorta and human atherosclerotic lesions hydrolyze the sphingomyelin of retained low-density lipoprotein. Proposed role for arterial-wall sphingomyelinase in subendothelial retention and aggregation of atherogenic lipoproteins.

1996 • 326 citations

Depletion of plasma-membrane sphingomyelin rapidly alters the distribution of cholesterol between plasma membranes and intracellular cholesterol pools in cultured fibroblasts

1988 • 323 citations

Secretory Sphingomyelinase, a Product of the Acid Sphingomyelinase Gene, Can Hydrolyze Atherogenic Lipoproteins at Neutral pH

1998 • 313 citations

Sphingomyelinase in normal human spleens and in spleens from subjects with Niemann-Pick disease

1967 • 302 citations

Multiple pathways originate at the Fas/APO-1 (CD95) receptor: sequential involvement of phosphatidylcholine-specific phospholipase C and acidic sphingomyelinase in the propagation of the apoptotic signal.

1995 • 295 citations

The glutathione redox couple modulates zinc transfer from metallothionein to zinc-depleted sorbitol dehydrogenase

1998 • 291 citations

Sphingomyelin and derivatives as cellular signals

1991 • 275 citations

Zn2+-stimulated Sphingomyelinase Is Secreted by Many Cell Types and Is a Product of the Acid Sphingomyelinase Gene

1996 • 274 citations

Cloned mammalian neutral sphingomyelinase: Functions in sphingolipid signaling?

1998 • 267 citations

Human Vascular Endothelial Cells Are a Rich and Regulatable Source of Secretory Sphingomyelinase

1998 • 267 citations

The spectrum of anionic oligosaccharides released by endo-beta-N-acetylglucosaminidase H from glycoproteins. Structural studies and interactions with the phosphomannosyl receptor.

1983 • 244 citations

Development of the Lipid-Rich Core in Human Atherosclerosis

1996 • 229 citations

Collagenases and tissue inhibitors of metalloproteinases: a functional balance in tissue degradation

1996 • 224 citations

Inflammatory mediators in demyelinating disorders of the CNS and PNS

1992 • 213 citations

Human acid sphingomyelinase. Isolation, nucleotide sequence and expression of the full-length and alternatively spliced cDNAs

1991 • 210 citations

Sphingomyelinase Treatment Induces ATP-independent Endocytosis

1998 • 204 citations

Phagocytic activity of macrophages and microglial cells during the course of acute and chronic relapsing experimental autoimmune encephalomyelitis

1994 • 202 citations

Lipid composition and fluidity of the human immunodeficiency virus.

1988 • 201 citations

Phagocytosis of aggregated lipoprotein by macrophages: low density lipoprotein receptor-dependent foam-cell formation.

1989 • 200 citations

Metalloproteinase Activity Secreted by Fibrogenic Cells in the Processing of Prolysyl Oxidase

1996 • 183 citations

Lipoprotein lipase and sphingomyelinase synergistically enhance the association of atherogenic lipoproteins with smooth muscle cells and extracellular matrix. A possible mechanism for low density lipoprotein and lipoprotein(a) retention and macrophage foam cell formation.

1993 • 179 citations

Lipid accumulation in rabbit aortic intima 2 hours after bolus infusion of low density lipoprotein. A deep-etch and immunolocalization study of ultrarapidly frozen tissue.

1991 • 177 citations

Sphingomyelinase activity at pH 7.4 in human brain and a comparison to activity at pH 5.0

1976 • 173 citations

The dithizone, Timm's sulphide silver and the selenium methods demonstrate a chelatable pool of zinc in CNS

1985 • 171 citations

Distribution of newly synthesized lysosomal enzymes in the endocytic pathway of normal rat kidney cells.

1991 • 164 citations

Sphingomyelinase enhances low density lipoprotein uptake and ability to induce cholesteryl ester accumulation in macrophages.

1991 • 161 citations

Theearly andlate processing of lysosomal enzymes: Proteolysis and compartmentation

1992 • 160 citations

Zinc interactions and conserved motifs of the cGMP-binding cGMP-specific phosphodiesterase suggest that it is a zinc hydrolase.

1994 • 155 citations

The Distal Pathway of Lipoprotein-induced Cholesterol Esterification, but Not Sphingomyelinase-induced Cholesterol Esterification, Is Energy-dependent

1996 • 137 citations

Overexpression of human alpha-galactosidase A results in its intracellular aggregation, crystallization in lysosomes, and selective secretion.

1992 • 135 citations

The Phospholipid Composition of Extracellular Herpes Simplex Virions Differs from That of Host Cell Nuclei

1994 • 122 citations

A New Zn2+-stimulated Sphingomyelinase in Fetal Bovine Serum

1989 • 111 citations

Niemann-Pick disease: a frequent missense mutation in the acid sphingomyelinase gene of Ashkenazi Jewish type A and B patients.

1991 • 102 citations

The response of central glia to peripheral nerve injury

1993 • 94 citations

Intracellular Zinc Movement and Its Effect on the Carbohydrate Metabolism of Isolated Rat Hepatocytes

1996 • 90 citations

Processing of human acid sphingomyelinase in normal and I-cell fibroblasts.

1994 • 90 citations

Lipoproteins Containing Apo B Extracted from Human Aortas Structure and Function^a

1985 • 80 citations

Expression of human cathepsin D in Xenopus oocytes: phosphorylation and intracellular targeting.

1987 • 73 citations

Regulation of the threshold for lipoprotein-induced acyl-CoA:cholesterol O-acyltransferase stimulation in macrophages by cellular sphingomyelin content.

1994 • 71 citations

Partial synthesis and properties of a series of N-acyl sphingomyelins.

1987 • 68 citations

The metal ion dependence of phospholipase C from Bacillus cereus

1975 • 68 citations

Sphingomyelinase in Pig and Human Epidermis

1978 • 64 citations

Lysosomal enzyme phosphorylation. II. Protein recognition determinants in either lobe of procathepsin D are sufficient for phosphorylation of both the amino and carboxyl lobe oligosaccharides

1992 • 64 citations

Acid hydrolases in early and late endosome fractions from rat liver.

1991 • 58 citations

Purification and characterization of sphingomyelinase from human brain.

1977 • 55 citations

Lysosomal enzyme phosphorylation. I. Protein recognition determinants in both lobes of procathepsin D mediate its interaction with UDP-GlcNAc:lysosomal enzyme N-acetylglucosamine-1-phosphotransferase

1992 • 54 citations

Localization of cholesterol in sphingomyelinase-treated fibroblasts

1995 • 53 citations

The active site of lysosomal sphingomyelinase: Evidence for the involvement of hydrophobic and ionic groups

1983 • 51 citations

Macrophage uptake of cholesterol-containing particles derived from LDL and isolated from atherosclerotic lesions

1990 • 51 citations

Functional Analysis of the Glycosylation of Murine Acid Sphingomyelinase

1996 • 42 citations

The Phosphorylation of Bovine DNase I Asn-linked Oligosaccharides Is Dependent on Specific Lysine and Arginine Residues

1997 • 40 citations

A Novel Mutagenesis Strategy Identifies Distantly Spaced Amino Acid Sequences That Are Required for the Phosphorylation of Both the Oligosaccharides of Procathepsin D by N-Acetylglucosamine 1-Phosphotransferase

1995 • 39 citations

Fluorine-, pyrene-, and nitroxide-labeled sphingomyelin: semi-synthesis and thermotropic properties.

1985 • 39 citations

Involvement of Tissue Inhibitors of Metalloproteinases (TIMPS) During Matrix Metalloproteinase Activation

1996 • 38 citations

Caenorhabditis elegansContains Two Distinct Acid Sphingomyelinases

1998 • 35 citations

The tumor promoter tetradecanoylphorbol-13-acetate elicits the redistribution of heavy metals in subcellular fractions of rabbit thymocytes as measured by plasma emission spectroscopy

1987 • 35 citations

Microbial Endoglycosidases for Analyses of Oligosaccharide Chains in Glycoproteins1

1994 • 32 citations

Purification and Cloning of Carp Nephrosin, a Secreted Zinc Endopeptidase of the Astacin Family

1997 • 28 citations

Cholesterol esterification as a limiting factor in accumulation of cell cholesterol: a comparison of two J774 macrophage cell lines

1989 • 18 citations

Partial purification and properties of acid sphingomyelinase from rat liver.

1983 • 17 citations

Apolipoprotein E Expression in Y1 Adrenal Cells Is Associated with Increased Intracellular Cholesterol Content and Reduced Free Cholesterol Efflux

1994 • 17 citations

Sphingomyelinases in human tissues. IV. Purification of sphingomyelinase from human placenta and effect of Triton X-100

1978 • 15 citations

Purification of Carboxypeptidase B by Zinc Chelate Chromatography

1989 • 7 citations