Bcl-2 and the Outer Mitochondrial Membrane in the Inactivation of Cytochrome c during Fas-mediated Apoptosis

Induction of Apoptotic Program in Cell-Free Extracts: Requirement for dATP and Cytochrome c

1996 • 5,133 citations

Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria Blocked

1997 • 4,921 citations

The Release of Cytochrome c from Mitochondria: A Primary Site for Bcl-2 Regulation of Apoptosis

1997 • 4,728 citations

X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death

1996 • 1,456 citations

Mitochondrial control of nuclear apoptosis.

1996 • 1,363 citations

Protease activation during apoptosis: Death by a thousand cuts?

1995 • 1,335 citations

Bcl-2 inhibits the mitochondrial release of an apoptogenic protease.

1996 • 1,143 citations

The biochemistry of programmed cell death

1995 • 997 citations

Mitochondrial permeability transition is a central coordinating event of apoptosis.

1996 • 857 citations

Bcl-xL forms an ion channel in synthetic lipid membranes

1997 • 817 citations

Appendix—Spectrum of horse-heart cytochrome c

1959 • 802 citations

Cell-free apoptosis in Xenopus egg extracts: Inhibition by Bcl-2 and requirement for an organelle fraction enriched in mitochondria

1994 • 577 citations

Apoptosis induced in Jurkat cells by several agents is preceded by intracellular acidification.

1996 • 488 citations

Targeting of Bcl-2 to the mitochondrial outer membrane by a COOH-terminal signal anchor sequence.

1993 • 390 citations

Formation of free nitric oxide from l-arginine by nitric oxide synthase: direct enhancement of generation by superoxide dismutase.

1994 • 247 citations

The protein product of the oncogene bcl-2 is a component of the nuclear envelope, the endoplasmic reticulum, and the outer mitochondrial membrane.

1994 • 233 citations

Loss of Function of Cytochrome c in Jurkat Cells Undergoing Fas-mediated Apoptosis

1996 • 225 citations

Events in Apoptosis

1996 • 109 citations

Regulation of manganese superoxide dismutase and other antioxidant genes in normal and leukemic hematopoietic cells and their relationship to cytotoxicity by tumor necrosis factor

1993 • 63 citations

The outer mitochondrial membrane channel, VDAC, is modulated by a protein localized in the intermembrane space

1993 • 58 citations

Regulation of manganese superoxide dismutase and other antioxidant genes in normal and leukemic hematopoietic cells and their relationship to cytotoxicity by tumor necrosis factor

1993 • 52 citations