(1S,2R)-D-erythro-2-(N-Myristoylamino)-1-phenyl-1-propanol as an Inhibitor of Ceramidase

Programmed Cell Death Induced by Ceramide

1993 • 1,779 citations

Glycosphingolipids in Cellular Interaction, Differentiation, and Oncogenesis

1981 • 1,650 citations

The sphingomyelin cycle and the second messenger function of ceramide.

1994 • 1,255 citations

Sphingosine inhibition of protein kinase C activity and of phorbol dibutyrate binding in vitro and in human platelets.

1986 • 1,150 citations

Inhibition of sphingolipid biosynthesis by fumonisins. Implications for diseases associated with Fusarium moniliforme

1991 • 1,094 citations

Ceramide activates heterotrimeric protein phosphatase 2A

1993 • 657 citations

Sphingomyelin turnover induced by vitamin D3 in HL-60 cells

1989 • 629 citations

Ceramide: an intracellular signal for apoptosis

1995 • 604 citations

Activation of the Sphingomyelin Cycle Through the Low-Affinity Neurotrophin Receptor

1994 • 583 citations

Role for Ceramide in Cell Cycle Arrest

1995 • 488 citations

Role of ceramide as a lipid mediator of 1 alpha,25-dihydroxyvitamin D3-induced HL-60 cell differentiation.

1990 • 476 citations

An update of the enzymology and regulation of sphingomyelin metabolism

1990 • 460 citations

Sphingosine-1-phosphate: a platelet-activating sphingolipid released from agonist-stimulated human platelets

1995 • 435 citations

Activation of the Sphingomyelin Signaling Pathway in Intact EL4 Cells and in a Cell-Free System By IL-1β

1993 • 433 citations

Tumor Necrosis Factor-α Activates the Sphingomyelin Signal Transduction Pathway in a Cell-Free System

1992 • 428 citations

Ceramide stimulates a cytosolic protein phosphatase.

1992 • 406 citations

Role for ceramide as an endogenous mediator of Fas-induced cytotoxicity.

1995 • 323 citations

Ganglioside metabolism. Enzymology, Topology, and regulation.

1993 • 310 citations

Inhibition of phorbol ester-dependent differentiation of human promyelocytic leukemic (HL-60) cells by sphinganine and other long-chain bases.

1986 • 307 citations

Selectivity of ceramide-mediated biology. Lack of activity of erythro-dihydroceramide.

1993 • 305 citations

Role of ceramide-activated protein phosphatase in ceramide-mediated signal transduction.

1994 • 288 citations

Interleukin-1-mediated PGE2 production and sphingomyelin metabolism. Evidence for the regulation of cyclooxygenase gene expression by sphingosine and ceramide.

1992 • 272 citations

Structural requirements for long-chain (sphingoid) base inhibition of protein kinase C in vitro and for the cellular effects of these compounds

1989 • 247 citations

Crosstalk among multiple signal-activated phospholipases

1992 • 241 citations

Retinoblastoma gene product as a downstream target for a ceramide-dependent pathway of growth arrest.

1995 • 226 citations

Synthesis of <scp>D</scp>‐Erythro‐ and <scp>D</scp>‐Threo‐Sphingosine Derivatives From <scp>L</scp>‐Serine

1988 • 224 citations

Differential Regulation of Sphingomyelinase and Ceramidase Activities by Growth Factors and Cytokines

1995 • 222 citations

Purification, Characterization, and Biosynthesis of Human Acid Ceramidase

1995 • 209 citations

Cell-permeable ceramides inhibit the stimulation of DNA synthesis and phospholipase D activity by phosphatidate and lysophosphatidate in rat fibroblasts.

1994 • 188 citations

Ceramidase and ceramide synthesis in human kidney and cerebellum

1975 • 183 citations

Identification of a distinct pool of sphingomyelin involved in the sphingomyelin cycle.

1994 • 174 citations

Ceramide: a signal for apoptosis or mitogenesis?

1995 • 173 citations

Cell Cycle Arrest Induced by an Inhibitor of Glucosylceramide Synthase

1995 • 165 citations

Improved Inhibitors of Glucosylceramide Synthase1

1992 • 149 citations

Ceramide-mediated growth inhibition and CAPP are conserved in Saccharomyces cerevisiae

1993 • 149 citations

A stereodivergent synthesis of D-erythro-sphingosine and D-threo-sphingosine from L-serine

1988 • 142 citations

Evidence That Ceramide Selectively Inhibits Protein Kinase C-α Translocation and Modulates Bradykinin Activation of Phospholipase D

1995 • 139 citations

Activation of phospholipase D by sphingoid bases in NG108-15 neural-derived cells.

1990 • 134 citations

Ceramide stimulates epidermal growth factor receptor phosphorylation in A431 human epidermoid carcinoma cells. Evidence that ceramide may mediate sphingosine action

1991 • 134 citations

Ceramide Mediates the Apoptotic Response of WEHI 231 Cells to Anti-immunoglobulin, Corticosteroids and Irradiation

1994 • 129 citations

Ceramide-mediated biology. Determination of structural and stereospecific requirements through the use of N-acyl-phenylaminoalcohol analogs.

1992 • 121 citations

A stereoselective synthesis of sphingosine, a protein kinase c inhibitor.

1988 • 119 citations

Identification of a defect in the phospholipase D/diacylglycerol pathway in cellular senescence

1994 • 117 citations

Free Sphingosine Formation from Endogenous Substrates by a Liver Plasma Membrane System with a Divalent Cation Dependence and a Neutral pH Optimum

1989 • 102 citations

Inhibition of experimental metastasis of murine Lewis lung carcinoma by an inhibitor of glucosylceramide synthase and its possible mechanism of action.

1990 • 99 citations

Modulation of cell growth and differentiation by ceramide

1992 • 99 citations

Effects of D‐threo‐PDMP, an inhibitor of glucosylceramide synthetase, on expression of cell surface glycolipid antigen and binding to adhesive proteins by B16 melanoma cells

1989 • 99 citations

Retinoblastoma protein dephosphorylation induced by D-erythro-sphingosine.

1992 • 82 citations

Ceramide induces interleukin 6 gene expression in human fibroblasts.

1995 • 81 citations

[51] Enzymes of ceramide biosynthesis

1992 • 81 citations

Ceramide regulates oxidant release in adherent human neutrophils

1994 • 77 citations

BIOCHEMISTRY OF THE SPHINGOLIPIDES

1956 • 73 citations

[26] Use of sphingosine as inhibitor of protein kinase C

1991 • 66 citations

Tumor necrosis factor α stimulates sphingomyelinase through the 55 kDa receptor in HL‐60 cells

1992 • 61 citations

Glycolipid depletion using a ceramide analogue (PDMP) alters growth, adhesion, and membrane lipid organization in human A431 cells

1992 • 58 citations

Acid and alkaline ceramidases of rat tissues

1986 • 57 citations

Ceramidase activity in porcine epidermis

1990 • 55 citations

Role of lysosomal acid ceramidase in the metabolism of ceramide in human skin fibroblasts

1981 • 54 citations

Ceramide: A Potential Second Messenger in the Nervous System

1995 • 49 citations

Effects of an Inhibitor of Glucosylceramide Synthase on Glycosphingolipid Synthesis and Neurite Outgrowth in Murine Neuroblastoma Cell Lines1

1991 • 45 citations

Sphingosine-1-phosphate, a novel second messenger involved in cell growth regulation and signal transduction, affects growth and invasiveness of human breast cancer cells

1994 • 42 citations

Stereoselectivity of Induction of the Retinoblastoma Gene Product (pRb) Dephosphorylation by D-erythro-Sphingosine Supports a Role for pRb in Growth Suppression by Sphingosine

1995 • 42 citations

Ceramide: A New Lipid “Second Messenger”?

2009 • 39 citations

Chemistry and biochemistry of sphingosine bases

1973 • 31 citations

Preferential inhibition of phorbol ester‐induced hydrolysis of phosphatidylethanolamine by N‐acetylsphingosine in NIH 3T3 fibroblasts

1995 • 13 citations

Selective inhibition by 4-hydroxynonenal of sphingosine-stimulated phospholipase D in NIH 3T3 cells

1992 • 12 citations

[25] Ceramidase from rat brain

1969 • 7 citations