Caspase-mediated Cleavage of the Ubiquitin-protein Ligase Nedd4 during Apoptosis

[19] Rapid and efficient site-specific mutagenesis without phenotypic selection

1987 • 5,413 citations

Efficient selection for high-expression transfectants with a novel eukaryotic vector

1991 • 5,120 citations

Caspases: the executioners of apoptosis

1997 • 4,674 citations

Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

1995 • 4,003 citations

Caspases: killer proteases

1997 • 2,440 citations

Yama/CPP32β, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase

1995 • 2,402 citations

A Combinatorial Approach Defines Specificities of Members of the Caspase Family and Granzyme B

1997 • 2,054 citations

DFF, a Heterodimeric Protein That Functions Downstream of Caspase-3 to Trigger DNA Fragmentation during Apoptosis

1997 • 1,848 citations

Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosis

1998 • 1,651 citations

Conversion of Bcl-2 to a Bax-like Death Effector by Caspases

1997 • 1,116 citations

Induction of endonucleolytic DNA cleavage in human acute myelogenous leukemia cells by etoposide, camptothecin, and other cytotoxic anticancer drugs: a cautionary note.

1989 • 937 citations

WW domains of Nedd4 bind to the proline-rich PY motifs in the epithelial Na+ channel deleted in Liddle's syndrome.

1996 • 828 citations

Membrane and Morphological Changes in Apoptotic Cells Regulated by Caspase-Mediated Activation of PAK2

1997 • 742 citations

Proteolytic activation of protein kinase C delta by an ICE-like protease in apoptotic cells.

1995 • 684 citations

Apopain/CPP32 cleaves proteins that are essential for cellular repair: a fundamental principle of apoptotic death.

1996 • 621 citations

Induction of apoptosis by the mouse Nedd2 gene, which encodes a protein similar to the product of the Caenorhabditis elegans cell death gene ced-3 and the mammalian IL-1 beta-converting enzyme.

1994 • 596 citations

Cleavage of huntingtin by apopain, a proapoptotic cysteine protease, is modulated by the polyglutamine tract

1996 • 580 citations

Proteolysis of Fodrin (Non-erythroid Spectrin) during Apoptosis

1995 • 539 citations

Identification of a set of genes with developmentally down-regulated expression in the mouse brain

1992 • 537 citations

Cleavage of lamin A by Mch2 alpha but not CPP32: multiple interleukin 1 beta-converting enzyme-related proteases with distinct substrate recognition properties are active in apoptosis.

1996 • 529 citations

The Regulation of Anoikis: MEKK-1 Activation Requires Cleavage by Caspases

1997 • 507 citations

The CED-3/ICE-like Protease Mch2 Is Activated during Apoptosis and Cleaves the Death Substrate Lamin A

1996 • 466 citations

Specific cleavage of the 70-kDa protein component of the U1 small nuclear ribonucleoprotein is a characteristic biochemical feature of apoptotic cell death.

1994 • 424 citations

GTPase cascades choreographing cellular behavior: Movement, morphogenesis, and more

1995 • 394 citations

ICE-like proteases in apoptosis

1995 • 353 citations

DNA-dependent protein kinase catalytic subunit: a target for an ICE-like protease in apoptosis.

1996 • 351 citations

Cleavage of Focal Adhesion Kinase by Caspases during Apoptosis

1997 • 338 citations

Cleavage of sterol regulatory element binding proteins (SREBPs) by CPP32 during apoptosis.

1996 • 318 citations

Microfilament reorganization during apoptosis: the role of Gas2, a possible substrate for ICE-like proteases.

1995 • 265 citations

Specific cleavage of the retinoblastoma protein by an ICE-like protease in apoptosis.

1996 • 247 citations

D4-GDI, a Substrate of CPP32, Is Proteolyzed during Fas-induced Apoptosis

1996 • 216 citations

The C2 Domain of the Ubiquitin Protein Ligase Nedd4 Mediates Ca2+-dependent Plasma Membrane Localization

1997 • 199 citations

Degradation of Retinoblastoma Protein in Tumor Necrosis Factor- and CD95-induced Cell Death

1997 • 170 citations

The ICE family of cysteine proteases as effectors of cell death.

1996 • 158 citations

cDNA Cloning, Expression Analysis, and Mapping of the MouseNedd4Gene

1997 • 142 citations

Functional Activation of Nedd2/ICH-1 (Caspase-2) Is an Early Process in Apoptosis

1997 • 142 citations

Role of multiple cellular proteases in the execution of programmed cell death

1995 • 141 citations

Cleavage of PITSLRE Kinases by ICE/CASP-1 and CPP32/CASP-3 during Apoptosis Induced by Tumor Necrosis Factor

1997 • 138 citations

Targeted proteolysis of the focal adhesion kinase pp125 FAK during c-MYC-induced apoptosis is suppressed by integrin signalling.

1996 • 128 citations

Heteronuclear Ribonucleoproteins C1 and C2, Components of the Spliceosome, Are Specific Targets of Interleukin 1β-converting Enzyme-like Proteases in Apoptosis

1996 • 127 citations

Dimerization and Autoprocessing of the Nedd2 (Caspase-2) Precursor Requires both the Prodomain and the Carboxyl-terminal Regions

1998 • 114 citations

Identification of the MDM2 Oncoprotein as a Substrate for CPP32-like Apoptotic Proteases

1997 • 103 citations

Subcellular Localization and Ubiquitin-conjugating Enzyme (E2) Interactions of Mammalian HECT Family Ubiquitin Protein Ligases

1997 • 86 citations

Immunolocalization of the ubiquitin-protein ligase Nedd4 in tissues expressing the epithelial Na+ channel (ENaC)

1997 • 85 citations

Interaction of WW Domains with Hematopoietic Transcription Factor p45/NF-E2 and RNA Polymerase II

1997 • 62 citations

Specific Cleavage of the Large Subunit of Replication Factor C in Apoptosis Is Mediated by CPP32-like Protease

1997 • 18 citations

Expression of p53, bcl-2, bax, bcl-x2 and c-myc in radiation-induced apoptosis in Burkitt's lymphoma cells.

1996 • 15 citations