Keratinocyte differentiation is induced by cell-permeant ceramides and its proliferation is promoted by sphingosine

A simple, rapid, and sensitive DNA assay procedure

1980 • 5,006 citations

Programmed Cell Death Induced by Ceramide

1993 • 1,779 citations

Functions of Sphingolipids and Sphingolipid Breakdown Products in Cellular Regulation

1989 • 1,251 citations

Physiology, Biochemistry, and Molecular Biology of the Skin

1992 • 791 citations

Sphingomyelin turnover induced by vitamin D3 in HL-60 cells

1989 • 629 citations

Identification of sphingomyelin turnover as an effector mechanism for the action of tumor necrosis factor alpha and gamma-interferon. Specific role in cell differentiation.

1991 • 621 citations

Role of ceramide as a lipid mediator of 1 alpha,25-dihydroxyvitamin D3-induced HL-60 cell differentiation.

1990 • 476 citations

Physiology, biochemistry, and molecular biology of the skin

1991 • 434 citations

Activation of the Sphingomyelin Signaling Pathway in Intact EL4 Cells and in a Cell-Free System By IL-1β

1993 • 433 citations

Tumor Necrosis Factor-α Activates the Sphingomyelin Signal Transduction Pathway in a Cell-Free System

1992 • 428 citations

Cell Death by Apoptosis in Epidermal Biology

1993 • 296 citations

Modulation of protein kinase C and diverse cell functions by sphingosine — a pharmacologically interesting compound linking sphingolipids and signal transduction

1989 • 281 citations

Lipid composition and metabolism in normal and diseased epidermis

1981 • 261 citations

Coordinate changes in gene expression which mark the spinous to granular cell transition in epidermis are regulated by protein kinase C.

1993 • 256 citations

Structural requirements for long-chain (sphingoid) base inhibition of protein kinase C in vitro and for the cellular effects of these compounds

1989 • 247 citations

Sphingosine stimulates cellular proliferation via a protein kinase C-independent pathway.

1990 • 230 citations

Chemistry and Metabolism of Sphingolipids. 3-Oxo Derivatives of N-Acetylsphingosine and N-Acetyldihydrosphingosine

1966 • 185 citations

Biochemical and morphological characterization of growth and differentiation of normal human neonatal keratinocytes in a serum‐free medium

1988 • 174 citations

Regulation of the epidermal growth factor receptor phosphorylation state by sphingosine in A431 human epidermoid carcinoma cells.

1988 • 151 citations

Glycosphingolipids and Ceramides in Human and Pig Epidermis

1978 • 130 citations

Sphingomyelinase and cell-permeable ceramide analogs stimulate cellular proliferation in quiescent Swiss 3T3 fibroblasts.

1992 • 128 citations

Ceramide-mediated biology. Determination of structural and stereospecific requirements through the use of N-acyl-phenylaminoalcohol analogs.

1992 • 121 citations

A specific enhancing effect of N,N-dimethylsphingosine on epidermal growth factor receptor autophosphorylation. Demonstration of its endogenous occurrence (and the virtual absence of unsubstituted sphingosine) in human epidermoid carcinoma A431 cells.

1990 • 115 citations

Modulation of cell growth and differentiation by ceramide

1992 • 99 citations

Effects of Pemphigus Antibody on the Regeneration of Cell-Cell Contact in Keratinocyte Cultures grown in Low to Normal Ca+ + Concentration

1987 • 86 citations

[59a] Fibrinoligase

1970 • 83 citations

The Croonian Lecture, 1988 - Inositol lipids and calcium signalling

1988 • 81 citations

Free Sphingosine in Human Epidermis

1990 • 68 citations

Sphingomyelinase in Pig and Human Epidermis

1978 • 64 citations

Protein Kinase C in Normal Human Epidermal Keratinocytes During Proliferation and Calcium-Induced Differentiation

1992 • 64 citations

Plasma membrane transglutaminase and cornified envelope competence in cultured human keratinocytes

1985 • 59 citations

Free sphingosines in porcine epidermis

1989 • 53 citations

Activation of keratinization of keratinocytes from fetal rat skin with N-(O-linoleoyl) ω-hydroxy fatty acyl sphingosyl glucose (lipokeratinogenoside) as a marker of epidermis

1990 • 22 citations

Composition of Free Long-Chain (Sphingoid) Bases in Stratum Corneum of Normal and Pathologic Human Skin Conditions

1992 • 20 citations

Lipid Modulators of Epidermal Proliferation and Differentiation

1991 • 10 citations