Differential Regulation of Sphingomyelinase and Ceramidase Activities by Growth Factors and Cytokines

Sphingosine-1-phosphate as second messenger in cell proliferation induced by PDGF and FCS mitogens

1993 • 879 citations

Sphingomyelin turnover induced by vitamin D3 in HL-60 cells

1989 • 629 citations

Identification of sphingomyelin turnover as an effector mechanism for the action of tumor necrosis factor alpha and gamma-interferon. Specific role in cell differentiation.

1991 • 621 citations

Endothelin stimulates phospholipase C, Na+/H+ exchange, c-fos expression, and mitogenesis in rat mesangial cells.

1989 • 561 citations

Role for Ceramide in Cell Cycle Arrest

1995 • 488 citations

Physiology of the mesangial cell

1989 • 484 citations

Induction of apoptotic DNA damage and cell death by activation of the sphingomyelin pathway.

1994 • 459 citations

Activation of the Sphingomyelin Signaling Pathway in Intact EL4 Cells and in a Cell-Free System By IL-1β

1993 • 433 citations

Tumor Necrosis Factor-α Activates the Sphingomyelin Signal Transduction Pathway in a Cell-Free System

1992 • 428 citations

Intracellular Calcium Release Mediated by Sphingosine Derivatives Generated in Cells

1990 • 391 citations

Identification of arachidonic acid as a mediator of sphingomyelin hydrolysis in response to tumor necrosis factor alpha.

1994 • 340 citations

Sphingosine stimulates cellular proliferation via a protein kinase C-independent pathway.

1990 • 230 citations

Phosphatidic acid that accumulates in platelet-derived growth factor-stimulated Balb/c 3T3 cells is a potential mitogenic signal.

1992 • 195 citations

Ceramidase and ceramide synthesis in human kidney and cerebellum

1975 • 183 citations

Sphingomyelinase activity at pH 7.4 in human brain and a comparison to activity at pH 5.0

1976 • 173 citations

Sphingosine-1-phosphate, a metabolite of sphingosine, increases phosphatidic acid levels by phospholipase D activation

1992 • 154 citations

Interleukin-1 generates transmembrane signals from phospholipids through novel pathways in cultured rat mesangial cells.

1989 • 128 citations

Sphingosine 1-phosphate, a novel signaling molecule, stimulates DNA binding activity of AP-1 in quiescent Swiss 3T3 fibroblasts.

1994 • 86 citations

Differential regulation of fos and jun gene expression and AP-1 cis-element activity by endothelin isopeptides. Possible implications for mitogenic signaling by endothelin.

1992 • 81 citations

PDGF-induced mitogenic signaling is not mediated through protein kinase C and c-fos pathway in VSM cells

1993 • 69 citations

Interleukin-1 and the mesangial cell

1992 • 63 citations

Sphingolipids as mediators of effects of platelet-derived growth factor in vascular smooth muscle cells

1993 • 51 citations

Ceramide and Ganglioside Accumulation in Farber's Lipogranulomatosis.

1967 • 42 citations

Endothelin stimulates phosphatidic acid formation in cultured rat mesangial cells: Role of a protein kinase C‐regulated phospholipase D

1992 • 41 citations

Platelet‐activating factor stimulates multiple signaling pathways in cultured rat mesangial cells

1992 • 33 citations