Synergy between Tumor Necrosis Factor α and Interleukin 1β in Inducing Transcriptional Down-regulation of Muscarinic M2 Receptor Gene Expression

The MAPK signaling cascade

1995 • 3,300 citations

JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

1994 • 3,219 citations

The Transforming Growth Factor-beta Family

1990 • 3,028 citations

The stress-activated protein kinase subfamily of c-Jun kinases

1994 • 2,616 citations

The Biology of Cachectin/TNF -- A Primary Mediator of the Host Response

1989 • 1,679 citations

CYTOKINES: COORDINATORS OF IMMUNE AND INFLAMMATORY RESPONSES

1990 • 1,304 citations

The sphingomyelin cycle and the second messenger function of ceramide.

1994 • 1,255 citations

Interleukin-1 and Its Biologically Related Cytokines

1989 • 1,180 citations

Parallel signal processing among mammalian MAPKs

1995 • 1,015 citations

The sphingomyelin pathway in tumor necrosis factor and interleukin-1 signaling

1994 • 934 citations

Characterization of receptors for human tumour necrosis factor and their regulation by γ-interferon

1985 • 896 citations

Functional dichotomy of neutral and acidic sphingomyelinases in tumor necrosis factor signaling

1994 • 726 citations

Tumor necrosis factor Characterization at the molecular, cellular and in vivo level

1991 • 708 citations

Cytokines, endotoxin, and glucocorticoids regulate the expression of inducible nitric oxide synthase in hepatocytes.

1993 • 671 citations

Cross-coupling of the NF-kappa B p65 and Fos/Jun transcription factors produces potentiated biological function.

1993 • 639 citations

Tumor necrosis factor.

1991 • 568 citations

Tumor necrosis factor alpha and interferon gamma synergistically induce interleukin 8 production in a human gastric cancer cell line through acting concurrently on AP-1 and NF-kB-like binding sites of the interleukin 8 gene.

1992 • 450 citations

Interferon-gamma enhances expression of cellular receptors for tumor necrosis factor.

1986 • 302 citations

Tumor necrosis factor alpha stimulates AP-1 activity through prolonged activation of the c-Jun kinase

1994 • 294 citations

Enhancement of cAMP levels and of protein kinase activity by tumor necrosis factor and interleukin 1 in human fibroblasts: role in the induction of interleukin 6.

1988 • 288 citations

The interleukins ¹

1989 • 276 citations

Interleukin-1-mediated PGE2 production and sphingomyelin metabolism. Evidence for the regulation of cyclooxygenase gene expression by sphingosine and ceramide.

1992 • 272 citations

Marked synergism between tumor necrosis factor-alpha and interferon-gamma in regulation of keratinocyte-derived adhesion molecules and chemotactic factors.

1990 • 261 citations

Muscarinic receptor subtypes in airways

1993 • 254 citations

The interferon-stimulated response element and a kappa B site mediate synergistic induction of murine IP-10 gene transcription by IFN-gamma and TNF-alpha.

1995 • 245 citations

IL-1 and tumor necrosis factor synergistically stimulate fibroblast IL-6 production and stabilize IL-6 messenger RNA.

1990 • 242 citations

Cytokines as Mediators of Chronic Asthma

1994 • 194 citations

A muscarinic agonist inhibits reflex bronchoconstriction in normal but not in asthmatic subjects

1989 • 193 citations

Cyclic AMP--an intracellular second messenger for interleukin 1.

1988 • 182 citations

Ceramide: an endogenous regulator of apoptosis and growth suppresion

1995 • 181 citations

Interleukin 1 and tumor necrosis factor activate common multiple protein kinases in human fibroblasts

1991 • 160 citations

Interleukin 1: more than a mediator between leukocytes

1988 • 120 citations

Interleukin-1β-induced Ceramide and Diacylglycerol Generation 5 Lead to Activation of the c-Jun NH2-terminal Kinase and the Transcription Factor ATF2 in the Insulin-producing Cell Line RINm5F

1996 • 113 citations

Effects of Transforming Growth Factor β and Interleukin-1β on Expression of Cyclooxygenase 1 and 2 and Phospholipase A2 mRNA in Lung Fibroblasts and Endothelial Cells in Culture

1993 • 109 citations

Sphingolipid metabolites differentially regulate extracellular signal-regulated kinase and stress-activated protein kinase cascades

1996 • 106 citations

Inhibition of interleukin-8 expression by dexamethasone in human cultured airway epithelial cells.

1994 • 100 citations

Interleukin-1 represents a new modality for the activation of extracellular signal-regulated kinases/microtubule-associated protein-2 kinases.

1991 • 100 citations

Interleukin-1 activates p54 mitogen-activated protein (MAP) kinase/stress-activated protein kinase by a pathway that is independent of p21ras, Raf-1, and MAP kinase kinase.

1994 • 91 citations

Evidence for prejunctional muscarinic autoreceptors in human and guinea pig trachea.

1995 • 91 citations

Ceramide induces interleukin 6 gene expression in human fibroblasts.

1995 • 81 citations

Mechanisms of impaired beta-adrenoceptor-induced airway relaxation by interleukin-1beta in vivo in the rat.

1996 • 81 citations

Signal transduction pathway for IL-1. Involvement of a pertussis toxin-sensitive GTP-binding protein in the activation of adenylate cyclase.

1989 • 65 citations

Effect of inflammatory cell mediators on M2 muscarinic receptors in the lungs

1993 • 57 citations

Transcriptional Down-regulation of m2 Muscarinic Receptor Gene Expression in Human Embryonic Lung (HEL 299) Cells by Protein Kinase C

1995 • 43 citations

Beta-Adrenoceptor-medicated down-regulation of M2 muscarinic receptors: role of cyclic adenosine 5'-monophosphate-dependent protein kinase and protein kinase C.

1996 • 31 citations

Long‐term carbachol treatment‐induced down‐regulation of muscarinic M₂‐receptors but not m₂ receptor mRNA in a human lung cell line

1995 • 28 citations

Transforming growth factor-beta 1 induces transcriptional down-regulation of m2 muscarinic receptor gene expression.

1996 • 27 citations

Up‐regulation of ICAM‐1 expression on human dermal fibroblasts by IFN β in the presence of TNF‐α

1995 • 6 citations

Deleted Work

1955 • 0 citations