Sphingolipid Transport to the Apical Plasma Membrane Domain in Human Hepatoma Cells Is Controlled by PKC and PKA Activity: A Correlation with Cell Polarity in HepG2 Cells

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

1979 • 54,907 citations

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

1959 • 47,127 citations

Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues

2013 • 47,043 citations

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

1959 • 21,307 citations

A simplification of the protein assay method of Lowry et al. which is more generally applicable

1977 • 8,485 citations

Staurosporine, K-252 and UCN-01: potent but nonspecific inhibitors of protein kinases

1989 • 905 citations

A novel fluorescent ceramide analogue for studying membrane traffic in animal cells: accumulation at the Golgi apparatus results in altered spectral properties of the sphingolipid precursor.

1991 • 478 citations

Sorting of sphingolipids in epithelial (Madin-Darby canine kidney) cells.

1987 • 443 citations

Polarity of Epithelial and Neuronal Cells

1992 • 435 citations

Receptor-mediated transcytosis of IgA in MDCK cells is via apical recycling endosomes.

1994 • 384 citations

Biogenesis of the rat hepatocyte plasma membrane in vivo: comparison of the pathways taken by apical and basolateral proteins using subcellular fractionation.

1987 • 383 citations

Lipid recycling between the plasma membrane and intracellular compartments: transport and metabolism of fluorescent sphingomyelin analogues in cultured fibroblasts.

1989 • 221 citations

Regulation of apical transport in epithelial cells by a Gsclass of heterotrimeric G protein

1993 • 188 citations

Basolateral to apical transcytosis in polarized cells is indirect and involves BFA and trimeric G protein sensitive passage through the apical endosome

1994 • 186 citations

Protein kinase C activators inhibit receptor-mediated potocytosis by preventing internalization of caveolae

1994 • 184 citations

Endocytosis of GPI-anchored proteins in human lymphocytes: role of glycolipid-based domains, actin cytoskeleton, and protein kinases.

1996 • 156 citations

Organization and function of the cytoskeleton in polarized epithelial cells: a component of the protein sorting machinery

1994 • 156 citations

Modulation of the expression of an apical plasma membrane protein of Madin-Darby canine kidney epithelial cells: cell-cell interactions control the appearance of a novel intracellular storage compartment.

1987 • 146 citations

Exocytosis of vacuolar apical compartment (VAC): a cell-cell contact controlled mechanism for the establishment of the apical plasma membrane domain in epithelial cells.

1988 • 145 citations

Gs alpha stimulates transcytosis and apical secretion in MDCK cells through cAMP and protein kinase A.

1994 • 122 citations

5'nucleotidase is sorted to the apical domain of hepatocytes via an indirect route [published erratum appears in J Cell Biol 1993 Nov;123(3):following 767]

1992 • 121 citations

Phorbol myristate acetate-mediated stimulation of transcytosis and apical recycling in MDCK cells

1994 • 114 citations

Vesicle targeting to the apical domain regulates bile excretory function in isolated rat hepatocyte couplets

1995 • 105 citations

Regulation of activity and apical targeting of the Cl-/HCO3- exchanger in rat hepatocytes.

1994 • 99 citations

Bile canaliculus formation in cultured HEPG2 cells.

1993 • 97 citations

Generation of lipid polarity in intestinal epithelial (Caco-2) cells: sphingolipid synthesis in the Golgi complex and sorting before vesicular traffic to the plasma membrane.

1990 • 96 citations

Trafficking of glycosphingolipids in eukaryotic cells; sorting and recycling of lipids

1992 • 96 citations

Segregation of Glucosylceramide and Sphingomyelin Occurs in the Apical to Basolateral Transcytotic Route in HepG2 Cells

1997 • 90 citations

Sorting of sphingolipids in the endocytic pathway of HT29 cells.

1991 • 86 citations

Activators of protein kinase A stimulate apical but not basolateral transport in epithelial Madin-Darby canine kidney cells.

1994 • 77 citations

Selective regulation of apical endocytosis in polarized Madin-Darby canine kidney cells by mastoparan and cAMP

1994 • 75 citations

Possible role of both the alpha and beta gamma subunits of the heterotrimeric G protein, Gs, in transcytosis of the polymeric immunoglobulin receptor.

1993 • 72 citations

DBcAMP stimulates vesicle transport and HRP excretion in isolated perfused rat liver

1990 • 64 citations

The Formation of Bile Canaliculi in Human Hepatoma Cell Lines

1990 • 63 citations

Protein kinase C agonists inhibit bile secretion independently of effects on the microcirculation in the isolated perfused rat liver

1989 • 63 citations

A facile synthesis of ceramides

1975 • 57 citations

Fluorescent choleretic and cholestatic bile salts take different paths across the hepatocyte: transcytosis of glycolithocholate leads to an extensive redistribution of annexin II.

1994 • 57 citations

Phorbol ester-induced scattering of HT-29 human intestinal cancer cells is associated with down-modulation of E-cadherin

1993 • 48 citations

Differential targeting of glucosylceramide and galactosylceramide analogues after synthesis but not during transcytosis in Madin-Darby canine kidney cells.

1995 • 47 citations

Differential Colchicine Effects on the Transport of Membrane and Secretory Proteins in Rat Hepatocytes In Vivo : Bipolar Secretion of Albumin

1992 • 45 citations

Priority targeting of glycosyl-phosphatidylinositol-anchored proteins to the bile-canalicular (apical) plasma membrane of hepatocytes. Involvement of ‘late’ endosomes

1990 • 38 citations

Biosynthesis and intracellular transport of a bile canalicular plasma membrane protein: Studiesin vivo and in the perfused rat liver

1994 • 37 citations

Intracellular sites involved in the biogenesis of bile canaliculi in hepatic cells.

1994 • 33 citations

Cyclic AMP modulates the rate of ‘constitutive’ exocytosis of apical membrane proteins in Madin-Darby canine kidney cells

1995 • 30 citations

Polarized exocytosis in mdck cells is regulated by phosphorylation

1995 • 29 citations

Lipid Transport from the Hepatocyte into the Bile

1994 • 28 citations

Effects of Fetal Calf Serum and Disruption of Cadherin Function on the Formation of Bile Canaliculi between Hepatocytes

1994 • 23 citations

Exocytosis of Vacuolar Apical Compartment (VAC) in Madin-Darby Canine Kidney Epithelial Cells: cAMP Is Involved as Second Messenger

1993 • 22 citations

The tumor promoter 12-O-tetradecanoylphorbol-13-acetate blocks differentiation of HT-29 human colon cancer cells

1993 • 14 citations

Intracellular lumina and bile canaliculi in rat hepatocytes in vitro — a cytochemical study

1989 • 6 citations