Ceramide-Induced Apoptosis Is Mediated by Caspase Activation Independently from Retinoblastoma Protein Post-Translational Modification

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

The retinoblastoma protein and cell cycle control

1995 • 4,873 citations

Caspases: the executioners of apoptosis

1997 • 4,674 citations

Effects of an Rb mutation in the mouse

1992 • 1,779 citations

Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis

1992 • 1,285 citations

Phosphorylation of the retinoblastoma gene product is modulated during the cell cycle and cellular differentiation

1989 • 990 citations

The product of the retinoblastoma susceptibility gene has properties of a cell cycle regulatory element

1989 • 931 citations

Serine/threonine protein phosphatases

1995 • 635 citations

Identification of sphingomyelin turnover as an effector mechanism for the action of tumor necrosis factor alpha and gamma-interferon. Specific role in cell differentiation.

1991 • 621 citations

p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens

1994 • 617 citations

Apoptotic signaling through CD95 (Fas/Apo-1) activates an acidic sphingomyelinase.

1994 • 582 citations

Adhesion-dependent cell cycle progression linked to the expression of cyclin D1, activation of cyclin E-cdk2, and phosphorylation of the retinoblastoma protein.

1996 • 453 citations

Loss of Rb activates both p53-dependent and independent cell death pathways in the developing mouse nervous system.

1996 • 325 citations

Fas-induced Activation of the Cell Death-related Protease CPP32 Is Inhibited by Bcl-2 and by ICE Family Protease Inhibitors

1996 • 321 citations

Bcl-2 interrupts the ceramide-mediated pathway of cell death.

1996 • 302 citations

Inhibition of apoptosis by the retinoblastoma gene product.

1995 • 286 citations

Tissue Transglutaminase and Apoptosis: Sense and Antisense Transfection Studies with Human Neuroblastoma Cells

1994 • 253 citations

Specific cleavage of the retinoblastoma protein by an ICE-like protease in apoptosis.

1996 • 247 citations

Retinoblastoma gene product as a downstream target for a ceramide-dependent pathway of growth arrest.

1995 • 226 citations

Cytokine Response Modifier A (CrmA) Inhibits Ceramide Formation in Response to Tumor Necrosis Factor (TNF)-α: CrmA and Bcl-2 Target Distinct Components in the Apoptotic Pathway

1997 • 210 citations

prICE: a downstream target for ceramide-induced apoptosis and for the inhibitory action of Bcl-2

1996 • 203 citations

Tissue transglutaminase and apoptosis: sense and antisense transfection studies with human neuroblastoma cells.

1994 • 183 citations

Degradation of Retinoblastoma Protein in Tumor Necrosis Factor- and CD95-induced Cell Death

1997 • 170 citations

The Involvement of Protein Phosphatases in the Activation of ICE/CED-3 Protease, Intracellular Acidification, DNA Digestion, and Apoptosis

1996 • 158 citations

Induction of a retinoblastoma phosphatase activity by anticancer drugs accompanies p53-independent G1 arrest and apoptosis.

1995 • 158 citations

Tissue Transglutaminase-Dependent Posttranslational Modification of the Retinoblastoma Gene Product in Promonocytic Cells Undergoing Apoptosis

1997 • 129 citations

Interleukin-1β Induction of Mitogen-activated Protein Kinases in Human Mesangial Cells

1997 • 116 citations

Active Site Amino Acids That Participate in the Catalytic Mechanism of Nucleoside 2′-Deoxyribosyltransferase

1996 • 113 citations

Cell Anchorage Regulates Apoptosis through the Retinoblastoma Tumor Suppressor/E2F Pathway

1997 • 108 citations

Ceramide induces apoptosis in PC12 cells

1997 • 101 citations

Apoptosis is associated with cleavage of a 5 kDa fragment from RB which mimics dephosphorylation and modulates E2F binding

1997 • 79 citations

Retinoblastoma protein inhibits IFN-gamma induced apoptosis.

1996 • 71 citations

Repression of apoptosis in human B-lymphoma cells by CD40-ligand and Bcl-2: relationship to the cell-cycle and role of the retinoblastoma protein.

1996 • 68 citations

Retinoblastoma Protein-dependent Growth Signal Conflict and Caspase Activity Are Required for Protein Kinase C-signaled Apoptosis of Prostate Epithelial Cells

1997 • 58 citations

Fas stimulation induces RB dephosphorylation and proteolysis that is blocked by inhibitors of the ICE protease family

1997 • 47 citations

The human retinoblastoma gene product suppresses ceramide-induced apoptosis in human bladder tumor cells.

1996 • 30 citations